{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T07:58:59Z","timestamp":1772611139886,"version":"3.50.1"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jsm.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Among treatments for vulvo-vaginal atrophy (VVA), there is a new kind of energy-based device, the non-ablative CO2 laser.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to assess the efficacy and safety of the non-ablative CO2 laser in menopausal women with VVA as a monotherapy or in association with vaginal estriol or moisturizer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy-five women with VVA received laser treatment (Laser group), laser plus estriol gel (Laser+E) or laser plus moisturizers (Laser+M). The study protocol consisted of 3 monthly laser sessions (t0, t1, t2) and a gynecological examination at baseline and 1 month after last laser treatment (t3). Objective measures included VHI (Vaginal Health Index) and VuHI (Vulvar Health Index); subjective symptoms of VVA (Dryness, Burning, Itching, Dysuria) evaluated via visual analog scales, sexual function evaluated by FSFI (Female Sexual Function Index), FSDS (Female Sexual Distress Score) and MENQOL (Mopause-specific Quality Of Life). Adverse events and discomfort encountered during the procedure were also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcomes<\/jats:title><jats:p>Primary outcomes were the evaluation of VHI and VuHI and secondary outcomes were changes in VVA symptoms (VAS), sexual function (MENQOL, FSFI, FSDS) and discomfort during the procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy-five women (25 in Laser, 25 in Laser+E and 25 in Laser+M group) completed the study. At t3, mean VHI, VuHI, dryness, burning and itching VAS scores improved significantly with no differences between the groups. The lubrication domain of FSFI improved significantly only in the Laser+M group, while the pain domain improved significantly in all women with no differences between the groups. FSFI and FSDS overall scores and MENQOL sexual domain improved in all women with no significant difference between the groups. The mean score of the pain during the procedure was low at t0 and did not change throughout the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical implications<\/jats:title><jats:p>This study extends knowledge concerning the effectiveness of a new non-ablative CO2 laser in post-menopausal women with VVA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Strengths &amp; limitations<\/jats:title><jats:p>This is one of the first studies on this kind of laser and is the first to compare the effectiveness of laser treatment alone or in combination with vaginal estriol or moisturizers. Parameters of VVA and sexual function were evaluated using validated tools. Study limitations include short follow-up time, the limited number of participants and the absence of a sham-controlled group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Non-ablative CO2 laser seems to be an effective treatment for VVA in menopausal women. Our preliminary data shows that it can be effective as monotherapy or with adjuvant treatments.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jsxm.2022.02.027","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T21:18:57Z","timestamp":1648761537000},"page":"761-770","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Short-Term Efficacy and Safety of Non-Ablative Laser Treatment Alone or with Estriol or Moisturizers in Postmenopausal Women with Vulvovaginal Atrophy"],"prefix":"10.1093","volume":"19","author":[{"given":"Stefania","family":"Alvisi","sequence":"first","affiliation":[{"name":"Gynecology and Physiopathology of Human Reproduction, IRCCS Azienda Ospedaliero-Universitaria di Bologna , Bologna , Italy"},{"name":"Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna , Bologna , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Lami","sequence":"additional","affiliation":[{"name":"Gynecology and Physiopathology of Human Reproduction, IRCCS Azienda Ospedaliero-Universitaria di Bologna , Bologna , Italy"},{"name":"Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna , Bologna , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Baldassarre","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna , Bologna , Italy"},{"name":"Center for Applied Biomedical Research, Department of Surgical and Medical Sciences, S. Orsola-Malpighi University Hospital, Alma Mater Studiorum University of Bologna , Bologna , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacopo","family":"Lenzi","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum University of Bologna , Bologna , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Mancini","sequence":"additional","affiliation":[{"name":"Gynecology and Physiopathology of Human Reproduction, IRCCS Azienda Ospedaliero-Universitaria di Bologna , Bologna , Italy"},{"name":"Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna , Bologna , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Seracchioli","sequence":"additional","affiliation":[{"name":"Gynecology and Physiopathology of Human Reproduction, IRCCS Azienda Ospedaliero-Universitaria di Bologna , Bologna , Italy"},{"name":"Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna , Bologna , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cristina","family":"Meriggiola","sequence":"additional","affiliation":[{"name":"Gynecology and Physiopathology of Human Reproduction, IRCCS Azienda Ospedaliero-Universitaria di Bologna , Bologna , Italy"},{"name":"Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna , Bologna , Italy"},{"name":"Center for Applied Biomedical Research, Department of Surgical and Medical Sciences, S. Orsola-Malpighi University Hospital, Alma Mater Studiorum University of Bologna , Bologna , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,3,31]]},"reference":[{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1080\/09513590.2017.1309018","article-title":"Management of vaginal atrophy: a real mess. Results from the AGATA study","volume":"33","author":"Palma","year":"2017","journal-title":"Gynecol Endocrinol"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.maturitas.2015.07.020","article-title":"Update on management of genitourinary syndrome of menopause: A practical guide","volume":"82","author":"Palacios","year":"2015","journal-title":"Maturitas"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3109\/13697137.2014.946279","article-title":"Genitourinary syndrome of menopause: new terminology for vulvovaginal atrophy from the International Society for the Study of Women\u2019s Sexual Health and The North American Menopause Society","volume":"17","author":"Portman","year":"2014","journal-title":"Climacteric"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.ajog.2016.07.045","article-title":"Genitourinary syndrome of menopause: an overview of clinical manifestations, pathophysiology, etiology, evaluation, and management","volume":"215","author":"Gandhi","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1097\/GME.0000000000001260","article-title":"The burden of vulvovaginal atrophy on women\u2019s daily living: implications on quality of life from a face-to-face real-life survey","volume":"26","author":"Nappi","year":"2019","journal-title":"Menopause"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1097\/GME.0000000000001609","article-title":"The 2020 genitourinary syndrome of menopause position statement of The North American Menopause Society","volume":"27","year":"2020","journal-title":"Menopause"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1080\/09513590.2021.1943346","article-title":"Management of postmenopausal vulvovaginal atrophy: recommendations of the International Society for the Study of Vulvovaginal Disease","volume":"37","author":"P\u00e9rez-L\u00f3pez","year":"2021","journal-title":"Gynecol Endocrinol Off J Int Soc Gynecol Endocrinol"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"615","DOI":"10.3390\/medicina55100615","article-title":"Vaginal Health in Menopausal Women","volume":"55","author":"Alvisi","year":"2019","journal-title":"Medicina"},{"key":"2023041407192806800_","first-page":"CD001500","article-title":"Local oestrogen for vaginal atrophy in postmenopausal women","volume":"2016","author":"Lethaby","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1080\/13697137.2017.1284780","article-title":"Systematic indirect comparison of ospemifene versus local estrogens for vulvar and vaginal atrophy","volume":"20","author":"Bruyniks","year":"2017","journal-title":"Climacteric"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jsbmb.2016.03.016","article-title":"Serum steroid concentrations remain within normal postmenopausal values in women receiving daily 6.5 mg intravaginal prasterone for 12 weeks","volume":"159","author":"Martel","year":"2016","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1097\/GME.0000000000001238","article-title":"Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause","volume":"25","author":"Labrie","year":"2018","journal-title":"Menopause"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1080\/09513590.2017.1332589","article-title":"Effects of ospemifene on vaginal epithelium of post-menopausal women","volume":"33","author":"Alvisi","year":"2017","journal-title":"Gynecol Endocrinol"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1097\/GCO.0000000000000230","article-title":"The use of pulsed CO2 lasers for the treatment of vulvovaginal atrophy","volume":"27","author":"Salvatore","year":"2015","journal-title":"Curr Opin Obstet Gynecol"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/LGT.0000000000000462","article-title":"The Clinical Role of LASER for Vulvar and Vaginal Treatments in Gynecology and Female Urology: An ICS\/ISSVD Best Practice Consensus Document","volume":"23","author":"Preti","year":"2019","journal-title":"J Low Genit Tract Dis"},{"key":"2023041407192806800_","first-page":"225","article-title":"Technological evolution in the radiofrequency treatment of vaginal laxity and menopausal vulvo-vaginal atrophy and other genitourinary symptoms: first experiences with a novel dynamic quadripolar device","volume":"68","author":"Vicariotto","year":"2016","journal-title":"Minerva Ginecol"},{"key":"2023041407192806800_","first-page":"e93","volume":"127","author":"ACOG Committee Opinion No","year":"2016","journal-title":"The Use of Vaginal Estrogen in Women With a History of Estrogen-Dependent Breast Cancer. Obstet Gynecol"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"e539","DOI":"10.1016\/j.clbc.2021.01.006","article-title":"Microablative Fractional CO2 Laser for Vulvovaginal Atrophy in Women With a History of Breast Cancer: A Pilot Study at 4-week Follow-up","volume":"21","author":"Salvatore","year":"2021","journal-title":"Clin Breast Cancer"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1007\/s00192-019-04051-3","article-title":"Laser treatment for the management of genitourinary syndrome of menopause after breast cancer. Hope or hype?","volume":"30","author":"Tranoulis","year":"2019","journal-title":"Int Urogynecology J"},{"key":"2023041407192806800_","volume-title":"Fractional Laser Treatment of Vulvovaginal Atrophy and U.S. Food and Drug Administration Clearance n.d."},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"757","DOI":"10.3109\/13697137.2015.1045485","article-title":"Vaginal erbium laser: the second-generation thermotherapy for the genitourinary syndrome of menopause","volume":"18","author":"Gambacciani","year":"2015","journal-title":"Climacteric"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.3390\/cancers12061639","article-title":"Results of a Phase I-II Study on Laser Therapy for Vaginal Side Effects after Radiotherapy for Cancer of Uterine Cervix or Endometrium","volume":"12","author":"Perrone","year":"2020","journal-title":"Cancers"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1080\/09513590.2019.1680625","article-title":"Ospemifene plus fractional CO 2 laser: a powerful strategy to treat postmenopausal vulvar pain","volume":"36","author":"Murina","year":"2020","journal-title":"Gynecol Endocrinol"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1111\/1471-0528.16558","article-title":"Vaginal Er:YAG laser application in the menopausal ewe model: a randomized estrogen and sham-controlled trial","volume":"128","author":"Mackova","year":"2021","journal-title":"BJOG Int J Obstet Gynaecol"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/GME.0000000000000955","article-title":"Randomized, double-blind, placebo-controlled clinical trial for evaluating the efficacy of fractional CO2 laser compared with topical estriol in the treatment of vaginal atrophy in postmenopausal women","volume":"25","author":"Cruz","year":"2018","journal-title":"Menopause"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/0378-5122(95)00956-6","article-title":"Urogenital ageing: an old problem newly recognized","volume":"22","author":"Bachmann","year":"1995","journal-title":"Maturitas"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0378-5122(96)01038-9","article-title":"A menopause-specific quality of life questionnaire: development and psychometric properties","volume":"24","author":"Hilditch","year":"1996","journal-title":"Maturitas"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1097\/GME.0000000000000636","article-title":"Use of the Menopause-Specific Quality of Life (MENQOL) questionnaire in research and clinical practice: a comprehensive scoping review","volume":"23","author":"Sydora","year":"2016","journal-title":"Menopause N Y N"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/009262300278597","article-title":"The Female Sexual Function Index (FSFI): a multidimensional self-report instrument for the assessment of female sexual function","volume":"26","author":"Rosen","year":"2000","journal-title":"J Sex Marital Ther"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1080\/00926230290001448","article-title":"The Female Sexual Distress Scale (FSDS): initial validation of a standardized scale for assessment of sexually related personal distress in women","volume":"28","author":"Derogatis","year":"2002","journal-title":"J Sex Marital Ther"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/00926230590475206","article-title":"The female sexual function index (FSFI): cross-validation and development of clinical cutoff scores","volume":"31","author":"Wiegel","year":"2005","journal-title":"J Sex Marital Ther"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1743-6109.2007.00672.x","article-title":"Validation of the female sexual distress scale-revised for assessing distress in women with hypoactive sexual desire disorder","volume":"5","author":"DeRogatis","year":"2008","journal-title":"J Sex Med"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/13697137.2020.1829584","article-title":"CO2 laser and the genitourinary syndrome of menopause: a randomized sham-controlled trial","volume":"24","author":"Salvatore","year":"2021","journal-title":"Climacteric"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.jsxm.2021.01.188","article-title":"A double-blind randomized sham-controlled trial to evaluate the efficacy of fractional carbon dioxide laser therapy on genitourinary syndrome of menopause","volume":"18","author":"Cruff","year":"2021","journal-title":"J Sex Med"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1097\/GME.0000000000001542","article-title":"Treatment for vaginal atrophy using microablative fractional CO2 laser: a randomized double-blinded sham-controlled trial","volume":"27","author":"Ruanphoo","year":"2020","journal-title":"Menopause N Y N"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1001\/jama.2021.14892","article-title":"Effect of fractional carbon dioxide laser vs sham treatment on symptom severity in women with postmenopausal vaginal symptoms: a randomized clinical trial","volume":"326","author":"Li","year":"2021","journal-title":"JAMA"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/GME.0000000000001293","article-title":"Rethinking the techno vagina: a case series of patient complications following vaginal laser treatment for atrophy","volume":"26","author":"Gordon","year":"2019","journal-title":"Menopause"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1097\/GME.0000000000001577","article-title":"Vaginal laser treatment of genitourinary syndrome of menopause: does the evidence support the FDA safety communication?","volume":"27","author":"Guo","year":"2020","journal-title":"Menopause"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/GME.0000000000001661","article-title":"Vaginal energy-based devices: characterization of adverse events based on the last decade of MAUDE safety reports","volume":"28","author":"Wallace","year":"2021","journal-title":"Menopause"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/GME.0000000000001416","article-title":"A randomized clinical trial comparing vaginal laser therapy to vaginal estrogen therapy in women with genitourinary syndrome of menopause: The VeLVET Trial","volume":"27","author":"Paraiso","year":"2019","journal-title":"Menopause"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1097\/GME.0000000000001797","article-title":"Comparison of topical fractional CO2 laser and vaginal estrogen for the treatment of genitourinary syndrome in postmenopausal women: a randomized controlled trial","volume":"28","author":"Dutra","year":"2021","journal-title":"Menopause"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1097\/GME.0000000000001333","article-title":"Fractional CO2 laser versus promestriene and lubricant in genitourinary syndrome of menopause: a randomized clinical trial","volume":"26","author":"Politano","year":"2019","journal-title":"Menopause N Y N"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3109\/13697137.2014.899347","article-title":"A 12-week treatment with fractional CO 2 laser for vulvovaginal atrophy: a pilot study","volume":"17","author":"Salvatore","year":"2014","journal-title":"Climacteric"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/GME.0000000000001428","article-title":"Efficacy of fractional CO2 laser treatment in postmenopausal women with genitourinary syndrome: a multicenter study","volume":"27","author":"Filippini","year":"2020","journal-title":"Menopause"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1080\/13697137.2020.1804544","article-title":"Sexual function after vaginal erbium laser: the results of a large, multicentric, prospective study","volume":"23","author":"Gambacciani","year":"2020","journal-title":"Climacteric"},{"key":"2023041407192806800_","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ejogrb.2020.03.034","article-title":"Lasers in gynaecology","volume":"251","author":"Phillips","year":"2020","journal-title":"Eur J Obstet Gynecol Reprod Biol"}],"container-title":["The Journal of Sexual Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609522008219?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609522008219?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/19\/5\/761\/49877602\/jsm_19_5_761.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/19\/5\/761\/49877602\/jsm_19_5_761.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T13:53:17Z","timestamp":1700401997000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jsm\/article\/19\/5\/761\/6961270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,31]]},"references-count":46,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,3,31]]},"published-print":{"date-parts":[[2022,5,1]]}},"URL":"https:\/\/doi.org\/10.1016\/j.jsxm.2022.02.027","relation":{},"ISSN":["1743-6109","1743-6095"],"issn-type":[{"value":"1743-6109","type":"electronic"},{"value":"1743-6095","type":"print"}],"subject":[],"published-other":{"date-parts":[[2022,5]]},"published":{"date-parts":[[2022,3,31]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Short-Term Efficacy and Safety of Non-Ablative Laser Treatment Alone or with Estriol or Moisturizers in Postmenopausal Women with Vulvovaginal Atrophy","name":"articletitle","label":"Article Title"},{"value":"The Journal of Sexual Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsxm.2022.02.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2022, International Society of Sexual Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}