{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T10:57:28Z","timestamp":1761994648354,"version":"build-2065373602"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jsm.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Although testosterone deficiency has a well-known association with increased risk of cardiovascular disease (CVD), the threshold remains to be determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate whether there is a discriminatory testosterone level below which the CVD risk increases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 876 men 45 to 74 years old who underwent a general health checkup. The Framingham Risk Score was used to estimate the 10-year CVD risk; a high-sensitivity C-reactive protein (hsCRP) level of at least 1 mg\/L was considered an indicator of increased CVD risk. Aging symptoms and sexual function were evaluated with the Aging Males\u2019 Symptom Scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Locally weighted regression was performed to determine the testosterone threshold for Framingham CVD risk and increased hsCRP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age was 56.6 \u00b1 7.0 years. The mean total testosterone level was 394.3 \u00b1 115.7 ng\/dL. The mean 10-year Framingham CVD risk was 16.6 \u00b1 10.7%, and 169 (19.3%) had increased hsCRP. The locally weighted regression showed that total testosterone levels of 440 and 480 ng\/dL were associated with increased Framingham CVD risk and an increased probability of increased hsCRP, respectively. Men with sexual dysfunction (poor sexual performance, decreased morning erection, and loss of libido) had significantly greater CVD risk. Their risk appeared to increase at a relatively higher testosterone level, and it reached a plateau at a testosterone level of 300 to 350 ng\/dL. In contrast, the risk in those with no or less sexual dysfunction remained low at a higher testosterone level, and a threshold level of 425 to 475 ng\/dL was associated with increased CVD risk. A similar pattern and threshold were identified in the analyses of the relation between testosterone and hsCRP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data showed that a testosterone threshold of 440 ng\/dL was associated with increased Framingham 10-year CVD risk in middle-aged and elderly men. Poor sexual performance, decreased morning erection, and loss of libido had an impact on the testosterone threshold for CVD risk. The threshold level was higher in men with sexual dysfunction. Further study is required to evaluate the validity of these testosterone thresholds for CVD risk.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jsxm.2016.10.002","type":"journal-article","created":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T15:45:40Z","timestamp":1478879140000},"page":"1872-1880","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Testosterone Threshold for Increased Cardiovascular Risk in Middle-Aged and Elderly Men: A Locally Weighted Regression Analysis"],"prefix":"10.1093","volume":"13","author":[{"given":"Pin-Wen","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Neurology , Taipei, , Taiwan"},{"name":"Cathay General Hospital , Taipei, , Taiwan"},{"name":"Department of Medicine , New Taipei City, , Taiwan"},{"name":"School of Medicine , New Taipei City, , Taiwan"},{"name":"Fu Jen Catholic University , New Taipei City, , Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Chang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Urology , New Taipei City, , Taiwan"},{"name":"Taipei Medical University\u2013Shuang Ho Hospital , New Taipei City, , Taiwan"},{"name":"Department of Urology , Taipei, , Taiwan"},{"name":"School of Medicine , Taipei, , Taiwan"},{"name":"College of Medicine , Taipei, , Taiwan"},{"name":"Taipei Medical University , Taipei, , Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuan-Chou","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology , New Taipei City, , Taiwan"},{"name":"Taipei Medical University\u2013Shuang Ho Hospital , New Taipei City, , Taiwan"},{"name":"Department of Urology , Taipei, , Taiwan"},{"name":"School of Medicine , Taipei, , Taiwan"},{"name":"College of Medicine , Taipei, , Taiwan"},{"name":"Taipei Medical University , Taipei, , Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu-Shan","family":"Jaw","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering , Taipei, , Taiwan"},{"name":"National Taiwan University , Taipei, , Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Jeng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Urology , Taipei, , Taiwan"},{"name":"National Taiwan University Hospital and College of Medicine , Taipei, , Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Ping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology , Taipei, , Taiwan"},{"name":"National Taiwan University Hospital and College of Medicine , Taipei, , Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen-Hsun","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Urology , New Taipei City, , Taiwan"},{"name":"Taipei Medical University\u2013Shuang Ho Hospital , New Taipei City, , Taiwan"},{"name":"Department of Urology , Taipei, , Taiwan"},{"name":"School of Medicine , Taipei, , Taiwan"},{"name":"College of Medicine , Taipei, , Taiwan"},{"name":"Taipei Medical University , Taipei, , Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,12,1]]},"reference":[{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1743-6109.2010.01991.x","article-title":"Testosterone and metabolic syndrome: a meta-analysis study","volume":"8","author":"Corona","year":"2011","journal-title":"J Sex Med"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.mce.2015.06.031","article-title":"Obesity and late-onset hypogonadism","volume":"418","author":"Corona","year":"2015","journal-title":"Mol Cell Endocrinol"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/jsm.12777","article-title":"The prevalence and the risk factors of testosterone deficiency in newly diagnosed and previously known type 2 diabetic men","volume":"12","author":"Ho","year":"2015","journal-title":"J Sex Med"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"3632","DOI":"10.1210\/jcem.87.8.8762","article-title":"Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: the Rotterdam study","volume":"87","author":"Hak","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1210\/jc.2007-1792","article-title":"Low serum testosterone and mortality in older men","volume":"93","author":"Laughlin","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1111\/j.1743-6109.2009.01690.x","article-title":"Low testosterone is associated with an increased risk of MACE lethality in subjects with erectile dysfunction","volume":"7","author":"Corona","year":"2010","journal-title":"J Sex Med"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1161\/CIRCULATIONAHA.107.719005","article-title":"Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men: European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) prospective population study","volume":"116","author":"Khaw","year":"2007","journal-title":"Circulation"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1210\/jc.2011-1137","article-title":"Clinical review: endogenous testosterone and mortality in men: a systematic review and meta-analysis","volume":"96","author":"Araujo","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1530\/EJE-11-0447","article-title":"Hypogonadism as a risk factor for cardiovascular mortality in men: a meta-analytic study","volume":"165","author":"Corona","year":"2011","journal-title":"Eur J Endocrinol"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1136\/hrt.2010.210757","article-title":"Endogenous testosterone and cardiovascular disease in healthy men: a meta-analysis","volume":"97","author":"Ruige","year":"2011","journal-title":"Heart"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.urology.2015.03.049","article-title":"Association between testosterone supplementation therapy and thrombotic events in elderly men","volume":"86","author":"Ramasamy","year":"2015","journal-title":"Urology"},{"key":"2023041406292544600_","first-page":"226","article-title":"Can serum testosterone be used as a marker of overall health?","volume":"17","author":"Mederos","year":"2015","journal-title":"Rev Urol"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4103\/1008-682X.143250","article-title":"Biomarkers, erectile dysfunction, and cardiovascular risk prediction: the latest of an evolving concept","volume":"17","author":"Vlachopoulos","year":"2015","journal-title":"Asian J Androl"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3109\/13685538.2015.1004049","article-title":"Recommendations on the diagnosis, treatment and monitoring of hypogonadism in men","volume":"18","author":"Lunenfeld","year":"2015","journal-title":"Aging Male"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1111\/jsm.12952","article-title":"The International Society for Sexual Medicine's process of care for the assessment and management of testosterone deficiency in adult men","volume":"12","author":"Dean","year":"2015","journal-title":"J Sex Med"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1210\/jc.2005-2847","article-title":"Testosterone therapy in adult men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline","volume":"91","author":"Bhasin","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ijir.2008.41","article-title":"ISA, ISSAM, EAU, EAA and ASA recommendations: investigation, treatment and monitoring of late-onset hypogonadism in males","volume":"21","author":"Wang","year":"2009","journal-title":"Int J Impot Res"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1056\/NEJMoa0911101","article-title":"Identification of late-onset hypogonadism in middle-aged and elderly men","volume":"363","author":"Wu","year":"2010","journal-title":"N Engl J Med"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s40618-015-0425-1","article-title":"How to define hypogonadism? Results from a population of men consulting for sexual dysfunction","volume":"39","author":"Rastrelli","year":"2016","journal-title":"J Endocrinol Invest"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/aja.2011.138","article-title":"How to recognize late-onset hypogonadism in men with sexual dysfunction","volume":"14","author":"Corona","year":"2012","journal-title":"Asian J Androl"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.urology.2014.07.049","article-title":"Hypogonadal symptoms are associated with different serum testosterone thresholds in middle-aged and elderly men","volume":"84","author":"Ramasamy","year":"2014","journal-title":"Urology"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/bju.12970","article-title":"Hypogonadal symptoms in young men are associated with a serum total testosterone threshold of 400 ng\/dL","volume":"116","author":"Scovell","year":"2015","journal-title":"BJU Int"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/13685538.2015.1004047","article-title":"Testosterone threshold\u2014does one size fit all?","volume":"18","author":"Maganty","year":"2015","journal-title":"Aging Male"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1111\/j.2047-2927.2013.00139.x","article-title":"Frequency of sexual activity and cardiovascular risk in subjects with erectile dysfunction: cross-sectional and longitudinal analyses","volume":"1","author":"Corona","year":"2013","journal-title":"Andrology"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1111\/j.1743-6109.2008.00982.x","article-title":"Penile Doppler ultrasound in patients with erectile dysfunction (ED): role of peak systolic velocity measured in the flaccid state in predicting arteriogenic ED and silent coronary artery disease","volume":"5","author":"Corona","year":"2008","journal-title":"J Sex Med"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/jsm.12342","article-title":"Flaccid penile acceleration as a marker of cardiovascular risk in men without classical risk factors","volume":"11","author":"Rastrelli","year":"2014","journal-title":"J Sex Med"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3109\/13685538.2015.1129400","article-title":"Erectile dysfunction, loss of libido and low sexual frequency increase the risk of cardiovascular disease in men with low testosterone","volume":"19","author":"Ho","year":"2016","journal-title":"Aging Male"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1210\/jc.2007-1245","article-title":"Prevalence of symptomatic androgen deficiency in men","volume":"92","author":"Araujo","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3109\/13685539909003173","article-title":"A new \u201caging males\u201d symptoms rating scale","volume":"2","author":"Heinemann","year":"1999","journal-title":"Aging Male"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1161\/CIRCULATIONAHA.107.699579","article-title":"General cardiovascular risk profile for use in primary care: the Framingham Heart Study","volume":"117","author":"D'Agostino","year":"2008","journal-title":"Circulation"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"483","DOI":"10.7326\/0003-4819-151-7-200910060-00009","article-title":"C-reactive protein as a risk factor for coronary heart disease: a systematic review and meta-analyses for the U.S. Preventive Services Task Force","volume":"151","author":"Buckley","year":"2009","journal-title":"Ann Intern Med"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0140-6736(05)66911-5","article-title":"Men in Australia Telephone Survey (MATeS): a national survey of the reproductive health and concerns of middle-aged and older Australian men","volume":"366","author":"Holden","year":"2005","journal-title":"Lancet"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1210\/jcem.87.2.8201","article-title":"Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study","volume":"87","author":"Feldman","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1053\/meta.2000.8625","article-title":"Validation of a screening questionnaire for androgen deficiency in aging males","volume":"49","author":"Morley","year":"2000","journal-title":"Metabolism"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1056\/NEJMoa1206168","article-title":"Gonadal steroids and body composition, strength, and sexual function in men","volume":"369","author":"Finkelstein","year":"2013","journal-title":"N Engl J Med"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1111\/j.1464-410X.2010.09986.x","article-title":"Are there symptom-specific testosterone thresholds in aging men?","volume":"108","author":"Lackner","year":"2011","journal-title":"BJU Int"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.1210\/jc.2006-0401","article-title":"Association of specific symptoms and metabolic risks with serum testosterone in older men","volume":"91","author":"Zitzmann","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1111\/jsm.12546","article-title":"Commentary: Who is a candidate for testosterone therapy? A synthesis of international expert opinions","volume":"11","author":"Morgentaler","year":"2014","journal-title":"J Sex Med"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1210\/jc.2005-1326","article-title":"Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men","volume":"91","author":"Kupelian","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"4472","DOI":"10.1210\/jc.2015-2460","article-title":"The association of reproductive hormone levels and all-cause, cancer, and cardiovascular disease mortality in men","volume":"100","author":"Holmboe","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1210\/jc.2011-2591","article-title":"Testosterone treatment and mortality in men with low testosterone levels","volume":"97","author":"Shores","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1111\/jsm.12052","article-title":"Impaired masturbation-induced erections: a new cardiovascular risk factor for male subjects with sexual dysfunction","volume":"10","author":"Rastrelli","year":"2013","journal-title":"J Sex Med"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"3433","DOI":"10.1111\/j.1743-6109.2011.02474.x","article-title":"Poor response to alprostadil ICI test is associated with arteriogenic erectile dysfunction and higher risk of major adverse cardiovascular events","volume":"8","author":"Rastrelli","year":"2011","journal-title":"J Sex Med"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1111\/j.1743-6109.2010.01744.x","article-title":"Male sexuality and cardiovascular risk. A cohort study in patients with erectile dysfunction","volume":"7","author":"Corona","year":"2010","journal-title":"J Sex Med"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1111\/j.1742-1241.2010.02410.x","article-title":"Erectile dysfunction and coronary artery disease prediction: evidence-based guidance and consensus","volume":"64","author":"Jackson","year":"2010","journal-title":"Int J Clin Pract"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.jsxm.2016.01.023","article-title":"Coronary heart disease, diabetes, and sexuality in men","volume":"13","author":"Hackett","year":"2016","journal-title":"J Sex Med"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.eururo.2013.08.023","article-title":"A systematic review of the association between erectile dysfunction and cardiovascular disease","volume":"65","author":"Gandaglia","year":"2014","journal-title":"Eur Urol"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.juro.2014.08.108","article-title":"Association of peripheral microvascular dysfunction and erectile dysfunction","volume":"193","author":"Gerber","year":"2015","journal-title":"J Urol"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1111\/jsm.13069","article-title":"Basic science evidence for the link between erectile dysfunction and cardiometabolic dysfunction","volume":"12","author":"Musicki","year":"2015","journal-title":"J Sex Med"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"R47","DOI":"10.1530\/JOE-12-0582","article-title":"Testosterone: a vascular hormone in health and disease","volume":"217","author":"Kelly","year":"2013","journal-title":"J Endocrinol"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"E9","DOI":"10.1210\/jc.2013-3272","article-title":"In older men an optimal plasma testosterone is associated with reduced all-cause mortality and higher dihydrotestosterone with reduced ischemic heart disease mortality, while estradiol levels do not predict mortality","volume":"99","author":"Yeap","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.maturitas.2013.04.012","article-title":"A J-shaped association between plasma testosterone and risk of ischemic arterial event in elderly men: the French 3C cohort study","volume":"75","author":"Soisson","year":"2013","journal-title":"Maturitas"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1210\/jc.2007-1692","article-title":"Effects of graded doses of testosterone on erythropoiesis in healthy young and older men","volume":"93","author":"Coviello","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1210\/jc.2009-2354","article-title":"Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline","volume":"95","author":"Bhasin","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.eururo.2013.12.030","article-title":"Words of wisdom. Re: In older men an optimal plasma testosterone is associated with reduced all-cause mortality and higher dihydrotestosterone with reduced ischemic heart disease mortality, while estradiol levels do not predict mortality","volume":"65","author":"Ramasamy","year":"2014","journal-title":"Eur Urol"},{"key":"2023041406292544600_","first-page":"196","article-title":"Is late-onset hypogonadotropic hypogonadism a specific age-dependent disease, or merely an epiphenomenon caused by accumulating disease-burden?","volume":"41","author":"Corona","year":"2016","journal-title":"Minerva Endocrinol"},{"key":"2023041406292544600_","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/jsm.12790","article-title":"Influence of androgen receptor CAG polymorphism on sexual function recovery after testosterone therapy in late-onset hypogonadism","volume":"12","author":"Tirabassi","year":"2015","journal-title":"J Sex Med"}],"container-title":["The Journal of Sexual Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609516304593?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609516304593?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/13\/12\/1872\/49887081\/jsm_13_12_1872.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/13\/12\/1872\/49887081\/jsm_13_12_1872.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T21:51:49Z","timestamp":1692568309000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jsm\/article\/13\/12\/1872\/6940481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,1]]},"references-count":57,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2016,12,1]]},"published-print":{"date-parts":[[2016,12,1]]}},"URL":"https:\/\/doi.org\/10.1016\/j.jsxm.2016.10.002","relation":{},"ISSN":["1743-6109","1743-6095"],"issn-type":[{"type":"electronic","value":"1743-6109"},{"type":"print","value":"1743-6095"}],"subject":[],"published-other":{"date-parts":[[2016,12]]},"published":{"date-parts":[[2016,12,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Testosterone Threshold for Increased Cardiovascular Risk in Middle-Aged and Elderly Men: A Locally Weighted Regression Analysis","name":"articletitle","label":"Article Title"},{"value":"The Journal of Sexual Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsxm.2016.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016, International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}