{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:36:41Z","timestamp":1787683001449,"version":"build-2784847793"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160309"],"award-info":[{"award-number":["82160309"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","award":["2021BS08006"],"award-info":[{"award-number":["2021BS08006"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Translational Autoimmunity"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.jtauto.2024.100242","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T02:46:20Z","timestamp":1714704380000},"page":"100242","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Triptolide regulates neutrophil function through the Hippo signaling pathway to alleviate rheumatoid arthritis disease progression"],"prefix":"10.1016","volume":"8","author":[{"given":"Pengyuan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Sang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7895-1776","authenticated-orcid":false,"given":"Li","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.jtauto.2024.100242_bib1","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1002\/art.27584","article-title":"Rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League against Rheumatism collaborative initiative","volume":"62","author":"Aletaha","year":"2010","journal-title":"Arthritis Rheum."},{"issue":"7","key":"10.1016\/j.jtauto.2024.100242_bib2","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1002\/art.39117","article-title":"CCR2 expression in neutrophils plays a critical role in their migration into the joints in rheumatoid arthritis","volume":"67","author":"Talbot","year":"2015","journal-title":"Arthritis Rheumatol."},{"issue":"6","key":"10.1016\/j.jtauto.2024.100242_bib3","doi-asserted-by":"crossref","first-page":"R187","DOI":"10.1186\/ar4377","article-title":"Cyr61 is involved in neutrophil infiltration in joints by inducing IL-8 production by fibroblast-like synoviocytes in rheumatoid arthritis","volume":"15","author":"Zhu","year":"2013","journal-title":"Arthritis Res. Ther."},{"issue":"2","key":"10.1016\/j.jtauto.2024.100242_bib4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1365-2567.2006.02424.x","article-title":"Essential role of neutrophils in anti-type II collagen antibody and lipopolysaccharide-induced arthritis","volume":"119","author":"Tanaka","year":"2006","journal-title":"Immunology"},{"issue":"20","key":"10.1016\/j.jtauto.2024.100242_bib5","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1182\/blood-2012-09-456483","article-title":"Neutrophil myeloperoxidase regulates T-cell-driven tissue inflammation in mice by inhibiting dendritic cell function","volume":"121","author":"Odobasic","year":"2013","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.jtauto.2024.100242_bib6","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/rheumatology\/ket309","article-title":"Neutrophils produce interleukin-17B in rheumatoid synovial tissue","volume":"53","author":"Kouri","year":"2014","journal-title":"Rheumatology"},{"issue":"9990","key":"10.1016\/j.jtauto.2024.100242_bib7","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S0140-6736(14)61704-9","article-title":"Risk of serious infection in biological treatment of patients with rheumatoid arthritis: a systematic review and meta-analysis","volume":"386","author":"Singh","year":"2015","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.jtauto.2024.100242_bib8","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00784-016-1808-1","article-title":"Triptolide represses oral cancer cell proliferation, invasion, migration, and angiogenesis in co-inoculation with U937 cells","volume":"21","author":"Yang","year":"2017","journal-title":"Clin. Oral Invest."},{"issue":"3","key":"10.1016\/j.jtauto.2024.100242_bib9","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ."},{"issue":"Suppl 2","key":"10.1016\/j.jtauto.2024.100242_bib10","article-title":"Regulation of macrophage activation by proteins expressed on apoptotic neutrophils: subversion towards autoimmunity by proteinase 3","volume":"48","author":"Thieblemont","year":"2018","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.jtauto.2024.100242_bib11","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41420-020-0255-6","article-title":"The role of neutrophil death in chronic inflammation and cancer","volume":"6","author":"Brostjan","year":"2020","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.jtauto.2024.100242_bib12","doi-asserted-by":"crossref","first-page":"406","DOI":"10.3389\/fcimb.2019.00406","article-title":"ZBP1 and TAK1: master regulators of NLRP3 inflammasome\/pyroptosis, apoptosis, and necroptosis (PAN-optosis)","volume":"9","author":"Malireddi","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.jtauto.2024.100242_bib13","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.molimm.2018.06.012","article-title":"Triptolide inhibits the inflammatory activities of neutrophils to ameliorate chronic arthritis","volume":"101","author":"Huang","year":"2018","journal-title":"Mol. Immunol."},{"issue":"5","key":"10.1016\/j.jtauto.2024.100242_bib14","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00109-005-0022-4","article-title":"Mechanism of triptolide-induced apoptosis: effect on caspase activation and Bid cleavage and essentiality of the hydroxyl group of triptolide","volume":"84","author":"Wang","year":"2006","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.jtauto.2024.100242_bib15","doi-asserted-by":"crossref","unstructured":"G. Liu, et al., Triptolide ameliorates osteoarthritis by regulating nuclear factor kappa B-mediated inflammatory response, J. Pharm. Pharmacol.74(3) (2022)360-366.","DOI":"10.1093\/jpp\/rgab182"},{"key":"10.1016\/j.jtauto.2024.100242_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114423","article-title":"Activation of the tumor suppressive Hippo pathway by triptonide as a new strategy to potently inhibit aggressive melanoma cell metastasis","volume":"185","author":"Tan","year":"2021","journal-title":"Biochem. Pharmacol."},{"issue":"41","key":"10.1016\/j.jtauto.2024.100242_bib17","doi-asserted-by":"crossref","first-page":"24738","DOI":"10.1074\/jbc.M115.643783","article-title":"The steroid hormone 20-hydroxyecdysone up-regulates ste-20 family serine\/threonine kinase Hippo to induce programmed cell death","volume":"290","author":"Dong","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.jtauto.2024.100242_bib18","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/1759-7714.13787","article-title":"KIF4A enhanced cell proliferation and migration via Hippo signaling and predicted a poor prognosis in esophageal squamous cell carcinoma","volume":"12","author":"Sun","year":"2021","journal-title":"Thorac Cancer"},{"key":"10.1016\/j.jtauto.2024.100242_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109249","article-title":"Endothelial cell protein C receptor regulates neutrophil extracellular trap-mediated rheumatoid arthritis disease progression","volume":"112","author":"Liu","year":"2022","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jtauto.2024.100242_bib20","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.molimm.2019.05.010","article-title":"Emodin ameliorates rheumatoid arthritis by promoting neutrophil apoptosis and inhibiting neutrophil extracellular trap formation","volume":"112","author":"Zhu","year":"2019","journal-title":"Mol. Immunol."},{"issue":"10","key":"10.1016\/j.jtauto.2024.100242_bib21","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/nrrheum.2014.80","article-title":"The multifactorial role of neutrophils in rheumatoid arthritis","volume":"10","author":"Wright","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jtauto.2024.100242_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.584116","article-title":"Rheumatoid arthritis synovial fluid neutrophils drive inflammation through production of chemokines, reactive oxygen species, and neutrophil extracellular traps","volume":"11","author":"Wright","year":"2021","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.jtauto.2024.100242_bib23","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1136\/ard.2010.138065","article-title":"Changes in expression of membrane TNF, NF-kappaB activation and neutrophil apoptosis during active and resolved inflammation","volume":"70","author":"Wright","year":"2011","journal-title":"Ann. Rheum. Dis."},{"issue":"3","key":"10.1016\/j.jtauto.2024.100242_bib24","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/rheumatology\/ker338","article-title":"Analysis of SF and plasma cytokines provides insights into the mechanisms of inflammatory arthritis and may predict response to therapy","volume":"51","author":"Wright","year":"2012","journal-title":"Rheumatology"},{"issue":"3","key":"10.1016\/j.jtauto.2024.100242_bib25","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1189\/jlb.0306178","article-title":"Neutrophil apoptosis in rheumatoid arthritis is regulated by local oxygen tensions within joints","volume":"80","author":"Cross","year":"2006","journal-title":"J. Leukoc. Biol."},{"issue":"6","key":"10.1016\/j.jtauto.2024.100242_bib26","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1038\/sj.bjp.0704612","article-title":"2-Chloroadenosine but not adenosine induces apoptosis in rheumatoid fibroblasts independently of cell surface adenosine receptor signalling","volume":"135","author":"Koshiba","year":"2002","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.jtauto.2024.100242_bib27","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1124\/jpet.302.1.18","article-title":"Nonsteroidal anti-inflammatory drugs induce apoptosis in association with activation of peroxisome proliferator-activated receptor gamma in rheumatoid synovial cells","volume":"302","author":"Yamazaki","year":"2002","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"3","key":"10.1016\/j.jtauto.2024.100242_bib28","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.clim.2005.01.007","article-title":"Infliximab induces apoptosis of monocytes and T lymphocytes in a human-mouse chimeric model","volume":"115","author":"Shen","year":"2005","journal-title":"Clin Immunol"},{"issue":"8","key":"10.1016\/j.jtauto.2024.100242_bib29","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s13312-011-0098-6","article-title":"Rituximab","volume":"48","author":"Borker","year":"2011","journal-title":"Indian Pediatr."},{"key":"10.1016\/j.jtauto.2024.100242_bib30","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jaut.2019.01.003","article-title":"Neutrophil extracellular traps exert both pro- and anti-inflammatory actions in rheumatoid arthritis that are modulated by C1q and LL-37","volume":"98","author":"Ribon","year":"2019","journal-title":"J. Autoimmun."},{"issue":"12","key":"10.1016\/j.jtauto.2024.100242_bib31","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1038\/ncb2362","article-title":"Caspase 8 inhibits programmed necrosis by processing CYLD","volume":"13","author":"O'Donnell","year":"2011","journal-title":"Nat. Cell Biol."},{"issue":"5","key":"10.1016\/j.jtauto.2024.100242_bib32","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.4049\/jimmunol.173.5.2976","article-title":"Caspase-8 serves both apoptotic and nonapoptotic roles","volume":"173","author":"Kang","year":"2004","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.jtauto.2024.100242_bib33","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.cell.2009.05.037","article-title":"Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation","volume":"137","author":"Cho","year":"2009","journal-title":"Cell"},{"issue":"5938","key":"10.1016\/j.jtauto.2024.100242_bib34","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1126\/science.1172308","article-title":"RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis","volume":"325","author":"Zhang","year":"2009","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.jtauto.2024.100242_bib35","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.cell.2009.05.021","article-title":"Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha","volume":"137","author":"He","year":"2009","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.jtauto.2024.100242_bib36","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.celrep.2014.04.026","article-title":"MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates","volume":"7","author":"Dondelinger","year":"2014","journal-title":"Cell Rep."},{"issue":"5","key":"10.1016\/j.jtauto.2024.100242_bib37","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/cr.2016.26","article-title":"MLKL forms cation channels","volume":"26","author":"Xia","year":"2016","journal-title":"Cell Res."},{"issue":"21","key":"10.1016\/j.jtauto.2024.100242_bib38","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1101\/gad.1602907","article-title":"Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control","volume":"21","author":"Zhao","year":"2007","journal-title":"Genes Dev."}],"container-title":["Journal of Translational Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589909024000121?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589909024000121?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T21:45:10Z","timestamp":1718574310000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589909024000121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":38,"alternative-id":["S2589909024000121"],"URL":"https:\/\/doi.org\/10.1016\/j.jtauto.2024.100242","relation":{},"ISSN":["2589-9090"],"issn-type":[{"value":"2589-9090","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Triptolide regulates neutrophil function through the Hippo signaling pathway to alleviate rheumatoid arthritis disease progression","name":"articletitle","label":"Article Title"},{"value":"Journal of Translational Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtauto.2024.100242","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100242"}}