{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T05:20:10Z","timestamp":1793078410487,"version":"4.5.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:00:00Z","timestamp":1584403200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:00:00Z","timestamp":1584403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jsm.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The angiographically documented association between severity of coronary artery disease (CAD) and aorto-ilio-pudendal (A-I-P) artery disease and vascular erectile dysfunction (ED) was not yet settled.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To assess the relation between angiographically proved CAD and A-I-P artery disease in patients with ischemic heart disease (IHD)\u2013associated vascular ED.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>60 men were assigned to 3 study groups: Group 1 (n\u00a0=\u00a025), patients who had IHD and ED; group 2 (n\u00a0=\u00a025), patients who had IHD and had no ED; group 3 (n\u00a0=\u00a010), patients who had ED and had no suspected IHD. All patients were subjected to detailed medical, cardiac, and sexual history. International Index of Erectile Function and penile color Doppler ultrasound were used to assess ED. Quantitative coronary angiography and invasive angiography were used to assess the vascular tree for the right and left (A-I-P) arteries. Endothelial markers, that is, endothelial microparticles and endothelial progenitor cells were also assessed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Outcomes<\/jats:title>\n                  <jats:p>The main outcome measures are assessment of ED and angiographically proved CAD and A-I-P artery disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The mean age\u00a0\u00b1\u00a0SD of the 3 study groups were 50.4\u00a0\u00b1\u00a06.6, 51.4\u00a0\u00b1\u00a03.9, and 49.9\u00a0\u00b1\u00a06.1\u00a0years, respectively, with no statistically significant difference among groups (P\u00a0=\u00a0.380). There were significant higher rates of left main (LM) lesions (\u226550%), CAD (\u226570%), right and left internal pudendal artery lesions, and right and left internal iliac artery lesions in G1 in comparison with G2 and G3. Patients with ED alone had a higher rate of peripheral lesions compared with patients with CAD alone. 10 percent of patients with ED alone had CAD. Patients in G1 had notably higher rates of peripheral lesions than the other groups combined Patients with left internal pudendal artery lesions had a chance by 1.25 and 2.11 times to have LM lesions and significant CAD, respectively. There was a significant increase of endothelial microparticles in G1 in comparison with other groups (P\u00a0&amp;lt;\u00a0.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Implications<\/jats:title>\n                  <jats:p>The clinical implications are uses of peripheral angiograghy as a diagnostic tool in patients with CAD-associated vascular ED may have a clinical merit.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Strengths &amp; Limitations<\/jats:title>\n                  <jats:p>The strengths in the present study are the use of angiography, color Doppler ultrasound, and standardized instruments. The main limitations are the small sample size and lack of intervention and longitudinal data.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>ED correlates more with A-I-P vascular lesions compared with CAD alone. There was a statistically significant association between severity of CAD including LM significant lesions and A-I-P arteries disease in patients with CAD-associated vascular ED.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1016\/j.jsxm.2020.02.011","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T13:46:56Z","timestamp":1584366416000},"page":"1086-1093","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Relation Between Severity of Coronary Artery Disease and Aorto-Ilio-Pudendal Artery Disease in Patients with Ischemic Heart Disease\u2013Associated Vascular Erectile Dysfunction"],"prefix":"10.1093","volume":"17","author":[{"given":"Ahmed M.","family":"Sanad","sequence":"first","affiliation":[{"name":"Department of Cardiology \u00a0 , Ismailia , Egypt"},{"name":"Suez Canal University \u00a0 , Ismailia , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soha E.","family":"Younis","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology \u00a0 , Ismailia , Egypt"},{"name":"Suez Canal University \u00a0 , Ismailia , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Oraby","sequence":"additional","affiliation":[{"name":"Department of Cardiology \u00a0 , Ismailia , Egypt"},{"name":"Suez Canal University \u00a0 , Ismailia , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesham","family":"Hegazy","sequence":"additional","affiliation":[{"name":"Department of Cardiology \u00a0 , Ismailia , Egypt"},{"name":"Suez Canal University \u00a0 , Ismailia , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed I.","family":"El-Sakka","sequence":"additional","affiliation":[{"name":"Department of Urology \u00a0 , Ismailia , Egypt"},{"name":"Suez Canal University \u00a0 , Ismailia , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,3,17]]},"reference":[{"key":"2023011111085626600_bib1","first-page":"848","article-title":"Erectile dysfunction and coronary artery disease prediction: evidence-based guidance and consensus","volume":"64","author":"Jackson","year":"2010","journal-title":"Int J Clinpract"},{"key":"2023011111085626600_bib2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/01.ju.0000128572.31000.f0","article-title":"Coronary artery risk factors in patients with erectile Dysfunction","volume":"172","author":"El-Sakka","year":"2004","journal-title":"The J Urol"},{"key":"2023011111085626600_bib3","first-page":"2590","article-title":"Severity of erectile dysfunction could predict left ventricular diastolic dysfunction in patients without overt cardiac complaint","volume":"8","author":"El-Sakka","year":"2011","journal-title":"J\u00a0Sex Med"},{"key":"2023011111085626600_bib4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1161\/CIRCOUTCOMES.112.966903","article-title":"Prediction of cardiovascular events and all-cause mortality with erectile dysfunction. A systematic review and meta-analysis of cohort studies","volume":"6","author":"Vlachopoulos","year":"2013","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"2023011111085626600_bib5","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S0302-2838(03)00305-1","article-title":"Erectile dysfunction prevalence, time of onset and association withrisk factors in 300 consecutive patients with acute chest pain andangiographically documented coronary artery disease","volume":"44","author":"Montorsi","year":"2003","journal-title":"Eur Urol"},{"key":"2023011111085626600_bib6","first-page":"28","article-title":"The Second Princeton Consensus on Sexual Dysfunction and Cardiac Risk: new guidelines for sexual medicine","volume":"3","author":"Jackson","year":"2006","journal-title":"J\u00a0Sex Med"},{"key":"2023011111085626600_bib7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.29328\/journal.ibm.1001010","article-title":"Erectile Dysfunction and Coronary Artery Disease: Two manifestations, one same underlying mechanism","volume":"2","author":"Cardona-V\u00e9lez","year":"2018","journal-title":"Insights Biol Med"},{"key":"2023011111085626600_bib8","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1016\/j.jacc.2007.10.069","article-title":"Erectile dysfunction as a predictor of cardiovascular events and death in diabetic patients with angiographically proven asymptomatic coronary artery disease: a potential protective role for statins and 5-phosphodiesterase inhibitors","volume":"51","author":"Gazzaruso","year":"2008","journal-title":"J\u00a0Am Collcardiol"},{"key":"2023011111085626600_bib9","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1016\/j.jacc.2012.08.1016","article-title":"Zotarolimus-eluting peripheral stents for the treatment of erectile dysfunction in subjects with suboptimal response to phosphodiesterase-5 inhibitors","volume":"60","author":"Rogers","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"2023011111085626600_bib10","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/andr.12347","article-title":"Testosterone level and endothelial dysfunction in patients with vasculogenic erectile dysfunction","volume":"5","author":"Omar","year":"2017","journal-title":"Andrology"},{"key":"2023011111085626600_bib11","first-page":"1268","article-title":"Arterial erectile dysfunction and peripheral arterial disease reliability of a new phenotype of endothelial progenitor cells and endothelial micro- particles","volume":"33","author":"Condorelli","year":"2012","journal-title":"J\u00a0Androl"},{"key":"2023011111085626600_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for Cardiac Chamber Quantification by Echocardiography in Adults: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J\u00a0Am Soc Echocardiography"},{"key":"2023011111085626600_bib13","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S0090-4295(97)00238-0","article-title":"The International Index of Erectile Function (IIEF): a multidimensional scale for assessment of erectile dysfunction","volume":"49","author":"Rosen","year":"1997","journal-title":"Urology"},{"key":"2023011111085626600_bib14","first-page":"332","article-title":"Flow cytometric detection of endothelial microparticles (EMP): Effects of centrifugation and storage alter with the phenotype studied","volume":"125","author":"Van Ierssel","year":"2010","journal-title":"ThrombosisResearch"},{"key":"2023011111085626600_bib15","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/j.jacc.2007.01.087","article-title":"Percutaneous coronary intervention of functionally nonsignificant stenosis: 5-year follow-up of the DEFER Study","volume":"49","author":"Pijls","year":"2007","journal-title":"J\u00a0Am Collcardiol"},{"key":"2023011111085626600_bib16","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ihj.2013.02.013","article-title":"Association between erectile dysfunction and coronary artery disease and its severity","volume":"65","author":"Sai Ravi Shanker","year":"2013","journal-title":"Indian Heart J"},{"key":"2023011111085626600_bib17","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.urology.2004.03.016","article-title":"Screening For Ischemic Heart Disease in Patients With Erectile Dysfunction: Role Of Penile Doppler Ultrasonography","volume":"64","author":"El-Sakka","year":"2004","journal-title":"Urology"},{"key":"2023011111085626600_bib18","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1590\/S1677-5538.IBJU.2013.04.03","article-title":"Is there a relationship between severity of coronary artery disease and severity of erectile dysfunction?","volume":"39","author":"Canat","year":"2013","journal-title":"Int Braz J Urol"},{"key":"2023011111085626600_bib19","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1093\/eurheartj\/ehl142","article-title":"Association between erectile dysfunction and coronary artery disease. Role of coronary clinical presentation and extent of coronary vessels involvement: the COBRA trial","volume":"27","author":"Montorsi","year":"2006","journal-title":"Eur Heart J"},{"key":"2023011111085626600_bib20","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.jacc.2011.06.024","article-title":"Erectile dysfunction and risk of cardiovascular disease. Meta-analysis of prospective cohort studies","volume":"58","author":"Dong","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"2023011111085626600_bib21","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/aja.2010.116","article-title":"Transplantation of endothelial progenitor cells transfected with VEGF156 to restore erectile dysfunction in diabetic rats","volume":"13","author":"Gou","year":"2011","journal-title":"Asian J Androl"},{"key":"2023011111085626600_bib22","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00441-008-0710-9","article-title":"Endothelial microparticles in diseases","volume":"335","author":"Chironi","year":"2009","journal-title":"Cell Tissue Res"},{"key":"2023011111085626600_bib23","first-page":"97","article-title":"stem\/progenitor cells, atherosclerosis and cardiovascular regeneration","volume":"4","author":"Dotsenko","year":"2010","journal-title":"Open Cardiovasc Med J"},{"key":"2023011111085626600_bib24","first-page":"202","article-title":"Circulating endothelial progenitor cells and endothelial microparticles in patients with arterial erectile dysfunction and metabolic syndrome","volume":"33","author":"La Vignera","year":"2012","journal-title":"J\u00a0Androl"}],"container-title":["The Journal of Sexual Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609520301120?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609520301120?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/17\/6\/1086\/48527211\/jsm_17_6_1086.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/17\/6\/1086\/48527211\/jsm_17_6_1086.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T14:44:17Z","timestamp":1675953857000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jsm\/article\/17\/6\/1086\/6973810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,17]]},"references-count":24,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,3,17]]},"published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.1016\/j.jsxm.2020.02.011","relation":{},"ISSN":["1743-6109","1743-6095"],"issn-type":[{"value":"1743-6109","type":"electronic"},{"value":"1743-6095","type":"print"}],"subject":[],"published-other":{"date-parts":[[2020,6]]},"published":{"date-parts":[[2020,3,17]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Relation Between Severity of Coronary Artery Disease and Aorto-Ilio-Pudendal Artery Disease in Patients With Ischemic Heart Disease\u2013Associated Vascular Erectile Dysfunction","name":"articletitle","label":"Article Title"},{"value":"The Journal of Sexual Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsxm.2020.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}