{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:47:55Z","timestamp":1790099275710,"version":"4.0.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T00:00:00Z","timestamp":1645833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T00:00:00Z","timestamp":1645833600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jsm.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Intracavernosal injections (ICI) are a well-established treatment option for men with erectile dysfunction (ED); however, the anticipation of pain with injection remains a significant barrier to the use of ICI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the patient-anticipated degree of pain versus the experienced degree of pain pre- and post-ICI in men undergoing their first injection with an erectile agent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 51 patients who underwent their first ICI in our men\u2019s health clinic. Anticipated needle-associated pain was judged with a pre-injection score, and pain experienced during the injection was judged with a post-injection score. All patients graded their pre- and post-ICI pain using a standard 10-point scale (0\u201310).<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcomes<\/jats:title><jats:p>Pre- and post-ICI pain was defined with the visual analogue scale (0\u201310) in men undergoing their first penile injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Medians and interquartile ranges (IQRs) of the patients\u2019 age [65 years (54.5\u201368.0)], pre-injection pain [5 (4\u20137)], and post-injection pain [1 (1\u20132)] were recorded. Most men in the study had erectile dysfunction (68.6%) and\/or Peyronie\u2019s Disease (64.7%). The average pre-injection prediction pain score was 5.45 \u00b1 2.15; the average post-injection perceived pain score was 1.20 \u00b1 0.73. Thus, there was an average discrepancy of over 4 points in predicted pain vs perceived pain. A paired t-test was performed which showed a statistically significant difference between pre- and post-injection scores (P &amp;lt; .05). A Wilcoxson Signed Rank Test showed statistical significance in the difference between pre- and post-injection pain scores (P &amp;lt; .05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Implications<\/jats:title><jats:p>ICI is a safe, effective treatment for patients with ED and is associated with significantly less pain than is anticipated by patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Strengths &amp; Limitations<\/jats:title><jats:p>This is the first report to describe the discrepancy between pre-ICI anticipated pain and post-ICI experienced pain. Limitations include an overall small sample size.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients experience significantly less pain with ICI than they anticipate having. This represents an important factor to consider when counseling patients about available ED treatments.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jsxm.2022.01.520","type":"journal-article","created":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T07:13:05Z","timestamp":1645859585000},"page":"590-593","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pre- and Post-Injection Needle Pain in Patients Undergoing First Intracavernosal Injection"],"prefix":"10.1093","volume":"19","author":[{"given":"Bryce","family":"Baird","sequence":"first","affiliation":[{"name":"Department of Urology, Mayo Clinic Florida , Jacksonville, FL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan","family":"Wajswol","sequence":"additional","affiliation":[{"name":"Department of Urology, Mayo Clinic Florida , Jacksonville, FL , 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