{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T06:10:18Z","timestamp":1764828618298},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T00:00:00Z","timestamp":1521676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T00:00:00Z","timestamp":1521676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Beijing Natural Science Foundation","award":["7162152","81370698","81671448","2016GJK01"],"award-info":[{"award-number":["7162152","81370698","81671448","2016GJK01"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Health and Family Planning Key Laboratory of Male Reproductive Health"}],"content-domain":{"domain":["jsm.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Knowledge on the occurrence of erectile dysfunction (ED) and timely ovulatory intercourse failure (TOIF) in Chinese men of infertile couples is limited.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To obtain representative estimates of ED and TOIF in Chinese men of infertile couples and to analyze potential risk factors associated with ED.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>4,299 Chinese men of infertile couples with an average age of 32.85 \u00b1 5.98 years were surveyed using the 5-item International Index of Erectile Function (IIEF-5) questionnaire for their ED occurrence. Multiple logistic regression analysis was used to disclose risk factors associated with ED.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Outcomes<\/jats:title>\n                  <jats:p>The occurrence of ED was 57.8% and that of TOIF was up to 26.2% in Chinese men of infertile couples.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Based on IIEF-5 criteria, 34.9% of men had mild ED and only 2.6% had severe ED. Secondary infertility, infertility with known causes, and chronic prostatitis were significant risk factors associated with ED. TOIF was significantly higher (23.3%) in men of infertile couples with ED than in those without ED (8.6%), indicating that TOIF is likely a contributing factor to male infertility.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Implications<\/jats:title>\n                  <jats:p>Understanding the occurrence and types of ED and TOIF in men of infertile couples and their associated risk factors will help physicians treat clinical cases of male infertility more effectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Strengths and Limitations<\/jats:title>\n                  <jats:p>Large numbers of infertile outpatients from multiple hospital clinics across the country were included in this study. The concept of TOIF was raised for the 1st time and studied preliminarily in Chinese men of infertile couples. The lack of participants' psychological status, a control group of men of fertile couples, and measurement of testosterone levels was a limitation in this clinic-based study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The occurrence of ED was higher in Chinese men of infertile couples than in the general Chinese male population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1016\/j.jsxm.2018.02.019","type":"journal-article","created":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T14:51:19Z","timestamp":1521730279000},"page":"671-677","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Erectile Dysfunction and Associated Risk Factors in Chinese Males of Infertile Couples"],"prefix":"10.1093","volume":"15","author":[{"given":"Bin","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Urology , Beijing, \u00a0 China"},{"name":"Peking Union Medical College Hospital , Beijing, \u00a0 China"},{"name":"Peking Union Medical College , Beijing, \u00a0 China"},{"name":"Chinese Academy of Medical Sciences , Beijing, \u00a0 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Xu","sequence":"additional","affiliation":[{"name":"Reproductive Center of Jinghua Hospitals , Shenyang, Liaoning , China"},{"name":"Shenyang Oriental Medical Group , Shenyang, Liaoning , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichao","family":"Shi","sequence":"additional","affiliation":[{"name":"Center for Reproduction , Changzhou, Jiangsu , China"},{"name":"Changzhou Number 2 People's Hospital , Changzhou, Jiangsu , China"},{"name":"affiliated with Nanjing Medical University , Changzhou, Jiangsu , 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