{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T18:26:53Z","timestamp":1783967213495,"version":"3.55.0"},"reference-count":154,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T00:00:00Z","timestamp":1632096000000},"content-version":"vor","delay-in-days":262,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Translational Autoimmunity"],"published-print":{"date-parts":[[2021]]},"DOI":"10.1016\/j.jtauto.2021.100125","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T03:02:17Z","timestamp":1632193337000},"page":"100125","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Impact of genetic and environmental factors on autoimmune hepatitis"],"prefix":"10.1016","volume":"4","author":[{"given":"Kalliopi","family":"Zachou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinelopi","family":"Arvaniti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aggeliki","family":"Lyberopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George N.","family":"Dalekos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtauto.2021.100125_bib1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3748\/wjg.v21.i1.60","article-title":"Autoimmune hepatitis, one disease with many faces: etiopathogenetic, clinico-laboratory and histological characteristics","volume":"21","author":"Gatselis","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jtauto.2021.100125_bib2","doi-asserted-by":"crossref","first-page":"S100","DOI":"10.1016\/j.jhep.2015.03.005","article-title":"Autoimmune hepatitis \u2013 update 2015","volume":"62","author":"Manns","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jtauto.2021.100125_bib3","doi-asserted-by":"crossref","DOI":"10.1111\/liv.14900","article-title":"Autoimmune hepatitis in patients aged 70 years or older: disease characteristics, treatment response and outcome","author":"Dalekos","year":"2021","journal-title":"Liver Int."},{"key":"10.1016\/j.jtauto.2021.100125_bib4","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1111\/liv.14480","article-title":"Incidence, prevalence and mortality of autoimmune hepatitis in England 1997-2015. A population-based cohort study","volume":"40","author":"Gr\u00f8nb\u00e6k","year":"2020","journal-title":"Liver Int."},{"key":"10.1016\/j.jtauto.2021.100125_bib5","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.jhep.2013.10.020","article-title":"Autoimmune hepatitis in Denmark: incidence, prevalence, prognosis, and causes of death. A nationwide registry-based cohort study","volume":"60","author":"Gr\u00f8nb\u00e6k","year":"2014","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jtauto.2021.100125_bib6","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1111\/liv.14224","article-title":"Increased incidence of autoimmune hepatitis is associated with wider use of biological drugs","volume":"39","author":"Valgeirsson","year":"2019","journal-title":"Liver Int."},{"key":"10.1016\/j.jtauto.2021.100125_bib7","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.dld.2019.01.015","article-title":"Incidence, prevalence, and causes of death of patients with autoimmune hepatitis: a nationwide register-based cohort study in Finland","volume":"51","author":"Puustinen","year":"2019","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.jtauto.2021.100125_bib8","series-title":"Epidemiology and Clinical Characteristics of Autoimmune Hepatitis in the Netherlands","first-page":"1245","author":"van Gerven","year":"2014"},{"key":"10.1016\/j.jtauto.2021.100125_bib9","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/hep.22322","article-title":"International autoimmune hepatitis group, simplified criteria for the diagnosis of autoimmune hepatitis","volume":"48","author":"Hennes","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jtauto.2021.100125_bib10","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.jhep.2015.06.030","article-title":"European association for the study of the liver, EASL clinical practice guidelines: autoimmune hepatitis","volume":"63","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jtauto.2021.100125_bib11","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/apt.12470","article-title":"Review article: autoimmune hepatitis -- current management and challenges","volume":"38","author":"Zachou","year":"2013","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.jtauto.2021.100125_bib12","first-page":"1","article-title":"Hellenic association for the study of the liver clinical practice guidelines: autoimmune hepatitis","author":"Dalekos","year":"2019","journal-title":"Ann. Gastroenterol."},{"key":"10.1016\/j.jtauto.2021.100125_bib13","series-title":"Diagnosis and Management of Autoimmune Hepatitis in Adults and Children: 2019 Practice Guidance and Guidelines from the American Association for the Study of Liver Diseases Hepatology","first-page":"671","author":"Mack","year":"2020"},{"key":"10.1016\/j.jtauto.2021.100125_bib14","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s12072-021-10170-1","article-title":"The Asian Pacific Association for the Study of the Liver clinical practice guidance: the diagnosis and management of patients with autoimmune hepatitis","volume":"15","author":"Wang","year":"2021","journal-title":"Hepatol Int"},{"key":"10.1016\/j.jtauto.2021.100125_bib15","doi-asserted-by":"crossref","first-page":"102619","DOI":"10.1016\/j.jaut.2021.102619","article-title":"Regulatory T cells in autoimmune hepatitis: an updated overview","volume":"119","author":"Longhi","year":"2021","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jtauto.2021.100125_bib16","doi-asserted-by":"crossref","first-page":"4484","DOI":"10.4049\/jimmunol.176.7.4484","article-title":"Functional study of CD4 + CD25 + regulatory T cells in health and autoimmune hepatitis","volume":"176","author":"Longhi","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.jtauto.2021.100125_bib17","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s40246-020-00301-4","article-title":"Genetic risk factors for autoimmune hepatitis: implications for phenotypic heterogeneity and biomarkers for drug response","volume":"15","author":"Higuchi","year":"2021","journal-title":"Hum. Genom."},{"key":"10.1016\/j.jtauto.2021.100125_bib18","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jaut.2018.10.020","article-title":"Etiopathogenesis of autoimmune hepatitis","volume":"95","author":"Floreani","year":"2018","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jtauto.2021.100125_bib19","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.3748\/wjg.15.1025","article-title":"Influence of genes, sex, age and environment on the onset of autoimmune hepatitis","volume":"15","author":"B\u00e9land","year":"2009","journal-title":"WJG"},{"key":"10.1016\/j.jtauto.2021.100125_bib20","doi-asserted-by":"crossref","DOI":"10.1111\/eci.12899","article-title":"Epigenetic changes and their implications in autoimmune hepatitis","volume":"48","author":"Czaja","year":"2018","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.jtauto.2021.100125_bib21","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0016-5085(80)90080-3","article-title":"HLA associations with autoimmune-type chronic active hepatitis: identification of B8-DRw3 haplotype by family studies","volume":"79","author":"Mackay","year":"1980","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jtauto.2021.100125_bib22","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1002\/hep.1840070621","article-title":"Immunogenetic studies of autoimmune chronic active hepatitis: HLA, immunoglobulin allotypes and autoantibodies","volume":"7","author":"Krawitt","year":"1987","journal-title":"Hepatology"},{"key":"10.1016\/j.jtauto.2021.100125_bib23","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/hep.1840130415","article-title":"Susceptibility to autoimmune chronic active hepatitis: human leukocyte antigens DR4 and A1-B8-DR3 are independent risk factors","volume":"13","author":"Donaldson","year":"1991","journal-title":"Hepatology"},{"key":"10.1016\/j.jtauto.2021.100125_bib24","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1002\/hep.1840120609","article-title":"Association of autoimmune hepatitis with HLA-Bw54 and DR4 in Japanese patients","volume":"12","author":"Seki","year":"1990","journal-title":"Hepatology"},{"key":"10.1016\/j.jtauto.2021.100125_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0100565","article-title":"Human leukocyte antigen class II haplotypes affect clinical characteristics and progression of type 1 autoimmune hepatitis in Japan","volume":"9","author":"Umemura","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.jtauto.2021.100125_bib26","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/hep.1840190311","article-title":"Allelic sequence variation in the HLA class II genes and proteins in patients with autoimmune hepatitis","volume":"19","author":"Doherty","year":"1994","journal-title":"Hepatology"},{"key":"10.1016\/j.jtauto.2021.100125_bib27","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1053\/gast.1997.v112.pm9178696","article-title":"Allelic basis for HLA-encoded susceptibility to type 1 autoimmune hepatitis","volume":"112","author":"Strettell","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jtauto.2021.100125_bib28","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1053\/j.gastro.2014.04.022","article-title":"Genome-wide association study identifies variants associated with autoimmune hepatitis type 1","volume":"147","author":"de Boer","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jtauto.2021.100125_bib29","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1055\/s-2002-35705","article-title":"Genetics in autoimmune hepatitis","volume":"22","author":"Donaldson","year":"2002","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.jtauto.2021.100125_bib30","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1136\/gut.2003.031732","article-title":"Genetics of liver disease: immunogenetics and disease pathogenesis","volume":"53","author":"Donaldson","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.jtauto.2021.100125_bib31","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/0016-5085(93)90157-8","article-title":"Significance of HLA DR4 in type 1 autoimmune hepatitis","volume":"105","author":"Czaja","year":"1993","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jtauto.2021.100125_bib32","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/gene.2014.82","article-title":"Dutch Autoimmune Hepatitis Study Group, HLA-DRB1*03:01 and HLA-DRB1*04:01 modify the presentation and outcome in autoimmune hepatitis type-1","volume":"16","author":"van Gerven","year":"2015","journal-title":"Gene Immun."},{"key":"10.1016\/j.jtauto.2021.100125_bib33","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1034\/j.1600-0528.2002.017401.x","article-title":"Genetic susceptibilities for immune expression and liver cell injury in autoimmune hepatitis","volume":"174","author":"Czaja","year":"2000","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jtauto.2021.100125_bib34","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1002\/hep.510300611","article-title":"Pediatric and adult forms of type I autoimmune hepatitis in Argentina: evidence for differential genetic predisposition","volume":"30","author":"Pando","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.jtauto.2021.100125_bib35","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0168-8278(02)00182-4","article-title":"Clinical distinctions and pathogenic implications of type 1 autoimmune hepatitis in Brazil and the United States","volume":"37","author":"Czaja","year":"2002","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jtauto.2021.100125_bib36","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1007\/s10620-007-9859-4","article-title":"HLA DRB1*13 as a risk factor for type 1 autoimmune hepatitis in North American patients","volume":"53","author":"Czaja","year":"2008","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.jtauto.2021.100125_bib37","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0198-8859(00)00234-2","article-title":"Analysis of HLA haplotypes in autoimmune hepatitis type 1: identifying the major susceptibility locus","volume":"62","author":"Goldberg","year":"2001","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.jtauto.2021.100125_bib38","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1111\/j.1478-3231.2007.01581.x","article-title":"Genetic contribution of major histocompatibility complex class II region to type 1 autoimmune hepatitis susceptibility in Venezuela","volume":"27","author":"Fortes","year":"2007","journal-title":"Liver Int."},{"key":"10.1016\/j.jtauto.2021.100125_bib39","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/0198-8859(94)90008-6","article-title":"Chronic active autoimmune hepatitis in children. Strong association with a particular HLA-DR6 (DRB1*1301) haplotype","volume":"41","author":"Fainboim","year":"1994","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.jtauto.2021.100125_bib40","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s12328-015-0620-9","article-title":"Genetic factors affect the etiology, clinical characteristics and outcome of autoimmune hepatitis","volume":"8","author":"Umemura","year":"2015","journal-title":"Clin J Gastroenterol"},{"key":"10.1016\/j.jtauto.2021.100125_bib41","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/0016-5085(92)90041-V","article-title":"HLA class II molecules and autoimmune hepatitis susceptibility in Japanese patients","volume":"103","author":"Seki","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jtauto.2021.100125_bib42","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s12876-015-0360-9","article-title":"Evaluation of the role of HLA-DR antigens in Japanese type 1 autoimmune hepatitis","volume":"15","author":"Furumoto","year":"2015","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.jtauto.2021.100125_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0187325","article-title":"HLA-DRB1 and DQB1 alleles in Japanese type 1 autoimmune hepatitis: the predisposing role of the DR4\/DR8 heterozygous genotype","volume":"12","author":"Oka","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.jtauto.2021.100125_bib44","first-page":"967","article-title":"HLA genotyping in type-I autoimmune hepatitis in Western India","volume":"51","author":"Amarapurkar","year":"2003","journal-title":"J. Assoc. Phys. India"},{"key":"10.1016\/j.jtauto.2021.100125_bib45","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.humimm.2016.01.007","article-title":"HLA-DRB1 alleles of susceptibility and protection in Iranians with autoimmune hepatitis","volume":"77","author":"Baharlou","year":"2016","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.jtauto.2021.100125_bib46","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1053\/j.gastro.2005.12.020","article-title":"Polyclonal T-cell responses to cytochrome P450IID6 are associated with disease activity in autoimmune hepatitis type 2","volume":"130","author":"Ma","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jtauto.2021.100125_bib47","article-title":"Different immunogenetic background in autoimmune hepatitis type 1, type 2 and autoimmune sclerosing cholangitis","volume":"36","author":"Underhill","year":"2002","journal-title":"Journal of Hepatology - J HEPATOL."},{"key":"10.1016\/j.jtauto.2021.100125_bib48","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1824-7288-36-73","article-title":"HLA-DRB1 as a risk factor in children with autoimmune hepatitis and its relation to hepatitis A infection","volume":"36","author":"Elfaramawy","year":"2010","journal-title":"Ital. J. Pediatr."},{"key":"10.1016\/j.jtauto.2021.100125_bib49","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/hep.510250211","article-title":"Associations between alleles of the major histocompatibility complex and type 1 autoimmune hepatitis","volume":"25","author":"Czaja","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.jtauto.2021.100125_bib50","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0016-5085(99)70458-0","article-title":"Cytokine polymorphisms associated with clinical features and treatment outcome in type 1 autoimmune hepatitis","volume":"117","author":"Czaja","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jtauto.2021.100125_bib51","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/hep.510300412","article-title":"Frequency and nature of cytokine gene polymorphisms in type 1 autoimmune hepatitis","volume":"30","author":"Cookson","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.jtauto.2021.100125_bib52","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/hep.510310110","article-title":"Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphisms and susceptibility to type 1 autoimmune hepatitis","volume":"31","author":"Agarwal","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.jtauto.2021.100125_bib53","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/S0198-8859(01)00344-5","article-title":"CTLA-4\/CD 28 region polymorphisms in children from families with autoimmune hepatitis","volume":"62","author":"Djilali-Saiah","year":"2001","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.jtauto.2021.100125_bib54","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1111\/j.1572-0241.2003.07525.x","article-title":"Cytotoxic T lymphocyte antigen-4 gene polymorphisms do not confer susceptibility to autoimmune hepatitis types 1 and 2 in Brazil","volume":"98","author":"Bittencourt","year":"2003","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.jtauto.2021.100125_bib55","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/j.1872-034X.2008.00337.x","article-title":"Association of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with type 1 autoimmune hepatitis in Japanese","volume":"38","author":"Umemura","year":"2008","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.jtauto.2021.100125_bib56","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1053\/jhep.2002.30084","article-title":"Genetic association of vitamin D receptor polymorphisms with primary biliary cirrhosis and autoimmune hepatitis","volume":"35","author":"Vogel","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.jtauto.2021.100125_bib57","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1440-1746.2005.03532.x","article-title":"Genetic association of vitamin D receptor polymorphisms with autoimmune hepatitis and primary biliary cirrhosis in the Chinese","volume":"20","author":"Fan","year":"2005","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jtauto.2021.100125_bib58","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.clim.2009.08.004","article-title":"Vitamin D receptor gene polymorphisms and susceptibility to type 1 diabetes in Crete, Greece","volume":"133","author":"Panierakis","year":"2009","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jtauto.2021.100125_bib59","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1111\/j.1572-0241.2005.41053.x","article-title":"Fas polymorphisms influence susceptibility to autoimmune hepatitis","volume":"100","author":"Hiraide","year":"2005","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.jtauto.2021.100125_bib60","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.clim.2009.11.004","article-title":"The most severe forms of type I autoimmune hepatitis are associated with genetically determined levels of TGF-beta1","volume":"134","author":"Paladino","year":"2010","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jtauto.2021.100125_bib61","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.humimm.2010.10.019","article-title":"Association of TBX21 promoter polymorphisms with type 1 autoimmune hepatitis in a Chinese population","volume":"72","author":"Chen","year":"2011","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.jtauto.2021.100125_bib62","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0071382","article-title":"Association of STAT4 polymorphisms with susceptibility to type-1 autoimmune hepatitis in the Japanese population","volume":"8","author":"Migita","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.jtauto.2021.100125_bib63","doi-asserted-by":"crossref","first-page":"5199","DOI":"10.4049\/jimmunol.164.10.5199","article-title":"Cloning and characterization of human Lnk, an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation","volume":"164","author":"Li","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.jtauto.2021.100125_bib64","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/jhg.2016.155","article-title":"Association of a single nucleotide polymorphism upstream of ICOS with Japanese autoimmune hepatitis type 1","volume":"62","author":"Higuchi","year":"2017","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.jtauto.2021.100125_bib65","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/jhg.2017.74","article-title":"Association of autoimmune hepatitis with Src homology 2 adaptor protein 3 gene polymorphisms in Japanese patients","volume":"62","author":"Umemura","year":"2017","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.jtauto.2021.100125_bib66","doi-asserted-by":"crossref","first-page":"3506","DOI":"10.1007\/s10620-016-4322-z","article-title":"A macrophage migration inhibitory factor polymorphism is associated with autoimmune hepatitis severity in US and Japanese patients","volume":"61","author":"Assis","year":"2016","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.jtauto.2021.100125_bib67","doi-asserted-by":"crossref","first-page":"29770","DOI":"10.1038\/srep29770","article-title":"Genetic association of PTPN22 polymorphisms with autoimmune hepatitis and primary biliary cholangitis in Japan","volume":"6","author":"Umemura","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jtauto.2021.100125_bib68","doi-asserted-by":"crossref","first-page":"7925","DOI":"10.1038\/s41598-019-44524-5","article-title":"Role of deleterious single nucleotide variants in the coding regions of TNFAIP3 for Japanese autoimmune hepatitis with cirrhosis","volume":"9","author":"Higuchi","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jtauto.2021.100125_bib69","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/s10038-018-0440-0","article-title":"Association of a single nucleotide polymorphism in TNIP1 with type-1 autoimmune hepatitis in the Japanese population","volume":"63","author":"Oka","year":"2018","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.jtauto.2021.100125_bib70","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cyto.2018.01.009","article-title":"Association of interleukin (IL)-4 variable number of tandem repeats (VNTRs) and IL-4-590 promoter polymorphisms with susceptibility to pediatric autoimmune hepatitis type 1","volume":"110","author":"Mansour","year":"2018","journal-title":"Cytokine"},{"key":"10.1016\/j.jtauto.2021.100125_bib71","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/gene.2016.7","article-title":"The early onset of type 1 autoimmune hepatitis has a strong genetic influence: role of HLA and KIR genes","volume":"17","author":"Podhorzer","year":"2016","journal-title":"Gene Immun."},{"key":"10.1016\/j.jtauto.2021.100125_bib72","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jaut.2009.03.005","article-title":"Female predominance and X chromosome defects in autoimmune diseases","volume":"33","author":"Invernizzi","year":"2009","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jtauto.2021.100125_bib73","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0140-6736(04)15541-4","article-title":"Frequency of monosomy X in women with primary biliary cirrhosis","volume":"363","author":"Invernizzi","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.jtauto.2021.100125_bib74","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/hep.21696","article-title":"Preferential X chromosome loss but random inactivation characterize primary biliary cirrhosis","volume":"46","author":"Miozzo","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jtauto.2021.100125_bib75","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1023\/A:1018836004279","article-title":"Immune phenotype of chronic liver disease","volume":"43","author":"Czaja","year":"1998","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.jtauto.2021.100125_bib76","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.hepres.2003.12.002","article-title":"Autoimmunity and the female liver","volume":"28","author":"McFarlane","year":"2004","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.jtauto.2021.100125_bib77","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1126\/science.283.5406.1277","article-title":"A gender gap in autoimmunity","volume":"283","author":"Whitacre","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.jtauto.2021.100125_bib78","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/0140-6736(91)92858-Y","article-title":"Identification of hepatitis A virus as a trigger for autoimmune chronic hepatitis type 1 in susceptible individuals","volume":"337","author":"Vento","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.jtauto.2021.100125_bib79","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/0168-8278(95)80336-X","article-title":"Zum B\u00fcschenfelde, Autoimmune hepatitis following hepatitis A virus infection","volume":"23","author":"Huppertz","year":"1995","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jtauto.2021.100125_bib80","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1023\/A:1026645629103","article-title":"Autoimmune hepatitis in a genetically susceptible patient: is it triggered by acute viral hepatitis A?","volume":"44","author":"Hilzenrat","year":"1999","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.jtauto.2021.100125_bib81","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1111\/j.1572-0241.2002.05751.x","article-title":"Autoimmune hepatitis preceded by acute hepatitis A infection","volume":"97","author":"Skoog","year":"2002","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.jtauto.2021.100125_bib82","first-page":"187","article-title":"Autoimmune hepatitis \u2013 sequel of a relapsing hepatitis A in a 75-year-old woman","volume":"70","author":"Gr\u00fcnhage","year":"2004","journal-title":"DIG"},{"key":"10.1016\/j.jtauto.2021.100125_bib83","doi-asserted-by":"crossref","first-page":"6069","DOI":"10.3748\/wjg.v11.i38.6069","article-title":"Autoimmune hepatitis triggered by acute hepatitis A","volume":"11","author":"Tanaka","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jtauto.2021.100125_bib84","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S1665-2681(19)31878-2","article-title":"Autoimmune hepatitis induced by the prolonged hepatitis A virus infection","volume":"7","author":"Tabak","year":"2008","journal-title":"Ann. Hepatol."},{"key":"10.1016\/j.jtauto.2021.100125_bib85","doi-asserted-by":"crossref","first-page":"315","DOI":"10.4166\/kjg.2011.57.5.315","article-title":"A case of autoimmune hepatitis following acute hepatitis A","volume":"57","author":"Kim","year":"2011","journal-title":"Korean J. Gastroenterol."},{"key":"10.1016\/j.jtauto.2021.100125_bib86","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1136\/gut.2006.111864","article-title":"Autoimmune hepatitis triggered by hepatitis A","volume":"56","author":"Singh","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.jtauto.2021.100125_bib87","first-page":"V12140669","volume":"177","author":"Grave","year":"2015","journal-title":"Autoimmune hepatitis preceded by hepatitis A, Ugeskr Laeger."},{"key":"10.1016\/j.jtauto.2021.100125_bib88","doi-asserted-by":"crossref","DOI":"10.14309\/crj.0000000000000441","article-title":"Postinfectious autoimmune hepatitis-induced liver failure: a consequence of hepatitis A virus infection","volume":"7","author":"Subramanian","year":"2020","journal-title":"ACG Case Rep J"},{"key":"10.1016\/j.jtauto.2021.100125_bib89","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/0140-6736(90)90070-L","article-title":"Type 2 autoimmune hepatitis and hepatitis C virus infection","volume":"335","author":"Lenzi","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.jtauto.2021.100125_bib90","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0140-6736(92)91332-3","article-title":"Anti-GOR and hepatitis C virus in autoimmune liver diseases","volume":"339","author":"Michel","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.jtauto.2021.100125_bib91","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/hep.1840160304","article-title":"Liver\/kidney microsome antibody type 1 and hepatitis C virus infection","volume":"16","author":"Lunel","year":"1992","journal-title":"Hepatology"},{"key":"10.1016\/j.jtauto.2021.100125_bib92","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S0168-8278(99)80092-0","article-title":"Epitope mapping of cytochrome P4502D6 autoantigen in patients with chronic hepatitis C during alpha-interferon treatment","volume":"30","author":"Dalekos","year":"1999","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jtauto.2021.100125_bib93","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/00042737-200201000-00007","article-title":"Increased incidence of anti-LKM autoantibodies in a consecutive cohort of hepatitis C patients from central Greece","volume":"14","author":"Dalekos","year":"2002","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jtauto.2021.100125_bib94","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/S0168-8278(03)00356-8","article-title":"Cytochrome P450 2A6: a new hepatic autoantigen in patients with chronic hepatitis C virus infection","volume":"39","author":"Dalekos","year":"2003","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jtauto.2021.100125_bib95","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1016\/0016-5085(94)90426-X","article-title":"Primary and secondary liver\/kidney microsomal autoantibody response following infection with hepatitis C virus","volume":"106","author":"Mackie","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jtauto.2021.100125_bib96","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00281-012-0328-6","article-title":"Autoimmune manifestations in viral hepatitis","volume":"35","author":"Vergani","year":"2013","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.jtauto.2021.100125_bib97","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.4049\/jimmunol.170.3.1481","article-title":"Cytochrome P4502D6(193-212): a new immunodominant epitope and target of virus\/self cross-reactivity in liver kidney microsomal autoantibody type 1-positive liver disease","volume":"170","author":"Kerkar","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.jtauto.2021.100125_bib98","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.2174\/092986708785747508","article-title":"Enzymes as target antigens of liver-specific autoimmunity: the case of cytochromes P450s","volume":"15","author":"Bogdanos","year":"2008","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.jtauto.2021.100125_bib99","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/hep.20109","article-title":"A murine model of type 2 autoimmune hepatitis: xenoimmunization with human antigens","volume":"39","author":"Lapierre","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.jtauto.2021.100125_bib100","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1002\/hep.23536","article-title":"Forkhead box p3+ regulatory T cell underlies male resistance to experimental type 2 autoimmune hepatitis","volume":"51","author":"Lapierre","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jtauto.2021.100125_bib101","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/hep.510240309","article-title":"Autoantibody prevalence in chronic hepatitis B virus infection: effect in interferon alfa","volume":"24","author":"Gregorio","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.jtauto.2021.100125_bib102","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0953-6205(02)00089-4","article-title":"Autoantibodies and defined target autoantigens in autoimmune hepatitis: an overview","volume":"13","author":"Dalekos","year":"2002","journal-title":"Eur. J. Intern. Med."},{"key":"10.1016\/j.jtauto.2021.100125_bib103","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1111\/j.1365-2036.2006.03165.x","article-title":"Clinical significance of organ- and non-organ-specific autoantibodies on the response to anti-viral treatment of patients with chronic hepatitis C","volume":"24","author":"Gatselis","year":"2006","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.jtauto.2021.100125_bib104","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1665-2681(19)30914-7","article-title":"Autoimmune hepatitis in patients with chronic HBV and HCV infections: patterns of clinical characteristics, disease progression and outcome","volume":"13","author":"Rigopoulou","year":"2013","journal-title":"Ann. Hepatol."},{"key":"10.1016\/j.jtauto.2021.100125_bib105","first-page":"232","article-title":"Microsomal autoantibodies in chronic infection with the HBsAg associated delta (delta) agent","volume":"54","author":"Crivelli","year":"1983","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jtauto.2021.100125_bib106","doi-asserted-by":"crossref","first-page":"S531","DOI":"10.1016\/S0168-8278(15)30782-0","article-title":"P0576\u00a0: impact of organ and non-organ-specific autoantibodies on the treatment outcome of patients with hepatitis D virus infection","volume":"62","author":"Zachou","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jtauto.2021.100125_bib107","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1016\/S0016-5085(96)70020-3","article-title":"Autoantibodies against glucuronosyltransferases differ between viral hepatitis and autoimmune hepatitis","volume":"111","author":"Strassburg","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jtauto.2021.100125_bib108","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2018.07.006","article-title":"Autoimmune liver disease serology in acute hepatitis E virus infection","volume":"94","author":"Terziroli Beretta-Piccoli","year":"2018","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jtauto.2021.100125_bib109","first-page":"115","article-title":"Hepatitis E viral association with autoimmune hepatitis: a viral trigger or cross-reactivity","volume":"15","author":"Elfert","year":"2021","journal-title":"CRG"},{"key":"10.1016\/j.jtauto.2021.100125_bib110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0085330","article-title":"Increased HEV seroprevalence in patients with autoimmune hepatitis","volume":"9","author":"Pischke","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.jtauto.2021.100125_bib111","doi-asserted-by":"crossref","first-page":"17452","DOI":"10.1038\/s41598-018-35882-7","article-title":"Increased seroprevalence of HAV and parvovirus B19 in children and of HEV in adults at diagnosis of autoimmune hepatitis","volume":"8","author":"Taubert","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jtauto.2021.100125_bib112","article-title":"High seroprevalence of anti\u2010hepatitis E antibodies in Austrian patients with autoimmune hepatitis","volume":"39","author":"Eder","year":"2018","journal-title":"Liver Int."},{"key":"10.1016\/j.jtauto.2021.100125_bib113","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/S0140-6736(95)91932-5","article-title":"A young woman with hepatitis after a sore throat","volume":"346","author":"Aceti","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.jtauto.2021.100125_bib114","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1007\/s005350050324","article-title":"Epstein-Barr virus infection resembling autoimmune hepatitis with lactate dehydrogenase and alkaline phosphatase anomaly","volume":"34","author":"Kojima","year":"1999","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.jtauto.2021.100125_bib115","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/01.inf.0000060825.68086.9c","article-title":"Autoimmune Hepatitis type 1 after Epstein-Barr virus infection","volume":"22","author":"Nobili","year":"2003","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.jtauto.2021.100125_bib116","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S0140-6736(95)91438-2","article-title":"Epstein-Barr virus as a trigger for autoimmune hepatitis in susceptible individuals","volume":"346","author":"Vento","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.jtauto.2021.100125_bib117","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S1665-2681(19)31398-5","article-title":"Autoimmune hepatitis type-2 and Epstein-Barr virus infection in a toddler: art of facts or an artifact?","volume":"12","author":"Zellos","year":"2013","journal-title":"Ann. Hepatol."},{"key":"10.1016\/j.jtauto.2021.100125_bib118","article-title":"Autoimmune hepatitis following Epstein-Barr virus infection","volume":"2008","author":"Cabibi","year":"2008","journal-title":"BMJ Case Rep."},{"key":"10.1016\/j.jtauto.2021.100125_bib119","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1002\/hep.23588","article-title":"Drug-induced autoimmune hepatitis: clinical characteristics and prognosis","volume":"51","author":"Bj\u00f6rnsson","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jtauto.2021.100125_bib120","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1007\/s10620-011-1611-4","article-title":"Drug-induced autoimmune-like hepatitis","volume":"56","author":"Czaja","year":"2011","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.jtauto.2021.100125_bib121","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jhep.2013.02.029","article-title":"Use of TNF\u03b1 antagonists in refractory AIH: revealing the unforeseen","volume":"59","author":"Saitis","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jtauto.2021.100125_bib122","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.jhep.2019.02.014","article-title":"Electronic address: easloffice@easloffice.eu, clinical practice guideline panel: chair:, panel members, EASL governing board representative:, EASL clinical practice guidelines: drug-induced liver injury","volume":"70","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jtauto.2021.100125_bib123","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1073\/pnas.84.2.551","article-title":"Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug","volume":"84","author":"Beaune","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jtauto.2021.100125_bib124","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1172\/JCI114660","article-title":"Anti-liver endoplasmic reticulum autoantibodies are directed against human cytochrome P-450IA2. A specific marker of dihydralazine-induced hepatitis","volume":"85","author":"Bourdi","year":"1990","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jtauto.2021.100125_bib125","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.jhep.2011.02.024","article-title":"Drug induced liver injury and its relationship to autoimmune hepatitis","volume":"55","author":"Weiler-Normann","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jtauto.2021.100125_bib126","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1055\/s-2007-1007348","article-title":"Immunologic reactions in alcoholic liver disease","volume":"13","author":"Paronetto","year":"1993","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.jtauto.2021.100125_bib127","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/S0016-5085(98)70148-9","article-title":"Detection of circulating antibodies to malondialdehyde-acetaldehyde adducts in ethanol-fed rats","volume":"115","author":"Xu","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jtauto.2021.100125_bib128","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1007\/s12072-013-9448-x","article-title":"Autoimmune hepatitis: the role of environmental risk factors: a population-based study","volume":"7","author":"Ngu","year":"2013","journal-title":"Hepatol Int"},{"key":"10.1016\/j.jtauto.2021.100125_bib129","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ejim.2020.12.024","article-title":"Alcoholic liver disease and autoimmune hepatitis: sometimes a closer look under the surface is needed","volume":"85","author":"Rigopoulou","year":"2021","journal-title":"Eur. J. Intern. Med."},{"key":"10.1016\/j.jtauto.2021.100125_bib130","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1172\/JCI115836","article-title":"A T cell-dependent experimental liver injury in mice inducible by concanavalin A","volume":"90","author":"Tiegs","year":"1992","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jtauto.2021.100125_bib131","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/hep.21076","article-title":"Increased prevalence of primary biliary cirrhosis near Superfund toxic waste sites","volume":"43","author":"Ala","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.jtauto.2021.100125_bib132","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ejim.2017.05.006","article-title":"Geoepidemiology, clinical manifestations and outcome of primary biliary cholangitis in Greece","volume":"42","author":"Gatselis","year":"2017","journal-title":"Eur. J. Intern. Med."},{"key":"10.1016\/j.jtauto.2021.100125_bib133","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1080\/14737159.2016.1217159","article-title":"Molecular diagnostic testing for primary biliary cholangitis","volume":"16","author":"Gatselis","year":"2016","journal-title":"Expert Rev. Mol. Diagn"},{"key":"10.1016\/j.jtauto.2021.100125_bib134","doi-asserted-by":"crossref","first-page":"5874","DOI":"10.4049\/jimmunol.174.9.5874","article-title":"Chemical xenobiotics and mitochondrial autoantigens in primary biliary cirrhosis: identification of antibodies against a common environmental, cosmetic, and food additive, 2-octynoic acid","volume":"174","author":"Amano","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.jtauto.2021.100125_bib135","first-page":"248157","article-title":"Xenobiotic exposure and autoimmune hepatitis","volume":"2010","author":"Gilbert","year":"2010","journal-title":"Hepat Res Treat"},{"key":"10.1016\/j.jtauto.2021.100125_bib136","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1517\/14728222.2013.838219","article-title":"MicroRNAs and multiple sclerosis: from physiopathology toward therapy","volume":"17","author":"Zare-Shahabadi","year":"2013","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.jtauto.2021.100125_bib137","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0136908","article-title":"Circulating microRNA profiles in patients with type-1 autoimmune hepatitis","volume":"10","author":"Migita","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.jtauto.2021.100125_bib138","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.clinbiochem.2017.08.010","article-title":"Serum microRNA profiles in patients with chronic hepatitis B, chronic hepatitis C, primary biliary cirrhosis, autoimmune hepatitis, nonalcoholic steatohepatitis, or drug-induced liver injury","volume":"50","author":"Yamaura","year":"2017","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.jtauto.2021.100125_bib139","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.molimm.2017.11.008","article-title":"BMSCs-derived miR-223-containing exosomes contribute to liver protection in experimental autoimmune hepatitis","volume":"93","author":"Chen","year":"2018","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.jtauto.2021.100125_bib140","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.toxlet.2016.06.010","article-title":"MicroRNA-674-5p\/5-LO axis involved in autoimmune reaction of Concanavalin A-induced acute mouse liver injury","volume":"258","author":"Su","year":"2016","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.jtauto.2021.100125_bib141","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1139\/cjpp-2018-0467","article-title":"Inhibition of microRNA-155 attenuates concanavalin-A-induced autoimmune hepatitis by regulating Treg\/Th17 cell differentiation","volume":"96","author":"Xia","year":"2018","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.jtauto.2021.100125_bib142","doi-asserted-by":"crossref","first-page":"10","DOI":"10.2302\/kjm.60.10","article-title":"Epigenetics and autoimmunity, with special emphasis on methylation","volume":"60","author":"Renaudineau","year":"2011","journal-title":"Keio J. Med."},{"key":"10.1016\/j.jtauto.2021.100125_bib143","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1101\/gad.276568.115","article-title":"Role of TET enzymes in DNA methylation, development, and cancer","author":"D Rasmussen","year":"2016","journal-title":"Genes Dev."},{"key":"10.1016\/j.jtauto.2021.100125_bib144","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1136\/gutjnl-2012-302962","article-title":"Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease","volume":"62","author":"Pirola","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.jtauto.2021.100125_bib145","article-title":"Epigenetic modifications in the biology of nonalcoholic fatty liver disease: the role of DNA hydroxymethylation and TET proteins","volume":"94","author":"Pirola","year":"2015","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.jtauto.2021.100125_bib146","doi-asserted-by":"crossref","DOI":"10.1186\/s13148-015-0098-9","article-title":"DNA methylation profiling of the X chromosome reveals an aberrant demethylation on CXCR3 promoter in primary biliary cirrhosis","volume":"7","author":"Lleo","year":"2015","journal-title":"Clin. Epigenet."},{"key":"10.1016\/j.jtauto.2021.100125_bib147","first-page":"128","article-title":"Genome-wide analysis of DNA methylation, copy number variation, and gene expression in monozygotic twins discordant for primary biliary cirrhosis","volume":"5","author":"Selmi","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jtauto.2021.100125_bib148","doi-asserted-by":"crossref","unstructured":"Zachou K, Arvaniti P, Lyberopoulou A, Sevdali E, Speletas M, Ioannou M, Koukoulis G.K, Renaudineau Y, Dalekos G.N. Altered DNA Methylation Pattern Characterizes the Peripheral Immune Cells of Patients with Autoimmune Hepatitis. medRxivhttps:\/\/doi.org\/10.1101\/2021.07.01.21259836.","DOI":"10.1101\/2021.07.01.21259836"},{"key":"10.1016\/j.jtauto.2021.100125_bib149","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/cmi.2010.78","article-title":"The epigenetics of autoimmunity","volume":"8","author":"Meda","year":"2011","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.jtauto.2021.100125_bib150","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1586\/1744666X.2015.994507","article-title":"Autoimmune disease in the epigenetic era: how has epigenetics changed our understanding of disease and how can we expect the field to evolve?","volume":"11","author":"Jeffries","year":"2015","journal-title":"Expet Rev. Clin. Immunol."},{"key":"10.1016\/j.jtauto.2021.100125_bib151","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.cell.2013.03.011","article-title":"Methylation-dependent and -independent genomic targeting principles of the MBD protein family","volume":"153","author":"Baubec","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.jtauto.2021.100125_bib152","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s12016-009-8172-8","article-title":"Epigenetic therapeutics in autoimmune disease","volume":"39","author":"Szyf","year":"2010","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.jtauto.2021.100125_bib153","doi-asserted-by":"crossref","first-page":"108314","DOI":"10.1016\/j.clim.2019.108314","article-title":"Linking genetic variation with epigenetic profiles in Sj\u00f6gren\u2019s syndrome","volume":"210","author":"Arvaniti","year":"2020","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jtauto.2021.100125_bib154","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004663","article-title":"Methylation QTLs are associated with coordinated changes in transcription factor binding, histone modifications, and gene expression levels","volume":"10","author":"Banovich","year":"2014","journal-title":"PLoS Genet."}],"container-title":["Journal of Translational Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589909021000459?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589909021000459?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T23:37:52Z","timestamp":1762904272000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589909021000459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":154,"alternative-id":["S2589909021000459"],"URL":"https:\/\/doi.org\/10.1016\/j.jtauto.2021.100125","relation":{},"ISSN":["2589-9090"],"issn-type":[{"value":"2589-9090","type":"print"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of genetic and environmental factors on autoimmune hepatitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Translational Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtauto.2021.100125","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100125"}}