{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T21:57:59Z","timestamp":1783720679244,"version":"3.55.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T00:00:00Z","timestamp":1593648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T00:00:00Z","timestamp":1593648000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801679"],"award-info":[{"award-number":["81801679"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771817"],"award-info":[{"award-number":["81771817"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801679"],"award-info":[{"award-number":["81801679"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771817"],"award-info":[{"award-number":["81771817"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jsm.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Lifelong premature ejaculation (LPE) has been linked to altered brain function and structure. Although the middle temporal gyrus (MTG) is consistently more affected in LPE, its functional and structural changes have yet to be determined at the subregional level.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To explore the functional and structural changes of MTG in LPE at the subregional level based on a combined analysis of multimodal magnetic resonance imaging data.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>25 patients with LPE and 21 healthy controls underwent resting-state functional and structural magnetic resonance imaging scans. The MTG was parcellated into the anterior part of the MTG (aMTG), middle part of the MTG, posterior part of the MTG, and sulcus part of the MTG. Resting-state functional connectivity (rsFC) and gray matter volume (GMV) of each MTG subregion were calculated and compared between the 2 groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Outcomes<\/jats:title>\n                  <jats:p>The functional and structural changes of MTG at the subregional level were assessed in patients with LPE and controls, as well as the correlation of them with premature ejaculation diagnostic tool and Beck Depression Inventory.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Despite similar rsFC patterns of each MTG subregion in both groups, quantitative comparison analyses revealed that patients with LPE showed increased rsFC between the left aMTG and the right cuneus (0.34\u00a0\u00b1\u00a00.12 vs 0.17\u00a0\u00b1\u00a00.17), between the right aMTG and the right parahippocampal gyrus (0.36\u00a0\u00b1\u00a00.16 vs 0.15\u00a0\u00b1\u00a00.10), and between the right middle MTG and the left MTG (0.40\u00a0\u00b1\u00a00.14 vs 0.18\u00a0\u00b1\u00a00.15) relative to controls (P\u00a0&amp;lt;\u00a0.05, cluster-level family-wise error corrected). Moreover, validation analyses revealed that these results remained significant after adjusting for depression. However, there were no significant group differences in GMV in all the MTG subregions (P\u00a0&amp;gt;\u00a0.05, Bonferroni corrected). In addition, no significant correlations between rsFC and GMV of the MTG subregions and the clinical variables were found in patients with LPE (P\u00a0&amp;gt;\u00a0.05, Bonferroni corrected).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Implications<\/jats:title>\n                  <jats:p>Functional hyperconnectivity in the MTG subregions may facilitate a more sophisticated understanding of the neuropathological mechanism underlying LPE.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Strengths and Limitations<\/jats:title>\n                  <jats:p>There are no previous studies examining functional and structural changes in LPE at the MTG subregional level. The main limitation is the small sample size.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We present evidence that individuals with LPE have a selective functional hyperconnectivity yet preserved structural integrity in the MTG subregions, which may facilitate a more sophisticated understanding of the neuropathological mechanism underlying LPE by highlighting the critical role of the MTG in this disorder.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1016\/j.jsxm.2020.05.006","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T21:51:08Z","timestamp":1593726668000},"page":"1457-1466","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Selective Functional Hyperconnectivity in the Middle Temporal Gyrus Subregions in Lifelong Premature Ejaculation"],"prefix":"10.1093","volume":"17","author":[{"given":"Tingting","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Radiology , Hefei, , China"},{"name":"The First Affiliated Hospital of Anhui Medical University , Hefei, , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongdong","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Hefei, , China"},{"name":"Reproductive Medicine Center , Hefei, , China"},{"name":"The First Affiliated Hospital of Anhui Medical University , Hefei, , China"},{"name":"NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract , Hefei, , China"},{"name":"Anhui Medical University , Hefei, , China"},{"name":"Key Laboratory of Population Health Across Life Cycle , Hefei, , China"},{"name":"Anhui Medical University , Hefei, , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Radiology , Hefei, , China"},{"name":"The First Affiliated Hospital of Anhui Medical University , Hefei, , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology , Hefei, , China"},{"name":"The First Affiliated Hospital of Anhui Medical University , Hefei, , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology , Hefei, , China"},{"name":"The First Affiliated Hospital of Anhui Medical University , Hefei, , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology , Hefei, , China"},{"name":"The First Affiliated Hospital of Anhui Medical University , Hefei, , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenming","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiology , Hefei, , China"},{"name":"The First Affiliated Hospital of Anhui Medical University , Hefei, , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiology , Hefei, , China"},{"name":"The First Affiliated Hospital of Anhui Medical University , Hefei, , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiansheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology , Hefei, , China"},{"name":"The First Affiliated Hospital of Anhui Medical University , Hefei, , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Radiology , Hefei, , China"},{"name":"The First Affiliated Hospital of Anhui Medical University , Hefei, , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,7,2]]},"reference":[{"key":"2023011111134361600_bib1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/sm2.28","article-title":"An update of the International Society of Sexual Medicine's guidelines for the diagnosis and treatment of premature ejaculation (PE)","volume":"2","author":"Althof","year":"2014","journal-title":"Sex Med"},{"key":"2023011111134361600_bib2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/bcpt.12546","article-title":"Physiology and pharmacology of ejaculation","volume":"119 Suppl 3","author":"Clement","year":"2016","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"2023011111134361600_bib3","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.yhbeh.2011.02.008","article-title":"Brain circuits for mating behavior in cats and brain activations and de-activations during sexual stimulation and ejaculation and orgasm in humans","volume":"59","author":"Holstege","year":"2011","journal-title":"Horm Behav"},{"key":"2023011111134361600_bib4","first-page":"992","article-title":"Are there differences in brain morphology in patients with lifelong premature ejaculation?","volume":"16","author":"Atalay","year":"2019","journal-title":"J\u00a0Sex Med"},{"key":"2023011111134361600_bib5","first-page":"1272","article-title":"Abnormal white matter microstructure in lifelong premature ejaculation patients identified by tract-based spatial statistical analysis","volume":"15","author":"Gao","year":"2018","journal-title":"J\u00a0Sex Med"},{"key":"2023011111134361600_bib6","first-page":"1474","article-title":"Changes of cerebral current source by audiovisual erotic stimuli in premature ejaculation patients","volume":"5","author":"Hyun","year":"2008","journal-title":"J\u00a0Sex Med"},{"key":"2023011111134361600_bib7","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/s41598-017-00421-3","article-title":"Functional insights into aberrant brain responses and integration in patients with lifelong premature ejaculation","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci Rep"},{"key":"2023011111134361600_bib8","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.nicl.2018.05.025","article-title":"Short- and long-range synergism disorders in lifelong premature ejaculation evaluated using the functional connectivity density and network property","volume":"19","author":"Lu","year":"2018","journal-title":"Neuroimage Clin"},{"key":"2023011111134361600_bib9","doi-asserted-by":"crossref","first-page":"448","DOI":"10.3389\/fnins.2019.00448","article-title":"Abnormal resting-state functional connectivity in the whole brain in lifelong premature ejaculation patients based on machine learning approach","volume":"13","author":"Xu","year":"2019","journal-title":"Front Neurosci"},{"key":"2023011111134361600_bib10","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.27099","article-title":"Altered functional connectivity of hypothalamus in lifelong premature ejaculation patients","author":"Gao","year":"2020","journal-title":"J\u00a0Magn Reson Imaging"},{"key":"2023011111134361600_bib11","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1162\/jocn_a_00263","article-title":"Convergent connectivity and graded specialization in the rostral human temporal lobe as revealed by diffusion-weighted imaging probabilistic tractography","volume":"24","author":"Binney","year":"2012","journal-title":"J\u00a0Cogn Neurosci"},{"key":"2023011111134361600_bib12","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/cercor\/bhg124","article-title":"Contributions of sensory input, auditory search and verbal comprehension to cortical activity during speech processing","volume":"14","author":"Giraud","year":"2004","journal-title":"Cereb Cortex"},{"key":"2023011111134361600_bib13","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0028-3932(02)00162-8","article-title":"A\u00a0procedure for identifying regions preferentially activated by attention to semantic and phonological relations using functional magnetic resonance imaging","volume":"41","author":"McDermott","year":"2003","journal-title":"Neuropsychologia"},{"key":"2023011111134361600_bib14","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1006\/brln.1998.1953","article-title":"Brain activation during silent word generation evaluated with functional MRI","volume":"64","author":"Friedman","year":"1998","journal-title":"Brain Lang"},{"key":"2023011111134361600_bib15","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/010503999424734","article-title":"Stimulus-dependent central processing of auditory stimuli: a PET study","volume":"28","author":"Mirz","year":"1999","journal-title":"Scand Audiol"},{"key":"2023011111134361600_bib16","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1093\/cercor\/bhq148","article-title":"Heterogeneity of the left temporal lobe in semantic representation and control: priming multiple versus single meanings of ambiguous words","volume":"21","author":"Whitney","year":"2011","journal-title":"Cereb Cortex"},{"key":"2023011111134361600_bib17","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.neuroimage.2004.11.003","article-title":"Cerebral mechanisms of prosodic integration: evidence from connected speech","volume":"24","author":"Hesling","year":"2005","journal-title":"Neuroimage"},{"key":"2023011111134361600_bib18","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/BF00227301","article-title":"Localization of grasp representations in humans by PET: 1. Observation versus execution","volume":"111","author":"Rizzolatti","year":"1996","journal-title":"Exp Brain Res"},{"key":"2023011111134361600_bib19","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1162\/089892998562744","article-title":"Neuroanatomical correlates of human reasoning","volume":"10","author":"Goel","year":"1998","journal-title":"J\u00a0Cogn Neurosci"},{"key":"2023011111134361600_bib20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/1471-2202-13-99","article-title":"Impaired social brain network for processing dynamic facial expressions in autism spectrum disorders","volume":"13","author":"Sato","year":"2012","journal-title":"BMC Neurosci"},{"key":"2023011111134361600_bib21","doi-asserted-by":"crossref","first-page":"18883","DOI":"10.1038\/srep18883","article-title":"Tractography-based parcellation of the human middle temporal gyrus","volume":"5","author":"Xu","year":"2015","journal-title":"Sci Rep"},{"key":"2023011111134361600_bib22","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.1093\/cercor\/bhw157","article-title":"The human brainnetome atlas: a new brain atlas based on connectional architecture","volume":"26","author":"Fan","year":"2016","journal-title":"Cereb Cortex"},{"key":"2023011111134361600_bib23","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1196\/annals.1401.004","article-title":"Neuronal activity related to anticipated reward in frontal cortex: does it represent value or reflect motivation?","volume":"1121","author":"Roesch","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"2023011111134361600_bib24","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/cne.20735","article-title":"Human brain activation during sexual stimulation of the penis","volume":"493","author":"Georgiadis","year":"2005","journal-title":"J\u00a0Comp Neurol"},{"key":"2023011111134361600_bib25","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S1053-8119(03)00408-7","article-title":"Brain processing of visual sexual stimuli in healthy men: a functional magnetic resonance imaging study","volume":"20","author":"Mouras","year":"2003","journal-title":"Neuroimage"},{"key":"2023011111134361600_bib26","first-page":"1423","article-title":"An evidence-based unified definition of lifelong and acquired premature ejaculation: report of the second International Society for Sexual Medicine Ad Hoc Committee for the definition of premature ejaculation","volume":"11","author":"Serefoglu","year":"2014","journal-title":"J\u00a0Sex Med"},{"key":"2023011111134361600_bib27","first-page":"2232","article-title":"The premature ejaculation diagnostic tool (PEDT): linguistic validity of the Chinese version","volume":"11","author":"Huang","year":"2014","journal-title":"J\u00a0Sex Med"},{"key":"2023011111134361600_bib28","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1001\/archpsyc.1961.01710120031004","article-title":"An inventory for measuring depression","volume":"4","author":"Beck","year":"1961","journal-title":"Arch Gen Psychiatry"},{"key":"2023011111134361600_bib29","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s12021-016-9299-4","article-title":"DPABI: data processing & analysis for (resting-state) brain imaging","volume":"14","author":"Yan","year":"2016","journal-title":"Neuroinformatics"},{"key":"2023011111134361600_bib30","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuroimage.2007.07.007","article-title":"A\u00a0fast diffeomorphic image registration algorithm","volume":"38","author":"Ashburner","year":"2007","journal-title":"Neuroimage"},{"key":"2023011111134361600_bib31","first-page":"136","article-title":"Changes in male rat sexual behavior and brain activity revealed by functional magnetic resonance imaging in response to chronic mild stress","volume":"15","author":"Chen","year":"2018","journal-title":"J\u00a0Sex Med"},{"key":"2023011111134361600_bib32","first-page":"521","article-title":"The impact of intravaginal ejaculatory latency time and erectile function on anxiety and depression in the four types of premature ejaculation: a large cross-sectional study in a Chinese population","volume":"11","author":"Gao","year":"2014","journal-title":"J\u00a0Sex Med"},{"key":"2023011111134361600_bib33","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.physbeh.2004.08.023","article-title":"Central regulation of ejaculation","volume":"83","author":"Coolen","year":"2004","journal-title":"Physiol Behav"},{"key":"2023011111134361600_bib34","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/andr.12701","article-title":"Graph analysis of DTI-based connectome: decreased local efficiency of subcortical regions in PE patients with high sympathetic activity","volume":"8","author":"Chen","year":"2020","journal-title":"Andrology"},{"key":"2023011111134361600_bib35","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0006-8993(01)02453-2","article-title":"Central representation of the sympathetic nervous system in the cerebral cortex","volume":"903","author":"Westerhaus","year":"2001","journal-title":"Brain Res"},{"key":"2023011111134361600_bib36","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.neuropsychologia.2007.10.024","article-title":"Timing of visuo-spatial information processing: electrical source imaging related to line bisection judgements","volume":"46","author":"Waberski","year":"2008","journal-title":"Neuropsychologia"},{"key":"2023011111134361600_bib37","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-019-00168-7","article-title":"Altered spontaneous functional activity of the right precuneus and cuneus in patients with persistent postural-perceptual dizziness","author":"Li","year":"2019","journal-title":"Brain Imaging Behav"},{"key":"2023011111134361600_bib38","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1002\/jmri.25808","article-title":"Alterations in cortical thickness in nonmedicated premature ejaculation patients: a morphometric MRI study","volume":"47","author":"Guo","year":"2018","journal-title":"J\u00a0Magn Reson Imaging"}],"container-title":["The Journal of Sexual Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609520306135?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609520306135?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/17\/8\/1457\/48527982\/jsm_17_8_1457.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/17\/8\/1457\/48527982\/jsm_17_8_1457.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T14:47:07Z","timestamp":1675954027000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jsm\/article\/17\/8\/1457\/6973977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,2]]},"references-count":38,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,7,2]]},"published-print":{"date-parts":[[2020,8,1]]}},"URL":"https:\/\/doi.org\/10.1016\/j.jsxm.2020.05.006","relation":{},"ISSN":["1743-6109","1743-6095"],"issn-type":[{"value":"1743-6109","type":"electronic"},{"value":"1743-6095","type":"print"}],"subject":[],"published-other":{"date-parts":[[2020,8]]},"published":{"date-parts":[[2020,7,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selective Functional Hyperconnectivity in the Middle Temporal Gyrus Subregions in Lifelong Premature Ejaculation","name":"articletitle","label":"Article Title"},{"value":"The Journal of Sexual Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsxm.2020.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}