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Surgical stress or inflammatory changes likely play a role in erectile dysfunction after cavernous nerve injury. However, the efficacy of a tissue sealing sheet for preventing erectile function after nerve-sparing radical prostatectomy remains unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To evaluate the effect of a tissue sealing sheet on erectile dysfunction after cavernous nerve dissection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Male Sprague-Dawley rats were randomly divided into three groups and subjected to sham operation or bilateral cavernous nerve dissection with (sheet group) or without (non-sheet group) a tissue sealing sheet. In the sheet group, cavernous nerves were sealed with a tissue sealing sheet immediately after cavernous nerve dissection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures<\/jats:title>\n                  <jats:p>Erectile function was assessed by measuring intracavernous pressure and arterial pressure during pelvic nerve electrostimulation at 4 weeks after surgery. Expressions of interleukin-6, tumor growth factor-\u03b21, and heme-oxygenase-1 in the major pelvic ganglion were examined by real-time polymerase chain reaction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Mean intracavernous pressure along with mean arterial pressure in the sheet group were similar to those in the sham group and showed a significant positive response compared with the non-sheet group (P &amp;lt; .05). Furthermore, expressions of interleukin-6, tumor growth factor-\u03b21, and heme-oxygenase-1 were significantly lower in the sheet group than in the non-sheet group (P &amp;lt; .05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Use of a tissue sealing sheet attenuated postoperative inflammatory changes and oxidative stress and improved erectile function after cavernous nerve injury in rats. The tissue sealing sheet might become a useful therapeutic approach to preserve erectile function after nerve-sparing radical prostatectomy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1016\/j.jsxm.2016.07.015","type":"journal-article","created":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T19:07:07Z","timestamp":1472152027000},"page":"1448-1454","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of Tissue Sealing Sheet on Erectile Dysfunction in a Rat Model of Nerve-Sparing Radical Prostatectomy"],"prefix":"10.1093","volume":"13","author":[{"given":"Shinichi","family":"Yamashita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Kamiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihide","family":"Kawasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Izumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Kawamorita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Mitsuzuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisanobu","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Kaiho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Urology \u00a0 , Sendai, , Japan"},{"name":"Tohoku University Graduate School of Medicine \u00a0 , Sendai, , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,10,1]]},"reference":[{"key":"2024032602350817400_bib1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/pros.2990040506","article-title":"Radical prostatectomy with preservation of sexual function: anatomical and pathological considerations","volume":"4","author":"Walsh","year":"1983","journal-title":"Prostate"},{"key":"2024032602350817400_bib2","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1097\/01.ju.0000181825.54480.eb","article-title":"Potency following robotic radical prostatectomy: a questionnaire based analysis of outcomes after conventional nerve sparing and prostatic fascia sparing techniques","volume":"174","author":"Menon","year":"2005","journal-title":"J Urol"},{"key":"2024032602350817400_bib3","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.eururo.2011.12.048","article-title":"Anatomic grading of nerve sparing during robot-assisted radical prostatectomy","volume":"61","author":"Schatloff","year":"2012","journal-title":"Eur Urol"},{"key":"2024032602350817400_bib4","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.eururo.2006.05.038","article-title":"Nerve distribution along the prostatic capsule","volume":"51","author":"Eichelberg","year":"2007","journal-title":"Eur Urol"},{"key":"2024032602350817400_bib5","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1097\/01.ju.0000135648.33110.df","article-title":"Anatomical analysis of the neurovascular bundle supplying penile cavernous tissue to ensure a reliable nerve graft after radical prostatectomy","volume":"172","author":"Takenaka","year":"2004","journal-title":"J Urol"},{"key":"2024032602350817400_bib6","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.eururo.2008.09.022","article-title":"Nerves at the ventral prostatic capsule contribute to erectile function: initial electrophysiological assessment in humans","volume":"55","author":"Kaiho","year":"2009","journal-title":"Eur Urol"},{"key":"2024032602350817400_bib7","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1111\/iju.12586","article-title":"Long-term quality of life after radical prostatectomy: 8-year longitudinal study in Japan","volume":"21","author":"Namiki","year":"2014","journal-title":"Int J Urol"},{"key":"2024032602350817400_bib8","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/andr.12060","article-title":"Have rates of erectile dysfunction improved within the past 17 years after radical prostatectomy? 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