{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:49:57Z","timestamp":1773017397649,"version":"3.50.1"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T00:00:00Z","timestamp":1592611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T00:00:00Z","timestamp":1592611200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jsm.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Men with Peyronie's disease (PD) may experience penile narrowing. Little data on penile girth changes and their psychosocial impact exist.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To assess girth discrepancy in men with PD and its association with patient bother.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a retrospective observational study. All patients with PD at our institution who were seen in the sexual medicine clinic and who completed 3 validated instruments the PD questionnaire (PDQ), Self-Esteem and Relationship (SEAR) questionnaire, and a depression questionnaire, the Center for Epidemiologic Studies Depression Scale (CES-D), and a curvature assessment were included. Patient and PD characteristics are described. Associations of instability and bother to girth differences are assessed. 2 outcomes for girth differences are classified as (i) girth difference of \u2265 1\u00a0cm vs less and (ii) girth differences of \u226510% vs less. Unadjusted and adjusted effects of PD and patient characteristics are assessed on the outcome of high bother using logistic regression models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Outcomes<\/jats:title>\n                  <jats:p>The main outcomes of this study were penile girth changes, instability, and questionnaire scores. High bother was defined as a PDQ bother score of \u22659.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of131 men had midshaft curvature and were the focus of the study. Their mean age was 59\u00a0\u00b1\u00a09 (range 31\u201378) years. PD duration was 16\u00a0\u00b1\u00a025 (range 1\u2013180) months, with a mean degree of primary curvature of 37\u00a0\u00b1\u00a020o. Mean girth difference between base and point of maximum curvature was 0.78\u00a0\u00b1\u00a00.53\u00a0cm equating to a mean girth difference at point of maximum curvature of 6\u00a0\u00b1\u00a04%. Instability was present in 53% of men. There were 54 men with a girth difference of \u2265 1\u00a0cm and 23 men with a \u226510% change in girth. There was no difference in CES-D, SEAR, or PDQ domain scores or high bother in men with significant girth changes. Univariable analysis of predictors of high bother included the degree of curvature (odds ratio [OR]: 1.06; P\u00a0&amp;lt;\u00a0.001), instability (OR 6.62; P\u00a0&amp;lt;\u00a0.001), CES-D sum (OR 1.09; P\u00a0=\u00a0.002), and SEAR score (OR 0.96; P\u00a0=\u00a0.001). On multivariate analysis, only the degree of primary curvature was predictive of high bother (OR 1.06; P\u00a0&amp;lt;\u00a0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Implications<\/jats:title>\n                  <jats:p>Penile girth changes have little impact on overall psychosocial well-being. The degree of penile curvature is the primary predictor of patient bother.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Strengths and Limitations<\/jats:title>\n                  <jats:p>Strengths include a large patient population and use of validated questionnaires. Limitations include single-center, retrospective study and subjective instability grading.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Penile girth discrepancy in men with PD has limited psychosocial impact. Clinically significant bother was associated with the degree of primary curvature.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1016\/j.jsxm.2020.05.003","type":"journal-article","created":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T18:11:30Z","timestamp":1592676690000},"page":"1560-1565","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluating the Impact of Penile Girth Discrepancy on Patient Bother in Men with Peyronie's Disease: An Observational Study"],"prefix":"10.1093","volume":"17","author":[{"given":"Carolyn A.","family":"Salter","sequence":"first","affiliation":[{"name":"Department of Urology , New York, NY , USA"},{"name":"Memorial Sloan Kettering Cancer Center , New York, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Department of Urology , New York, NY , USA"},{"name":"Memorial Sloan 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