{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:03:23Z","timestamp":1786993403862,"version":"build-2736575974"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T00:00:00Z","timestamp":1571875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T00:00:00Z","timestamp":1571875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Beijing Municipal Natural Science Foundation","award":["7194327"],"award-info":[{"award-number":["7194327"]}]},{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["7194327"],"award-info":[{"award-number":["7194327"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jsm.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Acellular dermal matrix (ADM) is a common filler used widely in clinical practice to increase penile girth for cosmetic reasons, but there are few studies on its complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of this study was to investigate and analyze the complications of penile girth enhancement (PGE) with ADM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The medical records of 78 patients who underwent PGE with ADM between June 2016 and January 2019 were retrospectively reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measure<\/jats:title>\n                    <jats:p>Related complications and their subsequent management were summarized and analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>78 patients (mean age 31.14 years [21\u221266 years]) received PGE with ADM. At the 3-month follow-up, the penile circumference was increased by 1.1 (0.5\u22122.1) cm on average. There were 47 patients with erectile discomfort, 12 with delayed healing, 10 with unobvious augmentation effect, 8 with wound hematoma, 7 with prepuce edema, 4 with wound infection, and 3 patients with skin necrosis of the dorsal side. 7 patients eventually underwent ADM removal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Implications<\/jats:title>\n                    <jats:p>These adverse complications indicate that ADM should be used with caution for PGE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Strength &amp; Limitations<\/jats:title>\n                    <jats:p>This study adds important data, as there are few published reports on the complications of PGE with ADM. However, this study did not compare postoperative complications with ADM to those seen with other filler material.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Even with standardized surgical methods and rigorous postoperative care, complications of PGE using ADM are severe, which indicates that it is not an ideal or safe method for PGE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.jsxm.2019.09.010","type":"journal-article","created":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T18:30:33Z","timestamp":1571941833000},"page":"2011-2017","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Complications and Management of Penile Girth Enhancement with Acellular Dermal Matrix"],"prefix":"10.1093","volume":"16","author":[{"given":"Tingmin","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Urology, Peking University People\u2019s Hospital , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology, Peking University People\u2019s Hospital , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Urology, Peking University People\u2019s Hospital , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology, Peking University People\u2019s Hospital , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anpu","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Peking University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiushi","family":"Lin","sequence":"additional","affiliation":[{"name":"International Center for Mathematical Research, Peking University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Urology, Peking University People\u2019s Hospital , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology, Peking University People\u2019s Hospital , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,10,24]]},"reference":[{"key":"2023012309480365200_bib1","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.eururo.2008.07.080","article-title":"A\u00a0critical analysis of penile enhancement procedures for patients with normal penile size: Surgical techniques, success, and complications","volume":"54","author":"Vardi","year":"2008","journal-title":"Eur Urol"},{"key":"2023012309480365200_bib2","first-page":"1945","article-title":"Original technique for penile girth augmentation through porcine dermal acellular grafts: Results in a 69-patient series","volume":"9","author":"Alei","year":"2012","journal-title":"J\u00a0Sex Med"},{"key":"2023012309480365200_bib3","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.eururo.2005.02.021","article-title":"Augmentation phalloplasty surgery for penile dysmorphophobia in young adults: Considerations regarding patient selection, outcome evaluation and techniques applied","volume":"48","author":"Spyropoulos","year":"2005","journal-title":"Eur Urol"},{"key":"2023012309480365200_bib4","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1097\/MOU.0b013e32830fe427","article-title":"Penile enlargement","volume":"18","author":"Colombo","year":"2008","journal-title":"Curr Opin Urol"},{"key":"2023012309480365200_bib5","doi-asserted-by":"crossref","first-page":"6323","DOI":"10.1038\/s41598-019-41652-w","article-title":"Cosmetic penile enhancement surgery: A 3-year single-centre retrospective clinical evaluation of 355 cases","volume":"9","author":"Littara","year":"2019","journal-title":"Sci Rep"},{"key":"2023012309480365200_bib6","author":"Whitehead E. Allograft dermal matrix graft (Alloderm\u00ae) for pericavernosal penile widening in normal men. Abstract presented at: First World Congress on Aesthetic Medicine, March 15\u221217, 2004, Rio de Janeiro, Brazil."},{"key":"2023012309480365200_bib7","doi-asserted-by":"crossref","first-page":"e13135","DOI":"10.1097\/MD.0000000000013135","article-title":"Acellular dermal matrix in premature ejaculation: A preliminary study","volume":"97","author":"Zhang","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"2023012309480365200_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00007890-199507150-00001","article-title":"Transplanted acellular allograft dermal matrix. 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Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}