{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:38:00Z","timestamp":1793410680301,"version":"4.5.0"},"reference-count":163,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T00:00:00Z","timestamp":1568160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Translational Autoimmunity"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.jtauto.2019.100017","type":"journal-article","created":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T01:42:22Z","timestamp":1568770942000},"page":"100017","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["The complement system in liver diseases: Evidence-based approach and therapeutic options"],"prefix":"10.1016","volume":"2","author":[{"given":"Thomas","family":"Lung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Sakem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"Risch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"W\u00fcrzner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Colucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Cerny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urs","family":"Nydegger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3864","key":"10.1016\/j.jtauto.2019.100017_bib1","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1126\/science.163.3864.286","article-title":"Human C\u20193: evidence for the liver as the primary site of synthesis","volume":"163","author":"Alper","year":"1969","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.jtauto.2019.100017_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2249.1997.d01-890.x","article-title":"Extrahepatic complement biosynthesis: where, when and why?","volume":"107","author":"Morgan","year":"1997","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jtauto.2019.100017_bib3","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1741-7015-11-88","article-title":"Biologic therapy for autoimmune diseases: an update","volume":"11","author":"Rosman","year":"2013","journal-title":"BMC Med."},{"issue":"Suppl 2","key":"10.1016\/j.jtauto.2019.100017_bib4","doi-asserted-by":"crossref","first-page":"i82","DOI":"10.1136\/annrheumdis-2011-200587","article-title":"New approaches to the assessment and treatment of the idiopathic inflammatory myopathies","volume":"71","author":"Miller","year":"2012","journal-title":"Ann. Rheum. Dis."},{"issue":"6","key":"10.1016\/j.jtauto.2019.100017_bib5","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1172\/JCI78086","article-title":"Genetic basis of autoimmunity","volume":"125","author":"Marson","year":"2015","journal-title":"J.\u00a0Clin. Investig."},{"issue":"5","key":"10.1016\/j.jtauto.2019.100017_bib6","first-page":"333","article-title":"The complement sstem in liver diseases","volume":"3","author":"Qin","year":"2006","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.jtauto.2019.100017_bib7","series-title":"Mosaic of Autoimmunity","first-page":"704","author":"Perricone","year":"2019"},{"issue":"9","key":"10.1016\/j.jtauto.2019.100017_bib8","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/ncprheum0895","article-title":"Nature and functions of autoantibodies","volume":"4","author":"Elkon","year":"2008","journal-title":"Nat. Clin. Pract. Rheumatol."},{"issue":"10","key":"10.1016\/j.jtauto.2019.100017_bib9","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1097\/MEG.0000000000000424","article-title":"Autoimmune liver disease and concomitant extrahepatic autoimmune disease","volume":"27","author":"Muratori","year":"2015","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.jtauto.2019.100017_bib10","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/nrneph.2017.156","article-title":"The renaissance of complement therapeutics","volume":"14","author":"Ricklin","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"issue":"5\u20136","key":"10.1016\/j.jtauto.2019.100017_bib11","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1159\/000198223","article-title":"Profiles of serum complement in patients with hepatobiliary diseases","volume":"18","author":"Potter","year":"1978","journal-title":"Digestion"},{"issue":"8","key":"10.1016\/j.jtauto.2019.100017_bib12","doi-asserted-by":"crossref","first-page":"3831","DOI":"10.4049\/jimmunol.1203487","article-title":"Complement in immune and inflammatory disorders: pathophysiological mechanisms","volume":"190","author":"Ricklin","year":"2013","journal-title":"J.\u00a0Immunol."},{"issue":"2","key":"10.1016\/j.jtauto.2019.100017_bib13","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.clim.2015.08.009","article-title":"Applying complement therapeutics to rare diseases","volume":"161","author":"Reis","year":"2015","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jtauto.2019.100017_bib14","doi-asserted-by":"crossref","first-page":"363278","DOI":"10.1155\/2015\/363278","article-title":"Red blood cell destruction in autoimmune hemolytic anemia: role of complement and potential new targets for therapy","volume":"2015","author":"Berentsen","year":"2015","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.jtauto.2019.100017_bib15","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.molimm.2017.05.012","article-title":"Intracellular complement - the complosome - in immune cell regulation","volume":"89","author":"Arbore","year":"2017","journal-title":"Mol. Immunol."},{"issue":"1","key":"10.1016\/j.jtauto.2019.100017_bib16","doi-asserted-by":"crossref","first-page":"4186","DOI":"10.1038\/s41467-018-06706-z","article-title":"Complement receptor CD46 co-stimulates optimal human CD8(+) T cell effector function via fatty acid metabolism","volume":"9","author":"Arbore","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jtauto.2019.100017_bib17","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev-immunol-042617-053245","article-title":"Complement and the regulation of T cell responses","volume":"36","author":"West","year":"2018","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jtauto.2019.100017_bib18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/bs.ai.2018.02.001","article-title":"Unexpected roles for intracellular complement in the regulation of Th1 responses","volume":"138","author":"West","year":"2018","journal-title":"Adv. Immunol."},{"issue":"10","key":"10.1016\/j.jtauto.2019.100017_bib19","doi-asserted-by":"crossref","first-page":"4981","DOI":"10.4049\/jimmunol.1202017","article-title":"FcgammaRIIb on liver sinusoidal endothelium clears small immune complexes","volume":"189","author":"Ganesan","year":"2012","journal-title":"J.\u00a0Immunol."},{"issue":"12","key":"10.1016\/j.jtauto.2019.100017_bib20","doi-asserted-by":"crossref","DOI":"10.1111\/pim.12593","article-title":"Involvement of neutrophils in Chagas disease pathology","volume":"40","author":"de Andrade","year":"2018","journal-title":"Parasite Immunol."},{"issue":"4","key":"10.1016\/j.jtauto.2019.100017_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0007324","article-title":"Human collectin-11 (COLEC11) and its synergic genetic interaction with MASP2 are associated with the pathophysiology of Chagas disease","volume":"13","author":"Sandri","year":"2019","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"6","key":"10.1016\/j.jtauto.2019.100017_bib22","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/j.cell.2016.07.026","article-title":"Opposing effects of fasting metabolism on tissue tolerance in bacterial and viral inflammation","volume":"166","author":"Wang","year":"2016","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.jtauto.2019.100017_bib23","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1002\/hep.23228","article-title":"Activation of the complement system in human nonalcoholic fatty liver disease","volume":"50","author":"Rensen","year":"2009","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.jtauto.2019.100017_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0122026","article-title":"Association between complement C3 and prevalence of fatty liver disease in an adult population: a cross-sectional study from the Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIHealth) cohort study","volume":"10","author":"Jia","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.jtauto.2019.100017_bib25","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1053\/j.gastro.2010.04.041","article-title":"Complement and alcoholic liver disease: role of C1q in the pathogenesis of ethanol-induced liver injury in mice","volume":"139","author":"Cohen","year":"2010","journal-title":"Gastroenterology"},{"issue":"10","key":"10.1016\/j.jtauto.2019.100017_bib26","doi-asserted-by":"crossref","first-page":"662","DOI":"10.4254\/wjh.v10.i10.662","article-title":"Complements are involved in alcoholic fatty liver disease, hepatitis and fibrosis","volume":"10","author":"Lin","year":"2018","journal-title":"World J. Hepatol."},{"issue":"4","key":"10.1016\/j.jtauto.2019.100017_bib27","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/MPG.0000000000001653","article-title":"Post-transplant recurrent bile salt export pump disease: a form of antibody-mediated graft dysfunction and utilization of C4d","volume":"65","author":"Patel","year":"2017","journal-title":"J.\u00a0Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.jtauto.2019.100017_bib28","series-title":"Familial Intrahepatic Cholestasis: New and Wide Perspectives","author":"Vitale","year":"2019"},{"issue":"6","key":"10.1016\/j.jtauto.2019.100017_bib29","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.4049\/jimmunol.1600628","article-title":"Systems analysis of the complement-induced priming phase of liver regeneration","volume":"197","author":"Min","year":"2016","journal-title":"J.\u00a0Immunol."},{"issue":"24","key":"10.1016\/j.jtauto.2019.100017_bib30","first-page":"4253","article-title":"New markers for tracking endoderm induction and hepatocyte differentiation from human pluripotent stem cells","volume":"142","author":"Holtzinger","year":"2015","journal-title":"Development"},{"issue":"4","key":"10.1016\/j.jtauto.2019.100017_bib31","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.jhep.2017.12.016","article-title":"Adult hepatocytes direct liver organogenesis through non-parenchymal cell recruitment in the kidney","volume":"68","author":"Utoh","year":"2018","journal-title":"J.\u00a0Hepatol."},{"issue":"4","key":"10.1016\/j.jtauto.2019.100017_bib32","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1172\/JCI110687","article-title":"Complement biosynthesis by the human hepatoma-derived cell line HepG2","volume":"70","author":"Morris","year":"1982","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.jtauto.2019.100017_bib33","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3389\/fncel.2013.00045","article-title":"Origin and differentiation of microglia","volume":"7","author":"Ginhoux","year":"2013","journal-title":"Front. Cell. Neurosci."},{"issue":"1","key":"10.1016\/j.jtauto.2019.100017_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00281-017-0664-7","article-title":"Introduction to complement in health and disease: novel aspects and insights","volume":"40","author":"Morgan","year":"2018","journal-title":"Semin. Immunopathol."},{"issue":"2","key":"10.1016\/j.jtauto.2019.100017_bib35","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/cei.12952","article-title":"Production of complement components by cells of the immune system","volume":"188","author":"Lubbers","year":"2017","journal-title":"Clin. Exp. Immunol."},{"issue":"5","key":"10.1016\/j.jtauto.2019.100017_bib36","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/S0959-437X(00)00234-3","article-title":"Hepatocyte differentiation: from the endoderm and beyond","volume":"11","author":"Zaret","year":"2001","journal-title":"Curr. Opin. Genet. Dev."},{"issue":"1","key":"10.1016\/j.jtauto.2019.100017_bib37","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/imr.12474","article-title":"Evolutionn of the complement system: from defense of the single cell to guardian of the intravascular space","volume":"274","author":"Elvington","year":"2016","journal-title":"Immunol. Rev."},{"issue":"6","key":"10.1016\/j.jtauto.2019.100017_bib38","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1097\/MOT.0000000000000365","article-title":"Emerging advancements in liver regeneration and organogenesis as tools for liver replacement","volume":"21","author":"Huppert","year":"2016","journal-title":"Curr. Opin. Organ Transplant."},{"issue":"18","key":"10.1016\/j.jtauto.2019.100017_bib39","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/j.cub.2005.07.059","article-title":"Novel genes required for meiotic chromosome segregation are identified by a high-throughput knockout screen in fission yeast","volume":"15","author":"Gregan","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.jtauto.2019.100017_bib40","series-title":"Cracking Down the Aging Code","first-page":"326","author":"Mitteldorf","year":"2016"},{"issue":"6921","key":"10.1016\/j.jtauto.2019.100017_bib41","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature01408","article-title":"DNA damage and repair","volume":"421","author":"Friedberg","year":"2003","journal-title":"Nature"},{"issue":"1\u20133","key":"10.1016\/j.jtauto.2019.100017_bib42","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0162-3109(99)00021-1","article-title":"Genetic disruption of the murine complement C3 promoter region generates deficient mice with extrahepatic expression of C3 mRNA","volume":"42","author":"Circolo","year":"1999","journal-title":"Immunopharmacology"},{"issue":"3","key":"10.1016\/j.jtauto.2019.100017_bib43","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/ni.3094","article-title":"Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets","volume":"16","author":"Robinette","year":"2015","journal-title":"Nat. Immunol."},{"issue":"8","key":"10.1016\/j.jtauto.2019.100017_bib44","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1053\/j.gastro.2016.01.025","article-title":"Inflammation in alcoholic and nonalcoholic fatty liver disease: friend or foe?","volume":"150","author":"Gao","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jtauto.2019.100017_bib45","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1387\/ijdb.072465v","article-title":"Expression of complement components coincides with early patterning and organogenesis in Xenopus laevis","volume":"152","author":"McLin","year":"2008","journal-title":"Int. J. Dev. Biol."},{"issue":"1","key":"10.1016\/j.jtauto.2019.100017_bib46","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.1038\/s41467-018-06611-5","article-title":"Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control","volume":"9","author":"Brosch","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jtauto.2019.100017_bib47","doi-asserted-by":"crossref","first-page":"15096","DOI":"10.1038\/ncomms15096","article-title":"Developmental activities of the complement pathway in migrating neurons","volume":"8","author":"Gorelik","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jtauto.2019.100017_bib48","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.molimm.2017.08.003","article-title":"Regulation of epithelial cell expressed C3 in the intestine - relevance for the pathophysiology of inflammatory bowel disease?","volume":"90","author":"Sunderhauf","year":"2017","journal-title":"Mol. Immunol."},{"issue":"1","key":"10.1016\/j.jtauto.2019.100017_bib49","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1046\/j.1365-2249.2000.01238.x","article-title":"The endothelium is an extrahepatic site of synthesis of the seventh component of the complement system","volume":"121","author":"Langeggen","year":"2000","journal-title":"Clin. Exp. Immunol."},{"issue":"9","key":"10.1016\/j.jtauto.2019.100017_bib50","doi-asserted-by":"crossref","first-page":"4624","DOI":"10.4049\/jimmunol.152.9.4624","article-title":"Complement component C7. Assessment of in vivo synthesis after liver transplantation reveals that hepatocytes do not synthesize the majority of human C7","volume":"152","author":"W\u00fcrzner","year":"1994","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jtauto.2019.100017_bib51","article-title":"Alterations of gut microbiome in autoimmune hepatitis","author":"Wei","year":"2019","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.jtauto.2019.100017_bib52","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/cei.12474","article-title":"Immune homeostasis, dysbiosis and therapeutic modulation of the gut microbiota","volume":"179","author":"Peterson","year":"2015","journal-title":"Clin. Exp. Immunol."},{"issue":"4","key":"10.1016\/j.jtauto.2019.100017_bib53","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1055\/s-0036-1593879","article-title":"The microbiome and the liver: the basics","volume":"36","author":"Victor","year":"2016","journal-title":"Semin. Liver Dis."},{"issue":"6","key":"10.1016\/j.jtauto.2019.100017_bib54","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1084\/jem.20031244","article-title":"Selective generation of gut tropic T cells in gut-associated lymphoid tissue (GALT): requirement for GALT dendritic cells and adjuvant","volume":"198","author":"Johansson-Lindbom","year":"2003","journal-title":"J.\u00a0Exp. Med."},{"issue":"3","key":"10.1016\/j.jtauto.2019.100017_bib55","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/cei.13040","article-title":"C4B gene influences intestinal microbiota through complement activation in patients with paediatric-onset inflammatory bowel disease","volume":"190","author":"Nissila","year":"2017","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jtauto.2019.100017_bib56","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.smim.2018.02.008","article-title":"The intestinal complement system in inflammatory bowel disease: shaping intestinal barrier function","volume":"37","author":"Sina","year":"2018","journal-title":"Semin. Immunol."},{"issue":"6","key":"10.1016\/j.jtauto.2019.100017_bib57","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1111\/j.1530-0277.1995.tb01020.x","article-title":"Lack of plasma complement activation in severe acute alcoholic hepatitis","volume":"19","author":"Bird","year":"1995","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.jtauto.2019.100017_bib58","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.diabres.2017.09.017","article-title":"Association between hemoglobin glycation index and hepatic steatosis in non-diabetic individuals","volume":"134","author":"Fiorentino","year":"2017","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.jtauto.2019.100017_bib59","doi-asserted-by":"crossref","first-page":"4121837","DOI":"10.1155\/2016\/4121837","article-title":"Inflammation thread runs across medical laboratory specialities","volume":"2016","author":"Nydegger","year":"2016","journal-title":"Mediat. Inflamm."},{"issue":"2","key":"10.1016\/j.jtauto.2019.100017_bib60","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/j.1365-2249.2006.03153.x","article-title":"Anti-C1q antibodies in hepatitis C virus infection","volume":"145","author":"Saadoun","year":"2006","journal-title":"Clin. Exp. Immunol."},{"issue":"3","key":"10.1016\/j.jtauto.2019.100017_bib61","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1053\/ajkd.2001.22071","article-title":"Anti-C1q antibodies may help in diagnosing a renal flare in lupus nephritis","volume":"37","author":"Moroni","year":"2001","journal-title":"Am. J. Kidney Dis."},{"issue":"12","key":"10.1016\/j.jtauto.2019.100017_bib62","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/ng.257","article-title":"Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease","volume":"40","author":"Romeo","year":"2008","journal-title":"Nat. Genet."},{"issue":"12","key":"10.1016\/j.jtauto.2019.100017_bib63","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1038\/ng.3417","article-title":"A\u00a0genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis","volume":"47","author":"Buch","year":"2015","journal-title":"Nat. Genet."},{"issue":"7","key":"10.1016\/j.jtauto.2019.100017_bib64","doi-asserted-by":"crossref","DOI":"10.3390\/genes8070183","article-title":"Genetic contribution to alcohol dependence: investigation of a heterogeneous German sample of individuals with alcohol dependence, chronic alcoholic pancreatitis, and alcohol-related cirrhosis","volume":"8","author":"Treutlein","year":"2017","journal-title":"Genes"},{"issue":"3","key":"10.1016\/j.jtauto.2019.100017_bib65","first-page":"82","article-title":"Direkte Ethanolmetabolite in Blut und Urin: relevanz in Diagnose und Therapie alkoholbezogener St\u00f6rungen","volume":"10","author":"Wurst","year":"2009","journal-title":"J.\u00a0Neurol. Neurochir. Psychiatr."},{"issue":"10","key":"10.1016\/j.jtauto.2019.100017_bib66","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1002\/eji.1830171015","article-title":"Human complement factor H: expression of an additional truncated gene product of 43 kDa in human liver","volume":"17","author":"Schwaeble","year":"1987","journal-title":"Eur. J. Immunol."},{"issue":"10","key":"10.1016\/j.jtauto.2019.100017_bib67","doi-asserted-by":"crossref","first-page":"6761","DOI":"10.1021\/acs.analchem.9b00841","article-title":"Dual energy transfer-based fluorescent nanoprobe for imaging mir-21 in nonalcoholic fatty liver cells with low background","volume":"91","author":"Chai","year":"2019","journal-title":"Anal. Chem."},{"issue":"10","key":"10.1016\/j.jtauto.2019.100017_bib68","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0110053","article-title":"Complement alternative pathway activation in human nonalcoholic steatohepatitis","volume":"9","author":"Segers","year":"2014","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.jtauto.2019.100017_bib69","doi-asserted-by":"crossref","first-page":"6873","DOI":"10.1167\/iovs.15-17432","article-title":"Rare variants in the functional domains of complement factor H are associated with age-related macular degeneration","volume":"56","author":"Triebwasser","year":"2015","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jtauto.2019.100017_bib70","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-1-4939-8672-9_3","article-title":"Phospholipases: an overview","volume":"1835","author":"Aloulou","year":"2018","journal-title":"Methods Mol. Biol."},{"issue":"2","key":"10.1016\/j.jtauto.2019.100017_bib71","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.clim.2007.05.008","article-title":"Effect of chronic ethanol consumption on the expression of complement components and acute-phase proteins in liver","volume":"124","author":"Bykov","year":"2007","journal-title":"Clin. Immunol."},{"issue":"3\u20134","key":"10.1016\/j.jtauto.2019.100017_bib72","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jaut.2009.09.010","article-title":"Serum inflammatory cytokines, complement components, and soluble interleukin 2 receptor in primary biliary cirrhosis","volume":"33","author":"Barak","year":"2009","journal-title":"J.\u00a0Autoimmun."},{"issue":"59","key":"10.1016\/j.jtauto.2019.100017_bib73","first-page":"1451","article-title":"Serum C3 complement concentrations correlate with liver function in patients with liver cirrhosis","volume":"51","author":"Baumann","year":"2004","journal-title":"Hepato-Gastroenterology"},{"issue":"3","key":"10.1016\/j.jtauto.2019.100017_bib74","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1006\/clin.1998.4542","article-title":"Complement system is not activated in primary biliary cirrhosis","volume":"87","author":"Gardinali","year":"1998","journal-title":"Clin. Immunol. Immunopathol."},{"issue":"3","key":"10.1016\/j.jtauto.2019.100017_bib75","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.yexmp.2014.09.004","article-title":"Increased activity of the complement system in the liver of patients with alcoholic hepatitis","volume":"97","author":"Shen","year":"2014","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.jtauto.2019.100017_bib76","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jaut.2018.10.013","article-title":"The utility of complement assays in clinical immunology: a comprehensive review","volume":"95","author":"Lung","year":"2018","journal-title":"J.\u00a0Autoimmun."},{"issue":"1","key":"10.1016\/j.jtauto.2019.100017_bib77","first-page":"35","article-title":"Nonalcoholic fatty liver disease: diagnosis and management","volume":"88","author":"Wilkins","year":"2013","journal-title":"Am. Fam. Physician"},{"issue":"4","key":"10.1016\/j.jtauto.2019.100017_bib78","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/apt.15087","article-title":"Systematic review with meta-analysis: non-alcoholic fatty liver disease is associated with a history of osteoporotic fractures but not with low bone mineral density","volume":"49","author":"Mantovani","year":"2019","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"1124","key":"10.1016\/j.jtauto.2019.100017_bib79","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1136\/postgradmedj-2018-136316","article-title":"Diagnosis and management of non-alcoholic fatty liver disease","volume":"95","author":"Jennison","year":"2019","journal-title":"Postgrad. Med. J."},{"issue":"19","key":"10.1016\/j.jtauto.2019.100017_bib80","doi-asserted-by":"crossref","first-page":"9521","DOI":"10.1073\/pnas.1901974116","article-title":"Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis","volume":"116","author":"BasuRay","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.jtauto.2019.100017_bib81","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1074\/jbc.M112.396614","article-title":"Complement-mediated activation of calcium-independent phospholipase A2gamma: role of protein kinases and phosphorylation","volume":"288","author":"Elimam","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"issue":"12","key":"10.1016\/j.jtauto.2019.100017_bib82","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1055\/a-0725-9297","article-title":"Reflections on thyroid autoimmunity: a personal overview from the past into the future","volume":"50","author":"Rapoport","year":"2018","journal-title":"Horm. Metab. Res."},{"issue":"1","key":"10.1016\/j.jtauto.2019.100017_bib83","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1056\/NEJMoa1816721","article-title":"Kelch-like protein 11 antibodies in seminoma-associated paraneoplastic encephalitis","volume":"381","author":"Mandel-Brehm","year":"2019","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"6","key":"10.1016\/j.jtauto.2019.100017_bib84","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1084\/jem.20071859","article-title":"Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection","volume":"205","author":"Holdener","year":"2008","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.jtauto.2019.100017_bib85","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3389\/fimmu.2018.00163","article-title":"Autoantibodies in autoimmune hepatitis: can epitopes tell us about the etiology of the disease?","volume":"9","author":"Christen","year":"2018","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.jtauto.2019.100017_bib86","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.bpg.2017.09.013","article-title":"Intestinal microbiome and permeability in patients with autoimmune hepatitis","volume":"31","author":"Cai","year":"2017","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"issue":"2","key":"10.1016\/j.jtauto.2019.100017_bib87","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1159\/000007916","article-title":"Antiganglioside GM1 antibodies and their complement activating capacity in central and peripheral nervous system disorders and in controls","volume":"39","author":"Uetz-von Allmen","year":"1998","journal-title":"Eur. Neurol."},{"issue":"7","key":"10.1016\/j.jtauto.2019.100017_bib88","article-title":"Association of anti-gt1a antibodies with an outbreak of guillain-barre syndrome and analysis of ganglioside mimicry in an associated Campylobacter jejuni strain","volume":"10","author":"Zhang","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.jtauto.2019.100017_bib89","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/cei.12224","article-title":"Escherichia coli infection induces autoimmune cholangitis and anti-mitochondrial antibodies in non-obese diabetic (NOD).B6 (Idd10\/Idd18) mice","volume":"175","author":"Wang","year":"2014","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jtauto.2019.100017_bib90","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2018.07.006","article-title":"Autoimmune liver dieases serology in acute hepatitis E virus infection","volume":"24","author":"Terziroli Beretta-Piccoli","year":"2018","journal-title":"J.\u00a0Autoimmun."},{"issue":"6","key":"10.1016\/j.jtauto.2019.100017_bib91","first-page":"85","article-title":"The etiiology, diagnosis and prevention of liver cirrhosis","volume":"110","author":"Wiegand","year":"2013","journal-title":"Dtsch Aerztebl Int"},{"issue":"5 Suppl","key":"10.1016\/j.jtauto.2019.100017_bib92","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1002\/hep.22881","article-title":"Hepatitis B: the virus and disease","volume":"49","author":"Liang","year":"2009","journal-title":"Hepatology"},{"issue":"48","key":"10.1016\/j.jtauto.2019.100017_bib93","doi-asserted-by":"crossref","first-page":"E11369","DOI":"10.1073\/pnas.1809028115","article-title":"Role of humoral immunity against hepatitis B virus core antigen in the pathogenesis of acute liver failure","volume":"115","author":"Chen","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.jtauto.2019.100017_bib94","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.imbio.2016.01.014","article-title":"Complement C5 controls liver lipid profile, promotes liver homeostasis and inflammation in C57BL\/6 genetic background","volume":"221","author":"Bavia","year":"2016","journal-title":"Immunobiology"},{"issue":"1","key":"10.1016\/j.jtauto.2019.100017_bib95","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s15010-016-0942-7","article-title":"Complement 5a is an indicator of significant fibrosis and earlier cirrhosis in patients chronically infected with hepatitis B virus","volume":"45","author":"Deng","year":"2017","journal-title":"Infection"},{"issue":"3","key":"10.1016\/j.jtauto.2019.100017_bib96","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s00535-016-1244-7","article-title":"Novel and highly sensitive immunoassay for total hepatitis B surface antigen, including that complexed with hepatitis B surface antibody","volume":"52","author":"Matsumoto","year":"2017","journal-title":"J.\u00a0Gastroenterol."},{"key":"10.1016\/j.jtauto.2019.100017_bib97","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.3389\/fimmu.2018.01001","article-title":"The complement system and C1q in chronic hepatitis C virus infection and mixed cryoglobulinemia","volume":"9","author":"El-Shamy","year":"2018","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.jtauto.2019.100017_bib98","first-page":"7459","article-title":"Hepatitis B virus inhibits the expression of complement C3 and C4, in vitro and in vivo","volume":"15","author":"Zhu","year":"2018","journal-title":"Oncol Lett"},{"issue":"3","key":"10.1016\/j.jtauto.2019.100017_bib99","doi-asserted-by":"crossref","first-page":"425","DOI":"10.5604\/12321966.1219181","article-title":"Hepatitis C virus epidemiology and prevention in Polish and Swiss population - similar and contrasting experiences","volume":"23","author":"Sakem","year":"2016","journal-title":"Ann. Agric. Environ. Med."},{"key":"10.1016\/j.jtauto.2019.100017_bib100","article-title":"Primary immunodeficiencies - epidemiology, spending on therapy, diagnostic and thereputic needs in Poland","author":"Jahnz-rozyk","year":"2017","journal-title":"J.\u00a0Health Policy Pol."},{"issue":"2","key":"10.1016\/j.jtauto.2019.100017_bib101","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/tme.12405","article-title":"Hepatitis E: the current state of play","volume":"27","author":"Ankcorn","year":"2017","journal-title":"Transfus. Med."},{"issue":"2","key":"10.1016\/j.jtauto.2019.100017_bib102","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.virusres.2010.04.011","article-title":"Fusion of C3d molecule with neutralization epitope(s) of hepatitis E virus enhances antibody avidity maturation and neutralizing activity following DNA immunization","volume":"151","author":"Yang","year":"2010","journal-title":"Virus Res."},{"issue":"1\u20132","key":"10.1016\/j.jtauto.2019.100017_bib103","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2298\/SARH1602063B","article-title":"Epidemiological characteristics and clinical manifestations of hepatitis E virus infection in Bulgaria: a report on 20 patients","volume":"144","author":"Baymakova","year":"2016","journal-title":"Srpski arhiv zu celokupno lekarstvo"},{"issue":"10","key":"10.1016\/j.jtauto.2019.100017_bib104","doi-asserted-by":"crossref","first-page":"4939","DOI":"10.1128\/JVI.00224-16","article-title":"Complement opsonization promotes Herpes simplex virus 2 infection of human dendritic cells","volume":"90","author":"Crisci","year":"2016","journal-title":"J.\u00a0Virol."},{"issue":"10","key":"10.1016\/j.jtauto.2019.100017_bib105","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1002\/1521-4141(2002010)32:10<2954::AID-IMMU2954>3.0.CO;2-2","article-title":"Mechanism of host cell protection from complement in murine cytomegalovirus (CMV) infection: identification of a CMV-responsive element in the CD46 promoter region","volume":"32","author":"Nomura","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jtauto.2019.100017_bib106","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.exger.2014.03.020","article-title":"New advances in CMV and immunosenescence","volume":"55","author":"Sansoni","year":"2014","journal-title":"Exp. Gerontol."},{"issue":"20","key":"10.1016\/j.jtauto.2019.100017_bib107","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s11908-018-0610-4","article-title":"Immune monitoring for CMV in transplantation","volume":"April","author":"Yong","year":"2018","journal-title":"Curr. Infect. Dis. Rep."},{"issue":"4","key":"10.1016\/j.jtauto.2019.100017_bib108","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006345","article-title":"IL-33\/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection","volume":"13","author":"Popovic","year":"2017","journal-title":"PLoS Pathog."},{"issue":"5","key":"10.1016\/j.jtauto.2019.100017_bib109","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.cell.2015.07.043","article-title":"Rational design of an epstein-barr virus vaccine targeting the receptor-binding site","volume":"162","author":"Kanekiyo","year":"2015","journal-title":"Cell"},{"issue":"4\u20135","key":"10.1016\/j.jtauto.2019.100017_bib110","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0161-5890(99)00049-8","article-title":"Evasion of pathogens by avoiding recognition or eradication by complement, in part via molecular mimicry","volume":"36","author":"Wurzner","year":"1999","journal-title":"Mol. Immunol."},{"issue":"23","key":"10.1016\/j.jtauto.2019.100017_bib111","doi-asserted-by":"crossref","first-page":"12708","DOI":"10.1128\/JVI.00886-12","article-title":"Incorporation of host complement regulatory proteins into Newcastle disease virus enhances complement evasion","volume":"86","author":"Biswas","year":"2012","journal-title":"J.\u00a0Virol."},{"issue":"Pt 3","key":"10.1016\/j.jtauto.2019.100017_bib112","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1099\/0022-1317-71-3-593","article-title":"Cell surface expression of yellow fever virus non-structural glycoprotein NS1: consequences of interaction with antibody","volume":"71","author":"Schlesinger","year":"1990","journal-title":"J.\u00a0Gen. Virol."},{"issue":"11","key":"10.1016\/j.jtauto.2019.100017_bib113","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.tim.2018.05.012","article-title":"Yellow fever virus: knowledge gaps impeding the fight against an old foe","volume":"26","author":"Duam","year":"2018","journal-title":"Trends Microbiol."},{"issue":"14","key":"10.1016\/j.jtauto.2019.100017_bib114","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00633-18","article-title":"Dengue virus induces increased activity of the complement alternative pathway in infected cells","volume":"92","author":"Cabezas","year":"2018","journal-title":"J.\u00a0Virol."},{"issue":"1","key":"10.1016\/j.jtauto.2019.100017_bib115","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1093\/infdis\/jix562","article-title":"Severity of disease in humanized mice infected with Ebola virus or reston virus is associated with magnitude of early viral replication in liver","volume":"217","author":"Spengler","year":"2017","journal-title":"J.\u00a0Infect. Dis."},{"issue":"5","key":"10.1016\/j.jtauto.2019.100017_bib116","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1128\/JVI.75.5.2324-2330.2001","article-title":"Infectivity-enhancing antibodies to Ebola virus glycoprotein","volume":"75","author":"Takada","year":"2001","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.jtauto.2019.100017_bib117","doi-asserted-by":"crossref","DOI":"10.1038\/news030623-10","article-title":"Immune system may help Ebola infect","author":"Clarke","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jtauto.2019.100017_bib118","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1099\/vir.0.81199-0","article-title":"Mannose-binding lectin binds to Ebola and Marburg envelope glycoproteins, resulting in blocking of virus interaction with DC-SIGN and complement-mediated virus neutralization","volume":"86","author":"Ji","year":"2005","journal-title":"J.\u00a0Gen. Virol."},{"issue":"1","key":"10.1016\/j.jtauto.2019.100017_bib119","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1136\/annrheumdis-2013-203863","article-title":"International recommendations for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies","volume":"73","author":"Agmon-Levin","year":"2014","journal-title":"Ann. Rheum. Dis."},{"issue":"10","key":"10.1016\/j.jtauto.2019.100017_bib120","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1515\/cclm-2018-0052","article-title":"International Consensus on Antinuclear Antibody Patterns: defining negative results and reporting unidentified patterns","volume":"56","author":"Herold","year":"2018","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.jtauto.2019.100017_bib121","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1177\/0961203316640920","article-title":"Report on the second international consensus on ANA pattern (ICAP) workshop in dresden 2015","volume":"25","author":"Chan","year":"2016","journal-title":"Lupus"},{"issue":"1","key":"10.1016\/j.jtauto.2019.100017_bib122","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jaut.2010.07.003","article-title":"ASIA\u2019 - autoimmune\/inflammatory syndrome induced by adjuvants","volume":"36","author":"Shoenfeld","year":"2011","journal-title":"J.\u00a0Autoimmun."},{"issue":"4","key":"10.1016\/j.jtauto.2019.100017_bib123","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/BOR.0000000000000394","article-title":"From microbiome to infectome in autoimmunity","volume":"29","author":"Bogdanos","year":"2017","journal-title":"Curr. Opin. Rheumatol."},{"issue":"1","key":"10.1016\/j.jtauto.2019.100017_bib124","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3748\/wjg.v21.i1.60","article-title":"Autoimmune hepatitis, one disease with many faces: etiopathogenetic, clinico-laboratory and histological characteristics","volume":"21","author":"Gatselis","year":"2015","journal-title":"World J. Gastroenterol."},{"issue":"18","key":"10.1016\/j.jtauto.2019.100017_bib125","doi-asserted-by":"crossref","first-page":"E3689","DOI":"10.1073\/pnas.1619386114","article-title":"Selective in vivo removal of pathogenic anti-MAG autoantibodies, an antigen-specific treatment option for anti-MAG neuropathy","volume":"114","author":"Herrendorff","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.jtauto.2019.100017_bib126","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1080\/00365521.2017.1386710","article-title":"Prognostic value of lectin pathway molecules and complement proteins in ascitic fluid and blood in patients with liver cirrhosis","volume":"53","author":"Glargaard","year":"2018","journal-title":"Scand. J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.jtauto.2019.100017_bib127","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41390-018-0009-9","article-title":"Gastrointestinal pathogens in anti-FH antibody positive and negative Hemolytic Uremic Syndrome","volume":"84","author":"Togarsimalemath","year":"2018","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.jtauto.2019.100017_bib128","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1056\/NEJMe1804945","article-title":"Progress in primary biliary cholangitis","volume":"378","author":"Carey","year":"2018","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"4 Pt B","key":"10.1016\/j.jtauto.2019.100017_bib129","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/j.bbadis.2017.09.012","article-title":"Pathological features of primary sclerosing cholangitis identified by bile proteomic analysis","volume":"1864","author":"Rupp","year":"2018","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jtauto.2019.100017_bib130","series-title":"The Role of the NLRP3 Inflammasome and the Activation of IL-1beta in the Pathogenesis of Chronic Viral Hepatic Inflammation","author":"Molyvdas","year":"2018"},{"issue":"48","key":"10.1016\/j.jtauto.2019.100017_bib131","doi-asserted-by":"crossref","first-page":"8489","DOI":"10.3748\/wjg.v23.i48.8489","article-title":"Exploring pathogenesis of primary biliary cholangitis by proteomics: a pilot study","volume":"23","author":"Deng","year":"2017","journal-title":"World J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.jtauto.2019.100017_bib132","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/BOR.0b013e328341a229","article-title":"IgG4-related systemic disease: the age of discovery","volume":"23","author":"Khosroshahi","year":"2011","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.jtauto.2019.100017_bib133","series-title":"Hemolytic Anemia Resulting from Physical Injury of Red Cells","first-page":"755","author":"Baker","year":"2010"},{"issue":"3","key":"10.1016\/j.jtauto.2019.100017_bib134","article-title":"The extended use of eculizumab in pregnancy and complement Activation(-)Associated diseases affecting maternal, fetal and neonatal kidneys-the future is now?","volume":"8","author":"Stefanovic","year":"2019","journal-title":"J.\u00a0Clin. Med."},{"issue":"1","key":"10.1016\/j.jtauto.2019.100017_bib135","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00281-017-0645-x","article-title":"Complement activation, a threat to pregnancy","volume":"40","author":"Girardi","year":"2018","journal-title":"Semin. Immunopathol."},{"issue":"2 Pt 2","key":"10.1016\/j.jtauto.2019.100017_bib136","doi-asserted-by":"crossref","first-page":"S72","DOI":"10.1016\/0090-1229(89)90072-X","article-title":"The concept of anti-idiotypic regulation of selected autoimmune diseases by intravenous immunoglobulin","volume":"53","author":"Nydegger","year":"1989","journal-title":"Clin. Immunol. Immunopathol."},{"issue":"1","key":"10.1016\/j.jtauto.2019.100017_bib137","article-title":"SENIORLAB: a prospective observational study investigating laboratory parameters and their reference intervals in the elderly","volume":"96","author":"Risch","year":"2017","journal-title":"Medicine (Baltim.)"},{"issue":"9","key":"10.1016\/j.jtauto.2019.100017_bib138","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1212\/WNL.0000000000002417","article-title":"Cutaneous adverse events in multiple sclerosis patients treated with daclizumab","volume":"86","author":"Cortese","year":"2016","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.jtauto.2019.100017_bib139","first-page":"333","article-title":"The complement system in liver diseases","volume":"3","author":"Qin","year":"2006","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.jtauto.2019.100017_bib140","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.smim.2018.03.003","article-title":"Intracellular complement activation-An alarm raising mechanism?","volume":"38","author":"Reichhardt","year":"2018","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.jtauto.2019.100017_bib141","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.4049\/jimmunol.171.3.1581","article-title":"Complement activation determines the therapeutic activity of Rituximab in vivo","volume":"171","author":"DiGaetano","year":"2003","journal-title":"J.\u00a0Immunol."},{"issue":"1\u20132","key":"10.1016\/j.jtauto.2019.100017_bib142","first-page":"97","article-title":"Focus on: alcohol and the immune system","volume":"33","author":"Molina","year":"2010","journal-title":"Alcohol Res. Health"},{"issue":"1","key":"10.1016\/j.jtauto.2019.100017_bib143","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1177\/1756283X10378925","article-title":"Treatment of alcoholic liver disease","volume":"4","author":"Frazier","year":"2011","journal-title":"Therap Adv Gastroenterol"},{"issue":"4","key":"10.1016\/j.jtauto.2019.100017_bib144","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/alcalc\/agx030","article-title":"A\u00a0randomized, placebo-controlled study of high-dose baclofen in alcohol-dependent patients-the ALPADIR study","volume":"52","author":"Reynaud","year":"2017","journal-title":"Alcohol Alcohol"},{"issue":"11","key":"10.1016\/j.jtauto.2019.100017_bib145","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/nrgastro.2017.106","article-title":"Direct-acting antiviral agents for HCV infection affecting people who inject drugs","volume":"14","author":"Grebely","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jtauto.2019.100017_bib146","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.intimp.2016.11.022","article-title":"The efficacy and safety comparison between tenofovir and entecavir in treatment of chronic hepatitis B and HBV related cirrhosis: a systematic review and Meta-analysis","volume":"42","author":"Han","year":"2017","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"10.1016\/j.jtauto.2019.100017_bib147","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.ccc.2016.03.006","article-title":"Infections in liver disease","volume":"32","author":"Nanchal","year":"2016","journal-title":"Crit. Care Clin."},{"issue":"33","key":"10.1016\/j.jtauto.2019.100017_bib148","doi-asserted-by":"crossref","first-page":"6030","DOI":"10.3748\/wjg.v23.i33.6030","article-title":"Autoimmune hepatitis: standard treatment and systematic review of alternative treatments","volume":"23","author":"Terziroli Beretta-Piccoli","year":"2017","journal-title":"World J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.jtauto.2019.100017_bib149","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/liv.13458","article-title":"International Autoimmune Hepatitis G. Autoimmune hepatitis: from current knowledge and clinical practice to future research agenda","volume":"38","author":"Sebode","year":"2018","journal-title":"Liver Int."},{"issue":"1","key":"10.1016\/j.jtauto.2019.100017_bib150","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.transproceed.2006.10.222","article-title":"Histoblood groups other than HLA in organ transplantation","volume":"39","author":"Nydegger","year":"2007","journal-title":"Transplant. Proc."},{"issue":"7","key":"10.1016\/j.jtauto.2019.100017_bib151","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/ki.2011.497","article-title":"Pros and cons for C4d as a biomarker","volume":"81","author":"Cohen","year":"2012","journal-title":"Kidney Int."},{"issue":"1","key":"10.1016\/j.jtauto.2019.100017_bib152","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.bcp.2013.12.013","article-title":"Ischemia\/reperfusion injury: effect of simultaneous inhibition of plasma cascade systems versus specific complement inhibition","volume":"88","author":"Duehrkop","year":"2014","journal-title":"Biochem. Pharmacol."},{"issue":"6","key":"10.1016\/j.jtauto.2019.100017_bib153","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19061750","article-title":"Review. JpEd. Complement activation in liver transplantation: role of donor macrosteatosis and implications in delayed graft function","volume":"19","author":"N\u00fa\u00f1ez","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.jtauto.2019.100017_bib154","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1002\/lt.25187","article-title":"Morphological characterization of chronic antibody mediated rejection in ABO-identical or compatible pediatric liver graft recipients","volume":"24","author":"Dao","year":"2018","journal-title":"Liver Transplant."},{"issue":"4","key":"10.1016\/j.jtauto.2019.100017_bib155","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.trim.2012.08.004","article-title":"The value of C4d deposit in post liver transplant liver biopsies","volume":"27","author":"Fayek","year":"2012","journal-title":"Transpl. Immunol."},{"issue":"2","key":"10.1016\/j.jtauto.2019.100017_bib156","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.jss.2013.09.009","article-title":"Human C1 inhibitor attenuates liver ischemia-reperfusion injury and promotes liver regeneration","volume":"187","author":"Saidi","year":"2014","journal-title":"J.\u00a0Surg. Res."},{"issue":"7","key":"10.1016\/j.jtauto.2019.100017_bib157","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/gerona\/glx249","article-title":"Short-term low-dose mTORC1 inhibition in aged rats counter-regulates age-related gene changes and blocks age-related kidney pathology","volume":"73","author":"Shavlakadze","year":"2018","journal-title":"J\u00a0Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.jtauto.2019.100017_bib158","doi-asserted-by":"crossref","first-page":"15691","DOI":"10.1038\/ncomms15691","article-title":"Cellular senescence drives age-dependent hepatic steatosis","volume":"8","author":"Ogrodnik","year":"2017","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.jtauto.2019.100017_bib159","doi-asserted-by":"crossref","first-page":"44","DOI":"10.2174\/1573399814666180417122030","article-title":"Complement components, C3 and C4, and the metabolic syndrome","volume":"15","author":"Copenhaver","year":"2019","journal-title":"Curr. Diabetes Rev."},{"issue":"9","key":"10.1016\/j.jtauto.2019.100017_bib160","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/nrm2233","article-title":"Cellular senescence: when bad things happen to good cells","volume":"8","author":"Campisi","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.jtauto.2019.100017_bib161","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1172\/JCI95148","article-title":"Mechanisms and functions of cellular senescence","volume":"128","author":"Herranz","year":"2018","journal-title":"J.\u00a0Clin. Investig."},{"issue":"6","key":"10.1016\/j.jtauto.2019.100017_bib162","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.18632\/aging.101474","article-title":"The expression of C1 inhibitor (C1INH) in macrophages is upregulated by retinal pigment epithelial cells - implication in subretinal immune privilege in the aging eye","volume":"10","author":"Luo","year":"2018","journal-title":"Aging (Albany NY)"},{"issue":"3","key":"10.1016\/j.jtauto.2019.100017_bib163","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2174\/1871528113666140522112003","article-title":"Inflammaging in skin and other tissues - the roles of complement system and macrophage","volume":"13","author":"Zhuang","year":"2014","journal-title":"Inflamm. Allergy - Drug Targets"}],"container-title":["Journal of Translational Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589909019300176?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589909019300176?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T23:35:06Z","timestamp":1762904106000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589909019300176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":163,"alternative-id":["S2589909019300176"],"URL":"https:\/\/doi.org\/10.1016\/j.jtauto.2019.100017","relation":{},"ISSN":["2589-9090"],"issn-type":[{"value":"2589-9090","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The complement system in liver diseases: Evidence-based approach and therapeutic options","name":"articletitle","label":"Article Title"},{"value":"Journal of Translational Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtauto.2019.100017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100017"}}