{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T06:03:11Z","timestamp":1769925791414,"version":"3.49.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"vor","delay-in-days":2200,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,30]],"date-time":"2016-11-30T00:00:00Z","timestamp":1480464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"National Key Basic Research Program of China","award":["2013CB945204"],"award-info":[{"award-number":["2013CB945204"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81503655"],"award-info":[{"award-number":["81503655"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jsm.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Hyperactivity of the sympathetic nervous system can play an important role in lifelong premature ejaculation (PE). Our previous study found that amyloid precursor protein (APP) levels in seminal plasma of patients with PE were clearly increased. Amyloid-\u03b2 (A\u03b2) is derived from APP. Excessive A\u03b2, especially A\u03b242, can cause neuronal dysfunction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To determine whether APP and A\u03b242 are associated with an abnormal penile sympathetic skin response (PSSR).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>From November 2015 to April 2016, 24 patients with lifelong PE (mean age\u00a0= 29.2 \u00b1 5.3) with self-estimated intravaginal ejaculatory latency time no longer than 2 minutes and 10 control subjects (mean age\u00a0=\u00a028.0 \u00b1 5.5) were enrolled consecutively from andrology clinics. PSSR was measured in patients with lifelong PE. APP and A\u03b242 levels in seminal plasma were determined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures<\/jats:title>\n                  <jats:p>PSSR in patients with lifelong PE and APP and A\u03b242 levels in all subjects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patients with PE presented 1.5-fold higher levels of APP (P\u00a0= .004) than control subjects. Seminal plasma protein concentration (C) in the PE group was lower than that in the control group (P\u00a0= .007). APP divided by C (APP\/C) was 2.0-fold higher (P &amp;lt; .001) in the PE group. A\u03b242 level was not different between the PE and control groups, but A\u03b242 divided by C (A\u03b242\/C) was significantly higher in the PE group (P &amp;lt; .001). No differences in APP and APP\/C were found between patients with PE in the abnormal and normal PSSR groups. The abnormal PSSR group presented significantly higher A\u03b242 (P\u00a0= .007) and A\u03b242\/C (P &amp;lt; .001) levels. The latency of PSSR was negatively correlated with A\u03b242\/C (r\u00a0=\u00a0\u22120.436; P\u00a0= .033).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>These results showed that patients with lifelong PE had higher APP and A\u03b242 levels in seminal plasma. Abnormal PSSR was related to a higher A\u03b242 level. Drugs that decrease A\u03b2 could be treatment of PE.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1016\/j.jsxm.2016.11.002","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T18:46:09Z","timestamp":1483728369000},"page":"98-105","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Relationship Between Amyloid Precursor Protein in Seminal Plasma and Abnormal Penile Sympathetic Skin Response in Lifelong Premature Ejaculation"],"prefix":"10.1093","volume":"14","author":[{"given":"Zhiwei","family":"Hong","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine \u00a0 \u00a0 , Nanjing , China"},{"name":"Jinling Hospital \u00a0 \u00a0 , Nanjing , China"},{"name":"Medical School of Nanjing University \u00a0 \u00a0 , Nanjing , 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