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We used multiple logistic regression analysis to examine the moderation effect of substance use between sexual dysfunction and depression by including an interaction term.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcomes<\/jats:title><jats:p>Self-reported diagnosed and treated depression within the last 12 months and the moderation effect of substance use on the association between sexual dysfunction and depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Men and women with at least 1 sexual dysfunction were more likely to be affected by depression as compared to those without sexual dysfunction. A moderation effect of frequent cannabis use was found between sexual dysfunction and depression among women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Implications<\/jats:title><jats:p>Clinicians and therapists addressing addiction, depression, and dysfunction should keep the complex interactions in mind.<\/jats:p><\/jats:sec><jats:sec><jats:title>Strengths &amp; Limitations<\/jats:title><jats:p>This study provides new data on the association between sexual dysfunction and depression among German adults in a nationally representative sample and the moderation effect of substance use on this association. Further studies should disentangle the pathways between sexual dysfunction, cannabis use, and depression through moderated mediation analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Frequent cannabis use plays a moderating role in the association between sexual dysfunction and depression among German adult women.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jsxm.2022.03.610","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T21:06:42Z","timestamp":1649970402000},"page":"940-949","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Frequent Cannabis Use Moderates the Relationship Between Sexual Dysfunction and Depression Among Female German Adults"],"prefix":"10.1093","volume":"19","author":[{"given":"Matthias Hans","family":"Belau","sequence":"first","affiliation":[{"name":"University Medical Centre Hamburg-Eppendorf, Institute of Medical Biometry and 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