{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T04:51:41Z","timestamp":1695012701646},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T00:00:00Z","timestamp":1486512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T00:00:00Z","timestamp":1486512000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Ivix Ltd"}],"content-domain":{"domain":["jsm.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Low sexual desire is a frequent sexual problem in women, with only one drug for the condition approved by the Food and Drug Administration.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To evaluate the ability of a novel synthetic peptide, BP101, to facilitate sexual behavior after intranasal administration or infusion into certain brain areas in female rats.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Bilaterally ovariectomized female rats, primed with a suboptimal combination of estradiol benzoate (EB) and progesterone, were used as a model of low sexual motivation. Sexual behavior was tested with stud male rats after acute (experiment 1) or long-term (experiment 2) intranasal administration of BP101 or peptide infusion into the olfactory bulb, medial preoptic area, ventromedial hypothalamic nucleus, or ventral tegmental area (experiment 3).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures<\/jats:title>\n                  <jats:p>Frequency of solicitations (SF), as an indicator of sexual motivation in female rats, and lordosis frequency and ratio, as measurements of female consummatory sexual behavior.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Acute intranasal BP101 administration moderately increased SF, with the highest tested dose of 300 \u03bcg\/kg causing an 80% increase. Female rats receiving BP101 75 or 300 \u03bcg\/kg daily on days 6 to 16 of the peptide administration displayed twofold higher SF compared with the placebo-treated animals, an increase comparable to optimally hormone-primed female rats. Infusion of BP101 1 and 5 \u03bcg per rat into the medial preoptic area, but not into the olfactory bulb, ventromedial hypothalamic nucleus, or ventral tegmental area, increased SF in female rats supplemented with EB 10 or 20 \u03bcg. The effect was relatively more pronounced in female rats receiving EB 10 \u03bcg (\u2248300%) compared with EB 20 \u03bcg (\u224850%) with direct brain infusions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>BP101 displays a potent stimulatory effect on sexual motivation in the female rat, and the medial preoptic area seems to be the site of its action. BP101 is effective in female rats receiving different hormone supplementations, making the present data generalizable to pre- and postmenopausal women with hypoactive sexual desire.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1016\/j.jsxm.2017.01.008","type":"journal-article","created":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T18:45:59Z","timestamp":1486579559000},"page":"336-346","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["BP101 Peptide Promotes Female Sexual Receptivity in the Rat"],"prefix":"10.1093","volume":"14","author":[{"given":"Alexander","family":"Andreev-Andrievskiy","sequence":"first","affiliation":[{"name":"Biology Faculty \u00a0 , Moscow , Russia"},{"name":"M.V. Lomonosov Moscow State University \u00a0 , Moscow , Russia"},{"name":"MSU Institute of Mitoengineering LLC , Moscow , Russia"},{"name":"Institute for Biomedical problems RAS , Moscow , Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikhail","family":"Lomonosov","sequence":"additional","affiliation":[{"name":"Aivix Ltd , Moscow , Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anfisa","family":"Popova","sequence":"additional","affiliation":[{"name":"Biology Faculty \u00a0 , Moscow , Russia"},{"name":"M.V. Lomonosov Moscow State University \u00a0 , Moscow , Russia"},{"name":"MSU Institute of Mitoengineering LLC , Moscow , Russia"},{"name":"Institute for Biomedical problems RAS , Moscow , Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgeniia","family":"Lagereva","sequence":"additional","affiliation":[{"name":"MSU Institute of Mitoengineering LLC , Moscow , Russia"},{"name":"Institute for Biomedical problems RAS , Moscow , Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Cl\u00e9ment","sequence":"additional","affiliation":[{"name":"Pelvipharm\/INSERM U1179 , Montigny-Le-Bretonneux , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramiz","family":"Salimov","sequence":"additional","affiliation":[{"name":"Aivix Ltd , Moscow , Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitriy","family":"Golikov","sequence":"additional","affiliation":[{"name":"Aivix Ltd , Moscow , Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,2,8]]},"reference":[{"key":"2023011111050473400_bib1","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1097\/GME.0000000000000131","article-title":"Hypoactive sexual desire in women","volume":"20","author":"Kingsberg","year":"2013","journal-title":"Menopause"},{"key":"2023011111050473400_bib2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/sj.ijir.3901250","article-title":"Sexual problems among women and men aged 40\u201380\u2009y: prevalence and correlates identified in the Global Study of Sexual Attitudes and Behaviors","volume":"17","author":"Laumann","year":"2004","journal-title":"Int J Impot Res"},{"key":"2023011111050473400_bib3","volume-title":"Press announcements\u2014FDA approves first treatment for sexual desire disorder","author":"US Food and Drug Administration"},{"key":"2023011111050473400_bib4","first-page":"1231","article-title":"Flibanserin treatment increases appetitive sexual motivation in the female rat","volume":"10","author":"Gelez","year":"2013","journal-title":"J\u00a0Sex Med"},{"key":"2023011111050473400_bib5","first-page":"694","article-title":"Flibanserin and 8-OH-DPAT implicate serotonin in association between female marmoset monkey sexual behavior and changes in pair-bond quality","volume":"9","author":"Aubert","year":"2012","journal-title":"J\u00a0Sex Med"},{"key":"2023011111050473400_bib6","first-page":"1074","article-title":"Treatment of hypoactive sexual desire disorder in premenopausal women: efficacy of flibanserin in the VIOLET Study","volume":"9","author":"DeRogatis","year":"2012","journal-title":"J\u00a0Sex Med"},{"key":"2023011111050473400_bib7","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1097\/GME.0000000000000134","article-title":"Efficacy and safety of flibanserin in postmenopausal women with hypoactive sexual desire disorder","volume":"21","author":"Simon","year":"2014","journal-title":"Menopause"},{"key":"2023011111050473400_bib8","first-page":"1807","article-title":"Efficacy of flibanserin in women with hypoactive sexual desire disorder: results from the BEGONIA Trial","volume":"10","author":"Katz","year":"2013","journal-title":"J\u00a0Sex Med"},{"key":"2023011111050473400_bib9","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s00213-013-3194-6","article-title":"Brain neuronal activation induced by flibanserin treatment in female rats","volume":"230","author":"Gelez","year":"2013","journal-title":"Psychopharmacology"},{"key":"2023011111050473400_bib10","first-page":"1134","article-title":"Efficacy and safety of testosterone in the management of hypoactive sexual desire disorder in postmenopausal women","volume":"9","author":"Davis","year":"2012","journal-title":"J\u00a0Sex Med"},{"key":"2023011111050473400_bib11","first-page":"269","article-title":"Bremelanotide: an overview of preclinical CNS effects on female sexual function","volume":"4","author":"Pfaus","year":"2007","journal-title":"J\u00a0Sex Med"},{"key":"2023011111050473400_bib12","first-page":"824","article-title":"Toward personalized sexual medicine (part 3): testosterone combined with a serotonin1A receptor agonist increases sexual satisfaction in women with HSDD and FSAD, and dysfunctional activation of sexual inhibitory mechanisms","volume":"10","author":"van Rooij","year":"2013","journal-title":"J\u00a0Sex Med"},{"key":"2023011111050473400_bib13","first-page":"810","article-title":"Toward personalized sexual medicine (part 2): testosterone combined with a PDE5 inhibitor increases sexual satisfaction in women with HSDD and FSAD, and a low sensitive system for sexual cues","volume":"10","author":"Poels","year":"2013","journal-title":"J\u00a0Sex Med"},{"key":"2023011111050473400_bib14","article-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"2006"},{"key":"2023011111050473400_bib15","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/0018-506X(79)90033-3","article-title":"Dose-response and time-response relationships between progesterone and the display of patterns of receptive and proceptive behavior in the female rat","volume":"13","author":"Fadem","year":"1979","journal-title":"Horm Behav"},{"key":"2023011111050473400_bib16","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0018-506X(80)90016-1","article-title":"The effects of estrogen and progesterone on female rat proceptive behavior","volume":"14","author":"Tennent","year":"1980","journal-title":"Horm Behav"},{"key":"2023011111050473400_bib17","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0031-9384(83)80003-1","article-title":"Hormonal regulation of female proceptivity and its influence on male sexual preference in rats","volume":"31","author":"Landau","year":"1983","journal-title":"Physiol Behav"},{"key":"2023011111050473400_bib18","first-page":"264","article-title":"Precopulatory behaviour of male rats: developmental aspects and dependence on female's solicitation","volume":"32","author":"Hlinak","year":"1990","journal-title":"Act Nerv Super (Praha)"},{"key":"2023011111050473400_bib19","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.beproc.2015.05.011","article-title":"The function and meaning of female rat paracopulatory (proceptive) behaviors","volume":"118","author":"Bergheim","year":"2015","journal-title":"Behav Processes"},{"key":"2023011111050473400_bib20","first-page":"1506","article-title":"Pathways of sexual desire","volume":"6","author":"Pfaus","year":"2009","journal-title":"J\u00a0Sex Med"},{"key":"2023011111050473400_bib21","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1016\/B978-0-12-397175-3.00050-8","article-title":"Female sexual behavior","volume-title":"Knobil and Neill's physiology of reproduction","author":"Pfaus","year":"2015"},{"key":"2023011111050473400_bib22","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.brainres.2003.10.056","article-title":"Paced mating behavior in the female rat following lesions of three regions responsive to vaginocervical stimulation","volume":"999","author":"Guarraci","year":"2004","journal-title":"Brain Res"},{"key":"2023011111050473400_bib23","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1037\/0735-7044.114.6.1191","article-title":"MPOA lesions affect female pacing of copulation in rats","volume":"114","author":"Yang","year":"2000","journal-title":"Behav Neurosci"},{"key":"2023011111050473400_bib24","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1159\/000084893","article-title":"Differential regulation of female rat olfactory preference and copulatory pacing by the lateral septum and medial preoptic area","volume":"81","author":"Xiao","year":"2005","journal-title":"Neuroendocrinology"},{"key":"2023011111050473400_bib25","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0006-8993(00)02076-X","article-title":"Neuronal activity in female rat preoptic area associated with sexually motivated behavior","volume":"862","author":"Kato","year":"2000","journal-title":"Brain Res"},{"key":"2023011111050473400_bib26","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1006\/hbeh.1994.1041","article-title":"Estrogen-induced changes in the neural impulse flow from the female rat preoptic region","volume":"28","author":"Sakuma","year":"1994","journal-title":"Horm Behav"},{"key":"2023011111050473400_bib27","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.physbeh.2013.09.008","article-title":"Infusions of ascorbic acid into the medial preoptic area facilitate appetitive sexual behavior in the female rat","volume":"122","author":"Graham","year":"2013","journal-title":"Physiol Behav"},{"key":"2023011111050473400_bib28","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.pbb.2012.06.020","article-title":"Differential effects of dopamine antagonists infused to the medial preoptic area on the sexual behavior of female rats primed with estrogen and progesterone","volume":"102","author":"Graham","year":"2012","journal-title":"Pharmacol Biochem Behav"},{"key":"2023011111050473400_bib29","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.bbr.2012.01.048","article-title":"The role of the estrogen receptor \u03b1 in the medial preoptic area in sexual incentive motivation, proceptivity and receptivity, anxiety, and wheel running in female rats","volume":"230","author":"Spiteri","year":"2012","journal-title":"Behav Brain Res"},{"key":"2023011111050473400_bib30","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0006-8993(93)90294-W","article-title":"c-Fos proto-oncogene activity induced by mating in the preoptic area, hypothalamus and amygdala in the female rat: role of afferent input via the pelvic nerve","volume":"621","author":"Rowe","year":"1993","journal-title":"Brain Res"},{"key":"2023011111050473400_bib31","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.yhbeh.2009.05.008","article-title":"Clitoral stimulation induces conditioned place preference and Fos activation in the rat","volume":"57","author":"Parada","year":"2010","journal-title":"Horm Behav"},{"key":"2023011111050473400_bib32","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1159\/000126760","article-title":"Sexual stimulation induces Fos immunoreactivity within GnRH neurons of the female rat preoptic area: interaction with steroid hormones","volume":"60","author":"Pfaus","year":"1994","journal-title":"Neuroendocrinology"},{"key":"2023011111050473400_bib33","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.brainres.2007.07.071","article-title":"Effects of sexual experience on conspecific odor preference and male odor-induced activation of the vomeronasal projection pathway and the nucleus accumbens in female rats","volume":"1175","author":"Hosokawa","year":"2007","journal-title":"Brain Res"},{"key":"2023011111050473400_bib34","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.neuroscience.2007.05.052","article-title":"Neuronal activation by stimuli that predict sexual reward in female rats","volume":"148","author":"Coria-Avila","year":"2007","journal-title":"Neuroscience"},{"key":"2023011111050473400_bib35","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1037\/0735-7044.109.2.354","article-title":"Increased extracellular dopamine in the nucleus accumbens and striatum of the female rat during paced copulatory behavior","volume":"109","author":"Mermelstein","year":"1995","journal-title":"Behav Neurosci"},{"key":"2023011111050473400_bib36","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.pbb.2003.12.008","article-title":"Sexual-incentive motivation and paced sexual behavior in female rats after treatment with drugs modifying dopaminergic neurotransmission","volume":"77","author":"Ellingsen","year":"2004","journal-title":"Pharmacol Biochem Behav"},{"key":"2023011111050473400_bib37","first-page":"1757","article-title":"Acute and repeated flibanserin administration in female rats modulates monoamines differentially across brain areas: a microdialysis study","volume":"7","author":"Allers","year":"2010","journal-title":"J\u00a0Sex Med"},{"key":"2023011111050473400_bib38","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0006-8993(93)91711-Z","article-title":"Female sexual behavior following intracerebral infusion of the 5-HT 1A agonist, 8-OH-DPAT, into the medial preoptic area","volume":"601","author":"Uphouse","year":"1993","journal-title":"Brain Res"}],"container-title":["The Journal of Sexual Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609517300553?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609517300553?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/14\/3\/336\/48526506\/jsm_14_3_336.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/14\/3\/336\/48526506\/jsm_14_3_336.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T14:44:17Z","timestamp":1673448257000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jsm\/article\/14\/3\/336\/6973666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,8]]},"references-count":38,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,2,8]]},"published-print":{"date-parts":[[2017,3,1]]}},"URL":"https:\/\/doi.org\/10.1016\/j.jsxm.2017.01.008","relation":{},"ISSN":["1743-6109","1743-6095"],"issn-type":[{"value":"1743-6109","type":"electronic"},{"value":"1743-6095","type":"print"}],"subject":[],"published-other":{"date-parts":[[2017,3]]},"published":{"date-parts":[[2017,2,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BP101 Peptide Promotes Female Sexual Receptivity in the Rat","name":"articletitle","label":"Article Title"},{"value":"The Journal of Sexual Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsxm.2017.01.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017, International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}