{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T12:52:01Z","timestamp":1782305521047,"version":"3.54.5"},"reference-count":174,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T00:00:00Z","timestamp":1566518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["2018JJ3756"],"award-info":[{"award-number":["2018JJ3756"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["2017SK2042"],"award-info":[{"award-number":["2017SK2042"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["2017JJ3453"],"award-info":[{"award-number":["2017JJ3453"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011002","name":"National Natural Science Foundation of China-Yunnan Joint Fund","doi-asserted-by":"publisher","award":["81861138016"],"award-info":[{"award-number":["81861138016"]}],"id":[{"id":"10.13039\/501100011002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011002","name":"National Natural Science Foundation of China-Yunnan Joint Fund","doi-asserted-by":"publisher","award":["81830097"],"award-info":[{"award-number":["81830097"]}],"id":[{"id":"10.13039\/501100011002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011002","name":"National Natural Science Foundation of China-Yunnan Joint Fund","doi-asserted-by":"publisher","award":["81430074"],"award-info":[{"award-number":["81430074"]}],"id":[{"id":"10.13039\/501100011002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011002","name":"National Natural Science Foundation of China-Yunnan Joint Fund","doi-asserted-by":"publisher","award":["81602767"],"award-info":[{"award-number":["81602767"]}],"id":[{"id":"10.13039\/501100011002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2016YFC0903900"],"award-info":[{"award-number":["2016YFC0903900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2014CB541904"],"award-info":[{"award-number":["2014CB541904"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010224","name":"Philosophy and Social Science Foundation of Hunan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010224","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Translational Autoimmunity"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.jtauto.2019.100014","type":"journal-article","created":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T11:57:21Z","timestamp":1566820641000},"page":"100014","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["The pathogenesis of bullous skin diseases"],"prefix":"10.1016","volume":"2","author":[{"given":"Miao","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7071-5306","authenticated-orcid":false,"given":"Christopher","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianjin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtauto.2019.100014_bib1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00403-014-1531-1","article-title":"Geographic variations in epidemiology of two autoimmune bullous diseases: pemphigus and bullous pemphigoid","volume":"307","author":"Alpsoy","year":"2015","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.jtauto.2019.100014_bib2","doi-asserted-by":"crossref","first-page":"86","DOI":"10.2340\/00015555-1854","article-title":"Development of a disease registry for autoimmune bullous diseases: initial analysis of the pemphigus vulgaris subset","volume":"95","author":"Shah","year":"2015","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.jtauto.2019.100014_bib3","first-page":"434","article-title":"Prospective analysis of the incidence of autoimmune bullous disorders in Lower Franconia, Germany","volume":"7","author":"Bertram","year":"2009","journal-title":"J.\u00a0der Deutschen Dermatologischen Gesellschaft"},{"key":"10.1016\/j.jtauto.2019.100014_bib4","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/j.1365-4632.2006.03044.x","article-title":"Epidemiologic survey of pemphigus vulgaris with oral manifestations in northern Greece: retrospective study of 129 patients","volume":"46","author":"Michailidou","year":"2007","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib5","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1046\/j.1365-2133.2000.03659.x","article-title":"The distribution of pemphigus vulgaris-IgG subclasses and their reactivity with desmoglein 3 and 1 in pemphigus patients and their first-degree relatives","volume":"143","author":"Kricheli","year":"2000","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib6","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S0190-9622(94)70206-3","article-title":"Prevalence of autoimmune diseases in the family members of patients with pemphigus vulgaris","volume":"31","author":"Firooz","year":"1994","journal-title":"J.\u00a0Am. Acad. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib7","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3389\/fmed.2018.00226","article-title":"The genetics of pemphigus vulgaris","volume":"5","author":"Vodo","year":"2018","journal-title":"Front. Med."},{"key":"10.1016\/j.jtauto.2019.100014_bib8","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/bjd.17191","article-title":"Subtype-specific inherited predisposition to pemphigus in the Chinese population","volume":"180","author":"Zhang","year":"2019","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib9","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1111\/j.1365-2133.2012.11040.x","article-title":"Association between HLA-DRB1 polymorphisms and pemphigus vulgaris: a meta-analysis","volume":"167","author":"Yan","year":"2012","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib10","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1111\/exd.13778","article-title":"The association between ST 18 gene polymorphism and severe pemphigus disease among Iranian population","volume":"27","author":"Etesami","year":"2018","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib11","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1096\/fj.08-111013","article-title":"The transcription factor ST18 regulates proapoptotic and proinflammatory gene expression in fibroblasts","volume":"22","author":"Yang","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.jtauto.2019.100014_bib12","doi-asserted-by":"crossref","first-page":"427","DOI":"10.3109\/08916934.2012.697593","article-title":"Cytokine networks in Pemphigus vulgaris: an integrated viewpoint","volume":"45","author":"Giordano","year":"2012","journal-title":"Autoimmunity"},{"key":"10.1016\/j.jtauto.2019.100014_bib13","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1038\/jid.2012.46","article-title":"Population-specific association between a polymorphic variant in ST18, encoding a pro-apoptotic molecule, and pemphigus vulgaris","volume":"132","author":"Sarig","year":"2012","journal-title":"J.\u00a0Investig. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib14","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/1346-8138.12363","article-title":"Lack of association between the single nucleotide polymorphism of ST18 and pemphigus in Chinese population","volume":"41","author":"Yue","year":"2014","journal-title":"J.\u00a0Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006008","article-title":"Identification of a functional risk variant for pemphigus vulgaris in the ST18 gene","volume":"12","author":"Vodo","year":"2016","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jtauto.2019.100014_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.00770","article-title":"ST18 enhances PV-IgG-Induced loss of keratinocyte cohesion in parallel to increased ERK activation","volume":"10","author":"Radeva","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jtauto.2019.100014_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.01788","article-title":"The p.Arg435His variation of IgG3 with high affinity to FcRn is associated with susceptibility for pemphigus vulgaris\u2014analysis of four different ethnic cohorts","volume":"9","author":"Recke","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jtauto.2019.100014_bib18","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1001\/jama.1982.03320440053036","article-title":"Penicillamine-induced pemphigus","volume":"247","author":"Zone","year":"1982","journal-title":"J.\u00a0Am. Med. Assoc."},{"key":"10.1016\/j.jtauto.2019.100014_bib19","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1365-2133.1995.tb05038.x","article-title":"Pemphigus vulgaris induced by captopril","volume":"132","author":"Butt","year":"1995","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib20","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/j.1365-4362.1978.tb06083.x","article-title":"Pemphigus erythematosus and heroin addiction","volume":"17","author":"Fellner","year":"1978","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib21","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/j.1365-2230.2008.02835.x","article-title":"Exacerbation of pemphigus after influenza vaccination","volume":"33","author":"De Simone","year":"2008","journal-title":"Clin. Exp. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib22","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/j.1346-8138.2007.00373.x","article-title":"Pemphigus vulgaris following antirabies vaccination","volume":"34","author":"Yalcin","year":"2007","journal-title":"J.\u00a0Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib23","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/08916930400027078","article-title":"Pemphigus following hepatitis B vaccination-coincidence or causality?","volume":"38","author":"Berkun","year":"2005","journal-title":"Autoimmunity"},{"key":"10.1016\/j.jtauto.2019.100014_bib24","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1080\/000155502762064755","article-title":"Exacerbation of Pemphigus Foliaceus after Tetanus Vaccination Accompanied by Synthesis of Auto-Antibodies against Paraneoplastic Pemphigus Antigens","volume":"82","author":"Korang","year":"2002","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.jtauto.2019.100014_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2019.04.020","article-title":"Walnut antigens can trigger autoantibody development in patients with pemphigus vulgaris through a \u201chit-and-run\u201d mechanism","author":"Lin","year":"2019","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.jtauto.2019.100014_bib26","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1017\/S204579601700052X","article-title":"Association between schizophrenia and an autoimmune bullous skin disease-pemphigus: a population-based large-scale study","volume":"28","author":"Kridin","year":"2019","journal-title":"Epidemiol. Psychiatr. Sci."},{"key":"10.1016\/j.jtauto.2019.100014_bib27","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00403-017-1790-8","article-title":"Pemphigus trigger factors: special focus on pemphigus vulgaris and pemphigus foliaceus","volume":"310","author":"Tavakolpour","year":"2018","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.jtauto.2019.100014_bib28","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1111\/j.1365-2133.2012.11144.x","article-title":"Enrichment of total serum IgG4 in patients with pemphigus","volume":"167","author":"Funakoshi","year":"2012","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib29","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0923-1811(00)00158-4","article-title":"Predominant IgG4 subclass in autoantibodies of pemphigus vulgaris and foliaceus","volume":"26","author":"Futei","year":"2001","journal-title":"J.\u00a0Dermatol. Sci."},{"key":"10.1016\/j.jtauto.2019.100014_bib30","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1172\/JCI114426","article-title":"Monovalent Fab\u2019 immunoglobulin fragments from endemic pemphigus foliaceus autoantibodies reproduce the human disease in neonatal Balb\/c mice","volume":"85","author":"Rock","year":"1990","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.jtauto.2019.100014_bib31","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jdermsci.2009.12.014","article-title":"Bidimensional analysis of desmoglein 1 distribution on the outermost corneocytes provides the structural and functional information of the stratum corneum","volume":"57","author":"Naoe","year":"2010","journal-title":"J.\u00a0Dermatol. Sci."},{"key":"10.1016\/j.jtauto.2019.100014_bib32","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1083\/jcb.137.5.1091","article-title":"Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris","volume":"137","author":"Koch","year":"1997","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.jtauto.2019.100014_bib33","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.1172\/JCI57379","article-title":"Desmoglein 3-specific CD4+ T cells induce pemphigus vulgaris and interface dermatitis in mice","volume":"121","author":"Takahashi","year":"2011","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.jtauto.2019.100014_bib34","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1056\/NEJM198205203062001","article-title":"Induction of pemphigus in neonatal mice by passive transfer of IgG from patients with the disease","volume":"306","author":"Anhalt","year":"1982","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.jtauto.2019.100014_bib35","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/jid.2011.390","article-title":"Desmoglein as a target in skin disease and beyond","volume":"132","author":"Amagai","year":"2012","journal-title":"J.\u00a0Investig. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib36","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1038\/labinvest.3780168","article-title":"Assembly pathway of desmoglein 3 to desmosomes and its perturbation by pemphigus vulgaris-IgG in cultured keratinocytes, as revealed by time-lapsed labeling immunoelectron microscopy","volume":"80","author":"Sato","year":"2000","journal-title":"Lab. Investig."},{"key":"10.1016\/j.jtauto.2019.100014_bib37","doi-asserted-by":"crossref","first-page":"7623","DOI":"10.1074\/jbc.M512447200","article-title":"Desmoglein endocytosis and desmosome disassembly are coordinated responses to pemphigus autoantibodies","volume":"281","author":"Calkins","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jtauto.2019.100014_bib38","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/jid.2008.339","article-title":"Disruption of desmosome assembly by monovalent human pemphigus vulgaris monoclonal antibodies","volume":"129","author":"Mao","year":"2009","journal-title":"J.\u00a0Investig. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib39","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1038\/jid.2015.109","article-title":"Large-scale electron microscopy maps of patient skin and mucosa provide insight into pathogenesis of blistering diseases","volume":"135","author":"Sokol","year":"2015","journal-title":"J.\u00a0Investig. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib40","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1172\/JCI23475","article-title":"Pemphigus foliaceus IgG causes dissociation of desmoglein 1-containing junctions without blocking desmoglein 1 trans interactions","volume":"115","author":"Waschke","year":"2005","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.jtauto.2019.100014_bib41","doi-asserted-by":"crossref","first-page":"23778","DOI":"10.1074\/jbc.M501365200","article-title":"Desmosome signaling. Inhibition of p38MAPK prevents pemphigus vulgaris IgG-induced cytoskeleton reorganization","volume":"280","author":"Berkowitz","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jtauto.2019.100014_bib42","doi-asserted-by":"crossref","first-page":"13804","DOI":"10.1074\/jbc.M611365200","article-title":"Desmoglein versus non-desmoglein signaling in pemphigus acantholysis: characterization of novel signaling pathways downstream of pemphigus vulgaris antigens","volume":"282","author":"Chernyavsky","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jtauto.2019.100014_bib43","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.2353\/ajpath.2008.080391","article-title":"Autoantibodies in the autoimmune disease pemphigus foliaceus induce blistering via p38 mitogen-activated protein kinase-dependent signaling in the skin","volume":"173","author":"Berkowitz","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jtauto.2019.100014_bib44","doi-asserted-by":"crossref","first-page":"8936","DOI":"10.1074\/jbc.M109.087999","article-title":"p38MAPK signaling and desmoglein-3 internalization are linked events in pemphigus acantholysis","volume":"285","author":"Jolly","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jtauto.2019.100014_bib45","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1074\/jbc.M110.172874","article-title":"p38 MAPK activation is downstream of the loss of intercellular adhesion in pemphigus vulgaris","volume":"286","author":"Mao","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jtauto.2019.100014_bib46","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1083\/jcb.153.4.823","article-title":"A\u00a0central role for the armadillo protein plakoglobin in the autoimmune disease pemphigus vulgaris","volume":"153","author":"Caldelari","year":"2001","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.jtauto.2019.100014_bib47","doi-asserted-by":"crossref","first-page":"3298","DOI":"10.1038\/sj.emboj.7601224","article-title":"Pemphigus vulgaris identifies plakoglobin as key suppressor of c-Myc in the skin","volume":"25","author":"Williamson","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.jtauto.2019.100014_bib48","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.jaad.2017.07.012","article-title":"Developing biomarkers for predicting clinical relapse in pemphigus patients treated with rituximab","volume":"77","author":"Albers","year":"2017","journal-title":"J.\u00a0Am. Acad. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib49","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/jid.2014.291","article-title":"Persistence of anti-desmoglein 3 IgG(+) B-cell clones in pemphigus patients over years","volume":"135","author":"Hammers","year":"2015","journal-title":"J.\u00a0Investig. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib50","doi-asserted-by":"crossref","first-page":"622","DOI":"10.3389\/fimmu.2018.00622","article-title":"B\u00a0cell modulation strategies in autoimmune diseases: new concepts","volume":"9","author":"Musette","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jtauto.2019.100014_bib51","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1056\/NEJMc1508234","article-title":"Long-term remissions in recalcitrant pemphigus vulgaris","volume":"373","author":"Ahmed","year":"2015","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.jtauto.2019.100014_bib52","doi-asserted-by":"crossref","first-page":"175ra30","DOI":"10.1126\/scitranslmed.3005166","article-title":"Long-term remissions of severe pemphigus after rituximab therapy are associated with prolonged failure of desmoglein B cell response","volume":"5","author":"Colliou","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jtauto.2019.100014_bib53","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/bjd.13192","article-title":"Impaired function of CD19(+) CD24(hi) CD38(hi) regulatory B cells in patients with pemphigus","volume":"172","author":"Zhu","year":"2015","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib54","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1111\/bjd.15113","article-title":"Decreased level of interleukin-10-producing B cells in patients with pemphigus but not in patients with pemphigoid","volume":"176","author":"Kabuto","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib55","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1016\/j.jid.2017.05.032","article-title":"Pivotal role of lesional and perilesional T\/B lymphocytes in pemphigus pathogenesis","volume":"137","author":"Yuan","year":"2017","journal-title":"J.\u00a0Investig. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib56","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.1172\/JCI57379","article-title":"Desmoglein 3-specific CD4+ T cells induce pemphigus vulgaris and interface dermatitis in mice","volume":"121","author":"Takahashi","year":"2011","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.jtauto.2019.100014_bib57","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1172\/JCI28547","article-title":"T\u00a0cell control in autoimmune bullous skin disorders","volume":"116","author":"Hertl","year":"2006","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.jtauto.2019.100014_bib58","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1046\/j.1523-1747.1998.00086.x","article-title":"Recognition of desmoglein 3 by autoreactive T cells in pemphigus vulgaris patients and normals","volume":"110","author":"Hertl","year":"1998","journal-title":"J.\u00a0Investig. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib59","first-page":"293","article-title":"Langerhans cells prevent autoimmunity via expansion of keratinocyte antigen-specific regulatory T cells","volume":"27","author":"Kitashima","year":"2018","journal-title":"EBio Med."},{"key":"10.1016\/j.jtauto.2019.100014_bib60","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/intimm\/dxr020","article-title":"Antigen-independent development of Foxp3+ regulatory T cells suppressing autoantibody production in experimental pemphigus vulgaris","volume":"23","author":"Yokoyama","year":"2011","journal-title":"Int. Immunol."},{"key":"10.1016\/j.jtauto.2019.100014_bib61","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/1521-4141(200203)32:3<627::AID-IMMU627>3.0.CO;2-1","article-title":"Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigus vulgaris","volume":"32","author":"Tsunoda","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jtauto.2019.100014_bib62","unstructured":"Autoreactive B-Cell Elimination by Pathogenic IgG Specific for the Same Antigen: Implications for Peripheral Tolerance."},{"key":"10.1016\/j.jtauto.2019.100014_bib63","doi-asserted-by":"crossref","first-page":"607","DOI":"10.2340\/00015555-2611","article-title":"Mortality and cause of death in patients with pemphigus","volume":"97","author":"Kridin","year":"2017","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.jtauto.2019.100014_bib64","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/jid.2010.389","article-title":"Desmosome disassembly in response to pemphigus vulgaris IgG occurs in distinct phases and can Be reversed by expression of exogenous Dsg3","volume":"131","author":"Jennings","year":"2011","journal-title":"J.\u00a0Investig. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib65","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1016\/S0140-6736(17)30787-0","article-title":"Rituximab as first-line treatment of pemphigus","volume":"389","author":"Schmidt","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jtauto.2019.100014_bib66","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.jaad.2013.05.016","article-title":"Assessment of the rate of long-term complete remission off therapy in patients with pemphigus treated with different regimens including medium- and high-dose corticosteroids","volume":"69","author":"Almugairen","year":"2013","journal-title":"J.\u00a0Am. Acad. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib67","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1016\/S0140-6736(17)30070-3","article-title":"First-line rituximab combined with short-term prednisone versus prednisone alone for the treatment of pemphigus (Ritux 3): a prospective, multicentre, parallel-group, open-label randomised trial","volume":"389","author":"Joly","year":"2017","journal-title":"The Lancet"},{"key":"10.1016\/j.jtauto.2019.100014_bib68","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/bjh.12448","article-title":"Low-dose anti-CD20 veltuzumab given intravenously or subcutaneously is active in relapsed immune thrombocytopenia: a phase I study","volume":"162","author":"Liebman","year":"2013","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.jtauto.2019.100014_bib69","doi-asserted-by":"crossref","DOI":"10.1007\/s13317-017-0100-y","article-title":"Next-generation anti-CD20 monoclonal antibodies in autoimmune disease treatment","volume":"8","author":"Du","year":"2017","journal-title":"Autoimmunity Highlights"},{"key":"10.1016\/j.jtauto.2019.100014_bib70","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1001\/jamadermatol.2014.1939","article-title":"Subcutaneous veltuzumab, a humanized anti-CD20 antibody, in the treatment of refractory pemphigus vulgaris","volume":"150","author":"Ellebrecht","year":"2014","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jtauto.2019.100014_bib71","doi-asserted-by":"crossref","first-page":"978","DOI":"10.3389\/fimmu.2019.00978","article-title":"Current clinical trials in pemphigus and pemphigoid","volume":"10","author":"Izumi","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jtauto.2019.100014_bib72","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1517\/13543780902832679","article-title":"Ofatumumab, a second-generation anti-CD20 monoclonal antibody, for the treatment of lymphoproliferative and autoimmune disorders","volume":"18","author":"Castillo","year":"2009","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.jtauto.2019.100014_bib73","first-page":"51","article-title":"Ofatumumab: a novel monoclonal anti-CD20 antibody","volume":"3","author":"Lin","year":"2010","journal-title":"Pharmgenomics Pers Med"},{"key":"10.1016\/j.jtauto.2019.100014_bib74","doi-asserted-by":"crossref","first-page":"e240","DOI":"10.1111\/ajd.12615","article-title":"Successful use of Bruton\u2019s kinase inhibitor, ibrutinib, to control paraneoplastic pemphigus in a patient with paraneoplastic autoimmune multiorgan syndrome and chronic lymphocytic leukaemia","volume":"58","author":"Lee","year":"2017","journal-title":"Australas. J. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib75","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1111\/bcp.13351","article-title":"A\u00a0phase I trial of PRN1008, a novel reversible covalent inhibitor of Bruton\u2019s tyrosine kinase, in healthy volunteers","volume":"83","author":"Smith","year":"2017","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.jtauto.2019.100014_bib76","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.coph.2019.01.001","article-title":"Pharmacological advances in pemphigus","volume":"46","author":"Bilgic","year":"2019","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.jtauto.2019.100014_bib77","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1126\/science.aaf6756","article-title":"Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease","volume":"353","author":"Ellebrecht","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.jtauto.2019.100014_bib78","doi-asserted-by":"crossref","first-page":"978","DOI":"10.3389\/fimmu.2019.00978","article-title":"Current clinical trials in pemphigus and pemphigoid","volume":"10","author":"Izumi","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jtauto.2019.100014_bib79","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1111\/j.1365-4632.2009.04345.x","article-title":"Pemphigus vulgaris is the most common autoimmune bullous disease in Northwestern Romania","volume":"49","author":"Baican","year":"2010","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib80","doi-asserted-by":"crossref","first-page":"a180","DOI":"10.1136\/bmj.a180","article-title":"Bullous pemphigoid and pemphigus vulgaris--incidence and mortality in the UK: population based cohort study","volume":"337","author":"Langan","year":"2008","journal-title":"BMJ"},{"key":"10.1016\/j.jtauto.2019.100014_bib81","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jdermsci.2017.11.014","article-title":"Association of HLA class I and class II alleles with bullous pemphigoid in Chinese Hans","volume":"89","author":"Fang","year":"2018","journal-title":"J.\u00a0Dermatol. Sci."},{"key":"10.1016\/j.jtauto.2019.100014_bib82","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1016\/j.jid.2018.02.021","article-title":"The HLA-DQB1*03:01 is associated with bullous pemphigoid in the han Chinese population","volume":"138","author":"Sun","year":"2018","journal-title":"J.\u00a0Investig. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib83","doi-asserted-by":"crossref","first-page":"8","DOI":"10.5021\/ad.2018.30.1.8","article-title":"HLA-C*17, DQB1*03:01, DQA1*01:03 and DQA1*05:05 alleles associated to bullous pemphigoid in Brazilian population","volume":"30","author":"Chagury","year":"2018","journal-title":"Ann. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib84","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1365-2249.2010.04239.x","article-title":"Relationship between target antigens and major histocompatibility complex (MHC) class II genes in producing two pathogenic antibodies simultaneously","volume":"162","author":"Zakka","year":"2010","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jtauto.2019.100014_bib85","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1046\/j.1365-2133.2001.04380.x","article-title":"Mucous membrane pemphigoid: HLA-DQB1*0301 is associated with all clinical sites of involvement and may be linked to antibasement membrane IgG production","volume":"145","author":"Setterfield","year":"2001","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib86","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.jid.2017.11.023","article-title":"HLA-DQB1*03:01 as a biomarker for genetic susceptibility to bullous pemphigoid induced by DPP-4 inhibitors","volume":"138","author":"Ujiie","year":"2018","journal-title":"J.\u00a0Investig. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib87","doi-asserted-by":"crossref","first-page":"e132","DOI":"10.1111\/ijd.14456","article-title":"Alogliptin-induced bullous pemphigoid associated with HLA-DQB1*03:01: a case report","volume":"58","author":"Takata","year":"2019","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib88","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1172\/JCI3335","article-title":"Identification and characterization of autoreactive T cell responses to bullous pemphigoid antigen 2 in patients and healthy controls","volume":"102","author":"B\u00fcdinger","year":"1998","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.jtauto.2019.100014_bib89","first-page":"1","article-title":"Association between HLA-DQB1*03:01 and Bullous pemphigoid in Iranian patients","volume":"10","author":"Esmaili","year":"2013","journal-title":"Iran J Immunol"},{"key":"10.1016\/j.jtauto.2019.100014_bib90","doi-asserted-by":"crossref","first-page":"8569","DOI":"10.1073\/pnas.93.16.8569","article-title":"A\u00a0common major histocompatibility complex class II allele HLA-DQB1* 0301 is present in clinical variants of pemphigoid","volume":"93","author":"Delgado","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jtauto.2019.100014_bib91","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1346-8138.2000.tb02141.x","article-title":"Polymorphisms of HLA-DR and -DQ genes in Japanese patients with bullous pemphigoid","volume":"27","author":"Okazaki","year":"2000","journal-title":"J.\u00a0Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib92","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1046\/j.1365-2133.1998.02169.x","article-title":"Cytokine pattern in blister fluid and serum of patients with bullous pemphigoid: relationships with disease intensity","volume":"138","author":"Ameglio","year":"1998","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib93","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0923-1811(97)00044-3","article-title":"Increased serum levels of interleukin (IL)-5, IL-6 and IL-8 in bullous pemphigoid","volume":"16","author":"Inaoki","year":"1998","journal-title":"J.\u00a0Dermatol. Sci."},{"key":"10.1016\/j.jtauto.2019.100014_bib94","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1080\/000155599750010689","article-title":"Blister fluid cytokines in cutaneous inflammatory bullous disorders","volume":"79","author":"Rhodes","year":"1999","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.jtauto.2019.100014_bib95","doi-asserted-by":"crossref","first-page":"636","DOI":"10.3389\/fimmu.2019.00636","article-title":"Proinflammatory cytokine gene polymorphisms in bullous pemphigoid","volume":"10","author":"Tabatabaei-Panah","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jtauto.2019.100014_bib96","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1365-2133.2005.06938.x","article-title":"Cytokine gene polymorphisms in bullous pemphigoid in a Chinese population","volume":"154","author":"Chang","year":"2006","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib97","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/exd.12732","article-title":"Polymorphisms in the mitochondrially encoded ATP synthase 8 gene are associated with susceptibility to bullous pemphigoid in the German population","volume":"24","author":"Hirose","year":"2015","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib98","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1111\/ijd.12967","article-title":"The impact of the CYP2D6 gene polymorphism on the risk of pemphigoid","volume":"54","author":"Rychlik-Sych","year":"2015","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib99","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.jaad.2018.09.038","article-title":"Bullae for you: the increasing importance and implications of drug-induced bullous pemphigoid","volume":"79","author":"Heymann","year":"2018","journal-title":"J.\u00a0Am. Acad. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib100","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1111\/jdv.12366","article-title":"Drug-induced pemphigoid: a review of the literature","volume":"28","author":"Stavropoulos","year":"2014","journal-title":"J.\u00a0Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.jtauto.2019.100014_bib101","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1365-4632.2009.03839.x","article-title":"Medication history of a series of patients with bullous pemphigoid from northern Greece - observations and discussion","volume":"48","author":"Patsatsi","year":"2009","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib102","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1365-4362.1991.tb03867.x","article-title":"Pemphigus and bullous pemphigoid due to drugs","volume":"30","author":"Ruocco","year":"1991","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib103","doi-asserted-by":"crossref","first-page":"983","DOI":"10.2340\/00015555-3010","article-title":"Dipeptidyl peptidase-4 inhibitor-associated bullous pemphigoid: recurrence with epitope spreading","volume":"98","author":"Takama","year":"2018","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.jtauto.2019.100014_bib104","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/bjd.14601","article-title":"Bullous pemphigoid and dipeptidyl peptidase IV inhibitors: a case-noncase study in the French Pharmacovigilance Database","volume":"175","author":"B\u00e9n\u00e9","year":"2016","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib105","article-title":"Bullous pemphigoid associated with dipeptidyl peptidase IV inhibitors. A case report and review of literature","volume":"8","author":"Attaway","year":"2014","journal-title":"J.\u00a0Dermatol. Case Rep."},{"key":"10.1016\/j.jtauto.2019.100014_bib106","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/fcp.12083","article-title":"Bullous pemphigoid induced by vildagliptin: a report of three cases","volume":"29","author":"B\u00e9n\u00e9","year":"2015","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.jtauto.2019.100014_bib107","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1159\/000443330","article-title":"Three cases of bullous pemphigoid associated with dipeptidyl peptidase-4 inhibitors - one due to linagliptin","volume":"232","author":"Mendon\u00e7a","year":"2016","journal-title":"Dermatology"},{"key":"10.1016\/j.jtauto.2019.100014_bib108","doi-asserted-by":"crossref","first-page":"542","DOI":"10.3389\/fimmu.2018.00542","article-title":"Bullous pemphigoid triggered by thermal burn under medication with a dipeptidyl peptidase-IV inhibitor: a case report and review of the literature","volume":"9","author":"Mai","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jtauto.2019.100014_bib109","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.jaad.2017.12.038","article-title":"Dipeptidyl peptidase IV inhibitors, a risk factor for bullous pemphigoid: retrospective multicenter case-control study from France and Switzerland","volume":"78","author":"Benzaquen","year":"2018","journal-title":"J.\u00a0Am. Acad. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib110","first-page":"e153","article-title":"Increased prevalence of diabetes mellitus in bullous pemphigoid patients during the last decade","volume":"32","author":"Fania","year":"2018","journal-title":"J.\u00a0Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.jtauto.2019.100014_bib111","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1001\/jamadermatol.2013.1073","article-title":"A\u00a0case report of bullous pemphigoid induced by dipeptidyl peptidase-4 inhibitors","volume":"149","author":"Aouidad","year":"2013","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jtauto.2019.100014_bib112","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.jaad.2018.05.030","article-title":"Oral diabetes medications other than dipeptidyl peptidase 4 inhibitors are not associated with bullous pemphigoid: a Finnish nationwide case-control study","volume":"79","author":"Varpuluoma","year":"2018","journal-title":"J.\u00a0Am. Acad. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib113","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1001\/2013.jamadermatol.376","article-title":"The associations between bullous pemphigoid and drug use: a UK case-control study","volume":"149","author":"Lloyd-Lavery","year":"2013","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jtauto.2019.100014_bib114","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.jaad.2018.07.008","article-title":"Bullous disorders associated with anti\u2013PD-1 and anti\u2013PD-L1 therapy: a retrospective analysis evaluating the clinical and histopathologic features, frequency, and impact on cancer therapy","volume":"79","author":"Siegel","year":"2018","journal-title":"J.\u00a0Am. Acad. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib115","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.autrev.2011.04.003","article-title":"Autoimmune bullous diseases","volume":"10","author":"Sagi","year":"2011","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.jtauto.2019.100014_bib116","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000010377","article-title":"Bullous pemphigoid associated with chronic hepatitis C virus infection in a hepatitis B virus endemic area","volume":"97","author":"Jang","year":"2018","journal-title":"Medicine"},{"key":"10.1016\/j.jtauto.2019.100014_bib117","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/0968-0004(93)90022-F","article-title":"Autoimmune disease and molecular mimicry: an hypothesis","volume":"18","author":"Baum","year":"1993","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.jtauto.2019.100014_bib118","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1093\/jjco\/hyr049","article-title":"A\u00a0case of bullous pemphigoid exacerbated by irradiation after breast conservative radiotherapy","volume":"41","author":"Isohashi","year":"2011","journal-title":"Jpn. J. Clin. Oncol."},{"key":"10.1016\/j.jtauto.2019.100014_bib119","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1524-4741.2010.01060.x","article-title":"Bullous pemphigoid following adjuvant radiotherapy for breast cancer","volume":"17","author":"Olsha","year":"2011","journal-title":"Breast J."},{"key":"10.1016\/j.jtauto.2019.100014_bib120","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.lpm.2016.09.019","article-title":"Bullous pemphigoid triggered by radiotherapy for breast cancer","volume":"46","author":"Kluger","year":"2017","journal-title":"Presse Med."},{"key":"10.1016\/j.jtauto.2019.100014_bib121","first-page":"219","article-title":"Radiation-induced pemphigus or pemphigoid disease in 3 patients with distinct underlying malignancies","volume":"97","author":"Shon","year":"2016","journal-title":"Cutis"},{"key":"10.1016\/j.jtauto.2019.100014_bib122","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1159\/000051588","article-title":"Bullous pemphigoid in a patient treated with UVA-1 phototherapy for disseminated morphea","volume":"202","author":"Sacher","year":"2001","journal-title":"Dermatology"},{"key":"10.1016\/j.jtauto.2019.100014_bib123","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1600-0781.2011.00609.x","article-title":"Localized bullous pemphigoid induced by photodynamic therapy","volume":"27","author":"Rakvit","year":"2011","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"10.1016\/j.jtauto.2019.100014_bib124","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.autrev.2017.03.010","article-title":"Bullous pemphigoid","volume":"16","author":"Ba\u011fc\u0131","year":"2017","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.jtauto.2019.100014_bib125","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/1346-8138.13031","article-title":"Role of physical factors in the pathogenesis of bullous pemphigoid: case report series and a comprehensive review of the published work","volume":"43","author":"D\u0103nescu","year":"2016","journal-title":"J.\u00a0Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib126","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1111\/jdv.15444","article-title":"Neurological disorders are associated with bullous pemphigoid","volume":"33","author":"Papakonstantinou","year":"2019","journal-title":"J.\u00a0Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.jtauto.2019.100014_bib127","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/jid.2010.301","article-title":"On behalf of the French study group for bullous diseases, risk factors for bullous pemphigoid in the elderly: a prospective case-control study","volume":"131","author":"Bastuji-Garin","year":"2011","journal-title":"J.\u00a0Investig. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib128","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.jaad.2014.07.052","article-title":"A\u00a0population-based study of the association between bullous pemphigoid and neurologic disorders","volume":"71","author":"Brick","year":"2014","journal-title":"J.\u00a0Am. Acad. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib129","doi-asserted-by":"crossref","DOI":"10.1111\/bjd.17882","article-title":"Presence of anti-BP180 and anti-BP 230 in the CSF of patients with bullous pemphigoid and neurologic disease: is there any intrathecal synthesis?","author":"Meudec","year":"2019","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib130","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1016\/j.jid.2019.01.034","article-title":"Demographics and autoantibody profiles of pemphigoid patients with underlying neurologic diseases","volume":"139","author":"Messingham","year":"2019","journal-title":"J.\u00a0Investig. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib131","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1111\/jdv.15679","article-title":"Review of autoimmune blistering diseases: the pemphigoid diseases","volume":"33","author":"Daniel","year":"2019","journal-title":"J.\u00a0Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.jtauto.2019.100014_bib132","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/1523-1747.ep12337492","article-title":"Tight clustering of extracellular BP180 epitopes recognized by bullous pemphigoid autoantibodies","volume":"109","author":"Zillikens","year":"1997","journal-title":"J.\u00a0Investig. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib133","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00403-018-1817-9","article-title":"BPDAI and ABSIS correlate with serum anti-BP180 NC16A IgG but not with anti-BP230 IgG in patients with bullous pemphigoid","volume":"310","author":"Daneshpazhooh","year":"2018","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.jtauto.2019.100014_bib134","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.3389\/fimmu.2017.01752","article-title":"BP180 is critical in the autoimmunity of bullous pemphigoid","volume":"8","author":"Liu","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jtauto.2019.100014_bib135","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/1523-1747.ep12337492","article-title":"Tight clustering of extracellular BP180 epitopes recognized by bullous pemphigoid autoantibodies","volume":"109","author":"Zillikens","year":"1997","journal-title":"J.\u00a0Investig. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib136","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/jdv.15325","article-title":"Characteristics of IgG subclasses and complement deposition in BP230-type bullous pemphigoid","volume":"33","author":"Zheng","year":"2018","journal-title":"J.\u00a0Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.jtauto.2019.100014_bib137","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/bjd.14822","article-title":"Complement in bullous pemphigoid: results from a large observational study","volume":"176","author":"Romeijn","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib138","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0923-1811(02)00109-3","article-title":"BP180 ELISA using bacterial recombinant NC16a protein as a diagnostic and monitoring tool for bullous pemphigoid","volume":"30","author":"Kobayashi","year":"2002","journal-title":"J.\u00a0Dermatol. Sci."},{"key":"10.1016\/j.jtauto.2019.100014_bib139","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev-pathol-012615-044313","article-title":"Mechanisms of disease: pemphigus and bullous pemphigoid","volume":"11","author":"Hammers","year":"2016","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.jtauto.2019.100014_bib140","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/bjd.18156","article-title":"Bullous pemphigoid autoantibody-mediated complement fixation is abolished by the low-molecular-weight heparin tinzaparin sodium","volume":"181","author":"Gutjahr","year":"2019","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib141","first-page":"57","article-title":"Effector mechanisms activated by human IgG subclass antibodies: clinical and molecular aspects. Review article","volume":"52","author":"Jefferis","year":"1994","journal-title":"Ann. Biol. Clin."},{"key":"10.1016\/j.jtauto.2019.100014_bib142","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00403-007-0734-0","article-title":"The relevance of the IgG subclass of autoantibodies for blister induction in autoimmune bullous skin diseases","volume":"299","author":"Sitaru","year":"2007","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.jtauto.2019.100014_bib143","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/bjd.14411","article-title":"Bullous pemphigoid suggestive of complement-independent blister formation with anti-BP180 IgG4 autoantibodies","volume":"175","author":"Dainichi","year":"2016","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib144","doi-asserted-by":"crossref","first-page":"5792","DOI":"10.4049\/jimmunol.1003402","article-title":"Antibodies to pathogenic epitopes on type XVII collagen cause skin fragility in a complement-dependent and -independent manner","volume":"188","author":"Natsuga","year":"2012","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jtauto.2019.100014_bib145","doi-asserted-by":"crossref","first-page":"4415","DOI":"10.4049\/jimmunol.1400095","article-title":"Bullous pemphigoid autoantibodies directly induce blister formation without complement activation","volume":"193","author":"Ujiie","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jtauto.2019.100014_bib146","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1001\/jamadermatol.2016.3357","article-title":"Correlation of serum levels of IgE autoantibodies against BP180 with bullous pemphigoid disease activity","volume":"153","author":"van Beek","year":"2017","journal-title":"JAMA Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib147","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2340\/0001555565273274","article-title":"Serum IgE levels in patients with bullous pemphigoid","volume":"65","author":"Nieboer","year":"1985","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.jtauto.2019.100014_bib148","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1001\/archderm.1974.01630090016003","article-title":"IgE levels in sera of patients with pemphigus or bullous pemphigoid","volume":"110","author":"Arbesman","year":"1974","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib149","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00403-017-1789-1","article-title":"IgE autoantibodies and their association with the disease activity and phenotype in bullous pemphigoid: a systematic review","volume":"310","author":"Saniklidou","year":"2018","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.jtauto.2019.100014_bib150","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2340\/0001555564243246","article-title":"Serum IgE levels in patients with bullous pemphigoid and its correlation to the activity of the disease and anti-basement membrane zone antibodies","volume":"64","author":"Asbrink","year":"1984","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.jtauto.2019.100014_bib151","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/S0190-9622(83)70073-3","article-title":"Bullous pemphigoid: a cause of peripheral blood eosinophilia","volume":"8","author":"Bushkell","year":"1983","journal-title":"J.\u00a0Am. Acad. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib152","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S0190-9622(87)80227-X","article-title":"Blood eosinophilia as a severity marker for bullous pemphigoid","volume":"16","author":"Bernard","year":"1987","journal-title":"J.\u00a0Am. Acad. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib153","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1586\/1744666X.2016.1123092","article-title":"IgE-mediated mechanisms in bullous pemphigoid and other autoimmune bullous diseases","volume":"12","author":"van Beek","year":"2016","journal-title":"Expert Rev. Clin. Immunol."},{"key":"10.1016\/j.jtauto.2019.100014_bib154","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.jid.2017.11.031","article-title":"Eosinophils mediate tissue injury in the autoimmune skin disease bullous pemphigoid","volume":"138","author":"Lin","year":"2018","journal-title":"J.\u00a0Investig. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib155","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/sj.jid.5700681","article-title":"IgE basement membrane zone antibodies induce eosinophil infiltration and histological blisters in engrafted human skin on SCID mice","volume":"127","author":"Zone","year":"2007","journal-title":"J.\u00a0Investig. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib156","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1038\/sj.jid.5700958","article-title":"A\u00a0pathogenic role for IgE in autoimmunity: bullous pemphigoid IgE reproduces the early phase of lesion development in human skin grafted to nu\/nu mice","volume":"127","author":"Fairley","year":"2007","journal-title":"J.\u00a0Investig. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib157","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1046\/j.1523-1747.2002.19529.x","article-title":"Severity and phenotype of bullous pemphigoid relate to autoantibody profile against the NH2- and COOH-terminal regions of the BP180 ectodomain","volume":"119","author":"Hofmann","year":"2002","journal-title":"J.\u00a0Investig. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib158","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.0022-202X.2005.23853.x","article-title":"Mapping the binding sites of anti-BP180 immunoglobulin E autoantibodies in bullous pemphigoid","volume":"125","author":"Fairley","year":"2005","journal-title":"J.\u00a0Investig. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib159","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1046\/j.1523-1747.2003.12146.x","article-title":"Identification of a potential effector function for IgE autoantibodies in the organ-specific autoimmune disease bullous pemphigoid","volume":"120","author":"Dimson","year":"2003","journal-title":"J.\u00a0Investig. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib160","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1046\/j.1523-1747.2003.12146.x","article-title":"Identification of a potential effector function for IgE autoantibodies in the organ-specific autoimmune disease bullous pemphigoid","volume":"120","author":"Dimson","year":"2003","journal-title":"J.\u00a0Investig. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib161","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0107725","article-title":"Human eosinophils express the high affinity IgE receptor, FcepsilonRI, in bullous pemphigoid","volume":"9","author":"Messingham","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jtauto.2019.100014_bib162","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1111\/bjd.16034","article-title":"IgE autoantibodies in bullous pemphigoid","volume":"177","author":"Ujiie","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib163","doi-asserted-by":"crossref","DOI":"10.1111\/dth.12829","article-title":"Omalizumab as an alternative therapeutic tool in the treatment of bullous pemphigoid: a case report","volume":"32","author":"Vico Alonso","year":"2019","journal-title":"Dermatol. Ther."},{"key":"10.1016\/j.jtauto.2019.100014_bib164","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1111\/jdv.13758","article-title":"Successful treatment of bullous pemphigoid with omalizumab as corticosteroid-sparing agent: report of two cases and review of literature","volume":"30","author":"Balakirski","year":"2016","journal-title":"J.\u00a0Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.jtauto.2019.100014_bib165","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.jaci.2008.11.035","article-title":"Pathogenicity of IgE in autoimmunity: successful treatment of bullous pemphigoid with omalizumab","volume":"123","author":"Fairley","year":"2009","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.jtauto.2019.100014_bib166","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.clim.2018.12.015","article-title":"IgE blockade in autoimmunity: omalizumab induced remission of bullous pemphigoid","volume":"198","author":"James","year":"2019","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jtauto.2019.100014_bib167","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.1038\/jid.2013.236","article-title":"Association of serum B-cell activating factor level and proportion of memory and transitional B cells with clinical response after rituximab treatment of bullous pemphigoid patients","volume":"133","author":"Hall","year":"2013","journal-title":"J.\u00a0Investig. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib168","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jaad.2019.03.049","article-title":"Rituximab therapy in patients with bullous pemphigoid: a retrospective study of 20 patients","volume":"81","author":"Polansky","year":"2019","journal-title":"J.\u00a0Am. Acad. Dermatol."},{"key":"10.1016\/j.jtauto.2019.100014_bib169","article-title":"Integrating longitudinal serum IL-17 and IL-23 follow-up, along with autoantibodies variation, contributes to predict bullous pemphigoid outcome","volume":"5","author":"Pl\u00e9e","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jtauto.2019.100014_bib170","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.autrev.2019.03.009","article-title":"Serum and blister fluid levels of cytokines and chemokines in pemphigus and bullous pemphigoid","volume":"18","author":"Kowalski","year":"2019","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.jtauto.2019.100014_bib171","doi-asserted-by":"crossref","first-page":"8980534","DOI":"10.1155\/2017\/8980534","article-title":"Correlation between IL36alpha and IL17 and activity of the disease in selected autoimmune blistering diseases","volume":"2017","author":"Zebrowska","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.jtauto.2019.100014_bib172","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jaut.2018.09.003","article-title":"IL-17A is functionally relevant and a potential therapeutic target in bullous pemphigoid","volume":"96","author":"Chakievska","year":"2019","journal-title":"J.\u00a0Autoimmun."},{"key":"10.1016\/j.jtauto.2019.100014_bib173","doi-asserted-by":"crossref","first-page":"978","DOI":"10.3389\/fimmu.2019.00978","article-title":"Current clinical trials in pemphigus and pemphigoid","volume":"10","author":"Izumi","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jtauto.2019.100014_bib174","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jdermsci.2016.04.009","article-title":"Increased expression of NLRP3 inflammasome components and interleukin-18 in patients with bullous pemphigoid","volume":"83","author":"Fang","year":"2016","journal-title":"J.\u00a0Dermatol. Sci."}],"updated-by":[{"DOI":"10.1016\/j.jtauto.2020.100041","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000}}],"container-title":["Journal of Translational Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589909019300140?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589909019300140?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:17:19Z","timestamp":1778905039000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589909019300140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":174,"alternative-id":["S2589909019300140"],"URL":"https:\/\/doi.org\/10.1016\/j.jtauto.2019.100014","relation":{},"ISSN":["2589-9090"],"issn-type":[{"value":"2589-9090","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The pathogenesis of bullous skin diseases","name":"articletitle","label":"Article Title"},{"value":"Journal of Translational Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtauto.2019.100014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100014"}}