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The included studies were evaluated by 2 independent reviewers for eligibility. We used an adapted Assessment Tool for Prevalence Studies to evaluate the quality of enrolled studies. Data were analyzed and graphed using the STATA software (version 16.0; Stata Corporation, College Station, TX, USA). The ORs with 95% CIs were pooled using a fixed or random-effects model according to heterogeneity. Subgroup analysis was performed to explore the source of heterogeneity. Sensitivity analysis was conducted to evaluate the stability of the results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcomes<\/jats:title><jats:p>The pooled prevalence of ED in IBD patients was calculated, and the OR value and 95% CIs were used to assess the strength of the association between IBD-related risk factors and ED.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fourteen studies included 32,858 individuals totally were enrolled for this meta-analysis. The overall pooled prevalence estimate of ED in IBD patients was 27% (95% CI: 20\u201334%). Operation (OR 1.28; 95% CI: 1.17\u20131.39; P &amp;lt; .00001; I2 = 0.0%), disease activity (OR 2.06; 95% CI: 1.07\u20133.05; P &amp;lt; .00001), and depression (crude OR 3.31; 95% CI: 1.08\u20135.54; P = .004; I2 = 0.0%) significantly increase the risk of ED in people with IBD. The association of depression and ED was further confirmed by calculating the pooled estimates of adjusted OR (1.58; 95% CI: 0.05\u20133.12; P &amp;lt; .05; I2 = 0.0%). The pooled prevalence estimates of ED were 30, 33, and 17% in the age &amp;lt;40, IIEF diagnostic tool, and IPAA surgery subgroups, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Implications<\/jats:title><jats:p>IBD patients had a significantly increased prevalence of ED, indicating that erectile function in men with IBD should be concerned by clinicians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Strengths &amp; Limitations<\/jats:title><jats:p>The strength of this study is that this is the first meta-analysis to assess the global prevalence and risk factors of ED in IBD patients. A limitation is that the results after pooling the included articles showed significant heterogeneity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of our meta-analysis and systematic review provide evidence of the high prevalence and risk factors of ED in IBD patients.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jsxm.2022.03.615","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T04:47:20Z","timestamp":1651121240000},"page":"950-960","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["The Prevalence and Associated Risk Factors of Erectile Dysfunction in Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-analysis"],"prefix":"10.1093","volume":"19","author":[{"given":"Xu","family":"Wu","sequence":"first","affiliation":[{"name":"The Department of Urology, The First Affiliated Hospital of Anhui Medical University , Hefei , 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