{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:20:10Z","timestamp":1788826810872,"version":"build-2803163510"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T00:00:00Z","timestamp":1537401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T00:00:00Z","timestamp":1537401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jsm.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The effectiveness of phosphodiesterase type 5 (PDE5) inhibitors over the conservative management of Peyronie\u2019s disease (PD) has been widely questioned.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To determine the role of sildenafil 25 mg film formulation twice a day (S25 b.i.d.) in the improvement of curvature after treatment of collagenase of Clostridium hystoliticum (CCH) in penile curvature owing to PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From April 2017 to April 2018, 161 consecutive patients were treated with S25 b.i.d.\u00a0+ CCH or CCH alone. Adjustment variables consisted of age, penile curvature, and the 15-question International Index of Erectile Function (IIEF-15) questionnaire at baseline using 1:1 propensity-score matching. Overall, 50 patients were considered subdivided into the following: 25 patients who received S25 b.i.d.\u00a0+ CCH (group A) and 25 who received CCH alone (group B). Patients received CCH injection using a shortened protocol and vacuum device in both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measure<\/jats:title>\n                    <jats:p>The primary outcome of the study was the change in penile curvature after treatment, and secondary outcomes were the change in sexual function (IIEF-15) and in the Peyronie\u2019s Disease Questionnaire (PDQ) and its subscores, PDQ-PS (psychosexual symptoms), PDQ-PP (penile pain), and PDQ-SB (symptom bother).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, mean penile curvature was 47.0\u00b0 (SD 21.88), the mean IIEF-EF (erectile function) was 23.56 (SD 4.10), and the mean PDQ was 27.06 (SD 13.55). After the treatment, we observed a mean change for penile curvature of 25.6 (SD 9.05) in group A and \u201325.6 (SD 9.7) in group B (P &amp;lt; .01), for IIEF-EF of 2.28 (SD 2.33) in group A and 1.36 (SD 1.77) in group B (P\u00a0= .03), for PDQ-PS of \u20133.04 (SD 2.95) in group A and of \u20132.12 (SD 2.06) in group B (P\u00a0= .11), for PDQ-PP of \u20131.0 (SD 4.48) in group A and of \u20130.88 (SD 2.04) in group B (P\u00a0= .60), for PDQ-SB of \u20135.84 (SD 4.58) in group A and of \u20134.16 (SD 4.45) in group B (P\u00a0= .60), and for Female Sexual Function Index of 3.8 (SD 2.45) in group A and of 2.72 (SD 2.28) in group B (P\u00a0= .14). We found a rate of global satisfaction of 70.83% in group A and of 84.0% in group B (P\u00a0= .27).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Implications<\/jats:title>\n                    <jats:p>Addition of S25 b.i.d. to CCH is superior to CCH alone for improving penile curvature and erectile function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Strength &amp; Limitations<\/jats:title>\n                    <jats:p>This is the first study comparing sildenafil\u00a0+ CCH vs CCH alone for the treatment of PD. Lack of randomization and direct verification of appropriate use of penile modeling could be considered limitations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this study, combination therapy was superior in terms of penile curvature and erectile dysfunction improvement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.jsxm.2018.08.012","type":"journal-article","created":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T14:26:53Z","timestamp":1537453613000},"page":"1472-1477","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Sildenafil 25 mg ODT\u00a0+ Collagenase\n                    <i>Clostridium hystoliticum<\/i>\n                    vs Collagenase\n                    <i>Clostridium hystoliticum<\/i>\n                    Alone for the Management of Peyronie\u2019s Disease: A Matched-Pair Comparison Analysis"],"prefix":"10.1093","volume":"15","author":[{"given":"Andrea","family":"Cocci","sequence":"first","affiliation":[{"name":"Department of Urology \u00a0 , Florence , Italy"},{"name":"University of Florence \u00a0 , Florence , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianmartin","family":"Cito","sequence":"additional","affiliation":[{"name":"Department of Urology \u00a0 , Florence , Italy"},{"name":"University of Florence \u00a0 , Florence , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Urz\u00ec","sequence":"additional","affiliation":[{"name":"Urology Section \u00a0 , Catania , Italy"},{"name":"University of Catania \u00a0 , Catania , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Minervini","sequence":"additional","affiliation":[{"name":"Department of Urology \u00a0 , Florence , Italy"},{"name":"University of Florence \u00a0 , Florence , 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