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In the 2015-2016 cycle, while 71.7% (95% CI, 67.7\u201375.7%) US adults aged 20-59 years engaged in sexual activity \u2265 12 times\/year (monthly), only 36.1% (95% CI, 31.6\u201340.7%) of them engaged in sexual activity \u2265 52 times\/year (weekly). Since the 2005\u20132006 cycle, the estimated prevalence of sexual activity, \u226552 times\/year and \u226512 times\/year, were both stable over time among overall and each age group (all P for trend &amp;gt;0.1). During a median follow-up of 5.7 years (range, 1\u201311 years) and 71,960 person-years of observation, among 12,598 participants with eligible information on mortality status, 228 deaths occurred, including 29 associated with cardiovascular disease and 62 associated with cancer. Overall, participants with higher sexual activity frequency were at a lower risk of all-cause death in a dose-response manner (P for trend = 0.020) during the follow-up period. In addition, the multivariable-adjusted hazard ratios for all-cause mortality, CVD mortality, cancer mortality, and other cause mortality among participants who had sex \u226552 times\/year compared with those having sex 0\u20131 time\/year were 0.51 (95% CI, 0.34 to 0.76), 0.79 (95% CI, 0.19 to 3.21), 0.31 (95% CI, 0.11 to 0.84), and 0.52 (95% CI, 0.28 to 0.96), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Implications<\/jats:title>\n                    <jats:p>Sexual activity appears to be a health indicator of all-cause and cancer mortality in US middle-aged adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Strengths &amp; Limitations<\/jats:title>\n                    <jats:p>Clear strengths of the present study include the large representative sample of the noninstitutionalized US population as well as the identification of precise estimates in relation to sexual activity and mortality. However, because of the observational nature of the study design, causality could not be determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sexual activity was found to be associated with a lower risk of mortality from all cause and cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.jsxm.2020.05.028","type":"journal-article","created":{"date-parts":[[2020,7,12]],"date-time":"2020-07-12T00:01:01Z","timestamp":1594512061000},"page":"1903-1913","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Trends in Sexual Activity and Associations with All-Cause and Cause-Specific Mortality Among US Adults"],"prefix":"10.1093","volume":"17","author":[{"given":"Chao","family":"Cao","sequence":"first","affiliation":[{"name":"Program in Physical Therapy , St Louis, MO , USA"},{"name":"Washington University School of Medicine , St Louis, MO , USA"},{"name":"Center for Human Nutrition , St Louis, MO , USA"},{"name":"Washington University School of Medicine , St Louis, MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology and Prevention Research , Calgary, , Canada"},{"name":"Alberta Health Services , Calgary, , Canada"},{"name":"Departments of Oncology and Community Health Sciences , Calgary, AB , Canada"},{"name":"Cumming School of Medicine , Calgary, AB , Canada"},{"name":"University of Calgary , Calgary, AB , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianlin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics , Houston, TX , USA"},{"name":"School of Public Health , Houston, TX , USA"},{"name":"The University of Texas Health Science Center at Houston , Houston, TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A.","family":"Cavazos-Rehg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry , St. Louis, MO , USA"},{"name":"Washington University School of Medicine , St. Louis, MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinran","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences , St Louis, MO , USA"},{"name":"Department of Surgery , St Louis, MO , USA"},{"name":"Washington University School of Medicine , St Louis, MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daragh","family":"McDermott","sequence":"additional","affiliation":[{"name":"Division of Psychology , Cambridge, , UK"},{"name":"School of Psychology and Sports Sciences , Cambridge, , UK"},{"name":"Anglia Ruskin University , Cambridge, , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Veronese","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Geriatrics , Palermo, , Italy"},{"name":"University of Palermo , Palermo, , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Waldhoer","sequence":"additional","affiliation":[{"name":"Department of Epidemiology , , Vienna , Austria"},{"name":"Center for Public Health , , Vienna , Austria"},{"name":"Medical University of Vienna , , Vienna , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petre Cristian","family":"Ilie","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital Foundation Trust , King's Lynn, , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahrokh F.","family":"Shariat","sequence":"additional","affiliation":[{"name":"Department of Urology , , Vienna , Austria"},{"name":"Medical University of Vienna , , Vienna , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Smith","sequence":"additional","affiliation":[{"name":"The Cambridge Centre for Sport and Exercise Sciences , Cambridge, , UK"},{"name":"Anglia Ruskin University , Cambridge, , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,7,12]]},"reference":[{"key":"2023011111094602400_bib1","author":"World Health Organization. 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