{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:13:28Z","timestamp":1788344008353,"version":"build-2803163510"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003569","name":"Korean Ministry of Food and Drug Safety","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Across Co, Ltd"},{"DOI":"10.13039\/501100003569","name":"Korean Ministry of Food and Drug Safety","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["jsm.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,4,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Studies about the clinical utility of fillers on penile augmentation (PA) are lacking. Furthermore, no randomized study has compared the utilities of fillers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To compare the efficacy and safety between hyaluronic acid (HA) and polylactic acid (PLA) filler injection for PA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This prospective, randomized patient\/evaluator-blind, comparative multicenter study consisted of an initial 2-week baseline period and 48-week patient\/evaluator-blind post-injection period. 72 patients with small penis syndrome were enrolled from 3 institutions between March\u2013July 2016. Patients were divided into 2\u00a0groups: the HA group, comprising 36 patients injected with HA, and the PLA group, comprising 36 patients injected with PLA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures<\/jats:title>\n                  <jats:p>Penile girth and satisfaction were assessed at baseline and at 4, 12, 24, and 48 weeks after injection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Penile girth increases adequately lasted \u226448 weeks in both groups (16.95 \u00b1 10.53 and 13.49 \u00b1 9.98 mm of mean increase in the HA and PLA groups, respectively; P &amp;lt; .001). The mean penile girth increase in the HA group was significantly greater than that in the PLA group at 4 weeks (P &amp;lt; .001). Subsequently, it gradually decreased and was no longer significantly different at 48 weeks (P\u00a0= .075). Satisfaction levels increased after injection and were maintained \u226448 weeks. No significant differences were observed in the overall satisfaction level between the groups (P &amp;gt; .05). Filler injection\u2013related adverse events were mild and transient and occurred in 1 and 3 patients in the HA and PLA groups, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Implications<\/jats:title>\n                  <jats:p>This study provides an overview of the efficacy and safety of HA and PLA fillers, which are the most commonly used soft tissue fillers for PA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Strength and Limitations<\/jats:title>\n                  <jats:p>This study, to our knowledge, is the first to compare the efficacy and safety between different filler injections for human PA. However, it was impossible to perform a researcher-blinded trial because of the unique properties of fillers, and 31 patients (43.1%) were dropped during the study period.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Both HA and PLA filler injections for PA led to a significant augmentative effect without serious adverse events and had clinically comparable efficacy and safety.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1016\/j.jsxm.2019.01.310","type":"journal-article","created":{"date-parts":[[2019,3,2]],"date-time":"2019-03-02T01:29:05Z","timestamp":1551490145000},"page":"577-585","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["A Comparison of the Efficacy and Safety Between Hyaluronic Acid and Polylactic Acid Filler Injection in Penile Augmentation: A Multicenter, Patient\/Evaluator-Blinded, Randomized Trial"],"prefix":"10.1093","volume":"16","author":[{"given":"Dae Yul","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Urology \u00a0 \u00a0 \u00a0 , Seoul , Korea"},{"name":"College of Medicine \u00a0 \u00a0 \u00a0 , Seoul , Korea"},{"name":"Hallym University \u00a0 \u00a0 \u00a0 , Seoul , Korea"},{"name":"Kangdong Sacred Heart Hospital \u00a0 \u00a0 \u00a0 , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungtae","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Urology \u00a0 \u00a0 \u00a0 , Seoul , Korea"},{"name":"College of Medicine \u00a0 \u00a0 \u00a0 , Seoul , Korea"},{"name":"Hallym University \u00a0 \u00a0 \u00a0 , Seoul , Korea"},{"name":"Kangdong Sacred Heart Hospital \u00a0 \u00a0 \u00a0 , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Urology \u00a0 \u00a0 \u00a0 , Hwaseong , Korea"},{"name":"College of Medicine \u00a0 \u00a0 \u00a0 , Hwaseong , Korea"},{"name":"Hallym University \u00a0 \u00a0 \u00a0 , Hwaseong , Korea"},{"name":"Dongtan Sacred Heart Hospital \u00a0 \u00a0 \u00a0 , Hwaseong , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Ki","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Urology \u00a0 \u00a0 \u00a0 , Chuncheon , Korea"},{"name":"College of Medicine \u00a0 \u00a0 \u00a0 , Chuncheon , Korea"},{"name":"Hallym University \u00a0 \u00a0 \u00a0 , Chuncheon , Korea"},{"name":"Chuncheon Sacred Heart Hospital \u00a0 \u00a0 \u00a0 , Chuncheon , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,3,1]]},"reference":[{"key":"2023010718591739000_bib1","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1097\/MOU.0b013e3283318f31","article-title":"The status of penile enhancement 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Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}