{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:28:48Z","timestamp":1793395728633,"version":"4.5.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"vor","delay-in-days":285,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004212","name":"P\u00e4ivikki ja Sakari Sohlbergin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004212","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004371","name":"Tampereen yliopisto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004371","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010600","name":"Tays","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010600","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Translational Autoimmunity"],"published-print":{"date-parts":[[2021]]},"DOI":"10.1016\/j.jtauto.2021.100128","type":"journal-article","created":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T02:09:09Z","timestamp":1634350149000},"page":"100128","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Dissecting the contribution of single nucleotide polymorphisms in CCR9 and CCL25 genomic regions to the celiac disease phenotype"],"prefix":"10.1016","volume":"4","author":[{"given":"Laura","family":"Airaksinen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8220-3503","authenticated-orcid":false,"given":"Juliana XM.","family":"Cerqueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heini","family":"Huhtala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e4ivi","family":"Saavalainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawit A.","family":"Yohannes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markku","family":"M\u00e4ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalle","family":"Kurppa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elina","family":"Kilpel\u00e4inen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Shcherban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarno","family":"Palotie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katri","family":"Kaukinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7417-5151","authenticated-orcid":false,"given":"Katri","family":"Lindfors","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtauto.2021.100128_bib1","first-page":"1","article-title":"Coeliac disease","volume":"5","author":"Lindfors","year":"2019","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.jtauto.2021.100128_bib2","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/j.0001-2815.2004.00237.x","article-title":"HLA-DQ relative risks for coeliac disease in European populations: a study of the European Genetics Cluster on Coeliac Disease","volume":"63","author":"Margaritte-Jeannin","year":"2004","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.jtauto.2021.100128_bib3","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.cgh.2009.05.028","article-title":"Stratifying risk for celiac disease in a large at-risk United States population by using HLA alleles","volume":"7","author":"Pietzak","year":"2009","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jtauto.2021.100128_bib4","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.4049\/jimmunol.165.9.5069","article-title":"The role of thymus-expressed chemokine and its receptor CCR9 on lymphocytes in the regional specialization of the mucosal immune system","volume":"165","author":"Papadakis","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.jtauto.2021.100128_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.536326","article-title":"The regulatory function of CCR9+ dendritic cells in inflammation and autoimmunity","volume":"11","author":"Pathak","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jtauto.2021.100128_bib6","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201900989","article-title":"Circulating dendritic cells from celiac disease patients display a gut-homing profile and are differentially modulated by different gliadin-derived peptides","volume":"64","author":"Escudero-Hern\u00e1ndez","year":"2020","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.jtauto.2021.100128_bib7","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1053\/j.gastro.2007.04.023","article-title":"Reduced chemokine receptor 9 on intraepithelial lymphocytes in celiac disease suggests persistent epithelial activation","volume":"132","author":"Olaussen","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jtauto.2021.100128_bib8","unstructured":"A Phase II Study of CCX282-B in Patients With Celiac Disease - Full Text View - ClinicalTrials.gov, (n.d.). https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT00540657 (accessed April 26, 2021)."},{"key":"10.1016\/j.jtauto.2021.100128_bib9","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/ng.543","article-title":"Multiple common variants for celiac disease influencing immune gene expression","volume":"42","author":"Dubois","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jtauto.2021.100128_bib10","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/ng.998","article-title":"Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease","volume":"43","author":"Trynka","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jtauto.2021.100128_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152476","article-title":"Identification of non-HLA genes associated with celiac disease and country-specific differences in a large, international pediatric cohort","volume":"11","author":"Sharma","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jtauto.2021.100128_bib12","doi-asserted-by":"crossref","DOI":"10.1093\/ije\/dyx239","article-title":"Cohort profile: the national FINRISK study","volume":"47","author":"Borodulin","year":"2018","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.jtauto.2021.100128_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-017-01261-5","article-title":"Functional mapping and annotation of genetic associations with FUMA","volume":"8","author":"Watanabe","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jtauto.2021.100128_bib14","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1101\/gr.137323.112","article-title":"Annotation of functional variation in personal genomes using RegulomeDB","volume":"22","author":"Boyle","year":"2012","journal-title":"Genome Res."},{"issue":"80","key":"10.1016\/j.jtauto.2021.100128_bib15","first-page":"1318","article-title":"The GTEx Consortium atlas of genetic regulatory effects across human tissues","volume":"369","author":"Aguet","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jtauto.2021.100128_bib16","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/ng.2756","article-title":"Systematic identification of trans eQTLs as putative drivers of known disease associations","volume":"45","author":"Westra","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jtauto.2021.100128_bib17","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/ng.3737","article-title":"Identification of context-dependent expression quantitative trait loci in whole blood","volume":"49","author":"Zhernakova","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jtauto.2021.100128_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-04365-8","article-title":"IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes","volume":"9","author":"Momozawa","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jtauto.2021.100128_bib19","first-page":"1","article-title":"Independent and cumulative coeliac disease-susceptibility loci are associated with distinct disease phenotypes","author":"Cerqueira","year":"2021","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.jtauto.2021.100128_bib20","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/ng2088","article-title":"A new multipoint method for genome-wide association studies by imputation of genotypes","volume":"39","author":"Marchini","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jtauto.2021.100128_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152476","article-title":"Identification of non-HLA genes associated with celiac disease and country-specific differences in a large, international pediatric cohort","volume":"11","author":"Sharma","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jtauto.2021.100128_bib22","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature11247","article-title":"An integrated encyclopedia of DNA elements in the human genome","volume":"489","author":"Dunham","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jtauto.2021.100128_bib23","doi-asserted-by":"crossref","first-page":"4385","DOI":"10.1007\/s00018-018-2898-5","article-title":"Celiac disease biomarkers identified by transcriptome analysis of small intestinal biopsies","volume":"75","author":"Bragde","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.jtauto.2021.100128_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0215132","article-title":"RNA sequencing of intestinal mucosa reveals novel pathways functionally linked to celiac disease pathogenesis","volume":"14","author":"Leonard","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.jtauto.2021.100128_bib25","first-page":"13","article-title":"Genome-wide transcriptomic analysis of intestinal mucosa in celiac disease patients on a gluten-free diet and postgluten challenge","volume":"11","author":"Dotsenko","year":"2021","journal-title":"CMGH"},{"key":"10.1016\/j.jtauto.2021.100128_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000456","article-title":"Rapid and accurate multiple testing correction and power estimation for millions of correlated markers","volume":"5","author":"Han","year":"2009","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jtauto.2021.100128_bib27","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/s12859-021-04107-6","article-title":"Optimized permutation testing for information theoretic measures of multi-gene interactions","volume":"22","author":"Kunert-Graf","year":"2021","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.jtauto.2021.100128_bib28","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.152.7.3282","article-title":"Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivo","volume":"152","author":"Hamann","year":"1994","journal-title":"J. Immunol."},{"key":"10.1016\/j.jtauto.2021.100128_bib29","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1053\/j.gastro.2011.09.015","article-title":"Gut-tropic T cells that express integrin \u03b14\u03b27 and CCR9 Are required for induction of oral immune tolerance in mice","volume":"141","author":"Cassani","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jtauto.2021.100128_bib30","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/apt.16161","article-title":"Review article: exposure to microbes and risk of coeliac disease","volume":"53","author":"St\u00f8rdal","year":"2021","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.jtauto.2021.100128_bib31","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1001\/jama.2019.10329","article-title":"Association of gluten intake during the first 5 years of life with incidence of celiac disease autoimmunity and celiac disease among children at increased risk","volume":"322","author":"Andr\u00e9n Aronsson","year":"2019","journal-title":"JAMA, J. Am. Med. Assoc."},{"key":"10.1016\/j.jtauto.2021.100128_bib32","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.3109\/00365521.2014.923502","article-title":"Factors associated with long diagnostic delay in celiac disease","volume":"49","author":"Fuchs","year":"2014","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.jtauto.2021.100128_bib33","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/bmt.2009.131","article-title":"Donor single nucleotide polymorphism in the CCR9 gene affects the incidence of skin GVHD","volume":"45","author":"Inamoto","year":"2010","journal-title":"Bone Marrow Transplant."}],"container-title":["Journal of Translational Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589909021000484?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589909021000484?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T23:36:12Z","timestamp":1762904172000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589909021000484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":33,"alternative-id":["S2589909021000484"],"URL":"https:\/\/doi.org\/10.1016\/j.jtauto.2021.100128","relation":{},"ISSN":["2589-9090"],"issn-type":[{"value":"2589-9090","type":"print"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dissecting the contribution of single nucleotide polymorphisms in CCR9 and CCL25 genomic regions to the celiac disease phenotype","name":"articletitle","label":"Article Title"},{"value":"Journal of Translational Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtauto.2021.100128","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100128"}}