{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T09:37:19Z","timestamp":1792229839363,"version":"4.4.0"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T00:00:00Z","timestamp":1490918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T00:00:00Z","timestamp":1490918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jsm.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Inflammatory processes underlie biological mechanisms responsible for age-related disease and quality of life. Psychological stress can activate acute-phase reactants associated with inflammation, and sexual activity can assist in the management of stress.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To test whether inflammatory biomarkers (C-reactive protein [CRP], fibrinogen, and white blood cell [WBC] count) would mediate an association between frequency of sexual activity and quality of life in older adulthood.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Older adults from England (N\u00a0= 4,554; 2,049 men, 2,505 women; mean age\u00a0= 66.25 \u00b1 8.89 years) provided blood samples and completed self-report questionnaires on sexual activity, quality of life, and health-related behavior.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Outcomes<\/jats:title>\n                  <jats:p>CRP (milligrams per liter), fibrinogen (grams per liter), WBC count (109 cells\/L), and quality of life (self-report).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Frequency of sexual activity had a negative association with CRP and fibrinogen. An age-moderated effect also showed that frequency of sexual activity had a negative association with WBC count in older participants in the sample (&amp;gt;70 years of age). CRP mediated a positive association between frequency of sexual activity and quality of life. An age-moderated mediation effect also showed that WBC count mediated the association between sexual activity and quality of life in the oldest participants in the sample. All analyses controlled for demographic, anthropometric, and health-related factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Translation<\/jats:title>\n                  <jats:p>More frequent sexual activity might be a useful auxiliary approach to lowering stress-related inflammation and improving quality of life.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Strengths and Limitations<\/jats:title>\n                  <jats:p>Strengths of this study include the large sample and multiple control variables. Limitations include the cross-sectional nature of the data and some loss in sample representativeness.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Findings provide evidence that more sexually active older adults exhibit an anti-inflammatory status associated with a perception of higher quality of life. Further research using prospective designs and natural experimental methods is encouraged.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1016\/j.jsxm.2017.03.247","type":"journal-article","created":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T01:31:13Z","timestamp":1491010273000},"page":"654-658","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Biomarkers of Inflammation Mediate an Association Between Sexual Activity and Quality of Life in Older Adulthood"],"prefix":"10.1093","volume":"14","author":[{"given":"Mark S.","family":"Allen","sequence":"first","affiliation":[{"name":"School of Psychology \u00a0 , Wollongong, NSW , Australia"},{"name":"University of Wollongong \u00a0 , Wollongong, NSW , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,3,31]]},"reference":[{"key":"2023011111050745700_bib1","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1016\/S0140-6736(13)62222-9","article-title":"Associations between health and sexual lifestyles in Britain: findings from the Third National Survey of Sexual Attitudes and Lifestyles (Natsal-3)","volume":"382","author":"Field","year":"2013","journal-title":"Lancet"},{"key":"2023011111050745700_bib2","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0140-6736(09)61717-7","article-title":"C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis","volume":"375","author":"Emerging Risk Factors Collaboration","year":"2010","journal-title":"Lancet"},{"key":"2023011111050745700_bib3","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1056\/NEJMoa1107477","article-title":"C-reactive protein, fibrinogen, and cardiovascular disease prediction","volume":"367","author":"Emerging Risk Factors Collaboration","year":"2012","journal-title":"N\u00a0Engl J Med"},{"key":"2023011111050745700_bib4","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/01.psy.0000221371.43607.64","article-title":"Psychosocial and behavioral predictors of inflammation in middle-aged and older adults: the Chicago Health, Aging, and Social Relations Study","volume":"68","author":"McDade","year":"2006","journal-title":"Psychosom Med"},{"key":"2023011111050745700_bib5","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0889-1591(03)00048-5","article-title":"The inflammatory response is an integral part of the stress response: implications for atherosclerosis, insulin resistance, type II diabetes and metabolic syndrome X","volume":"17","author":"Black","year":"2003","journal-title":"Brain Behav Immun"},{"key":"2023011111050745700_bib6","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s10508-006-9071-1","article-title":"In the mood for love or vice versa? 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