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Erectile and neurogenic responses of the corpus cavernosum (CC) were evaluated. The acute effects of SILOD also were evaluated in vivo (0.03 mg\/kg intravenously) and ex vivo (10 nmol\/L). The effects of SILOD and tadalafil (TAD) on nitrergic relaxations were determined in human CC from patients with ED with a vascular etiology or ED secondary to RP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Erectile responses in vivo in rats and neurogenic contractions and relaxations of rat and human CC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Long-term treatment with SILOD significantly improved erectile responses and allowed for the potentiation of erectile responses by acute treatment with TAD (0.3 mg\/kg intravenously) in rats with BCNI. SILOD partly recovered nitrergic relaxations and normalized neurogenic contractions in CC from rats with BCNI. Long-term treatment with SILOD partly prevented BCNI-induced decreases in neuronal nitric oxide synthase expression. Acute administration of SILOD (0.03 mg\/kg intravenously) improved erectile responses in vivo and potentiated nitrergic relaxation and decreased neurogenic contractions ex vivo in CC from rats with BCNI. In human CC from patients with ED with a vascular etiology, TAD (30 nmol\/L), SILOD (10 nmol\/L), or their combination increased nitrergic relaxations. Potentiation by TAD was lost in human CC from patients with ED after RP but was recovered after co-treatment with SILOD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>\u03b1-Adrenergic modulation, especially selective \u03b11A-blockade, improves erectile and cavernosal functions after BCNI. Modulation of the adrenergic system, mainly in combination strategies, could have a role in the management of ED after RP.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jsxm.2016.10.005","type":"journal-article","created":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T17:02:10Z","timestamp":1479229330000},"page":"1844-1857","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["\u03b11A-Adrenergic Receptor Antagonism Improves Erectile and Cavernosal Responses in Rats with Cavernous Nerve Injury and Enhances Neurogenic Responses in Human Corpus Cavernosum from Patients with Erectile Dysfunction Secondary to Radical Prostatectomy"],"prefix":"10.1093","volume":"13","author":[{"given":"Juan I.","family":"Mart\u00ednez-Salamanca","sequence":"first","affiliation":[{"name":"Servicio de Urolog\u00eda , Madrid, , Spain"},{"name":"Hospital Universitario Puerta de Hierro , Madrid, , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"La Fuente","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Urologia , Porto, , Portugal"},{"name":"Hospital Santo Antonio , Porto, , Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Mart\u00ednez-Salamanca","sequence":"additional","affiliation":[{"name":"Servicio de Histolog\u00eda-Investigaci\u00f3n , Madrid, , Spain"},{"name":"Unidad de Investigaci\u00f3n Cardiovascular (IRYCIS\/UFV) , Madrid, , Spain"},{"name":"Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria , Madrid, , Spain"},{"name":"Hospital Universitario Ram\u00f3n y Cajal , Madrid, , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argentina","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Servicio de Histolog\u00eda-Investigaci\u00f3n , Madrid, , Spain"},{"name":"Unidad de Investigaci\u00f3n Cardiovascular (IRYCIS\/UFV) , Madrid, , Spain"},{"name":"Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria , Madrid, , Spain"},{"name":"Hospital Universitario Ram\u00f3n y Cajal , Madrid, , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto J.","family":"Pepe-Cardoso","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Urologia. 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