{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T07:57:36Z","timestamp":1788508656393,"version":"build-2803163510"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030_156859"],"award-info":[{"award-number":["310030_156859"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jsm.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Sexual Medicine"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.jsxm.2021.02.004","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T12:09:32Z","timestamp":1618574972000},"page":"875-888","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Apelin-13 Protects Corpus Cavernosum Against Fibrosis Induced by High-Fat Diet in an MMP-Dependent Mechanism"],"prefix":"10.1093","volume":"18","author":[{"given":"Mikael","family":"Sturny","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9a","family":"Anguenot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana P.","family":"Costa-Fraga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maiia E.","family":"Bragina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto Martins","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaela F.","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo A.","family":"Fraga-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Stergiopulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"10.1016\/j.jsxm.2021.02.004_bib0001","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.aju.2011.03.013","article-title":"Reversion of penile fibrosis: current information and a new horizon","volume":"9","author":"El-Sakka","year":"2011","journal-title":"Arab J Urol"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0002","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1743-6109.2008.01195.x","article-title":"Mechanisms of Penile Fibrosis","volume":"6","author":"Gonzalez-Cadavid","year":"2009","journal-title":"J Sex Med"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0003","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0021-9150(01)00740-7","article-title":"Distinct mechanisms implicated in atherosclerosis-induced erectile dysfunction in rabbits","volume":"162","author":"Behr-Roussel","year":"2002","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0004","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/S0090-4295(01)00974-8","article-title":"Effect of experimental hypercholesterolemia on cavernosal structures","volume":"57","author":"Yesilli","year":"2001","journal-title":"Urology"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0005","article-title":"More than a syllable in fib-ROS-is: the role of ROS on the fibrotic extracellular matrix and on cellular contacts","author":"Grosche","year":"2000","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0006","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3181\/0707-MR-190","article-title":"Mechanisms of fibrogenesis","volume":"233","author":"Kisseleva","year":"2008","journal-title":"Exp Biol Med Maywood NJ"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0007","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1111\/j.1743-6109.2010.01880.x","article-title":"Hypercholesterolemia-induced erectile dysfunction: endothelial nitric oxide synthase (eNOS) uncoupling in the mouse penis by NAD(P)H oxidase","volume":"7","author":"Musicki","year":"2010","journal-title":"J Sex Med"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0008","doi-asserted-by":"crossref","first-page":"324","DOI":"10.2164\/jandrol.109.008730","article-title":"Amelioration of penile fibrosis: myth or reality","volume":"31","author":"El-Sakka","year":"2010","journal-title":"J Androl"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0009","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ucl.2005.08.007","article-title":"Physiology of penile erection and pathophysiology of erectile dysfunction","volume":"32","author":"Dean","year":"2005","journal-title":"Urol Clin North Am"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0010","first-page":"2","article-title":"Fibrosis: recent advances in myofibroblast biology and new therapeutic perspectives. F1000","author":"Hinz","year":"2010","journal-title":"Biol Rep"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0011","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.2353\/ajpath.2007.070112","article-title":"The Myofibroblast","volume":"170","author":"Hinz","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0012","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nrm2125","article-title":"Matrix metalloproteinases and the regulation of tissue remodelling","volume":"8","author":"Page-McCaw","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0013","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/gb-2011-12-11-233","article-title":"Tissue inhibitors of metalloproteinases","volume":"12","author":"Murphy","year":"2011","journal-title":"Genome Biol"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0014","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1006\/bbrc.1998.9489","article-title":"Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor","volume":"251","author":"Tatemoto","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0015","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1046\/j.1471-4159.2000.0740034.x","article-title":"Characterization of apelin, the ligand for the APJ receptor","volume":"74","author":"Lee","year":"2000","journal-title":"J Neurochem"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0016","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0167-0115(01)00236-1","article-title":"The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism","volume":"99","author":"Tatemoto","year":"2001","journal-title":"Regul Pept"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0017","doi-asserted-by":"crossref","first-page":"21061","DOI":"10.1074\/jbc.M908417199","article-title":"Molecular and functional characteristics of APJ. Tissue distribution of mRNA and interaction with the endogenous ligand apelin","volume":"275","author":"Hosoya","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0018","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0167-4889(00)00143-9","article-title":"Molecular properties of apelin: tissue distribution and receptor binding","volume":"1538","author":"Kawamata","year":"2001","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0019","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1007\/s00395-007-0671-2","article-title":"Apelin-13 and apelin-36 exhibit direct cardioprotective activity against ischemiareperfusion injury","volume":"102","author":"Simpkin","year":"2007","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0020","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/CRD.0b013e3181b3fe0d","article-title":"The emerging role of apelin in cardiovascular disease and health","volume":"17","author":"Quazi","year":"2009","journal-title":"Cardiol Rev"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0021","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1517\/14728221003752743","article-title":"The apelinergic system: a promising therapeutic target","volume":"14","author":"Falc\u00e3o-Pires","year":"2010","journal-title":"Expert Opin Ther Targets"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0022","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1016\/j.bcp.2007.12.015","article-title":"The apelin\u2013APJ system in heart failure: pathophysiologic relevance and therapeutic potential","volume":"75","author":"Japp","year":"2008","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0023","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1093\/eurheartj\/ehr389","article-title":"Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1","volume":"33","author":"Pchejetski","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0024","doi-asserted-by":"crossref","first-page":"5306","DOI":"10.1210\/en.2010-0754","article-title":"Apelin mediates the induction of profibrogenic genes in human hepatic stellate cells","volume":"151","author":"Melgar-Lesmes","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0025","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.bpg.2011.02.011","article-title":"Anti-fibrogenic strategies and the regression of fibrosis","volume":"25","author":"Kisseleva","year":"2011","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0026","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/j.bbadis.2015.02.013","article-title":"Apelin protects against acute renal injury by inhibiting TGF-\u03b21","volume":"1852","author":"Chen","year":"2015","journal-title":"Biochim Biophys Acta BBA - Mol Basis Dis"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0027","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1159\/000337091","article-title":"The role of apelin on the alleviative effect of angiotensin receptor blocker in unilateral ureteral obstruction-induced renal fibrosis","volume":"2","author":"Nishida","year":"2012","journal-title":"Nephron Extra"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0028","doi-asserted-by":"crossref","first-page":"334","DOI":"10.4103\/2045-8932.87299","article-title":"Apelin and pulmonary hypertension","volume":"1","author":"Andersen","year":"2011","journal-title":"Pulm Circ"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0029","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.1111\/jsm.12158","article-title":"Expression of the apelin\u2013APJ pathway and effects on erectile function in a mouse model of vasculogenic erectile dysfunction","volume":"10","author":"Kwon","year":"2013","journal-title":"J Sex Med"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0030","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1111\/j.1743-6109.2007.00518.x","article-title":"A mouse model of hypercholesterolemia-induced erectile dysfunction","volume":"4","author":"Xie","year":"2007","journal-title":"J Sex Med"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0031","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/jsm.12757","article-title":"Diminazene protects corpus cavernosum against hypercholesterolemia-induced injury","volume":"12","author":"Fraga-Silva","year":"2015","journal-title":"J Sex Med"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0032","doi-asserted-by":"crossref","first-page":"e12891","DOI":"10.1111\/eci.12891","article-title":"Apelin-13 treatment enhances the stability of atherosclerotic plaques","volume":"48","author":"Fraga-Silva","year":"2018","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0033","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.peptides.2012.08.004","article-title":"In vivo, ex vivo, and in vitro studies on apelin's effect on myocardial glucose uptake","volume":"37","author":"Xu","year":"2012","journal-title":"Peptides"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0034","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1111\/jsm.12262","article-title":"An oral formulation of angiotensin-(1-7) reverses corpus cavernosum damages induced by hypercholesterolemia","volume":"10","author":"Fraga-Silva","year":"2013","journal-title":"J Sex Med"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0035","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jneumeth.2008.05.003","article-title":"The use of total protein stains as loading controls: an alternative to high-abundance single-protein controls in semi-quantitative immunoblotting","volume":"172","author":"Aldridge","year":"2008","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0036","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2015.00375","article-title":"Bypassing hazard of housekeeping genes: their evaluation in rat granule neurons treated with cerebrospinal fluid of multiple sclerosis subjects","volume":"9","author":"Mathur","year":"2015","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0037","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1136\/thorax.57.9.765","article-title":"\u00df-Actin and GAPDH housekeeping gene expression in asthmatic airways is variable and not suitable for normalising mRNA levels","volume":"57","author":"Glare","year":"2002","journal-title":"Thorax"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0038","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.ab.2010.02.036","article-title":"Reversible Ponceau staining as a loading control alternative to actin in Western blots","volume":"401","author":"Romero-Calvo","year":"2010","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0039","doi-asserted-by":"crossref","first-page":"e72457","DOI":"10.1371\/journal.pone.0072457","article-title":"Total protein analysis as a reliable loading control for quantitative fluorescent Western blotting","volume":"8","author":"Eaton","year":"2013","journal-title":"PLOS ONE"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0040","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1111\/jsm.12482","article-title":"An increased arginase activity is associated with corpus cavernosum mpairment induced by hypercholesterolemia","volume":"11","author":"Fraga-Silva","year":"2014","journal-title":"J Sex Med"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0041","doi-asserted-by":"crossref","first-page":"F631","DOI":"10.1152\/ajprenal.00379.2006","article-title":"In vitro models of TGF-beta-induced fibrosis suitable for high-throughput screening of antifibrotic agents","volume":"293","author":"Xu","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0042","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3109\/17453679509157688","article-title":"Collagen propeptides as indicators of collagen assembly","volume":"266","author":"Risteli","year":"1995","journal-title":"Acta Orthop Scand Suppl"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0043","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/cr.2008.328","article-title":"Non-smad pathways in TGF-\u03b2 signaling","volume":"19","author":"Zhang","year":"2009","journal-title":"Cell Res"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0044","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1096\/fj.03-1273rev","article-title":"TGF-\u03b2 signaling and the fibrotic response","volume":"18","author":"Leask","year":"2004","journal-title":"FASEB J"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0045","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1111\/j.1743-6109.2010.01880.x","article-title":"Hypercholesterolemia-induced erectile dysfunction: endothelial nitric oxide synthase (eNOS) uncoupling in the mouse penis by NAD(P)H oxidase","volume":"7","author":"Musicki","year":"2010","journal-title":"J Sex Med"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0046","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1002\/j.1939-4640.2003.tb02743.x","article-title":"Endothelial dysfunction in erectile dysfunction: role of the endothelium in erectile physiology and disease","volume":"24","author":"Bivalacqua","year":"2003","journal-title":"J Androl"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0047","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1046\/j.1464-410X.2003.04378.x","article-title":"The ageing male and erectile dysfunction","volume":"92","author":"Montorsi","year":"2003","journal-title":"BJU Int"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0048","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1111\/j.1743-6109.2011.02505.x","article-title":"Investigative models in erectile dysfunction: a state-of-the-art review of current animal models","volume":"8","author":"Chung","year":"2011","journal-title":"J Sex Med"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0049","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/j.1743-6109.2006.00282.x","article-title":"Original research\u2014basic science: erectile dysfunction in hypercholesterolemic atherosclerotic apolipoprotein E knockout mice","volume":"3","author":"Behr-Roussel","year":"2011","journal-title":"J Sex Med"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0050","first-page":"2013","article-title":"Treatment with CB2 agonist JWH-133 reduces histological features associated with erectile dysfunction in hypercholesterolemic mice","author":"Fraga-Silva","year":"2013","journal-title":"Clin Dev Immunol"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0051","first-page":"3343","article-title":"Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis","volume":"118","author":"Chun","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0052","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1016\/j.febslet.2010.04.025","article-title":"Activation of catalase by apelin prevents oxidative stress-linked cardiac hypertrophy","volume":"584","author":"Foussal","year":"2010","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0053","doi-asserted-by":"crossref","first-page":"3763","DOI":"10.1074\/jbc.M113.526210","article-title":"Apelin attenuates oxidative stress in human adipocytes","volume":"289","author":"Than","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0054","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1177\/107424840300800209","article-title":"Low density lipoproteins modulate collagen metabolism in fibroblasts","volume":"8","author":"Joseph","year":"2003","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0055","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1053\/gast.2003.50063","article-title":"Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat","volume":"124","author":"Iimuro","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0056","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s11095-007-9311-7","article-title":"Matrix metalloproteinase gene delivery for liver fibrosis","volume":"25","author":"Iimuro","year":"2008","journal-title":"Pharm Res"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0057","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1053\/j.gastro.2003.12.045","article-title":"Treatment with human metalloproteinase-8 gene delivery ameliorates experimental rat liver cirrhosis","volume":"126","author":"Siller-L\u00f3pez","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0058","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1242\/dmm.012062","article-title":"Diverse functions of matrix metalloproteinases during fibrosis","volume":"7","author":"Giannandrea","year":"2014","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0059","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1046\/j.0105-6263.2003.00447.x","article-title":"Expression of cavernous transforming growth factor-\u03b21 and its Type II receptor in patients with erectile dysfunction","volume":"27","author":"Ryu","year":"2004","journal-title":"Int J Androl"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0060","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1471-2407-12-26","article-title":"TGF-\u03b21 modulates the homeostasis between MMPs and MMP inhibitors through p38 MAPK and ERK1\/2 in highly invasive breast cancer cells","volume":"12","author":"Gomes","year":"2012","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0061","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.2741\/4077","article-title":"TGF-beta 1 induced fibroblast proliferation is mediated by the FGF-2\/ERK pathway","volume":"17","author":"Xiao","year":"2012","journal-title":"Front Biosci Landmark Ed"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0062","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nature02006","article-title":"Smad-dependent and Smad-independent pathways in TGF-\u03b2 family signalling","volume":"425","author":"Derynck","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0063","doi-asserted-by":"crossref","first-page":"41361","DOI":"10.1074\/jbc.M204597200","article-title":"Modulation of Smad2-mediated signaling by extracellular signal-regulated kinase","volume":"277","author":"Funaba","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jsxm.2021.02.004_bib0064","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.eururo.2005.01.008","article-title":"Isolation of primary endothelial and stromal cell cultures of the corpus cavernosum penis for basic research and tissue engineering","volume":"47","author":"Pilatz","year":"2005","journal-title":"Eur Urol"}],"container-title":["The Journal of Sexual Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609521002459?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609521002459?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T14:49:09Z","timestamp":1675954149000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jsm\/article\/18\/5\/875\/6956143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":64,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S1743609521002459"],"URL":"https:\/\/doi.org\/10.1016\/j.jsxm.2021.02.004","relation":{},"ISSN":["1743-6095"],"issn-type":[{"value":"1743-6095","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Apelin-13 Protects Corpus Cavernosum Against Fibrosis Induced by High-Fat Diet in an MMP-Dependent Mechanism","name":"articletitle","label":"Article Title"},{"value":"The Journal of Sexual Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsxm.2021.02.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2021, International Society of Sexual Medicine. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}