{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:01:03Z","timestamp":1790096463868,"version":"4.0.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jsm.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Sexual Medicine"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.jsxm.2016.05.004","type":"journal-article","created":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T11:00:41Z","timestamp":1466074841000},"page":"1125-1132","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":131,"title":["Efficacy and Safety of Gonadotropin-Releasing Hormone Agonist Treatment to Suppress Puberty in Gender Dysphoric Adolescents"],"prefix":"10.1093","volume":"13","author":[{"given":"Sebastian E.E.","family":"Schagen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy T.","family":"Cohen-Kettenis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henriette A.","family":"Delemarre-van de Waal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine E.","family":"Hannema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"10.1016\/j.jsxm.2016.05.004_bib1","first-page":"756","article-title":"Evidence for an altered sex ratio in clinic-referred adolescents with gender dysphoria","volume":"12","author":"Aitken","year":"2015","journal-title":"J\u00a0Sex Med"},{"key":"10.1016\/j.jsxm.2016.05.004_bib2","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.yhbeh.2013.02.020","article-title":"Gender identity development in adolescence","volume":"64","author":"Steensma","year":"2013","journal-title":"Horm Behav"},{"key":"10.1016\/j.jsxm.2016.05.004_bib3","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.1210\/jc.2009-0345","article-title":"Endocrine treatment of transsexual persons: an Endocrine Society clinical practice guideline","volume":"94","author":"Hembree","year":"2009","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.jsxm.2016.05.004_bib4","first-page":"2276","article-title":"Puberty suppression in adolescents with gender identity disorder: a prospective follow-up study","volume":"8","author":"de Vries","year":"2011","journal-title":"J\u00a0Sex Med"},{"key":"10.1016\/j.jsxm.2016.05.004_bib5","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.1530\/eje.1.02231","article-title":"Clinical management of gender identity disorder in adolescents: a protocol on psychological and paediatric endocrinology aspects","volume":"155","author":"Delemarre-van de Waal","year":"2006","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.jsxm.2016.05.004_bib6","doi-asserted-by":"crossref","first-page":"e752","DOI":"10.1542\/peds.2008-1783","article-title":"Consensus statement on the use of gonadotropin-releasing hormone analogs in children","volume":"123","author":"Carel","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.jsxm.2016.05.004_bib7","series-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"2000"},{"key":"10.1016\/j.jsxm.2016.05.004_bib8","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1146\/annurev.me.19.020168.001435","article-title":"Growth and physiological development during adolescence","volume":"19","author":"Marshall","year":"1968","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.jsxm.2016.05.004_bib9","series-title":"Growth at adolescence","author":"Tanner","year":"1962"},{"key":"10.1016\/j.jsxm.2016.05.004_bib10","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/pr.2012.189","article-title":"The world's tallest nation has stopped growing taller: the height of Dutch children from 1955 to 2009","volume":"73","author":"Schonbeck","year":"2013","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jsxm.2016.05.004_bib11","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1136\/bmj.320.7244.1240","article-title":"Establishing a standard definition for child overweight and obesity worldwide: international survey","volume":"320","author":"Cole","year":"2000","journal-title":"BMJ"},{"key":"10.1016\/j.jsxm.2016.05.004_bib12","doi-asserted-by":"crossref","first-page":"823064","DOI":"10.1155\/2013\/823064","article-title":"Male central precocious puberty: serum profile of anti-Mullerian hormone and inhibin B before, during, and after treatment with GnRH analogue","volume":"2013","author":"Grinspon","year":"2013","journal-title":"Int J Endocrinol"},{"key":"10.1016\/j.jsxm.2016.05.004_bib13","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1210\/jcem-67-2-368","article-title":"Resumption of puberty after long term luteinizing hormone-releasing hormone agonist treatment of central precocious puberty","volume":"67","author":"Manasco","year":"1988","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.jsxm.2016.05.004_bib14","first-page":"84","article-title":"Depot gonadotropin-releasing hormone agonist blunts the androgen-induced suppression of spermatogenesis in a clinical trial of male contraception","volume":"74","author":"Behre","year":"1992","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.jsxm.2016.05.004_bib15","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1159\/000442523","article-title":"Assessment of estradiol response after depot triptorelin administration in girls with central precocious puberty","volume":"85","author":"Freire","year":"2016","journal-title":"Horm Res Paediatr"},{"key":"10.1016\/j.jsxm.2016.05.004_bib16","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1210\/jcem.86.5.7439","article-title":"The effect of administering gonadotropin-releasing hormone agonist with recombinant-human growth hormone (GH) on the final height of girls with isolated GH deficiency: results from a controlled study","volume":"86","author":"Saggese","year":"2001","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.jsxm.2016.05.004_bib17","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1210\/jcem-73-4-902","article-title":"The effect of long-acting analog of luteinizing hormone-releasing hormone on growth hormone secretory dynamics in children with precocious puberty","volume":"73","author":"DiMartino-Nardi","year":"1991","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.jsxm.2016.05.004_bib18","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1530\/eje.0.1410027","article-title":"Sexual dimorphism in the maturation of the pituitary-gonadal axis, assessed by GnRH agonist challenge","volume":"141","author":"Potau","year":"1999","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.jsxm.2016.05.004_bib19","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13293-016-0067-9","article-title":"Consecutive lynestrenol and cross-sex hormone treatment in biological female adolescents with gender dysphoria: a retrospective analysis","volume":"7","author":"Tack","year":"2016","journal-title":"Biol Sex Differ"},{"key":"10.1016\/j.jsxm.2016.05.004_bib20","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.jpeds.2013.10.068","article-title":"Clinical management of youth with gender dysphoria in Vancouver","volume":"164","author":"Khatchadourian","year":"2014","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.jsxm.2016.05.004_bib21","doi-asserted-by":"crossref","first-page":"E270","DOI":"10.1210\/jc.2014-2439","article-title":"Bone mass in young adulthood following gonadotropin-releasing hormone analog treatment and cross-sex hormone treatment in adolescents with gender dysphoria","volume":"100","author":"Klink","year":"2015","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.jsxm.2016.05.004_bib22","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1097\/GME.0000000000000430","article-title":"Body composition and bone mineral density after ovarian hormone suppression with or without estradiol treatment","volume":"22","author":"Shea","year":"2015","journal-title":"Menopause"},{"key":"10.1016\/j.jsxm.2016.05.004_bib23","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1210\/jc.2015-4065","article-title":"Acute female hypogonadism alters adipose tissue fatty acid storage factors and chylomicronemia","volume":"101","author":"Santosa","year":"2016","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.jsxm.2016.05.004_bib24","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0015-0282(98)00098-3","article-title":"Pituitary desensitization to gonadotropin-releasing hormone increases abdominal adiposity in hyperandrogenic anovulatory women","volume":"70","author":"Dumesic","year":"1998","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jsxm.2016.05.004_bib25","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1056\/NEJMoa1206168","article-title":"Gonadal steroids and body composition, strength, and sexual function in men","volume":"369","author":"Finkelstein","year":"2013","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jsxm.2016.05.004_bib26","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1210\/jc.2009-0793","article-title":"The efficacy and safety of gonadotropin-releasing hormone analog treatment in childhood and adolescence: a single center, long-term follow-up study","volume":"95","author":"Magiakou","year":"2010","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.jsxm.2016.05.004_bib27","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1210\/jc.2012-2492","article-title":"Bone mineral density and body composition in short children born SGA during growth hormone and gonadotropin releasing hormone analog treatment","volume":"98","author":"Lem","year":"2013","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.jsxm.2016.05.004_bib28","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.jpeds.2008.04.028","article-title":"Interpretation of biomarkers of bone metabolism in children: impact of growth velocity and body size in healthy children and chronic disease","volume":"153","author":"Tuchman","year":"2008","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.jsxm.2016.05.004_bib29","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.psyneuen.2015.03.007","article-title":"Puberty suppression and executive functioning: An fMRI-study in adolescents with gender dysphoria","volume":"56","author":"Staphorsius","year":"2015","journal-title":"Psychoneuroendocrinology"}],"container-title":["The Journal of Sexual Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609516302193?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609516302193?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:58:49Z","timestamp":1753880329000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jsm\/article\/13\/7\/1125\/6940368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S1743609516302193"],"URL":"https:\/\/doi.org\/10.1016\/j.jsxm.2016.05.004","relation":{},"ISSN":["1743-6095"],"issn-type":[{"value":"1743-6095","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and Safety of Gonadotropin-Releasing Hormone Agonist Treatment to Suppress Puberty in Gender Dysphoric Adolescents","name":"articletitle","label":"Article Title"},{"value":"The Journal of Sexual Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsxm.2016.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016, International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}