{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T16:58:06Z","timestamp":1769878686795,"version":"3.49.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jsm.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,6,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Peyronie\u2019s disease (PD) is a progressive and devastating penile disorder that often results in severe penile curvature with penile shrinking, making vaginal insertion difficult or even impossible. Until now, in contrast to other penile disorders such as erectile dysfunction, PD is characterized by a paucity of conservative treatment options.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To investigate the current status quo in the management of PD across European experts in sexual medicine.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Members of the European Society of Sexual Medicine and of various andrology and urology societies across Europe, with the majority (78%) being urologists, were contacted via e-mail and newsletters and asked to fill in an online questionnaire. The survey comprised 56 items developed by an expert consensus of the educational committee of the European Society of Sexual Medicine. In the end, 401 participants responded to the entire survey, with 277 reporting treating PD patients themselves and knowing this penile entity very well.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures<\/jats:title>\n                  <jats:p>Main outcome measures include description of current strategies regarding diagnosis and treatment of PD as reported by specialists in this field.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the physicians treating PD patients, 94% performed penile palpation, and 74% perform ultrasonography. 45% assessed the degree of penile curvature by means of intravenous drug testing, but only 17% measured it accurately with a goniometer. Penile length, flaccid or in erect state, was measured by only 39% or 25%, respectively. Only 45% assessed testosterone. Primary treatment options were oral (65%), counseling (57%), and topical\/local therapy (30%). Among oral drug users, tadalafil 5 mg was the most commonly used (57%), followed by vitamin E (40%). Regarding intralesional therapy, collagenase clostridium histolyticum was the leading drug (34%), followed by calcium channel blockers (17%). Considering surgical procedures, the original Nesbit technique was the preferred procedure (33%). 36% of the specialists expressed their dissatisfaction with the currently available treatment options, and 64% reported the impression that their patients were mostly dissatisfied with the treatment outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Implications<\/jats:title>\n                  <jats:p>Innovative and presumably multi-modal treatment protocols for PD are urgently needed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Strengths &amp; Limitations<\/jats:title>\n                  <jats:p>The survey represents 1 of the largest studies on the management of PD. The results are representative for the standard management of PD mostly among European Urologists with specialization in sexual medicine and may therefore not be generalizable to regions outside Europe or to other physicians treating PD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Around one-third of experts and, from their perspective, around two-thirds of patients are dissatisfied with the currently available PD treatment options.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1016\/j.jsxm.2019.03.404","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T09:29:38Z","timestamp":1557912578000},"page":"901-908","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Current Strategies in the Management of Peyronie\u2019s Disease (PD)\u2014Results of a Survey of 401 Sexual Medicine Experts Across Europe"],"prefix":"10.1093","volume":"16","author":[{"given":"Hartmut","family":"Porst","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Burri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the European Society for Sexual Medicine (ESSM) Educational Committee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,5,15]]},"reference":[{"key":"2023010719011768100_bib1","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/sj.ijir.3900877","article-title":"Clinical presentations of Peyronie's disease","volume":"14","author":"Pryor","year":"2002","journal-title":"Int J Impotence Res"},{"key":"2023010719011768100_bib2","first-page":"1985","article-title":"The chronology of depression and distress in men with Peyronie's disease","volume":"5","author":"Nelson","year":"2008","journal-title":"J\u00a0Sex Med"},{"key":"2023010719011768100_bib3","doi-asserted-by":"crossref","first-page":"280","DOI":"10.21037\/tau.2016.04.05","article-title":"Peyronie\u2019s disease: a literature review on epidemiology, genetics, pathophysiology, diagnosis and work-up","volume":"5","author":"Al-Thakafi","year":"2016","journal-title":"Transl Androl Urol"},{"key":"2023010719011768100_bib4","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.sxmr.2015.10.002","article-title":"The genetic basics of Peyronie Disease: A Review","volume":"4","author":"Herati","year":"2016","journal-title":"Sex Med Rev"},{"key":"2023010719011768100_bib5","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.eururo.2006.02.059","article-title":"A\u00a0Critical Analysis of Nonsurgical Treatment of Peyronie\u2019s Disease","volume":"49","author":"Hauck","year":"2006","journal-title":"Eur Urol"},{"issue":"7","key":"2023010719011768100_bib6","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s11934-018-0800-5","article-title":"Contemporary Review of Peyronie\u2019s Disease Treatment","volume":"19","author":"Capoccia","year":"2018","journal-title":"Curr Urol Rep"},{"issue":"6","key":"2023010719011768100_bib7","first-page":"905","article-title":"Evidence-Based Management Guidelines on Peyronie's Disease","volume":"13","author":"Chung","year":"2016","journal-title":"J\u00a0Sex Med"},{"issue":"6","key":"2023010719011768100_bib8","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s11934-014-0415-4","article-title":"Update on medical management of Peyronie\u2019s disease","volume":"15","author":"Tan","year":"2014","journal-title":"Curr Urol Rep"},{"key":"2023010719011768100_bib9","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.eururo.2004.12.022","article-title":"Potassium paraaminobenzoate (POTABA) in the treatment of Peyronie\u2019s disease: A prospective, placebo-controlled, randomized study","volume":"47","author":"Weidner","year":"2005","journal-title":"Eur Urol"},{"issue":"1","key":"2023010719011768100_bib10","first-page":"248","article-title":"Clinical safety and effectiveness of collagenase clostridium histolyticum injection in patients with Peyronie's disease: a phase 3 open-label study","volume":"12","author":"Levine","year":"2015","journal-title":"J\u00a0Sex Med"},{"key":"2023010719011768100_bib11","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.sxmr.2017.03.005","article-title":"Collagenase Clostridium Histolyticum in the Treatment of Urologic Disease: Current and Future Impact","volume":"6","author":"Gabrielson","year":"2018","journal-title":"Sex Med Rev"},{"key":"2023010719011768100_bib12","first-page":"1220","article-title":"Safety and Efficacy of Collagenase Clostridium histolyticum in the Treatment of Acute-Phase Peyronie\u2019s Disease","volume":"14","author":"Nguyen","year":"2017","journal-title":"J\u00a0Sex Med"},{"key":"2023010719011768100_bib13","first-page":"684","article-title":"Results of SMSNA Survey Regarding Complications Following Intralesional Injection Therapy With Collagenase Clostridium Histolyticum for Peyronie\u2019s Disease","volume":"13","author":"Yafi","year":"2016","journal-title":"J\u00a0Sex Med"},{"key":"2023010719011768100_bib14","first-page":"568","article-title":"A\u00a0Worldwide Survey on Peyronie\u2019s Disease Surgical Practice Patterns Among Surgeons","volume":"15","author":"Chung","year":"2018","journal-title":"J\u00a0Sex Med"},{"issue":"7","key":"2023010719011768100_bib15","first-page":"397","article-title":"General urologists' attitudes towards the use of collagenase clostridium histolyticum (Xiapex) in Peyronie's Disease","volume":"15","author":"Tal","year":"2018","journal-title":"J\u00a0Sex Med"},{"issue":"6","key":"2023010719011768100_bib16","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.eururo.2018.07.005","article-title":"Clinical Efficacy of Injection and Mechanical Therapy for Peyronie\u2019s Disease: A Systematic Review of Literature","volume":"74","author":"Russo","year":"2018","journal-title":"Eur Urol"},{"key":"2023010719011768100_bib17","first-page":"954","article-title":"Urologist practice patterns in the management of Peyronie's disease: a nationwide survey","volume":"5","author":"Shindel","year":"2008","journal-title":"J\u00a0Sex Med"},{"issue":"2","key":"2023010719011768100_bib18","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/andr.292","article-title":"Peyronie's disease: urologist's knowledge base and practice patterns","volume":"3","author":"Sullivan","year":"2015","journal-title":"Androl"},{"key":"2023010719011768100_bib19","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.urology.2015.08.033","article-title":"An Analysis of Case Logs From American Urologists in the Treatment of Peyronie's Disease","volume":"87","author":"Oberlin","year":"2016","journal-title":"Urol"},{"issue":"1","key":"2023010719011768100_bib20","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4111\/kju.2014.55.1.57","article-title":"Urologists' Perceptions and Practice Patterns in Peyronie's Disease: A Korean Nation-wide Survey Including Patient Satisfaction","volume":"55","author":"Ko","year":"2014","journal-title":"Korean J Urol"},{"issue":"1","key":"2023010719011768100_bib21","first-page":"199","article-title":"Clinical efficacy, safety and tolerability of collagenase clostridium histolyticum for the treatment of Peyronie disease in 2 large double-blind, randomized, placebo-controlled phase 3 studies","volume":"190","author":"Gelbard","year":"2013","journal-title":"J\u00a0Urol"},{"issue":"2","key":"2023010719011768100_bib22","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.1365-2605.2011.01226.x","article-title":"Tadalafil once daily and extracorporeal shock wave therapy in the management of patients with Peyronie's disease and erectile dysfunction: results from a prospective randomized trial","volume":"35","author":"Palmieri","year":"2012","journal-title":"Int J Androl"},{"issue":"3","key":"2023010719011768100_bib23","first-page":"1019","article-title":"Favorable patient reported outcomes after penile plication for wide array of Peyronie disease abnormalities","volume":"189","author":"Hudak","year":"2013","journal-title":"J\u00a0Urol"},{"issue":"2","key":"2023010719011768100_bib24","first-page":"594","article-title":"Five-year follow-up of Peyronie's graft surgery: outcomes and patient satisfaction","volume":"8","author":"Chung","year":"2011","journal-title":"J\u00a0Sex Med"},{"issue":"5","key":"2023010719011768100_bib25","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.eururo.2004.04.027","article-title":"Straightening corporoplasty for Peyronie's disease: a review of 218 patients with median follow-up of 89 months","volume":"46","author":"Savoca","year":"2004","journal-title":"Eur Urol"}],"updated-by":[{"DOI":"10.1016\/j.jsxm.2019.07.006","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000}}],"container-title":["The Journal of Sexual Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609519309270?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609519309270?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/16\/6\/901\/48477084\/jsm_16_6_901.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/16\/6\/901\/48477084\/jsm_16_6_901.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,7]],"date-time":"2023-01-07T14:02:04Z","timestamp":1673100124000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jsm\/article\/16\/6\/901\/6966758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,15]]},"references-count":25,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,5,15]]},"published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.1016\/j.jsxm.2019.03.404","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.jsxm.2019.07.006","asserted-by":"object"}]},"ISSN":["1743-6109","1743-6095"],"issn-type":[{"value":"1743-6109","type":"electronic"},{"value":"1743-6095","type":"print"}],"subject":[],"published-other":{"date-parts":[[2019,6]]},"published":{"date-parts":[[2019,5,15]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Current Strategies in the Management of Peyronie\u2019s Disease (PD)\u2014Results of a Survey of 401 Sexual Medicine Experts Across Europe","name":"articletitle","label":"Article Title"},{"value":"The Journal of Sexual Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsxm.2019.03.404","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 International Society for Sexual Medicine. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}