{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:29:21Z","timestamp":1789086561656,"version":"build-2803163510"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T00:00:00Z","timestamp":1579651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T00:00:00Z","timestamp":1579651200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jsm.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Although premature ejaculation (PE) is a common sexual dysfunction, the available options for PE treatment remain unsatisfactory.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To evaluate the effect of on-demand oral pregabalin on the intravaginal ejaculation latency time (IELT).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Method<\/jats:title>\n                  <jats:p>We conducted a multiarm double-blinded placebo-controlled randomized clinical trial that enrolled 120 patients with PE who were divided equally into 3 groups (A, B, and C). 4 patients were excluded, 39 patients received 150\u00a0mg pregabalin (group A), 39 patients received 75\u00a0mg pregabalin (group B), and 38 patients received placebo (group C). All patients were encouraged to engage in sexual relations twice per week for 2\u00a0weeks and to take the medication 1\u20132\u00a0hours before sexual intercourse. A stopwatch was used to evaluate IELT.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measure<\/jats:title>\n                  <jats:p>The main outcome measure are the improvement of IELT and the reported adverse events.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>IELT significantly improved in patients who received 150\u00a0mg pregabalin, but there was no change in the other groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Implications<\/jats:title>\n                  <jats:p>Most PE patients showed a significant improvement after receiving on-demand pregabalin (150\u00a0mg).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Strength &amp; Limitations<\/jats:title>\n                  <jats:p>The strength of this study is that it is the first randomized controlled trial to evaluate the efficacy of pregabalin in treatment of PE. The main limitations were the small number of patients, IELT was the only primary outcome of the study, and the pregabalin cap can be identified by the patient.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Oral pregabalin seems to be a promising drug for additional evaluation as a new treatment for PE. More studies are needed to evaluate the suitable dose, duration, timing, and its safety profile.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1016\/j.jsxm.2019.12.014","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T23:07:45Z","timestamp":1579734465000},"page":"442-446","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["A Double Blind, Placebo Controlled, Randomized Trial to Evaluate the Efficacy and Tolerability of On-Demand Oral Pregablin (150\u00a0mg and 75\u00a0mg) in Treatment of Premature Ejaculation"],"prefix":"10.1093","volume":"17","author":[{"given":"Mohamed Refaat","family":"El Najjar","sequence":"first","affiliation":[{"name":"Dermatology and Venereology Department , , Cairo , Egypt"},{"name":"Faculty of Medicine , , Cairo , Egypt"},{"name":"Al Azhar University , , Cairo , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"El Hariri","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Department , , Cairo , Egypt"},{"name":"Faculty of Medicine , , Cairo , Egypt"},{"name":"Al Azhar University , , Cairo , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Ramadan","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Department , , Cairo , Egypt"},{"name":"Faculty of Medicine , , Cairo , Egypt"},{"name":"Al Azhar University , , Cairo , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abd-Alrahman","family":"Hefny Hashem","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Department , Al Sharqia, \u00a0 Egypt"},{"name":"Bilbeis Hospital , Al Sharqia, \u00a0 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,1,22]]},"reference":[{"key":"2023011111075038500_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4103\/aja.aja_9_17","article-title":"Validity of premature ejaculation diagnostic tool and its association with International Index of Erectile Function-15 in Chinese men with evidence-based-defined premature ejaculation","volume":"20","author":"Tang","year":"2018","journal-title":"Asian J Androl"},{"key":"2023011111075038500_bib2","first-page":"1423","article-title":"An evidence- based unified definition of lifelong and acquired premature ejaculation: Report of the second International Society for Sexual Medicine Ad Hoc Committee for the Definition of Premature Ejaculation","volume":"11","author":"Serefoglu","year":"2014","journal-title":"J\u00a0Sex Med"},{"key":"2023011111075038500_bib3","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.fertnstert.2015.08.035","article-title":"Premature ejaculation: Old story, new insights","volume":"104","author":"Jannini","year":"2015","journal-title":"Fertil Steril"},{"key":"2023011111075038500_bib4","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.eururo.2015.12.028","article-title":"Current pharmacological management of premature ejaculation: A systematic review and meta-analysis","volume":"69","author":"Castiglione","year":"2016","journal-title":"Eur Urol"},{"key":"2023011111075038500_bib5","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S2305-0500(14)60063-4","article-title":"A\u00a0new treatment for premature ejaculation? 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