{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T16:51:26Z","timestamp":1778345486370,"version":"3.51.4"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T00:00:00Z","timestamp":1548374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T00:00:00Z","timestamp":1548374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"crossref","award":["2017B030314108"],"award-info":[{"award-number":["2017B030314108"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"crossref","award":["2017B030314108"],"award-info":[{"award-number":["2017B030314108"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["jsm.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Exposure to air pollution poses a risk for morbidity in multiple diseases. However, the role of ambient air pollutant emissions in public sexual health is just beginning to be understood and remains controversial.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>We have determined to elucidate the specific role of gasoline vehicle exhaust (VE), a crucial source and toxicant of air pollution, in the penile erectile function via a rat model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>40 male Sprague Dawley rats, 12 weeks of age, were used in this experiment. Except for the control group (10 rats), rats were equally exposed to VE for total 2 hours, 4 hours, and 6 hours daily for 3 months consecutively. During each VE exposure periods, particulate matter (PM) mass concentrations of PM1, PM2.5, and PM10 were 1.43 \u00b1 0.036, 1.45 \u00b1 0.033, and 1.47 \u00b1 0.037 mg\/m3, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measure<\/jats:title>\n                  <jats:p>Erectile function, pulmonary function, serum inflammatory factors, and histologic examinations of the lung and penile tissues were evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Our study indicates that in\u00a0vivo, 4-hour, and 6-hour daily exposure to VE causes significant reduction of erectile function, as judged by intracavernous pressure measurement. Meanwhile, we have observed that the 4-hour and 6-hour VE exposure rats exhibited remarkable increased levels of serum inflammatory factors, decreased total lung capacity and chord compliance, thickened alveoli septum, destroyed alveoli, pulmonary fibrosis, as well as down-regulation of the messenger RNA and protein expression of endothelial and neuronal nitric oxide synthase in the penile tissue when compared with normal control rats.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Implications<\/jats:title>\n                  <jats:p>We speculated that the underlying mechanisms of VE inducing erectile dysfunction could be attributed to systemic inflammation, pulmonary dysfunction, and the reduction of nitric oxide synthase activity in the corpus cavernosum.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Strength &amp; Limitations<\/jats:title>\n                  <jats:p>For the first time, our study revealed the deleterious effect of VE on penile erection in\u00a0vivo. However, the VE exposure model might not entirely mimic the natural condition of ambient air pollution.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our results raise concerns about the potential role played by long-term exposure to gasoline VE in the\u00a0development of erectile dysfunction.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1016\/j.jsxm.2018.12.013","type":"journal-article","created":{"date-parts":[[2019,1,27]],"date-time":"2019-01-27T10:09:18Z","timestamp":1548583758000},"page":"155-167","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Elucidating Mechanisms of Long-Term Gasoline Vehicle Exhaust Exposure\u2013Induced Erectile Dysfunction in a Rat Model"],"prefix":"10.1093","volume":"16","author":[{"given":"Shankun","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Urology & Andrology , Guangzhou, Guangdong , China"},{"name":"Minimally Invasive Surgery Center , Guangzhou, Guangdong , China"},{"name":"Guangdong Provincial Key Laboratory of Urology , Guangzhou, Guangdong , China"},{"name":"The First Affiliated Hospital of Guangzhou Medical University , Guangzhou, Guangdong , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiamin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology & Andrology , Guangzhou, Guangdong , China"},{"name":"Minimally Invasive Surgery Center , Guangzhou, Guangdong , China"},{"name":"Guangdong Provincial Key Laboratory of Urology , Guangzhou, Guangdong , China"},{"name":"The First Affiliated Hospital of Guangzhou Medical University , Guangzhou, Guangdong , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Reproduction , Dongguan, Guangdong , China"},{"name":"Southern Medical University Affiliate Dongguan People's Hospital , Dongguan, Guangdong , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianmin","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Urology & Andrology , Guangzhou, Guangdong , China"},{"name":"Minimally Invasive Surgery Center , Guangzhou, Guangdong , China"},{"name":"Guangdong Provincial Key Laboratory of Urology , Guangzhou, Guangdong , China"},{"name":"The First Affiliated Hospital of Guangzhou Medical University , Guangzhou, Guangdong , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiguo","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Urology & Andrology , Guangzhou, Guangdong , China"},{"name":"Minimally Invasive Surgery Center , Guangzhou, Guangdong , China"},{"name":"Guangdong Provincial Key Laboratory of Urology , Guangzhou, Guangdong , China"},{"name":"The First Affiliated Hospital of Guangzhou Medical University , Guangzhou, Guangdong , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangzhou","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology & Andrology , Guangzhou, Guangdong , China"},{"name":"Minimally Invasive Surgery Center , Guangzhou, Guangdong , China"},{"name":"Guangdong Provincial Key Laboratory of Urology , Guangzhou, Guangdong , China"},{"name":"The First Affiliated Hospital of Guangzhou Medical University , Guangzhou, Guangdong , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihan","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Urology & Andrology , Guangzhou, Guangdong , China"},{"name":"Minimally Invasive Surgery Center , Guangzhou, Guangdong , China"},{"name":"Guangdong Provincial Key Laboratory of Urology , Guangzhou, Guangdong , China"},{"name":"The First Affiliated Hospital of Guangzhou Medical University , Guangzhou, Guangdong , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Urology , Hengyang, Hunan , China"},{"name":"The First Affiliated Hospital of University of South China , Hengyang, Hunan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jintai","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Urology & Andrology , Guangzhou, Guangdong , China"},{"name":"Minimally Invasive Surgery Center , Guangzhou, Guangdong , China"},{"name":"Guangdong Provincial Key Laboratory of Urology , Guangzhou, Guangdong , China"},{"name":"The First Affiliated Hospital of Guangzhou Medical University , Guangzhou, Guangdong , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhigang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Urology & Andrology , Guangzhou, Guangdong , China"},{"name":"Minimally Invasive Surgery Center , Guangzhou, Guangdong , China"},{"name":"Guangdong Provincial Key Laboratory of Urology , Guangzhou, Guangdong , China"},{"name":"The First Affiliated Hospital of Guangzhou Medical University , Guangzhou, Guangdong , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,1,25]]},"reference":[{"key":"2023012309424542100_bib1","first-page":"1939","article-title":"Impact of air pollution on the burden of chronic respiratory diseases in China: Time for urgent action","volume":"388","author":"Guan","year":"2016"},{"key":"2023012309424542100_bib2","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/S0140-6736(17)30505-6","article-title":"Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: An analysis of data from the Global Burden of Diseases Study 2015","volume":"389","author":"Cohen","year":"2017","journal-title":"Lancet"},{"issue":"Suppl. 1","key":"2023012309424542100_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/08958371003793846","article-title":"Is the air pollution health research community prepared to support a multipollutant air quality management framework?","volume":"22","author":"Mauderly","year":"2010","journal-title":"Inhal Toxicol"},{"key":"2023012309424542100_bib4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.neuro.2016.10.012","article-title":"Atypical microglial response to biodiesel exhaust in healthy and hypertensive rats","volume":"59","author":"Mumaw","year":"2017","journal-title":"Neurotoxicology"},{"key":"2023012309424542100_bib5","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1080\/10962247.2012.701193","article-title":"Winter and summer PM2.5 chemical compositions in fourteen Chinese cities","volume":"62","author":"Cao","year":"2012","journal-title":"J\u00a0Air Waste Manag Assoc"},{"key":"2023012309424542100_bib6","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1021\/pr500939c","article-title":"Effects of motor vehicle exhaust on male reproductive function and associated proteins","volume":"14","author":"Rengaraj","year":"2015","journal-title":"J\u00a0Proteome Res"},{"key":"2023012309424542100_bib7","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1289\/ehp.11074","article-title":"Meeting report: Atmospheric pollution and human reproduction","volume":"116","author":"Slama","year":"2008","journal-title":"Environ Health Perspect"},{"key":"2023012309424542100_bib8","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.envpol.2017.10.092","article-title":"Lifetime exposure to particulate air pollutants is negatively associated with lung function in non-asthmatic children","volume":"236","author":"Tsui","year":"2018","journal-title":"Environ Pollut"},{"key":"2023012309424542100_bib9","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1093\/ajh\/hpu302","article-title":"Air pollution and emergency department visits for hypertension in Edmonton and Calgary, Canada: A case-crossover study","volume":"28","author":"Brook","year":"2015","journal-title":"Am J Hypertens"},{"key":"2023012309424542100_bib10","doi-asserted-by":"crossref","first-page":"e147632","DOI":"10.1371\/journal.pone.0147632","article-title":"Biomarkers of exposure to polycyclic aromatic hydrocarbons and cognitive function among elderly in the United States (National Health and Nutrition Examination Survey: 2001\u20132002)","volume":"11","author":"Best","year":"2016","journal-title":"PLoS One"},{"key":"2023012309424542100_bib11","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.envint.2016.04.037","article-title":"Exposure to air pollutants during the early weeks of pregnancy, and placenta praevia and placenta accreta in the western part of Japan","volume":"92\u201393","author":"Michikawa","year":"2016","journal-title":"Environ Int"},{"key":"2023012309424542100_bib12","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.envpol.2018.01.021","article-title":"Seasonal variation of semen parameters correlates with environmental temperature and air pollution: A big data analysis over 6 years","volume":"235","author":"Santi","year":"2018","journal-title":"Environ Pollut"},{"key":"2023012309424542100_bib13","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.envres.2014.05.004","article-title":"Exposure to traffic pollution, acute inflammation and autonomic response in a panel of car commuters","volume":"133","author":"Sarnat","year":"2014","journal-title":"Environ Res"},{"key":"2023012309424542100_bib14","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s00408-012-9398-4","article-title":"Sexual dysfunction in men with COPD: Impact on quality of life and survival","volume":"190","author":"Collins","year":"2012","journal-title":"Lung"},{"key":"2023012309424542100_bib15","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.urology.2016.08.034","article-title":"Effects of fine particulate matter on erectile function and its potential mechanism in rats","volume":"102","author":"Wang","year":"2017","journal-title":"Urology"},{"key":"2023012309424542100_bib16","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12940-017-0216-6","article-title":"Erectile dysfunction and exposure to ambient air pollution in a nationally representative cohort of older men","volume":"16","author":"Tallon","year":"2017","journal-title":"Environ Health"},{"key":"2023012309424542100_bib17","doi-asserted-by":"crossref","first-page":"45666","DOI":"10.1038\/srep45666","article-title":"Exposure to ambient particulate matter induced COPD in a rat model and a description of the underlying mechanism","volume":"7","author":"He","year":"2017","journal-title":"Sci Rep"},{"key":"2023012309424542100_bib18","first-page":"1754","article-title":"Asthma and risk of erectile dysfunction\u2014A nationwide population-based study","volume":"8","author":"Chou","year":"2011","journal-title":"J\u00a0Sex Med"},{"key":"2023012309424542100_bib19","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/1479972315619382","article-title":"Erectile dysfunction in COPD patients","volume":"13","author":"Turan","year":"2016","journal-title":"Chron Respir Dis"},{"key":"2023012309424542100_bib20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.toxlet.2016.12.016","article-title":"Maternal exposure to fine particulate air pollution induces epithelial-to-mesenchymal transition resulting in postnatal pulmonary dysfunction mediated by transforming growth factor-beta\/Smad3 signaling","volume":"267","author":"Tang","year":"2017","journal-title":"Toxicol Lett"},{"key":"2023012309424542100_bib21","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/S0090-4295(97)00693-6","article-title":"Intracavernous pressure responses to physical and electrical stimulation of the cavernous nerve in rats","volume":"51","author":"Rehman","year":"1998","journal-title":"Urology"},{"key":"2023012309424542100_bib22","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.urology.2016.02.021","article-title":"Shengjing capsule improves erectile function through regulation of nitric oxide-induced relaxation in corpus cavernosum smooth muscle in a castrated rat model","volume":"91","author":"Zhao","year":"2016","journal-title":"Urology"},{"key":"2023012309424542100_bib23","first-page":"e193543","article-title":"Comparison of two cannulation methods for assessment of intracavernosal pressure in a rat model","volume":"13","author":"Zhao","year":"2018","journal-title":"PLoS One"},{"key":"2023012309424542100_bib24","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.urology.2017.02.020","article-title":"Effect of testosterone on the phenotypic modulation of corpus cavernosum smooth muscle cells in a castrated rat model","volume":"103","author":"Liu","year":"2017","journal-title":"Urology"},{"key":"2023012309424542100_bib25","first-page":"1206","article-title":"Pollution levels of PM1, PM2.5, and PM10 on Shanghai road","volume":"30","author":"Shen","year":"2011","journal-title":"Environment Chem"},{"key":"2023012309424542100_bib26","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.eururo.2017.03.032","article-title":"Meta-analysis of results of testosterone therapy on sexual function based on International Index of Erectile Function Scores","volume":"72","author":"Corona","year":"2017","journal-title":"Eur Urol"},{"key":"2023012309424542100_bib27","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.eururo.2013.08.023","article-title":"A\u00a0systematic review of the association between erectile dysfunction and cardiovascular disease","volume":"65","author":"Gandaglia","year":"2014","journal-title":"Eur Urol"},{"key":"2023012309424542100_bib28","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ijheh.2017.10.001","article-title":"Particulate matter air pollution, physical activity and systemic inflammation in Taiwanese adults","volume":"221","author":"Zhang","year":"2018","journal-title":"Int J Hyg Environ Health"},{"key":"2023012309424542100_bib29","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1111\/andr.12375","article-title":"Maintenance of the contractile phenotype in corpus cavernosum smooth muscle cells by Myocardin gene therapy ameliorates erectile dysfunction in bilateral cavernous nerve injury rats","volume":"5","author":"Zhang","year":"2017","journal-title":"Andrology"},{"key":"2023012309424542100_bib30","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1056\/NEJM200006153422407","article-title":"Erectile dysfunction","volume":"342","author":"Lue","year":"2000","journal-title":"N\u00a0Engl J Med"},{"key":"2023012309424542100_bib31","first-page":"920","article-title":"Assessment of androgen replacement therapy for erectile function in rats with type 2 diabetes mellitus by examining nitric oxide-related and inflammatory factors","volume":"11","author":"Kataoka","year":"2014","journal-title":"J\u00a0Sex Med"},{"key":"2023012309424542100_bib32","doi-asserted-by":"crossref","first-page":"e114913","DOI":"10.1371\/journal.pone.0114913","article-title":"The cardiopulmonary effects of ambient air pollution and mechanistic pathways: A comparative hierarchical pathway analysis","volume":"9","author":"Roy","year":"2014","journal-title":"PLoS One"},{"key":"2023012309424542100_bib33","doi-asserted-by":"crossref","first-page":"8306","DOI":"10.1038\/s41598-017-08859-1","article-title":"Psychological impact of vehicle exhaust exposure: Insights from an animal model","volume":"7","author":"Salvi","year":"2017","journal-title":"Sci Rep"},{"key":"2023012309424542100_bib34","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.envpol.2014.07.022","article-title":"Impact of urbanization level on urban air quality: A case of fine particles (PM(2.5)) in Chinese cities","volume":"194","author":"Han","year":"2014","journal-title":"Environ Pollut"},{"key":"2023012309424542100_bib35","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.envpol.2018.08.028","article-title":"Using rush hour and daytime exposure indicators to estimate the short-term mortality effects of air pollution: A case study in the Sichuan Basin, China","volume":"242","author":"Guo","year":"2018","journal-title":"Environ Pollut"},{"key":"2023012309424542100_bib36","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.scitotenv.2018.01.216","article-title":"Determining factors for levels of volatile organic compounds measured in different microenvironments of a heavy traffic urban area","volume":"627","author":"Phuc","year":"2018","journal-title":"Sci Total Environ"},{"key":"2023012309424542100_bib37","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jes.2016.05.039","article-title":"Characterization of particle number size distribution and new particle formation in Southern China","volume":"51","author":"Huang","year":"2017","journal-title":"J\u00a0Environ Sci (China)"},{"key":"2023012309424542100_bib38","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0140-6736(12)60520-0","article-title":"Erectile dysfunction","volume":"381","author":"Shamloul","year":"2013","journal-title":"Lancet"},{"key":"2023012309424542100_bib39","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12989-014-0070-4","article-title":"Exposure to traffic-related air pollution during physical activity and acute changes in blood pressure, autonomic and micro-vascular function in women: A cross-over study","volume":"11","author":"Weichenthal","year":"2014","journal-title":"Part Fibre Toxicol"},{"key":"2023012309424542100_bib40","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1136\/oemed-2015-103136","article-title":"Associations of short-term exposure to traffic-related air pollution with cardiovascular and respiratory hospital admissions in London, UK","volume":"73","author":"Samoli","year":"2016","journal-title":"Occup Environ Med"},{"key":"2023012309424542100_bib41","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1136\/heart.89.3.251","article-title":"Erectile dysfunction and the cardiovascular patient: Endothelial dysfunction is the common denominator","volume":"89","author":"Solomon","year":"2003","journal-title":"Heart"},{"key":"2023012309424542100_bib42","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1093\/eurheartj\/ehi749","article-title":"Coronary endothelial dysfunction is associated with erectile dysfunction and elevated asymmetric dimethylarginine in patients with early atherosclerosis","volume":"27","author":"Elesber","year":"2006","journal-title":"Eur Heart J"},{"key":"2023012309424542100_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1439-0272.2009.01021.x","article-title":"Cardiovascular diseases and erectile dysfunction: The two faces of the coin of androgen deficiency","volume":"43","author":"Yassin","year":"2011","journal-title":"Andrologia"},{"key":"2023012309424542100_bib44","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1139\/cjpp-2017-0113","article-title":"TNF-alpha antagonism with etanercept enhances penile NOS expression, cavernosal reactivity, and testosterone levels in aged rats","volume":"96","author":"Demirtas","year":"2018","journal-title":"Can J Physiol Pharmacol"},{"key":"2023012309424542100_bib45","first-page":"1540","article-title":"Testosterone deficiency causes endothelial dysfunction via elevation of asymmetric dimethylarginine and oxidative stress in castrated rats","volume":"14","author":"Kataoka","year":"2017","journal-title":"J\u00a0Sex Med"},{"key":"2023012309424542100_bib46","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1164\/rccm.200606-872OC","article-title":"Persistent endothelial dysfunction in humans after diesel exhaust inhalation","volume":"176","author":"Tornqvist","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"2023012309424542100_bib47","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12989-016-0116-x","article-title":"Platelet activation independent of pulmonary inflammation contributes to diesel exhaust particulate-induced promotion of arterial thrombosis","volume":"13","author":"Tabor","year":"2016","journal-title":"Part Fibre Toxicol"},{"key":"2023012309424542100_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2010.09.042","article-title":"Nitric oxide-mediated blood flow regulation as affected by smoking and nicotine","volume":"649","author":"Toda","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"2023012309424542100_bib49","first-page":"2535","article-title":"Glutamine with probiotics attenuates intestinal inflammation and oxidative stress in a rat burn injury model through altered iNOS gene aberrant methylation","volume":"9","author":"Gong","year":"2017","journal-title":"Am J Transl Res"},{"key":"2023012309424542100_bib50","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1016\/j.tiv.2011.08.008","article-title":"DIESEL particulate exposed macrophages alter endothelial cell expression of eNOS, iNOS, MCP1, and glutathione synthesis genes","volume":"25","author":"Weldy","year":"2011","journal-title":"Toxicol In\u00a0Vitro"},{"key":"2023012309424542100_bib51","first-page":"1568","article-title":"Erectile dysfunction is associated with subsequent cardiovascular and respiratory mortality in cohort of 1,436 Chinese elderly men","volume":"12","author":"Chung","year":"2015","journal-title":"J\u00a0Sex Med"},{"key":"2023012309424542100_bib52","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/sj.ijir.3901560","article-title":"The role of hypoxia in erectile dysfunction mechanisms","volume":"19","author":"Verratti","year":"2007","journal-title":"Int J Impot Res"},{"key":"2023012309424542100_bib53","first-page":"1992","article-title":"Sexual dysfunction in patients with obstructive sleep apnea: A systematic review and meta-analysis","volume":"12","author":"Liu","year":"2015","journal-title":"J\u00a0Sex Med"},{"key":"2023012309424542100_bib54","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.envpol.2017.04.080","article-title":"The use of a 0.20 \u03bcm particulate matter filter decreases cytotoxicity in lung epithelial cells following air-liquid interface exposure to motorcycle exhaust","volume":"227","author":"Yu","year":"2017","journal-title":"Environ Pollut"}],"container-title":["The Journal of Sexual Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609518313882?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609518313882?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/16\/2\/155\/48602652\/jsm_16_2_155.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/16\/2\/155\/48602652\/jsm_16_2_155.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T10:19:48Z","timestamp":1674469188000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jsm\/article\/16\/2\/155\/6980607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,25]]},"references-count":54,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,1,25]]},"published-print":{"date-parts":[[2019,2,1]]}},"URL":"https:\/\/doi.org\/10.1016\/j.jsxm.2018.12.013","relation":{},"ISSN":["1743-6109","1743-6095"],"issn-type":[{"value":"1743-6109","type":"electronic"},{"value":"1743-6095","type":"print"}],"subject":[],"published-other":{"date-parts":[[2019,2]]},"published":{"date-parts":[[2019,1,25]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elucidating Mechanisms of Long-Term Gasoline Vehicle Exhaust Exposure\u2013Induced Erectile Dysfunction in a Rat Model","name":"articletitle","label":"Article Title"},{"value":"The Journal of Sexual Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsxm.2018.12.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}