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The starting sildenafil dose was 50 mg, taken 1 hour before sexual activity, with subsequent adjustment to 100 or 25 mg based on efficacy and safety. Men taking nitrate therapy or nitric oxide donors and men with severe cardiac failure, unstable angina, or recent stroke or myocardial infarction were excluded. Efficacy analyses included all subjects with baseline and at least one postrandomization evaluation. Safety analyses included subjects who received study medication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>The International Index of Erectile Function and a global assessment question (\u201cDid the treatment improve your erections?\u201d).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean International Index of Erectile Function scores for question 3 (frequency of penetration), question 4 (maintenance of erections after penetration), and the erectile function domain were statistically significantly improved with sildenafil vs placebo for each age subgroup; orgasmic function, intercourse satisfaction, sexual desire, and overall satisfaction domain scores also were statistically significantly improved with sildenafil vs placebo. The percentage of men reporting improved erections on the global assessment question was statistically significantly higher with sildenafil vs placebo for all age subgroups; the percentage with sildenafil tended to decrease with increasing age (&amp;lt;65 years, 80%; 65\u201374 years, 69%; \u226575 years, 59%). The most common adverse events with sildenafil were headache and flushing in each age subgroup.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sildenafil is an effective and well-tolerated treatment for erectile dysfunction regardless of patient age, including men at least 75 years old.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jsxm.2016.02.166","type":"journal-article","created":{"date-parts":[[2016,4,29]],"date-time":"2016-04-29T15:56:38Z","timestamp":1461945398000},"page":"852-859","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Efficacy and Safety of Sildenafil by Age in Men with Erectile Dysfunction"],"prefix":"10.1093","volume":"13","author":[{"given":"Irwin","family":"Goldstein","sequence":"first","affiliation":[{"name":"San Diego Sexual Medicine , San Diego, CA , USA"},{"name":"Alvarado Hospital , San Diego, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Jung","family":"Tseng","sequence":"additional","affiliation":[{"name":"Pfizer Inc. , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Creanga","sequence":"additional","affiliation":[{"name":"Pfizer Inc. , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Stecher","sequence":"additional","affiliation":[{"name":"Pfizer Inc. , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jed C.","family":"Kaminetsky","sequence":"additional","affiliation":[{"name":"University Urology Associates , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,5,1]]},"reference":[{"key":"2023041406273580900_","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1001\/jama.1993.03510010089036","article-title":"Impotence. 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