{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T08:15:39Z","timestamp":1782461739712,"version":"3.54.5"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T00:00:00Z","timestamp":1562803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T00:00:00Z","timestamp":1562803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"am","delay-in-days":378,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100016945","name":"Sidney Kimmel Center for Prostate and Urologic Cancers","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100016945","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institutes of Health\/National Cancer Institute to Memorial Sloan Kettering Cancer Center","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}]},{"name":"Sidney Kimmel Center for Prostate and Urologic Cancers"},{"name":"National Institutes of Health\/National Cancer Institute","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}]}],"content-domain":{"domain":["jsm.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>There are some data suggesting that there is a relationship between the magnitude of Peyronie\u2019s disease (PD)\u2013associated penile curvature and low serum testosterone.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To evaluate the relationship between PD associated penile deformity and total testosterone (TT) and free testosterone (FT) levels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We identified patients diagnosed with PD who had early morning TT measurements. Because laboratories have different reference values, we analyzed testosterone values 2 ways, as raw values and as standardized values (TT and FT values converted into z-scores for each laboratory). Deformity assessment was conducted during an intracavernosal injection\u2013induced rigid erection. The association between T levels and magnitude of penile curvature was analyzed in a number of ways. First, an independent measure t-test tested differences in curvature degree by TT groups (low T: &amp;lt;300 ng\/dL; normal T: \u2265300 ng\/dL). Second, an association was sought between T levels based on quartiles of the normal range (&amp;lt;300, 300\u2013450, 450\u2013600, and &amp;gt;600 ng\/dL). These analyses were conducted for both TT and FT levels and using both raw and standardized T values. Third, multivariable analysis using multiple linear regression was performed in an attempt to define predictors of the degree of penile curvature. Factors entered into the model included: TT level, FT level, patient age, race (white vs other), number of co-morbidities, body mass index, presence of erectile dysfunction, duration of PD, and prostatectomy (yes vs no).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures<\/jats:title>\n                  <jats:p>The relationship between T levels and the magnitude of penile curvature.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>184 subjects met\u00a0all study criteria. Average age was 54 \u00b1 12 years. Mean TT level was 425 \u00b1 176 ng\/dL, and mean curvature magnitude was 35\u00b0 \u00b1 19\u00b0. The percent of subjects in the first through fourth TT quartiles was 26%, 34%, 24%, and 16%. As a continuous variable, there was no association between TT levels (r\u00a0=\u00a0\u22120.01, P\u00a0= .95) or FT levels (r\u00a0=\u00a0\u22120.08, P\u00a0= .30) and the curvature magnitude. When examining TT groups, there was no difference in mean curvature between the low TT group and the normal TT group (35.4\u00b0\u00a0\u00b1\u00a017\u00b0 vs 34\u00b0 \u00b1 20\u00b0, P\u00a0= .70). When analyzing the TT and FT levels standardized into z-scores, there was no association between degree of curvature and TT z-scores (r\u00a0=\u00a0\u22120.003, P\u00a0= .95) and FT z-scores (r\u00a0=\u00a0\u22120.08, P\u00a0= .43). There was also no association between testosterone levels and degree of curvature in the multivariable model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>There does not appear to be any association between testosterone levels and the magnitude of PD-associated penile deformity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1016\/j.jsxm.2019.05.021","type":"journal-article","created":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T22:09:20Z","timestamp":1562882960000},"page":"1283-1289","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Testosterone Levels Are Not Associated With Magnitude of Deformity in Men With Peyronie\u2019s Disease"],"prefix":"10.1093","volume":"16","author":[{"given":"John P.","family":"Mulhall","sequence":"first","affiliation":[{"name":"Sexual & Reproductive Medicine Program, Urology Service , New York, NY , USA"},{"name":"Department of Surgery , New York, NY , USA"},{"name":"Memorial Sloan-Kettering Cancer Center , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhito","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Sexual & Reproductive Medicine Program, Urology Service , New York, NY , USA"},{"name":"Department of Surgery , New York, NY , USA"},{"name":"Memorial Sloan-Kettering Cancer Center , New York, NY , USA"},{"name":"Department of Urology , Tokyo, \u00a0 Japan"},{"name":"Juntendo University , Tokyo, \u00a0 Japan"},{"name":"Graduate School of Medicine , Tokyo, \u00a0 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian J.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry\/Behavioral Sciences , New York, NY , USA"},{"name":"Memorial Sloan-Kettering Cancer Center , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,7,11]]},"reference":[{"key":"2023012309445843700_bib1","first-page":"905","article-title":"Evidence-based management of Peyronie's disease","volume":"13","author":"Chung","year":"2016","journal-title":"J\u00a0Sex Med"},{"key":"2023012309445843700_bib2","first-page":"2226","article-title":"Predicting delay in presentation in men with Peyronie's disease","volume":"7","author":"Mulhall","year":"2010","journal-title":"J\u00a0Sex Med"},{"issue":"Suppl. 5","key":"2023012309445843700_bib3","doi-asserted-by":"crossref","first-page":"S93","DOI":"10.1038\/sj.ijir.3901082","article-title":"Expanding the paradigm for plaque development in Peyronie's disease","volume":"15","author":"Mulhall","year":"2003","journal-title":"Int J Impot Res"},{"key":"2023012309445843700_bib4","first-page":"285","article-title":"Proposal: Trauma as the cause of the Peyronie's lesion","volume":"157","author":"Devine","year":"1997","journal-title":"J\u00a0Urol"},{"key":"2023012309445843700_bib5","first-page":"276","article-title":"The anatomy of the tunica albuginea in the normal penis and Peyronie's disease","volume":"157","author":"Brock","year":"1997","journal-title":"J\u00a0Urol"},{"key":"2023012309445843700_bib6","first-page":"2350","article-title":"Subjective and objective analysis of the prevalence of Peyronie's disease in a population of men presenting for prostate cancer screening","volume":"171","author":"Mulhall","year":"2004","journal-title":"J\u00a0Urol"},{"key":"2023012309445843700_bib7","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/sj.ijir.3900863","article-title":"Epidemiology of Peyronie's disease","volume":"14","author":"Sommer","year":"2002","journal-title":"Int J Impot Res"},{"key":"2023012309445843700_bib8","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1046\/j.1464-4096.2001.02436.x","article-title":"The prevalence of Peyronie's disease: Results of a large survey","volume":"88","author":"Schwarzer","year":"2001","journal-title":"BJU Int"},{"key":"2023012309445843700_bib9","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/sj.ijir.3900727","article-title":"Prevalence of Peyronie's disease in men over 50-y-old from Southern Brazil","volume":"13","author":"Rhoden","year":"2001","journal-title":"Int J Impot Res"},{"key":"2023012309445843700_bib10","first-page":"1007","article-title":"The incidence of Peyronie's disease in Rochester, Minnesota, 1950 through 1984","volume":"146","author":"Lindsay","year":"1991","journal-title":"J\u00a0Urol"},{"key":"2023012309445843700_bib11","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1159\/000049830","article-title":"Peyronie's disease: prevalence and association with cigarette smoking. 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Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}