{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T13:53:04Z","timestamp":1726494784300},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T00:00:00Z","timestamp":1629763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T00:00:00Z","timestamp":1629763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"am","delay-in-days":401,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jsm.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tools for diagnosing sexual dysfunction and for tracking outcomes of interest include clinician interviews, physical exam, and patient self-report. Limited work has described relationships among these three sources of information regarding female sexual dysfunction and vulvovaginal health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We describe correlations among data collected from clinician interviews, clinical gynecological examination, and patient self-report.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data are from a single-site, single-arm, prospective trial in 100 postmenopausal patients with a history of breast or endometrial cancer who sought treatment for vulvovaginal symptoms. The trial collected a standardized clinical gynecologic exam, clinician-reported outcome (ClinRO) measures of vulvovaginal dryness and pain, and patient-reported outcome (PRO) measures of sexual function, including PROMIS Sexual Function and Satisfaction (SexFS) lubrication, vaginal discomfort, labial discomfort, and clitoral discomfort and Female Sexual Function Index (FSFI) lubrication and pain. We examined polyserial correlations between measures with bootstrapped 95% confidence intervals from the baseline and 12\u201314-week timepoints.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>All of the relationships between the ClinRO variables and the PRO variables were in the expected direction (ie, positive), but the strength of the relationships varied substantially. At 12\u201314 weeks, there were medium-to-large correlations between ClinRO vaginal dryness and SexFS Lubrication (0.64), ClinRO vulvar dryness and SexFS Lubrication (0.46), ClinRO vulvar discomfort and SexFS Labial Discomfort (0.70), and ClinRO vulvar discomfort and SexFS Clitoral Discomfort (0.43). With one exception, the correlations between the exam variables and the corresponding PRO scores were small (range 0.01\u20130.27).<\/jats:p><\/jats:sec><jats:sec><jats:title>Strengths &amp; Limitations<\/jats:title><jats:p>Our study included a comprehensive, standardized gynecologic exam designed specifically to evaluate sexual dysfunction as well as established PRO measures with significant evidence for validity. A limitation of our findings is that the sample size was relatively small, and our sample was restricted to women who received cancer treatments known to have dramatic effects on vulvovaginal tissue quality.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Patient- and clinician-reported vulvovaginal dryness and discomfort were moderately correlated with each other but not with clinical gynecologic exam findings. Understanding the relationships among these different types of data highlights the distinct contributions of each to understand vulvovaginal tissue quality and patient sexual function after cancer.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jsxm.2021.07.011","type":"journal-article","created":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T02:40:37Z","timestamp":1629772837000},"page":"1768-1774","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Correspondence Between Clinician Ratings of Vulvovaginal Health and Patient-Reported Sexual Function After Cancer"],"prefix":"10.1093","volume":"18","author":[{"given":"Kathryn E.","family":"Flynn","sequence":"first","affiliation":[{"name":"Department of Medicine, Medical College of Wisconsin , Milwaukee, WI , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Lin","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Duke University School of Medicine , Durham, NC , USA"},{"name":"Department of Population Health Sciences, Duke University School of Medicine , Durham, NC , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne","family":"Carter","sequence":"additional","affiliation":[{"name":"Department of Surgery, Memorial Sloan Kettering Cancer Center , New York City, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond E.","family":"Baser","sequence":"additional","affiliation":[{"name":"Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center , New York City, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shari","family":"Goldfarb","sequence":"additional","affiliation":[{"name":"Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center , New York City, NY , USA"},{"name":"Department of Medicine, Memorial Sloan Kettering Cancer Center , New York City, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally","family":"Saban","sequence":"additional","affiliation":[{"name":"Department of Surgery, Memorial Sloan Kettering Cancer Center , New York City, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin P.","family":"Weinfurt","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Duke University School of Medicine , Durham, NC , USA"},{"name":"Department of Population Health Sciences, Duke University School of Medicine , Durham, NC , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,8,24]]},"reference":[{"key":"2023041407105734800_","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0174981","article-title":"Sexual function and satisfaction among heterosexual and sexual minority U.S. adults: A cross-sectional survey","volume":"12","author":"Flynn","year":"2017","journal-title":"PLoS One"},{"key":"2023041407105734800_","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1097\/AOG.0b013e3181898cdb","article-title":"Sexual problems and distress in United States women: Prevalence and correlates","volume":"112","author":"Shifren","year":"2008","journal-title":"Obstet Gynecol"},{"key":"2023041407105734800_","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/AOG.0000000000003324","article-title":"Female sexual dysfunction: ACOG practice bulletin clinical management guidelines for obstetrician-gynecologists, number 213","volume":"134","author":"American College of O, Gynecologists\u2019 Committee on Practice B-G","year":"2019","journal-title":"Obstet Gynecol"},{"key":"2023041407105734800_","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1097\/AOG.0000000000003941","article-title":"Female sexual dysfunction: Pharmacologic and therapeutic interventions","volume":"136","author":"Wheeler","year":"2020","journal-title":"Obstet Gynecol"},{"key":"2023041407105734800_","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3322\/caac.21337","article-title":"Physical examination of the female cancer patient with sexual concerns: What oncologists and patients should expect from consultation with a specialist","volume":"66","author":"Lindau","year":"2016","journal-title":"CA Cancer J Clin"},{"key":"2023041407105734800_","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00520-020-05472-3","article-title":"A single-arm, prospective trial investigating the effectiveness of a non-hormonal vaginal moisturizer containing hyaluronic acid in postmenopausal cancer survivors","volume":"29","author":"Carter","year":"2021","journal-title":"Support Care Cancer"},{"key":"2023041407105734800_","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.ygyno.2020.05.025","article-title":"A single-arm clinical trial investigating the effectiveness of a non-hormonal, hyaluronic acid-based vaginal moisturizer in endometrial cancer survivors","volume":"158","author":"Carter","year":"2020","journal-title":"Gynecol Oncol"},{"key":"2023041407105734800_","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jsxm.2016.11.317","article-title":"Validation of clinical tools for vaginal and vulvar symptom assessment in cancer patients and survivors","volume":"14","author":"Eaton","year":"2017","journal-title":"J Sex Med"},{"key":"2023041407105734800_","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.jclinepi.2010.04.011","article-title":"The Patient Reported Outcomes Measurement Information System (PROMIS) developed and tested its first wave of adult self-reported health outcome item banks: 2005-2008","volume":"63","author":"Cella","year":"2010","journal-title":"J Clin Epidemiol"},{"key":"2023041407105734800_","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1111\/jsm.12966","article-title":"Development and initial validation of the PROMIS((R)) sexual function and satisfaction measures version 2.0","volume":"12","author":"Weinfurt","year":"2015","journal-title":"J Sex Med"},{"key":"2023041407105734800_","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1007\/s11606-015-3333-3","article-title":"Development and validation of a single-item screener for self-reporting sexual problems in U.S. adults","volume":"30","author":"Flynn","year":"2015","journal-title":"J Gen Intern Med"},{"key":"2023041407105734800_","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1111\/jsm.12599","article-title":"Improving patients\u2019 understanding of terms and phrases commonly used in self-reported measures of sexual function","volume":"11","author":"Alexander","year":"2014","journal-title":"J Sex Med"},{"key":"2023041407105734800_","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/pon.1738","article-title":"Sexual functioning along the cancer continuum: Focus group results from the Patient-Reported Outcomes Measurement Information System (PROMIS(R))","volume":"20","author":"Flynn","year":"2011","journal-title":"Psychooncology"},{"key":"2023041407105734800_","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1007\/s11136-009-9523-x","article-title":"Using cognitive interviews to evaluate items for measuring sexual functioning across cancer populations: Improvements and remaining challenges","volume":"18","author":"Fortune-Greeley","year":"2009","journal-title":"Qual Life Res"},{"key":"2023041407105734800_","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1002\/cncr.24134","article-title":"Initial report of the cancer Patient-Reported Outcomes Measurement Information System (PROMIS) sexual function committee: Review of sexual function measures and domains used in oncology","volume":"115","author":"Jeffery","year":"2009","journal-title":"Cancer"},{"issue":"suppl 1","key":"2023041407105734800_","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1743-6109.2012.02995.x","article-title":"Development of the NIH PROMIS\u00ae sexual function and satisfaction measures in patients with cancer","volume":"10","author":"Flynn","year":"2013","journal-title":"J Sex Med"},{"key":"2023041407105734800_","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1477-7525-11-40","article-title":"Construct validity of the PROMIS(R) sexual function and satisfaction measures in patients with cancer","volume":"11","author":"Flynn","year":"2013","journal-title":"Health Qual Life Outcomes"},{"key":"2023041407105734800_","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1111\/jsm.12225","article-title":"Accuracy of 30-day recall for components of sexual function and the moderating effects of gender and mood","volume":"11","author":"Weinfurt","year":"2014","journal-title":"J Sex Med"},{"key":"2023041407105734800_","doi-asserted-by":"crossref","first-page":"391.e1","DOI":"10.1016\/j.ajog.2016.12.006","article-title":"Assessment of vulvar discomfort with sexual activity among women in the United States","volume":"216","author":"Flynn","year":"2017","journal-title":"Am J Obstet Gynecol"},{"key":"2023041407105734800_","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/009262300278597","article-title":"The Female Sexual Function Index (FSFI): A multidimensional self-report instrument for the assessment of female sexual function","volume":"26","author":"Rosen","year":"2000","journal-title":"J Sex Marital Ther"},{"key":"2023041407105734800_","article-title":"Statistical power analysis for the behavioral sciences","author":"Cohen","year":"1988","edition":"2nd ed."},{"key":"2023041407105734800_","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/00926230701267852","article-title":"The female sexual function index: A methodological critique and suggestions for improvement","volume":"33","author":"Meyer-Bahlburg","year":"2007","journal-title":"J Sex Marital Ther"}],"container-title":["The Journal of Sexual Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609521006184?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609521006184?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/18\/10\/1768\/49888569\/jsm_18_10_1768.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/18\/10\/1768\/49888569\/jsm_18_10_1768.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T14:39:11Z","timestamp":1699367951000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jsm\/article\/18\/10\/1768\/6955948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,24]]},"references-count":22,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,8,24]]},"published-print":{"date-parts":[[2021,10,1]]}},"URL":"https:\/\/doi.org\/10.1016\/j.jsxm.2021.07.011","relation":{},"ISSN":["1743-6109","1743-6095"],"issn-type":[{"type":"electronic","value":"1743-6109"},{"type":"print","value":"1743-6095"}],"subject":[],"published-other":{"date-parts":[[2021,10]]},"published":{"date-parts":[[2021,8,24]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Correspondence Between Clinician Ratings of Vulvovaginal Health and Patient-Reported Sexual Function After Cancer","name":"articletitle","label":"Article Title"},{"value":"The Journal of Sexual Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsxm.2021.07.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2021, International Society of Sexual Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}