{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:54:39Z","timestamp":1770508479237,"version":"3.49.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jsm.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,7,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Hyperuricemia may be related to the development of endothelial dysfunction and cardiovascular diseases. However, the association between hyperuricemia and erectile dysfunction (ED) is not currently clear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>The goal of this study is to investigate the effect of hyperuricemia on erectile function and possible mechanisms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Twenty-four 8-week-old male SD rats were randomly divided into 4 groups. Group A (control): Rats received normal saline and served as controls. Group B (hyperuricemia): rats were given oxonic acid 250 mg\/kg bw\/day through gastric gavage for 4 weeks. Group C (febuxostat): normal rats were treated with 5 mg\/kg febuxostat through gastric gavage for 4 weeks. Group D (hyperuricemia + Febuxostat): normal rats were treated with 250 mg\/kg bw\/day oxonic acid and 5 mg\/kg bw\/day febuxostat with 1 hour interval for 4 weeks.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Measurements<\/jats:title>\n                  <jats:p>The level of serum uric acid, the maximum intracavernosal pressure (ICPmax), mean arterial pressure (MAP), and the expression of endothelial nitric oxide synthase (eNOS), phospho-eNOS, neuronal NOS, Rho-associated protein kinaise (ROCK)1 and ROCK2 and the level of nitric oxide (NO) and reactive oxygen species (ROS) in cavernous tissue were determined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The level of serum uric acid and ROS in hyperuricemic rats was significantly higher than that in the other 3 groups (P &amp;lt; .05). After electrostimulation with 3 and 5 voltage, the ratio of ICPmax\/MAP in hyperuricemic rats was significantly less than that in other 3 groups (P &amp;lt; .05), respectively. eNOS, p-eNOS, and nNOS expression in hyperuricemic rats were significantly decreased compared to the other 3 groups (P &amp;lt; .05), respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Erectile function is impaired by hyperuricemia. The decrease of eNOS, p-eNOS, and nNOS protein expression and increase of ROS in cavernous tissue may be one of the key mechanisms of ED caused by hyperuricemia.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1016\/j.jsxm.2016.04.073","type":"journal-article","created":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T22:43:22Z","timestamp":1463611402000},"page":"1056-1062","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Hyperuricemia Is an Independent Risk Factor for Erectile Dysfunction"],"prefix":"10.1093","volume":"13","author":[{"given":"Hao","family":"Long","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Diseases \u00a0 \u00a0 , Luzhou, , China"},{"name":"Affiliated Hospital \u00a0 \u00a0 , Luzhou, , China"},{"name":"Luzhou Medical College \u00a0 \u00a0 , Luzhou, , 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