{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:18:41Z","timestamp":1789093121157,"version":"build-2803163510"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University Hospital","doi-asserted-by":"publisher","award":["KMUH101-1R45"],"award-info":[{"award-number":["KMUH101-1R45"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jsm.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Repeated evidence from animal models suggests a strong link between vascular endothelial growth factor (VGEF) and penile vasculature and erectile function because VEGF can alter the physiologic pathways involved in the regulation of penile vasomotor tone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate three VEGF polymorphisms and their link to erectile dysfunction (ED).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 688 Taiwanese men with a mean age of 55.6 years (SD\u00a0= 4.5) during a free health screening. All participants provided complete medical histories and underwent physical examinations. Fasting blood samples were obtained for biochemical analysis and hormone profiling. The allelic discrimination of three VEGF gene polymorphisms (460T\/C [rs833061], 1154G\/A [rs1570360], and 2578A\/C [rs699947]) was performed using validated TaqMan single-nucleotide polymorphism genotyping assays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcomes<\/jats:title><jats:p>Subjects underwent assessment using the simplified five-item International Index of Erectile Function to diagnose and assess ED severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results showed that diabetes mellitus (odds ratio [OR]\u00a0= 3.27, P &amp;lt; .01), hypertension (OR\u00a0=\u00a03.47, P &amp;lt; .01), and having the VEGF 2578A allele (OR\u00a0= 1.54, P\u00a0= .01) were the three most independent risk factors for ED. In univariate analysis, all three VEGF polymorphisms (460C, 1154A, and 2578A) were significantly associated with a higher prevalence of coronary artery disease (P &amp;lt; .01) and greater frequencies of hypertension were found in carriers of the 1154A allele and the 2578A allele (P\u00a0= .01). Multiple logistic regression analysis showed a significant association between VEGF 2578A allele carrier status and ED (OR\u00a0= 1.54, 95% CI\u00a0= 1.10\u223c2.15, P\u00a0= .01). Furthermore, the prevalence and severity of ED were significantly increased with an increment of the 2578A allele number (P &amp;lt; .05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Implications<\/jats:title><jats:p>VEGF 2578C\/A gene polymorphisms could be a genetic susceptibility factor for the development of ED.<\/jats:p><\/jats:sec><jats:sec><jats:title>Strength and Limitation<\/jats:title><jats:p>This is the first study to investigate the genetic susceptibility of VEGF polymorphisms to ED. This study was cross-sectional with a lack of functional and molecular production investigations. Data on the association among conditions might not allow definitive conclusions about causal links.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study showed that VEGF 2578A allele carriers in a Taiwanese population are at greater risk for ED.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jsxm.2017.02.009","type":"journal-article","created":{"date-parts":[[2017,3,30]],"date-time":"2017-03-30T16:32:09Z","timestamp":1490891529000},"page":"510-517","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Associations of<i>VEGF<\/i>Gene Polymorphisms with Erectile Dysfunction and Related Risk Factors"],"prefix":"10.1093","volume":"14","author":[{"given":"Yung-Chin","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Urology \u00a0 , Kaohsiung , Taiwan"},{"name":"Kaohsiung Medical University Hospital \u00a0 , Kaohsiung , Taiwan"},{"name":"Department of Urology \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"Faculty of Medicine \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"College of Medicine \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"Kaohsiung Medical University \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Pin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Urology \u00a0 , Kaohsiung , Taiwan"},{"name":"Kaohsiung Medical University Hospital \u00a0 , Kaohsiung , Taiwan"},{"name":"Department of Urology \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"Faculty of Medicine \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"College of Medicine \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"Kaohsiung Medical University \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"Graduate Institute of Medicine \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"College of Medicine \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"Kaohsiung Medical University \u00a0 \u00a0 , Kaohsiung , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Chun","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Urology \u00a0 , Kaohsiung , Taiwan"},{"name":"Kaohsiung Municipal Ta-Tung Hospital \u00a0 , Kaohsiung , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Hung","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Urology \u00a0 , Kaohsiung , Taiwan"},{"name":"Kaohsiung Medical University Hospital \u00a0 , Kaohsiung , Taiwan"},{"name":"Department of Urology \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"Faculty of Medicine \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"College of Medicine \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"Kaohsiung Medical University \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"Division of Cardiology \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"Department of Internal Medicine \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"Kaohsiung Medical University Hospital \u00a0 \u00a0 , Kaohsiung , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Shun","family":"Juan","sequence":"additional","affiliation":[{"name":"Department of Urology \u00a0 , Kaohsiung , Taiwan"},{"name":"Kaohsiung Medical University Hospital \u00a0 , Kaohsiung , Taiwan"},{"name":"Department of Urology \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"Faculty of Medicine \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"College of Medicine \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"Kaohsiung Medical University \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"Department of Urology \u00a0 , Kaohsiung , Taiwan"},{"name":"Kaohsiung Municipal Hsiao-Kang Hospital \u00a0 , Kaohsiung , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Urology \u00a0 , Kaohsiung , Taiwan"},{"name":"Kaohsiung Medical University Hospital \u00a0 , Kaohsiung , Taiwan"},{"name":"Department of Urology \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"Faculty of Medicine \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"College of Medicine \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"Kaohsiung Medical University \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Ying","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy \u00a0 , Taichung , Taiwan"},{"name":"China Medical University \u00a0 , Taichung , Taiwan"},{"name":"Sex Hormone Research Center \u00a0 , Taichung , Taiwan"},{"name":"China Medical University Hospital \u00a0 , Taichung , Taiwan"},{"name":"Department of Nursing \u00a0 , Taichung , Taiwan"},{"name":"Asia University \u00a0 , Taichung , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Nung","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Urology \u00a0 , Kaohsiung , Taiwan"},{"name":"Kaohsiung Medical University Hospital \u00a0 , Kaohsiung , Taiwan"},{"name":"Department of Urology \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"Faculty of Medicine \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"College of Medicine \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"Kaohsiung Medical University \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chii-Jye","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology \u00a0 , Kaohsiung , Taiwan"},{"name":"Kaohsiung Medical University Hospital \u00a0 , Kaohsiung , Taiwan"},{"name":"Department of Urology \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"Faculty of Medicine \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"College of Medicine \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"Kaohsiung Medical University \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Chu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology \u00a0 , Kaohsiung , Taiwan"},{"name":"Kaohsiung Medical University Hospital \u00a0 , Kaohsiung , Taiwan"},{"name":"Department of Urology \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"Faculty of Medicine \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"College of Medicine \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"Kaohsiung Medical University \u00a0 \u00a0 \u00a0 , Kaohsiung , Taiwan"},{"name":"Pingtung Hospital \u00a0 \u00a0 , Pingtung , Taiwan"},{"name":"Department of Health \u00a0 \u00a0 , Pingtung , Taiwan"},{"name":"Executive Yuan \u00a0 \u00a0 , Pingtung , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,4,1]]},"reference":[{"key":"2023011111052406100_bib1","first-page":"57","article-title":"Prevalence and correlates of erectile dysfunction by race and ethnicity among men aged 40 or older in the United States: from the Male Attitudes Regarding Sexual Health Survey","volume":"4","author":"Laumann","year":"2007","journal-title":"J\u00a0Sex Med"},{"key":"2023011111052406100_bib2","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1146\/annurev.med.54.101601.152212","article-title":"Erectile dysfunction","volume":"54","author":"Shabsigh","year":"2003","journal-title":"Annu Rev Med"},{"key":"2023011111052406100_bib3","doi-asserted-by":"crossref","first-page":"108","DOI":"10.4065\/84.2.108","article-title":"A\u00a0population-based, longitudinal study of erectile dysfunction and future coronary artery disease","volume":"84","author":"Inman","year":"2009","journal-title":"Mayo Clin Proc"},{"key":"2023011111052406100_bib4","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1210\/edrv.18.1.0287","article-title":"The biology of vascular endothelial growth factor","volume":"18","author":"Ferrara","year":"1997","journal-title":"Endocr Rev"},{"key":"2023011111052406100_bib5","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1126\/science.2479986","article-title":"Vascular endothelial growth factor is a secreted angiogenic mitogen","volume":"246","author":"Leung","year":"1989","journal-title":"Science"},{"key":"2023011111052406100_bib6","first-page":"318","article-title":"Vascular endothelial growth factor restores erectile function through inhibition of apoptosis in diabetic rat penile crura","volume":"173","author":"Yamanaka","year":"2005","journal-title":"J\u00a0Urol"},{"key":"2023011111052406100_bib7","first-page":"1310","article-title":"Vascular endothelial growth factor restores corporeal smooth muscle function in\u00a0vitro","volume":"165","author":"Byrne","year":"2001","journal-title":"J\u00a0Urol"},{"key":"2023011111052406100_bib8","first-page":"761","article-title":"The effect of vascular endothelial growth factor on a rat model of traumatic arteriogenic erectile dysfunction","volume":"167","author":"Lee","year":"2002","journal-title":"J\u00a0Urol"},{"key":"2023011111052406100_bib9","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1191\/1358863x02vm429ra","article-title":"The pathophysiology of erectile dysfunction related to endothelial dysfunction and mediators of vascular function","volume":"7","author":"Maas","year":"2002","journal-title":"Vasc Med"},{"key":"2023011111052406100_bib10","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.ymthe.2005.10.016","article-title":"Combined angiopoietin-1 and vascular endothelial growth factor gene transfer restores cavernous angiogenesis and erectile function in a rat model of hypercholesterolemia","volume":"13","author":"Ryu","year":"2006","journal-title":"Mol Ther"},{"key":"2023011111052406100_bib11","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.bbrc.2005.12.226","article-title":"Vascular endothelial growth factor restores erectile function through modulation of the insulinlike growth factor system and sex hormone receptors in diabetic rat","volume":"341","author":"Shirai","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"2023011111052406100_bib12","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1161\/01.CIR.93.8.1493","article-title":"Assignment of the vascular endothelial growth factor gene to human chromosome 6p21.3","volume":"93","author":"Vincenti","year":"1996","journal-title":"Circulation"},{"key":"2023011111052406100_bib13","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.1167\/iovs.07-1383","article-title":"VEGF polymorphisms are associated with severity of diabetic retinopathy","volume":"49","author":"Churchill","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2023011111052406100_bib14","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/ahg.12068","article-title":"ABCA1 rs4149313 polymorphism and susceptibility to coronary heart disease: a meta-analysis","volume":"78","author":"Fan","year":"2014","journal-title":"Ann Hum Genet"},{"key":"2023011111052406100_bib15","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1006\/cyto.2000.0692","article-title":"Identification of polymorphisms within the vascular endothelial growth factor (VEGF) gene: correlation with variation in VEGF protein production","volume":"12","author":"Watson","year":"2000","journal-title":"Cytokines"},{"key":"2023011111052406100_bib16","first-page":"812","article-title":"Haplotype analysis of the polymorphic human vascular endothelial growth factor gene promoter","volume":"63","author":"Stevens","year":"2003","journal-title":"Cancer Res"},{"key":"2023011111052406100_bib17","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1002\/ijc.22324","article-title":"Anatomical subsite discrepancy in relation to the impact of the consumption of alcohol, tobacco and betel quid on esophageal cancer","volume":"120","author":"Lee","year":"2007","journal-title":"Int J Cancer"},{"key":"2023011111052406100_bib18","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/sj.ijir.3901468","article-title":"Vascular risk factors and erectile dysfunction in a cohort of healthy men","volume":"18","author":"Ponholzer","year":"2006","journal-title":"Int\u00a0J Impot Res"},{"key":"2023011111052406100_bib19","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.urology.2009.02.073","article-title":"Is type 2 diabetes mellitus a cause of severe erectile dysfunction in patients with metabolic syndrome?","volume":"74","author":"Aslan","year":"2009","journal-title":"Urology"},{"key":"2023011111052406100_bib20","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/j.1439-0272.2009.00975.x","article-title":"Genetic association study of the GNB3 C825T, the ACE I\/D and the eNOS G894T polymorphisms and the risk to develop erectile dysfunction in a German ED population","volume":"42","author":"Eisenhardt","year":"2010","journal-title":"Andrologia"},{"key":"2023011111052406100_bib21","first-page":"1319","article-title":"Endothelial nitric oxide synthase polymorphisms and erectile dysfunction: a meta-analysis","volume":"12","author":"Liu","year":"2015","journal-title":"J\u00a0Sex Med"},{"key":"2023011111052406100_bib22","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.eururo.2004.04.032","article-title":"Intracavernosal injection of vascular endothelial growth factor improves erectile function in aged rats","volume":"46","author":"Park","year":"2004","journal-title":"Eur Urol"},{"key":"2023011111052406100_bib23","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1097\/00005344-200411000-00016","article-title":"Vascular endothelial growth factor-induced nitric oxide- and PGI2-dependent relaxation in human internal mammary arteries: a comparative study with KDR and Flt-1 selective mutants","volume":"44","author":"Wei","year":"2004","journal-title":"J\u00a0Cardiovasc Pharmacol"},{"key":"2023011111052406100_bib24","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0022-3565(24)38756-7","article-title":"Vascular endothelial growth factor-mediated endothelium-dependent relaxation is blunted in spontaneously hypertensive rats","volume":"296","author":"Liu","year":"2001","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"2023011111052406100_bib25","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1046\/j.1464-410X.2002.02792.x","article-title":"Intracavernosal injection of vascular endothelial growth factor induces nitric oxide synthase isoforms","volume":"89","author":"Lin","year":"2002","journal-title":"BJU Int"},{"key":"2023011111052406100_bib26","doi-asserted-by":"crossref","first-page":"11870","DOI":"10.1073\/pnas.0502488102","article-title":"Inactivation of phosphorylated endothelial nitric oxide synthase (Ser-1177) by O-GlcNAc in diabetes-associated erectile dysfunction","volume":"102","author":"Musicki","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023011111052406100_bib27","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.2174\/092986706778521986","article-title":"Growth factors and chemokines: a comparative functional approach between invertebrates and vertebrates","volume":"13","author":"Tettamanti","year":"2006","journal-title":"Curr Med Chem"},{"key":"2023011111052406100_bib28","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2174\/138945011793591581","article-title":"Vascular endothelial growth factor (VEGF) in the pathogenesis of diabetic nephropathy of type 1 diabetes mellitus","volume":"12","author":"Mironidou-Tzouveleki","year":"2011","journal-title":"Curr Drug Targets"},{"key":"2023011111052406100_bib29","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/jhh.2011.110","article-title":"Functional VEGF haplotypes affect the susceptibility to hypertension","volume":"27","author":"Sandrim","year":"2013","journal-title":"J\u00a0Hum Hypertens"},{"key":"2023011111052406100_bib30","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1590\/S0066-782X2009000400003","article-title":"Homocysteine and MTHFR and VEGF gene polymorphisms: impact on coronary artery disease","volume":"92","author":"Guerzoni","year":"2009","journal-title":"Arq Bras Cardiol"},{"key":"2023011111052406100_bib31","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00380-008-1057-6","article-title":"Vascular endothelial growth factor genetic variability and coronary artery disease in Brazilian population","volume":"23","author":"Biselli","year":"2008","journal-title":"Heart Vessels"},{"key":"2023011111052406100_bib32","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1136\/jmg.2004.025734","article-title":"VEGF polymorphisms and severity of atherosclerosis","volume":"42","author":"Howell","year":"2005","journal-title":"J\u00a0Med Genet"},{"key":"2023011111052406100_bib33","doi-asserted-by":"crossref","first-page":"e220","DOI":"10.1016\/j.ijcard.2013.12.156","article-title":"Vascular endothelial growth factor polymorphisms and coronary artery disease: a systemic review and meta-analysis","volume":"172","author":"Chen","year":"2014","journal-title":"Int J Cardiol"},{"key":"2023011111052406100_bib34","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3109\/08977194.2012.703664","article-title":"Impact of VEGF polymorphisms on the severity of peripheral artery disease in diabetic patients","volume":"30","author":"Bleda","year":"2012","journal-title":"Growth Factors"},{"key":"2023011111052406100_bib35","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1177\/1479164111426162","article-title":"Vascular endothelial growth factor polymorphisms are involved in the late vascular complications in type II diabetic patients","volume":"9","author":"Bleda","year":"2012","journal-title":"Diab Vasc Dis Res"},{"key":"2023011111052406100_bib36","first-page":"805801","article-title":"The associations between VEGF gene polymorphisms and diabetic retinopathy susceptibility: a meta-analysis of 11 case-control studies","volume":"2014","author":"Han","year":"2014","journal-title":"J\u00a0Diabetes Res"},{"key":"2023011111052406100_bib37","doi-asserted-by":"crossref","first-page":"e84069","DOI":"10.1371\/journal.pone.0084069","article-title":"Association of VEGF gene polymorphisms with diabetic retinopathy: a meta-analysis","volume":"8","author":"Gong","year":"2013","journal-title":"PLoS One"},{"key":"2023011111052406100_bib38","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1089\/gtmb.2015.0098","article-title":"The protective effects of the VEGF-2578C&gt;A and -1154G&gt;A polymorphisms against hypertension susceptibility","volume":"19","author":"Kim","year":"2015","journal-title":"Genet Test Mol Biomarkers"},{"key":"2023011111052406100_bib39","doi-asserted-by":"crossref","first-page":"6213","DOI":"10.1007\/s11033-011-1440-8","article-title":"Vascular endothelial growth factor (VEGF)\u00a0+ 405 C\/G polymorphism is associated with essential hypertension in a population from Tehran of Iran","volume":"39","author":"Hamedian","year":"2012","journal-title":"Mol Biol Rep"}],"container-title":["The Journal of Sexual Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609517301108?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609517301108?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/14\/4\/510\/48525885\/jsm_14_4_510.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/14\/4\/510\/48525885\/jsm_14_4_510.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T19:42:20Z","timestamp":1750189340000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jsm\/article\/14\/4\/510\/6973549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,1]]},"references-count":39,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,4,1]]},"published-print":{"date-parts":[[2017,4,1]]}},"URL":"https:\/\/doi.org\/10.1016\/j.jsxm.2017.02.009","relation":{},"ISSN":["1743-6109","1743-6095"],"issn-type":[{"value":"1743-6109","type":"electronic"},{"value":"1743-6095","type":"print"}],"subject":[],"published-other":{"date-parts":[[2017,4]]},"published":{"date-parts":[[2017,4,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Associations of VEGF Gene Polymorphisms With Erectile Dysfunction and Related Risk Factors","name":"articletitle","label":"Article Title"},{"value":"The Journal of Sexual Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsxm.2017.02.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017, International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}