{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T01:21:34Z","timestamp":1748913694280,"version":"3.37.3"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["310030_156859"],"award-info":[{"award-number":["310030_156859"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["#310030_156859"],"award-info":[{"award-number":["#310030_156859"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jsm.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The renin-angiotensin system (RAS) plays an important role in erectile function. The RAS contains 2 major axes: one deleterious, composed of ACE-Ang II-AT1 receptor, and another protective, composed of ACE2-Ang-(1-7)-Mas receptor. While aging is a well-known cause for development of male sexual disorders, little is known about local regulation of the RAS in age-related erectile dysfunction (ED).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>The present study aimed to assess regulation of the RAS in aging-associated ED rat model and evaluate possible options for disease management through pharmacological modulation of the RAS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Penile tissues were harvested from 3-, 12-, and 24-month-old Wistar rats. Local expression of major RAS components and ED markers was measured by RT-PCR. Protein expression of RAS components was assessed by western blot. Collagen deposition was measured by Sirius Red and immunohistochemical staining. Evaluation of collagen content was also performed in penile sections of Mas-knockout mice by Sirius Red and Masson\u2019s trichrome stainings. Finally, the effect of Ang-(1-7) pretreatment on TGF-\u03b2\u2013induced myofibroblast activation was studied in primary cavernosal and immortalized fibroblasts.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Outcomes<\/jats:title>\n                  <jats:p>Experimental results highlighted the essential role of the RAS in modulation of cavernosal fibrosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The present study demonstrates local expression of angiotensinogen mRNA alongside with major RAS components, which suggests local autonomous functioning of the RAS within penile tissue. Gene expression analysis revealed strong positive correlation between ACE-Ang II-AT1 axis with markers for inflammation and fibrosis. While corpus cavernosum from 24-month-old rats was characterized by increased collagen deposition, protein expression of ACE, AT1, and Mas was shown to be upregulated in the penile tissue of this group. At the same time, penile sections from Mas-knockout mice (FVB\/N background) were also shown to have increased collagen deposition. Finally, it was demonstrated that Ang-(1-7) treatment of primary cavernosal and immortalized fibroblasts was able to alleviate TGF-\u03b2\u2013induced fibroblast-to-myofibroblast transition.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Translation<\/jats:title>\n                  <jats:p>The present study suggests Ang-(1-7) treatment as a possible strategy for pharmacological management of fibrosis-associated ED in aging.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Strengths &amp; Limitations<\/jats:title>\n                  <jats:p>The link between the RAS and penile fibrosis, indicated by a holistic screening of different ED markers, was confirmed by in\u00a0vivo and in\u00a0vitro data. However, results, presented in the manuscript, need to be further reinforced by human data. Important to note, the main goal of the study was to characterize RAS regulation in aging condition rather than state any causal relationships.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Present study characterizes RAS regulation in aging-associated ED and indicates its important role in cavernosal fibrosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1016\/j.jsxm.2020.08.008","type":"journal-article","created":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T05:45:31Z","timestamp":1600148731000},"page":"2129-2140","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Characterization of the Renin-Angiotensin System in Aged Cavernosal Tissue and its Role in Penile Fibrosis"],"prefix":"10.1093","volume":"17","author":[{"given":"Maiia E.","family":"Bragina","sequence":"first","affiliation":[{"name":"Laboratory of Hemodynamics and Cardiovascular Technology , Lausanne, , Switzerland"},{"name":"\u00c9cole polytechnique f\u00e9d\u00e9rale de Lausanne , Lausanne, , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana","family":"Costa-Fraga","sequence":"additional","affiliation":[{"name":"Laboratory of Hemodynamics and Cardiovascular Technology , Lausanne, , Switzerland"},{"name":"\u00c9cole polytechnique f\u00e9d\u00e9rale de Lausanne , Lausanne, , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika\u00ebl","family":"Sturny","sequence":"additional","affiliation":[{"name":"Laboratory of Hemodynamics and Cardiovascular Technology , Lausanne, , Switzerland"},{"name":"\u00c9cole polytechnique f\u00e9d\u00e9rale de Lausanne , Lausanne, , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babak","family":"Ebadi","sequence":"additional","affiliation":[{"name":"Laboratory of Hemodynamics and Cardiovascular Technology , Lausanne, , Switzerland"},{"name":"\u00c9cole polytechnique f\u00e9d\u00e9rale de Lausanne , Lausanne, , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael T.","family":"Ruoccolo","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics , Belo Horizonte, Minas Gerais , Brazil"},{"name":"Universidade Federal de Minas Gerais , Belo Horizonte, Minas Gerais , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robson A.S.","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics , Belo Horizonte, Minas Gerais , Brazil"},{"name":"Universidade Federal de Minas Gerais , Belo Horizonte, Minas Gerais , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo A.","family":"Fraga-Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Hemodynamics and Cardiovascular Technology , Lausanne, , Switzerland"},{"name":"\u00c9cole polytechnique f\u00e9d\u00e9rale de Lausanne , Lausanne, , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Stergiopulos","sequence":"additional","affiliation":[{"name":"Laboratory of Hemodynamics and Cardiovascular Technology , Lausanne, , Switzerland"},{"name":"\u00c9cole polytechnique f\u00e9d\u00e9rale de Lausanne , Lausanne, , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,9,15]]},"reference":[{"key":"2023011111101963300_bib1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev.pharmtox.010909.105610","article-title":"Tissue renin-angiotensin-aldosterone systems: targets for pharmacological therapy","volume":"50","author":"Bader","year":"2010","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"2023011111101963300_bib2","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1152\/physrev.00036.2005","article-title":"Physiology of local renin-angiotensin systems","volume":"86","author":"Paul","year":"2006","journal-title":"Physiol Rev"},{"key":"2023011111101963300_bib3","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0002-9343(02)01241-X","article-title":"Vascular and cardiac benefits of angiotensin receptor blockers","volume":"113","author":"Schiffrin","year":"2002","journal-title":"Am J Med"},{"key":"2023011111101963300_bib4","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.pharmthera.2008.08.009","article-title":"AT2 receptors: functional relevance in cardiovascular disease","volume":"120","author":"Jones","year":"2008","journal-title":"Pharmacol Ther"},{"key":"2023011111101963300_bib5","doi-asserted-by":"crossref","first-page":"8258","DOI":"10.1073\/pnas.1432869100","article-title":"Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas","volume":"100","author":"Santos","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023011111101963300_bib6","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1111\/eci.12117","article-title":"Pathophysiological role of the renin-angiotensin system on erectile dysfunction","volume":"43","author":"Fraga-Silva","year":"2013","journal-title":"Eur J Clin Invest"},{"key":"2023011111101963300_bib7","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S0090-4295(01)01312-7","article-title":"Plasma levels of angiotensin II during different penile conditions in the cavernous and systemic blood of healthy men and patients with erectile dysfunction","volume":"58","author":"Becker","year":"2001","journal-title":"Urology"},{"key":"2023011111101963300_bib8","first-page":"346","article-title":"[Effects of angiotensin II on male rats with diabetic erectile dysfunction]","volume":"11","author":"Li","year":"2005","journal-title":"Zhonghua Nan Ke Xue"},{"key":"2023011111101963300_bib9","first-page":"1920","article-title":"Tissue angiotensin II as a modulator of erectile function. I. Angiotensin peptide content, secretion and effects in the corpus cavernosum","volume":"157","author":"Kifor","year":"1997","journal-title":"J\u00a0Urol"},{"key":"2023011111101963300_bib10","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/sj.ijir.3900915","article-title":"Captopril treatment reverses erectile dysfunction in male stroke prone spontaneously hypertensive rats","volume":"14","author":"Dorrance","year":"2002","journal-title":"Int J Impot Res"},{"key":"2023011111101963300_bib11","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/j.1476-5381.2011.01267.x","article-title":"Telmisartan, ramipril and their combination improve endothelial function in different tissues in a murine model of cholesterol-induced atherosclerosis","volume":"163","author":"Schlimmer","year":"2011","journal-title":"Br J Pharmacol"},{"key":"2023011111101963300_bib12","first-page":"696","article-title":"Losartan, an angiotensin type I receptor, restores erectile function by downregulation of cavernous renin-angiotensin system in streptozocin-induced diabetic rats","volume":"6","author":"Yang","year":"2009","journal-title":"J\u00a0Sex Med"},{"key":"2023011111101963300_bib13","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1159\/000477388","article-title":"Losartan preserves erectile function by suppression of apoptosis and fibrosis of corpus cavernosum and corporal veno-occlusive dysfunction in diabetic rats","volume":"42","author":"Li","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"2023011111101963300_bib14","doi-asserted-by":"crossref","first-page":"452","DOI":"10.4103\/aja.aja_8_19","article-title":"Losartan improves erectile function through suppression of corporal apoptosis and oxidative stress in rats with cavernous nerve injury","volume":"21","author":"Wang","year":"2019","journal-title":"Asian J Androl"},{"key":"2023011111101963300_bib15","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/ijir.2012.4","article-title":"Losartan improves erectile dysfunction in diabetic patients: a clinical trial","volume":"24","author":"Chen","year":"2012","journal-title":"Int J Impot Res"},{"key":"2023011111101963300_bib16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/08038020310021967","article-title":"Effect of the angiotensin II antagonist valsartan on sexual function in hypertensive men","volume":"2","author":"D\u00fcsing","year":"2003","journal-title":"Blood Press Suppl"},{"key":"2023011111101963300_bib17","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1111\/j.1464-410X.2012.11098.x","article-title":"Irbesartan promotes erection recovery after nerve-sparing radical retropubic prostatectomy: a retrospective long-term analysis","volume":"110","author":"Segal","year":"2012","journal-title":"BJU Int"},{"key":"2023011111101963300_bib18","first-page":"2414","article-title":"Effect of angiotensin II and its receptor antagonists on human corpus cavernous contractility and oxidative stress: modulation of nitric oxide mediated relaxation","volume":"185","author":"Ertemi","year":"2011","journal-title":"J\u00a0Urol"},{"key":"2023011111101963300_bib19","doi-asserted-by":"crossref","first-page":"H2588","DOI":"10.1152\/ajpheart.00173.2007","article-title":"Evidence that the vasodilator angiotensin-(1-7)-Mas axis plays an important role in erectile function","volume":"293","author":"da Costa Gon\u00e7alves","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2023011111101963300_bib20","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.fertnstert.2013.02.046","article-title":"Role of angiotensin II and angiotensin-(1-7) in diabetes-induced oxidative DNA damage in the corpus cavernosum","volume":"100","author":"Kilarkaje","year":"2013","journal-title":"Fertil Steril"},{"key":"2023011111101963300_bib21","first-page":"2430","article-title":"An oral formulation of angiotensin-(1-7) reverses corpus cavernosum damages induced by hypercholesterolemia","volume":"10","author":"Fraga-Silva","year":"2013","journal-title":"J\u00a0Sex Med"},{"key":"2023011111101963300_bib22","first-page":"289","article-title":"Diminazene protects corpus cavernosum against hypercholesterolemia-induced injury","volume":"12","author":"Fraga-Silva","year":"2015","journal-title":"J\u00a0Sex Med"},{"key":"2023011111101963300_bib23","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.sxmr.2015.10.011","article-title":"Aging and erectile dysfunction","volume":"4","author":"Echeverri Tirado","year":"2016","journal-title":"Sex Med Rev"},{"key":"2023011111101963300_bib24","first-page":"324","article-title":"Amelioration of penile fibrosis: myth or reality","volume":"31","author":"El-Sakka","year":"2010","journal-title":"J\u00a0Androl"},{"key":"2023011111101963300_bib25","first-page":"1088","article-title":"Age decreases nitric oxide synthase-containing nerve fibers in the rat penis","volume":"157","author":"Carrier","year":"1997","journal-title":"J\u00a0Urol"},{"key":"2023011111101963300_bib26","doi-asserted-by":"crossref","first-page":"H1340","DOI":"10.1152\/ajpheart.00121.2005","article-title":"Overexpression of arginase in the aged mouse penis impairs erectile function and decreases eNOS activity: influence of in\u00a0vivo gene therapy of anti-arginase","volume":"292","author":"Bivalacqua","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2023011111101963300_bib27","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.1158\/0008-5472.CAN-04-0496","article-title":"Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets","volume":"64","author":"Andersen","year":"2004","journal-title":"Cancer Res"},{"key":"2023011111101963300_bib28","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biol"},{"key":"2023011111101963300_bib29","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"2023011111101963300_bib30","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1017\/S1462399411001967","article-title":"Myofibroblast differentiation and survival in fibrotic disease","volume":"13","author":"Kis","year":"2011","journal-title":"Expert Rev Mol Med"},{"key":"2023011111101963300_bib31","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1161\/01.HYP.0000251865.35728.2f","article-title":"Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways","volume":"49","author":"Sampaio","year":"2007","journal-title":"Hypertension"},{"key":"2023011111101963300_bib32","first-page":"653","article-title":"Renin angiotensin system in rabbit corpus cavernosum: functional characterization of angiotensin II receptors","volume":"158","author":"Park","year":"1997","journal-title":"J\u00a0Urol"},{"key":"2023011111101963300_bib33","doi-asserted-by":"crossref","first-page":"33678","DOI":"10.1038\/srep33678","article-title":"Neprilysin is a mediator of alternative renin-angiotensin-system activation in the murine and human kidney","volume":"6","author":"Domenig","year":"2016","journal-title":"Sci Rep"},{"key":"2023011111101963300_bib34","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.aju.2013.05.004","article-title":"Treatments for fibrosis of the corpora cavernosa","volume":"11","author":"Egydio","year":"2013","journal-title":"Arab J Urol"},{"key":"2023011111101963300_bib35","first-page":"910","article-title":"Transforming growth factor-beta1 (TGF-beta1) is sufficient to induce fibrosis of rabbit corpus cavernosum in\u00a0vivo","volume":"162","author":"Nehra","year":"1999","journal-title":"J\u00a0Urol"},{"key":"2023011111101963300_bib36","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1464-410X.2004.04969.x","article-title":"Expression of transforming growth factor-beta1 in penile tissue from rats with bilateral cavernosal nerve ablation","volume":"94","author":"Hu","year":"2004","journal-title":"BJU Int"},{"key":"2023011111101963300_bib37","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/sj.ijir.3901261","article-title":"TGF-beta1 neutralizing antibodies decrease the fibrotic effects of ischemic priapism","volume":"16","author":"Sanli","year":"2004","journal-title":"Int J Impot Res"},{"key":"2023011111101963300_bib38","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.cardiores.2004.04.030","article-title":"TGF-beta1 and angiotensin networking in cardiac remodeling","volume":"63","author":"Rosenkranz","year":"2004","journal-title":"Cardiovasc Res"},{"key":"2023011111101963300_bib39","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI0214190","article-title":"TGF-beta1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II","volume":"109","author":"Schultz","year":"2002","journal-title":"J\u00a0Clin Invest"},{"key":"2023011111101963300_bib40","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1161\/01.CIR.101.10.1130","article-title":"Angiotensin II has multiple profibrotic effects in human cardiac fibroblasts","volume":"101","author":"Kawano","year":"2000","journal-title":"Circulation"},{"key":"2023011111101963300_bib41","first-page":"134","article-title":"Angiotensin-(1-7) and the regulation of anti-fibrotic signaling pathways","volume":"2","author":"Chappell","year":"2017","journal-title":"J\u00a0Cell Signal"},{"key":"2023011111101963300_bib42","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.jash.2008.05.003","article-title":"Ablation of angiotensin (1-7) receptor Mas in C57Bl\/6 mice causes endothelial dysfunction","volume":"2","author":"Rabelo","year":"2008","journal-title":"J\u00a0Am Soc Hypertens"},{"key":"2023011111101963300_bib43","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1042\/CS20160193","article-title":"Angiotensin-(1-7) decreases the expression of collagen I via TGF-\u03b21\/Smad2\/3 and subsequently inhibits fibroblast-myofibroblast transition","volume":"130","author":"Zhou","year":"2016","journal-title":"Clin Sci"},{"key":"2023011111101963300_bib44","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.3892\/or.2013.2370","article-title":"Angiotensin-converting enzyme 2 attenuates the metastasis of non-small cell lung cancer through inhibition of epithelial-mesenchymal transition","volume":"29","author":"Qian","year":"2013","journal-title":"Oncol Rep"},{"key":"2023011111101963300_bib45","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/2211-5463.12202","article-title":"Inhibition of the TGF\u03b2 signalling pathway by cGMP and cGMP-dependent kinase I in renal fibrosis","volume":"7","author":"Schinner","year":"2017","journal-title":"FEBS Open Bio"},{"key":"2023011111101963300_bib46","doi-asserted-by":"crossref","first-page":"3966","DOI":"10.1016\/j.febslet.2009.10.036","article-title":"Correlation of mRNA and protein in complex biological samples","volume":"583","author":"Maier","year":"2009","journal-title":"FEBS Lett"},{"key":"2023011111101963300_bib47","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1749-6632.2001.tb05635.x","article-title":"Implications of protein degradation in aging","volume":"928","author":"Goto","year":"2001","journal-title":"Ann N Y Acad Sci"},{"key":"2023011111101963300_bib48","first-page":"123","article-title":"Restoration of erectile capacity in normotensive aged rats by modulation of angiotensin receptor type 1","volume":"26","author":"Park","year":"2005","journal-title":"J\u00a0Androl"},{"key":"2023011111101963300_bib49","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.phrs.2007.05.008","article-title":"Different responses to angiotensin-(1-7) in young, aged and diabetic rabbit corpus cavernosum","volume":"56","author":"Yousif","year":"2007","journal-title":"Pharmacol Res"}],"container-title":["The Journal of Sexual Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S174360952030878X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S174360952030878X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/17\/11\/2129\/48527767\/jsm_17_11_2129.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/17\/11\/2129\/48527767\/jsm_17_11_2129.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T14:47:53Z","timestamp":1675954073000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jsm\/article\/17\/11\/2129\/6973921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,15]]},"references-count":49,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,9,15]]},"published-print":{"date-parts":[[2020,11,1]]}},"URL":"https:\/\/doi.org\/10.1016\/j.jsxm.2020.08.008","relation":{},"ISSN":["1743-6109","1743-6095"],"issn-type":[{"type":"electronic","value":"1743-6109"},{"type":"print","value":"1743-6095"}],"subject":[],"published-other":{"date-parts":[[2020,11]]},"published":{"date-parts":[[2020,9,15]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of the Renin-Angiotensin System in Aged Cavernosal Tissue and its Role in Penile Fibrosis","name":"articletitle","label":"Article Title"},{"value":"The Journal of Sexual Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsxm.2020.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 International Society for Sexual Medicine. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}