{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:31:08Z","timestamp":1793147468560,"version":"4.5.0"},"reference-count":229,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Translational Autoimmunity"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jtauto.2025.100267","type":"journal-article","created":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T03:10:53Z","timestamp":1736046653000},"page":"100267","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Iron metabolism in rheumatic diseases"],"prefix":"10.1016","volume":"10","author":[{"given":"Aliakbar","family":"Givian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Azizan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmadreza","family":"Jamshidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Mahmoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4324-2697","authenticated-orcid":false,"given":"Elham","family":"Farhadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtauto.2025.100267_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2020.100864","article-title":"Iron in infection and immunity","volume":"75","author":"Nairz","year":"2020","journal-title":"Mol Aspects Med"},{"issue":"11","key":"10.1016\/j.jtauto.2025.100267_bib2","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1093\/rheumatology\/kep221","article-title":"Iron homoeostasis in rheumatic disease","volume":"48","author":"Baker","year":"2009","journal-title":"Rheumatology"},{"issue":"9","key":"10.1016\/j.jtauto.2025.100267_bib3","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1080\/1744666X.2021.1953981","article-title":"Pathological mechanisms of abnormal iron metabolism and mitochondrial dysfunction in systemic lupus erythematosus","volume":"17","author":"Wincup","year":"2021","journal-title":"Expert Rev Clin Immunol"},{"key":"10.1016\/j.jtauto.2025.100267_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.643686","article-title":"Iron metabolism: an under investigated driver of renal pathology in lupus nephritis","volume":"8","author":"Wlazlo","year":"2021","journal-title":"Front. Med."},{"issue":"8","key":"10.1016\/j.jtauto.2025.100267_bib5","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0891-5849(02)01006-7","article-title":"The labile iron pool: characterization, measurement, and participation in cellular processes(1)","volume":"33","author":"Kakhlon","year":"2002","journal-title":"Free Radic. Biol. Med."},{"issue":"5","key":"10.1016\/j.jtauto.2025.100267_bib6","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.cmet.2015.09.006","article-title":"Ironing out ferroportin","volume":"22","author":"Drakesmith","year":"2015","journal-title":"Cell Metab"},{"issue":"17","key":"10.1016\/j.jtauto.2025.100267_bib7","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1056\/NEJMp048363","article-title":"Orchestration of iron homeostasis","volume":"352","author":"Fleming","year":"2005","journal-title":"N. Engl. J. Med."},{"issue":"8","key":"10.1016\/j.jtauto.2025.100267_bib8","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/nri3863","article-title":"Iron homeostasis in host defence and inflammation","volume":"15","author":"Ganz","year":"2015","journal-title":"Nat. Rev. Immunol."},{"issue":"11","key":"10.1016\/j.jtauto.2025.100267_bib9","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.15252\/embr.201540558","article-title":"The Iron age of host-microbe interactions","volume":"16","author":"Soares","year":"2015","journal-title":"EMBO Rep."},{"issue":"Suppl 1","key":"10.1016\/j.jtauto.2025.100267_bib10","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1046\/j.1365-2362.2002.0320s1070.x","article-title":"Iron and immunity: a double-edged sword","volume":"32","author":"Weiss","year":"2002","journal-title":"Eur. J. Clin. Invest."},{"issue":"11","key":"10.1016\/j.jtauto.2025.100267_bib11","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1038\/s41590-019-0495-x","article-title":"Quantitative analysis of T cell proteomes and environmental sensors during T cell differentiation","volume":"20","author":"Howden","year":"2019","journal-title":"Nat. Immunol."},{"issue":"2","key":"10.1016\/j.jtauto.2025.100267_bib12","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.medj.2020.10.004","article-title":"Hepcidin-mediated hypoferremia disrupts immune responses to vaccination and infection","volume":"2","author":"Frost","year":"2021","journal-title":"Med"},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib13","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/0008-8749(91)90336-A","article-title":"Role of iron in T cell activation: TH1 clones differ from TH2 clones in their sensitivity to inhibition of DNA synthesis caused by IgG Mabs against the transferrin receptor and the iron chelator deferoxamine","volume":"134","author":"Thorson","year":"1991","journal-title":"Cell. Immunol."},{"issue":"8","key":"10.1016\/j.jtauto.2025.100267_bib14","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1182\/blood-2004-07-2686","article-title":"Iron regulates T-lymphocyte sensitivity to the IFN-gamma\/STAT1 signaling pathway in vitro and in vivo","volume":"105","author":"Regis","year":"2005","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.jtauto.2025.100267_bib15","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.it.2005.12.002","article-title":"IFNgammaR2 trafficking tunes IFNgamma-STAT1 signaling in T lymphocytes","volume":"27","author":"Regis","year":"2006","journal-title":"Trends Immunol."},{"issue":"6","key":"10.1016\/j.jtauto.2025.100267_bib16","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0092-8674(00)80702-3","article-title":"A novel transcription factor, T-bet, directs Th1 lineage commitment","volume":"100","author":"Szabo","year":"2000","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.jtauto.2025.100267_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0136106","article-title":"Iron deficiency impairs intra-hepatic lymphocyte mediated immune response","volume":"10","author":"Bonaccorsi-Riani","year":"2015","journal-title":"PLoS One"},{"issue":"6383","key":"10.1016\/j.jtauto.2025.100267_bib18","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1126\/science.aal2022","article-title":"Erythrocytic ferroportin reduces intracellular iron accumulation, hemolysis, and malaria risk","volume":"359","author":"Zhang","year":"2018","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.jtauto.2025.100267_bib19","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.1111\/jcmm.13723","article-title":"HO-1 regulates the function of Treg: association with the immune intolerance in vitiligo","volume":"22","author":"Zhang","year":"2018","journal-title":"J. Cell Mol. Med."},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/16078454.2019.1700330","article-title":"Effect of iron chelation therapy on EPO-STAT5 signalling pathway and EPO resistance in iron-overloaded low-risk myelodysplastic syndrome patients","volume":"25","author":"Zhang","year":"2020","journal-title":"Hematology"},{"issue":"4","key":"10.1016\/j.jtauto.2025.100267_bib21","first-page":"336","article-title":"[Effect of iron chelation therapy on EPO-Stat5 signaling pathway and Treg expression in IPSS low risk\/medium risk-1 group myelodysplastic syndrome patients]","volume":"39","author":"Zhang","year":"2018","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"issue":"2","key":"10.1016\/j.jtauto.2025.100267_bib22","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.celrep.2019.06.039","article-title":"Acute iron deprivation reprograms human macrophage metabolism and reduces inflammation in vivo","volume":"28","author":"Pereira","year":"2019","journal-title":"Cell Rep."},{"issue":"3","key":"10.1016\/j.jtauto.2025.100267_bib23","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1046\/j.1365-2249.1997.d01-967.x","article-title":"Anomalies of the CD8+ T cell pool in haemochromatosis: HLA-A3-linked expansions of CD8+CD28- T cells","volume":"107","author":"Arosa","year":"1997","journal-title":"Clin. Exp. Immunol."},{"issue":"5","key":"10.1016\/j.jtauto.2025.100267_bib24","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/S0198-8859(01)00233-6","article-title":"T-cell receptor repertoire in hereditary hemochromatosis: a study of 32 hemochromatosis patients and 274 healthy subjects","volume":"62","author":"Cardoso","year":"2001","journal-title":"Hum. Immunol."},{"issue":"4","key":"10.1016\/j.jtauto.2025.100267_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0124246","article-title":"Lymphocyte gene expression signatures from patients and mouse models of hereditary hemochromatosis reveal a function of HFE as a negative regulator of CD8+ T-lymphocyte activation and differentiation in vivo","volume":"10","author":"Costa","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib26","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.bcmd.2006.04.004","article-title":"The CD8+ T-lymphocyte profile as a modifier of iron overload in HFE hemochromatosis: an update of clinical and immunological data from 70 C282Y homozygous subjects","volume":"37","author":"Cruz","year":"2006","journal-title":"Blood Cells Mol. Dis."},{"issue":"2","key":"10.1016\/j.jtauto.2025.100267_bib27","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1189\/jlb.0802420","article-title":"Pathways for the regulation of interferon-gamma-inducible genes by iron in human monocytic cells","volume":"74","author":"Oexle","year":"2003","journal-title":"J. Leukoc. Biol."},{"issue":"4","key":"10.1016\/j.jtauto.2025.100267_bib28","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.4049\/jimmunol.181.4.2723","article-title":"Attenuated inflammatory responses in hemochromatosis reveal a role for iron in the regulation of macrophage cytokine translation","volume":"181","author":"Wang","year":"2008","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.jtauto.2025.100267_bib29","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1084\/jem.192.2.227","article-title":"Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. I. Effects on microbial killing by activated peritoneal macrophages in vitro","volume":"192","author":"Vazquez-Torres","year":"2000","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib30","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/imr.12266","article-title":"Macrophage defense mechanisms against intracellular bacteria","volume":"264","author":"Weiss","year":"2015","journal-title":"Immunol. Rev."},{"issue":"10","key":"10.1016\/j.jtauto.2025.100267_bib31","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1172\/JCI119436","article-title":"Tumor necrosis factor alpha (TNFalpha) promotes growth of virulent Mycobacterium tuberculosis in human monocytes iron-mediated growth suppression is correlated with decreased release of TNFalpha from iron-treated infected monocytes","volume":"99","author":"Byrd","year":"1997","journal-title":"J. Clin. Invest."},{"issue":"18","key":"10.1016\/j.jtauto.2025.100267_bib32","doi-asserted-by":"crossref","first-page":"12236","DOI":"10.1074\/jbc.272.18.12236","article-title":"Functional requirement of the hypoxia-responsive element in the activation of the inducible nitric oxide synthase promoter by the iron chelator desferrioxamine","volume":"272","author":"Melillo","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.jtauto.2025.100267_bib33","first-page":"605","article-title":"Iron modulates interferon-gamma effects in the human myelomonocytic cell line THP-1","volume":"20","author":"Weiss","year":"1992","journal-title":"Exp. Hematol."},{"issue":"4","key":"10.1016\/j.jtauto.2025.100267_bib34","first-page":"354","article-title":"Effects of iron overload on the immune system","volume":"30","author":"Walker","year":"2000","journal-title":"Ann. Clin. Lab. Sci."},{"issue":"3","key":"10.1016\/j.jtauto.2025.100267_bib35","first-page":"903","article-title":"[Effects of iron overload on the apoptosis and function of splenic CD8+ T cells in mice]","volume":"24","author":"Chen","year":"2016","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"},{"issue":"10","key":"10.1016\/j.jtauto.2025.100267_bib36","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/0167-5699(95)80034-4","article-title":"Linkage of cell-mediated immunity to iron metabolism","volume":"16","author":"Weiss","year":"1995","journal-title":"Immunol. Today"},{"issue":"6","key":"10.1016\/j.jtauto.2025.100267_bib37","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1086\/516481","article-title":"Iron overload alters innate and T helper cell responses to Candida albicans in mice","volume":"175","author":"Mencacci","year":"1997","journal-title":"J. Infect. Dis."},{"issue":"15","key":"10.1016\/j.jtauto.2025.100267_bib38","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.1182\/blood-2011-04-351957","article-title":"Hepcidin regulation by innate immune and infectious stimuli","volume":"118","author":"Armitage","year":"2011","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.jtauto.2025.100267_bib39","doi-asserted-by":"crossref","first-page":"4148","DOI":"10.1182\/blood-2002-08-2459","article-title":"Cytokine-mediated regulation of iron transport in human monocytic cells","volume":"101","author":"Ludwiczek","year":"2003","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.jtauto.2025.100267_bib40","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.4049\/jimmunol.169.4.2204","article-title":"Role of IL-10 for induction of anemia during inflammation","volume":"169","author":"Tilg","year":"2002","journal-title":"J. Immunol."},{"issue":"10","key":"10.1016\/j.jtauto.2025.100267_bib41","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1182\/blood.V99.10.3505","article-title":"Regulation of ferritin genes and protein","volume":"99","author":"Torti","year":"2002","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.jtauto.2025.100267_bib42","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.beha.2004.09.001","article-title":"Modification of iron regulation by the inflammatory response","volume":"18","author":"Weiss","year":"2005","journal-title":"Best Pract. Res. Clin. Haematol."},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib43","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1053\/j.gastro.2006.10.018","article-title":"STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo","volume":"132","author":"Pietrangelo","year":"2007","journal-title":"Gastroenterology"},{"issue":"9","key":"10.1016\/j.jtauto.2025.100267_bib44","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1182\/blood-2006-06-027631","article-title":"Interleukin-6 induces hepcidin expression through STAT3","volume":"108","author":"Wrighting","year":"2006","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib45","doi-asserted-by":"crossref","first-page":"420","DOI":"10.4049\/jimmunol.158.1.420","article-title":"Pathways for the regulation of macrophage iron metabolism by the anti-inflammatory cytokines IL-4 and IL-13","volume":"158","author":"Weiss","year":"1997","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.jtauto.2025.100267_bib46","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1182\/blood.V87.6.2525.bloodjournal8762525","article-title":"Ferritin translation by interleukin-1and interleukin-6: the role of sequences upstream of the start codons of the heavy and light subunit genes","volume":"87","author":"Rogers","year":"1996","journal-title":"Blood"},{"issue":"9\u201310","key":"10.1016\/j.jtauto.2025.100267_bib47","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1089\/ars.2006.8.1865","article-title":"Redefining oxidative stress","volume":"8","author":"Jones","year":"2006","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jtauto.2025.100267_bib48","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1146\/annurev-biochem-061516-045037","article-title":"Oxidative stress","volume":"86","author":"Sies","year":"2017","journal-title":"Annu. Rev. Biochem."},{"issue":"23","key":"10.1016\/j.jtauto.2025.100267_bib49","doi-asserted-by":"crossref","first-page":"7023","DOI":"10.1113\/JP273839","article-title":"Oxidative phosphorylation: regulation and role in cellular and tissue metabolism","volume":"595","author":"Wilson","year":"2017","journal-title":"J Physiol"},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10408360701713104","article-title":"Oxidative stress and iron homeostasis: mechanistic and health aspects","volume":"45","author":"Galaris","year":"2008","journal-title":"Crit. Rev. Clin. Lab Sci."},{"issue":"12","key":"10.1016\/j.jtauto.2025.100267_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2019.118535","article-title":"Iron homeostasis and oxidative stress: an intimate relationship","volume":"1866","author":"Galaris","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"issue":"Pt 2","key":"10.1016\/j.jtauto.2025.100267_bib52","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1042\/bj3560549","article-title":"Apoptosis induced by exposure to a low steady-state concentration of H2O2 is a consequence of lysosomal rupture","volume":"356","author":"Antunes","year":"2001","journal-title":"Biochem. J."},{"issue":"10","key":"10.1016\/j.jtauto.2025.100267_bib53","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1021\/tx060101w","article-title":"Fenton chemistry and iron chelation under physiologically relevant conditions: electrochemistry and kinetics","volume":"19","author":"Merkofer","year":"2006","journal-title":"Chem. Res. Toxicol."},{"issue":"3","key":"10.1016\/j.jtauto.2025.100267_bib54","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.bbagen.2011.07.014","article-title":"Non-transferrin bound iron: a key role in iron overload and iron toxicity","volume":"1820","author":"Brissot","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib55","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00775-007-0297-8","article-title":"Nature of non-transferrin-bound iron: studies on iron citrate complexes and thalassemic sera","volume":"13","author":"Evans","year":"2008","journal-title":"J Biol Inorg Chem"},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib56","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0891-5849(88)90059-7","article-title":"A site-specific mechanism for free radical induced biological damage: the essential role of redox-active transition metals","volume":"5","author":"Chevion","year":"1988","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib57","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nchembio.2238","article-title":"Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis","volume":"13","author":"Kagan","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jtauto.2025.100267_bib58","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.freeradbiomed.2018.09.008","article-title":"Iron catalysis of lipid peroxidation in ferroptosis: regulated enzymatic or random free radical reaction?","volume":"133","author":"Stoyanovsky","year":"2019","journal-title":"Free Radic. Biol. Med."},{"issue":"7835","key":"10.1016\/j.jtauto.2025.100267_bib59","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41586-020-2938-9","article-title":"Fibrosis: from mechanisms to medicines","volume":"587","author":"Henderson","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jtauto.2025.100267_bib60","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev-physiol-012110-142225","article-title":"Epithelial-mesenchymal interactions in pulmonary fibrosis","volume":"73","author":"Chapman","year":"2011","journal-title":"Annu. Rev. Physiol."},{"issue":"3","key":"10.1016\/j.jtauto.2025.100267_bib61","doi-asserted-by":"crossref","first-page":"L525","DOI":"10.1152\/ajplung.00163.2007","article-title":"TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease","volume":"293","author":"Willis","year":"2007","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.jtauto.2025.100267_bib62","article-title":"Iron-dependent mitochondrial dysfunction contributes to the pathogenesis of pulmonary fibrosis","volume":"12","author":"Takahashi","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.jtauto.2025.100267_bib63","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1681\/ASN.2004050425","article-title":"Role of reactive oxygen species in TGF-beta1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells","volume":"16","author":"Rhyu","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib64","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/path.5401","article-title":"Critical role for iron accumulation in the pathogenesis of fibrotic lung disease","volume":"251","author":"Ali","year":"2020","journal-title":"J. Pathol."},{"issue":"2","key":"10.1016\/j.jtauto.2025.100267_bib65","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1161\/ATVBAHA.112.300663","article-title":"Role of proinflammatory CD68(+) mannose receptor(-) macrophages in peroxiredoxin-1 expression and in abdominal aortic aneurysms in humans","volume":"33","author":"Boytard","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"5","key":"10.1016\/j.jtauto.2025.100267_bib66","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1002\/JLB.3A0318-108R","article-title":"Iron alters macrophage polarization status and leads to steatohepatitis and fibrogenesis","volume":"105","author":"Handa","year":"2019","journal-title":"J. Leukoc. Biol."},{"issue":"11","key":"10.1016\/j.jtauto.2025.100267_bib67","first-page":"3322","article-title":"Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice","volume":"119","author":"Wang","year":"2009","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.jtauto.2025.100267_bib68","doi-asserted-by":"crossref","first-page":"G719","DOI":"10.1152\/ajpgi.00108.2002","article-title":"Iron activates NF-kappaB in Kupffer cells","volume":"283","author":"She","year":"2002","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"7","key":"10.1016\/j.jtauto.2025.100267_bib69","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1182\/blood-2011-01-330324","article-title":"Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses","volume":"118","author":"Zhang","year":"2011","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.jtauto.2025.100267_bib70","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1182\/blood-2011-02-337212","article-title":"Low hepcidin accounts for the proinflammatory status associated with iron deficiency","volume":"118","author":"Pagani","year":"2011","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.jtauto.2025.100267_bib71","doi-asserted-by":"crossref","first-page":"7516","DOI":"10.4049\/jimmunol.178.12.7516","article-title":"Cutting edge: essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis","volume":"178","author":"Peyssonnaux","year":"2007","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.jtauto.2025.100267_bib72","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.cyto.2005.01.002","article-title":"Interleukin-1-deficient mice exhibit high sensitivity to gut-derived sepsis caused by Pseudomonas aeruginosa","volume":"30","author":"Horino","year":"2005","journal-title":"Cytokine"},{"issue":"Pt B","key":"10.1016\/j.jtauto.2025.100267_bib73","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.biocel.2016.06.015","article-title":"Mitochondrial reactive oxygen species and inflammation: molecular mechanisms, diseases and promising therapies","volume":"81","author":"Rimessi","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"3","key":"10.1016\/j.jtauto.2025.100267_bib74","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1182\/blood-2010-06-290171","article-title":"Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity","volume":"117","author":"Metzler","year":"2011","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.jtauto.2025.100267_bib75","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.celrep.2014.06.044","article-title":"A myeloperoxidase-containing complex regulates neutrophil elastase release and actin dynamics during NETosis","volume":"8","author":"Metzler","year":"2014","journal-title":"Cell Rep."},{"issue":"3","key":"10.1016\/j.jtauto.2025.100267_bib76","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1083\/jcb.201006052","article-title":"Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps","volume":"191","author":"Papayannopoulos","year":"2010","journal-title":"J. Cell Biol."},{"issue":"3","key":"10.1016\/j.jtauto.2025.100267_bib77","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nm.4294","article-title":"An emerging role for neutrophil extracellular traps in noninfectious disease","volume":"23","author":"Jorch","year":"2017","journal-title":"Nat Med"},{"issue":"2","key":"10.1016\/j.jtauto.2025.100267_bib78","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1083\/jcb.200606027","article-title":"Novel cell death program leads to neutrophil extracellular traps","volume":"176","author":"Fuchs","year":"2007","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.jtauto.2025.100267_bib79","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1083\/jcb.200806072","article-title":"Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation","volume":"184","author":"Wang","year":"2009","journal-title":"J. Cell Biol."},{"issue":"40","key":"10.1016\/j.jtauto.2025.100267_bib80","doi-asserted-by":"crossref","first-page":"eabq5384","DOI":"10.1126\/sciadv.abq5384","article-title":"Plasma iron controls neutrophil production and function","volume":"8","author":"Frost","year":"2022","journal-title":"Sci. Adv."},{"issue":"3","key":"10.1016\/j.jtauto.2025.100267_bib81","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20160031","article-title":"Iron-chelating agent desferrioxamine stimulates formation of neutrophil extracellular traps (NETs) in human blood-derived neutrophils","volume":"36","author":"V\u00f6llger","year":"2016","journal-title":"Biosci. Rep."},{"issue":"7","key":"10.1016\/j.jtauto.2025.100267_bib82","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1172\/JCI23865","article-title":"HIF-1alpha expression regulates the bactericidal capacity of phagocytes","volume":"115","author":"Peyssonnaux","year":"2005","journal-title":"J. Clin. Invest."},{"issue":"51","key":"10.1016\/j.jtauto.2025.100267_bib83","doi-asserted-by":"crossref","first-page":"32529","DOI":"10.1074\/jbc.271.51.32529","article-title":"Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1","volume":"271","author":"Semenza","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"24","key":"10.1016\/j.jtauto.2025.100267_bib84","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.1182\/blood-2013-10-529982","article-title":"Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease","volume":"123","author":"Chen","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.jtauto.2025.100267_bib85","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1196\/annals.1297.063","article-title":"Iron accumulation during cellular senescence","volume":"1019","author":"Killilea","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"6","key":"10.1016\/j.jtauto.2025.100267_bib86","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.jtauto.2025.100267_bib87","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.cell.2019.10.005","article-title":"Cellular senescence: defining a path forward","volume":"179","author":"Gorgoulis","year":"2019","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.jtauto.2025.100267_bib88","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.tcb.2018.02.001","article-title":"Hallmarks of cellular senescence","volume":"28","author":"Hernandez-Segura","year":"2018","journal-title":"Trends Cell Biol."},{"issue":"7","key":"10.1016\/j.jtauto.2025.100267_bib89","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/nrm3823","article-title":"Cellular senescence: from physiology to pathology","volume":"15","author":"Mu\u00f1oz-Esp\u00edn","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.jtauto.2025.100267_bib90","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1083\/jcb.201009094","article-title":"Four faces of cellular senescence","volume":"192","author":"Rodier","year":"2011","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jtauto.2025.100267_bib91","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3389\/fgene.2018.00059","article-title":"Age- and tissue-specific expression of senescence biomarkers in mice","volume":"9","author":"Hudgins","year":"2018","journal-title":"Front. Genet."},{"key":"10.1016\/j.jtauto.2025.100267_bib92","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.mad.2017.11.012","article-title":"Ferrosenescence: the iron age of neurodegeneration?","volume":"174","author":"Sfera","year":"2018","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.jtauto.2025.100267_bib93","first-page":"124","article-title":"Mitochondrial dysfunction induced by frataxin deficiency is associated with cellular senescence and abnormal calcium metabolism","volume":"8","author":"Bolinches-Amor\u00f3s","year":"2014","journal-title":"Front. Cell. Neurosci."},{"issue":"38","key":"10.1016\/j.jtauto.2025.100267_bib94","doi-asserted-by":"crossref","first-page":"16381","DOI":"10.1073\/pnas.0906784106","article-title":"Elucidation of the mechanism of mitochondrial iron loading in Friedreich's ataxia by analysis of a mouse mutant","volume":"106","author":"Huang","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"10.1016\/j.jtauto.2025.100267_bib95","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1093\/hmg\/ddu745","article-title":"Unveiling a common mechanism of apoptosis in \u03b2-cells and neurons in Friedreich's ataxia","volume":"24","author":"Igoillo-Esteve","year":"2015","journal-title":"Hum. Mol. Genet."},{"issue":"2","key":"10.1016\/j.jtauto.2025.100267_bib96","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/84818","article-title":"Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits","volume":"27","author":"Puccio","year":"2001","journal-title":"Nat. Genet."},{"issue":"20","key":"10.1016\/j.jtauto.2025.100267_bib97","doi-asserted-by":"crossref","first-page":"5768","DOI":"10.1111\/j.1742-4658.2009.07269.x","article-title":"Is there more to aging than mitochondrial DNA and reactive oxygen species?","volume":"276","author":"Alexeyev","year":"2009","journal-title":"FEBS J."},{"issue":"11","key":"10.1016\/j.jtauto.2025.100267_bib98","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22116035","article-title":"Outcomes of deferoxamine action on H(2)O(2)-induced growth inhibition and senescence progression of human endometrial stem cells","volume":"22","author":"Shatrova","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.jtauto.2025.100267_bib99","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0891-5849(02)00959-0","article-title":"Lipofuscin: mechanisms of age-related accumulation and influence on cell function","volume":"33","author":"Brunk","year":"2002","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.jtauto.2025.100267_bib100","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1039\/C4MT00214H","article-title":"Iron-sensitive fluorescent probes: monitoring intracellular iron pools","volume":"7","author":"Ma","year":"2015","journal-title":"Metallomics"},{"issue":"4","key":"10.1016\/j.jtauto.2025.100267_bib101","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1002\/hep.510290435","article-title":"Determination of the chelatable iron pool of isolated rat hepatocytes by digital fluorescence microscopy using the fluorescent probe, phen green SK","volume":"29","author":"Petrat","year":"1999","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.jtauto.2025.100267_bib103","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.jtauto.2025.100267_bib104","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"issue":"2","key":"10.1016\/j.jtauto.2025.100267_bib105","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14553","article-title":"Dysregulation of iron homeostasis and ferroptosis in sevoflurane and isoflurane associated perioperative neurocognitive disorders","volume":"30","author":"Miao","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.jtauto.2025.100267_bib106","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.590226","article-title":"Iron metabolism in ferroptosis","volume":"8","author":"Chen","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib107","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/s41392-023-01606-1","article-title":"Targeting ferroptosis opens new avenues for the development of novel therapeutics","volume":"8","author":"Sun","year":"2023","journal-title":"Signal Transduct Target Ther"},{"issue":"8","key":"10.1016\/j.jtauto.2025.100267_bib108","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.tips.2021.05.001","article-title":"Iron metabolism: pathophysiology and pharmacology","volume":"42","author":"Roemhild","year":"2021","journal-title":"Trends Pharmacol. Sci."},{"issue":"6","key":"10.1016\/j.jtauto.2025.100267_bib109","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3324\/haematol.2011.056119","article-title":"Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis","volume":"97","author":"Mastrogiannaki","year":"2012","journal-title":"Haematologica"},{"issue":"15","key":"10.1016\/j.jtauto.2025.100267_bib110","doi-asserted-by":"crossref","first-page":"5108","DOI":"10.1016\/j.bmcl.2012.05.129","article-title":"Discovery of benzylisothioureas as potent divalent metal transporter 1 (DMT1) inhibitors","volume":"22","author":"Zhang","year":"2012","journal-title":"Bioorg Med Chem Lett"},{"issue":"5","key":"10.1016\/j.jtauto.2025.100267_bib111","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.jtauto.2025.100267_bib112","doi-asserted-by":"crossref","DOI":"10.3390\/ph11040127","article-title":"Hepcidin therapeutics","volume":"11","author":"Katsarou","year":"2018","journal-title":"Pharmaceuticals"},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib113","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41392-024-01969-z","article-title":"Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects","volume":"9","author":"Ru","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib114","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat. Chem. Biol."},{"issue":"3","key":"10.1016\/j.jtauto.2025.100267_bib115","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.chembiol.2018.11.016","article-title":"Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state","volume":"26","author":"Magtanong","year":"2019","journal-title":"Cell Chem. Biol."},{"issue":"5","key":"10.1016\/j.jtauto.2025.100267_bib116","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/s41556-019-0305-6","article-title":"ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway","volume":"21","author":"Chu","year":"2019","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib117","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1038\/s41467-019-09277-9","article-title":"A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis","volume":"10","author":"Zou","year":"2019","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib118","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1096\/fasebj.13.1.143","article-title":"Inverse regulation of lipid-peroxidizing and hydroperoxyl lipid-reducing enzymes by interleukins 4 and 13","volume":"13","author":"Schnurr","year":"1999","journal-title":"Faseb j"},{"issue":"1\u20132","key":"10.1016\/j.jtauto.2025.100267_bib119","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.jtauto.2025.100267_bib120","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1089\/ars.2017.7332","article-title":"The eicosanoids, redox-regulated lipid mediators in immunometabolic disorders","volume":"29","author":"Ara\u00fajo","year":"2018","journal-title":"Antioxid Redox Signal"},{"issue":"9","key":"10.1016\/j.jtauto.2025.100267_bib121","doi-asserted-by":"crossref","first-page":"6288","DOI":"10.1016\/S0021-9258(18)53251-8","article-title":"Selenoenzymes regulate the activity of leukocyte 5-lipoxygenase via the peroxide tone","volume":"268","author":"Weitzel","year":"1993","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib122","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41418-018-0179-3","article-title":"Programmed Necrosis and Disease:We interrupt your regular programming to bring you necroinflammation","volume":"26","author":"Kim","year":"2019","journal-title":"Cell Death Differ."},{"issue":"19","key":"10.1016\/j.jtauto.2025.100267_bib123","doi-asserted-by":"crossref","first-page":"31626","DOI":"10.18632\/oncotarget.16382","article-title":"Inhibition of iron overload-induced apoptosis and necrosis of bone marrow mesenchymal stem cells by melatonin","volume":"8","author":"Yang","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib124","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s10753-020-01338-2","article-title":"ROS-dependent lipid peroxidation and reliant antioxidant ferroptosis-suppressor-protein 1 in rheumatoid arthritis: a covert clue for potential therapy","volume":"44","author":"Xie","year":"2021","journal-title":"Inflammation"},{"issue":"9","key":"10.1016\/j.jtauto.2025.100267_bib125","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/s41590-021-00993-3","article-title":"Glutathione peroxidase 4-regulated neutrophil ferroptosis induces systemic autoimmunity","volume":"22","author":"Li","year":"2021","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib126","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/s41392-021-00804-z","article-title":"Dysregulated neutrophilic cell death in SLE: a spotlight on ferroptosis","volume":"6","author":"Ohl","year":"2021","journal-title":"Signal Transduct Target Ther"},{"issue":"8","key":"10.1016\/j.jtauto.2025.100267_bib127","doi-asserted-by":"crossref","first-page":"799","DOI":"10.2174\/1566524022666220525144630","article-title":"Ferroptosis inhibitor regulates the disease progression of systematic lupus erythematosus mice model through Th1\/Th2 ratio","volume":"23","author":"Yang","year":"2023","journal-title":"Curr. Mol. Med."},{"issue":"3","key":"10.1016\/j.jtauto.2025.100267_bib128","first-page":"651","article-title":"Ferroptosis in peripheral blood mononuclear cells of systemic lupus erythematosus","volume":"42","author":"Tao","year":"2024","journal-title":"Clin. Exp. Rheumatol."},{"issue":"5","key":"10.1016\/j.jtauto.2025.100267_bib129","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics16050651","article-title":"Nanodrug delivery systems for myasthenia gravis: advances and perspectives","volume":"16","author":"Huang","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jtauto.2025.100267_bib130","first-page":"98","article-title":"The relationship between serum iron levels and AChR-Ab and IL-6 in patients with myasthenia gravis","volume":"27","author":"Huang","year":"2023","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"3","key":"10.1016\/j.jtauto.2025.100267_bib131","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/ncb0311-184","article-title":"Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress","volume":"13","author":"Tabas","year":"2011","journal-title":"Nat. Cell Biol."},{"issue":"8","key":"10.1016\/j.jtauto.2025.100267_bib132","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41580-020-0250-z","article-title":"Mechanisms, regulation and functions of the unfolded protein response","volume":"21","author":"Hetz","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"8","key":"10.1016\/j.jtauto.2025.100267_bib133","doi-asserted-by":"crossref","first-page":"e6618","DOI":"10.1371\/journal.pone.0006618","article-title":"ER stress-inducible factor CHOP affects the expression of hepcidin by modulating C\/EBPalpha activity","volume":"4","author":"Oliveira","year":"2009","journal-title":"PLoS One"},{"issue":"5942","key":"10.1016\/j.jtauto.2025.100267_bib134","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1126\/science.1176639","article-title":"ER stress controls iron metabolism through induction of hepcidin","volume":"325","author":"Vecchi","year":"2009","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib135","article-title":"ER stress and iron homeostasis: a new frontier for the UPR","volume":"2011","author":"Oliveira","year":"2011","journal-title":"Biochemistry Research International"},{"key":"10.1016\/j.jtauto.2025.100267_bib136","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1438803","article-title":"Ferroptosis and endoplasmic reticulum stress in rheumatoid arthritis","volume":"15","author":"Ao","year":"2024","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.jtauto.2025.100267_bib137","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1007\/s10067-014-2599-x","article-title":"Inhibition of transient receptor potential melastatin 7 (TRPM7) channel induces RA FLSs apoptosis through endoplasmic reticulum (ER) stress","volume":"33","author":"Li","year":"2014","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.jtauto.2025.100267_bib138","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102411","article-title":"TRPM7 channel inhibition attenuates rheumatoid arthritis articular chondrocyte ferroptosis by suppression of the PKC\u03b1-NOX4 axis","volume":"55","author":"Zhou","year":"2022","journal-title":"Redox Biol."},{"issue":"3","key":"10.1016\/j.jtauto.2025.100267_bib139","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s10863-023-09968-5","article-title":"TRPM7 mediates endoplasmic reticulum stress and ferroptosis in sepsis-induced myocardial injury","volume":"55","author":"Deng","year":"2023","journal-title":"J. Bioenerg. Biomembr."},{"issue":"4","key":"10.1016\/j.jtauto.2025.100267_bib140","doi-asserted-by":"crossref","DOI":"10.3390\/ph11040107","article-title":"Influence of iron on bone homeostasis","volume":"11","author":"Balogh","year":"2018","journal-title":"Pharmaceuticals"},{"issue":"12","key":"10.1016\/j.jtauto.2025.100267_bib141","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.3324\/haematol.2014.104463","article-title":"Iron overload causes osteoporosis in thalassemia major patients through interaction with transient receptor potential vanilloid type 1 (TRPV1) channels","volume":"99","author":"Rossi","year":"2014","journal-title":"Haematologica"},{"issue":"4","key":"10.1016\/j.jtauto.2025.100267_bib142","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00198-008-0701-4","article-title":"Association between iron overload and osteoporosis in patients with hereditary hemochromatosis","volume":"20","author":"Valenti","year":"2009","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.jtauto.2025.100267_bib143","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.redox.2016.01.006","article-title":"Molecular regulatory mechanisms of osteoclastogenesis through cytoprotective enzymes","volume":"8","author":"Kanzaki","year":"2016","journal-title":"Redox Biol."},{"issue":"14","key":"10.1016\/j.jtauto.2025.100267_bib144","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1182\/blood-2009-12-260083","article-title":"Bone loss caused by iron overload in a murine model: importance of oxidative stress","volume":"116","author":"Tsay","year":"2010","journal-title":"Blood"},{"issue":"21","key":"10.1016\/j.jtauto.2025.100267_bib145","doi-asserted-by":"crossref","first-page":"14853","DOI":"10.1016\/S0021-9258(17)36541-9","article-title":"Dephosphorylation of osteopontin and bone sialoprotein by osteoclastic tartrate-resistant acid phosphatase. Modulation of osteoclast adhesion in vitro","volume":"269","author":"Ek-Rylander","year":"1994","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.jtauto.2025.100267_bib146","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1359\/jbmr.2003.18.10.1905","article-title":"Tartrate-resistant acid phosphatase knockout mice","volume":"18","author":"Hayman","year":"2003","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib147","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/0006-291X(89)92405-4","article-title":"Inhibition of osteoclastic acid phosphatase abolishes bone resorption","volume":"159","author":"Zaidi","year":"1989","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jtauto.2025.100267_bib148","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1042\/bj2980421","article-title":"Transcriptional regulation of the tartrate-resistant acid phosphatase (TRAP) gene by iron","volume":"298","author":"Alcantara","year":"1994","journal-title":"Biochem. J."},{"issue":"2","key":"10.1016\/j.jtauto.2025.100267_bib149","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/S0021-9258(17)42257-5","article-title":"Purple acid phosphatase of the human macrophage and osteoclast. Characterization, molecular properties, and crystallization of the recombinant di-iron-oxo protein secreted by baculovirus-infected insect cells","volume":"269","author":"Hayman","year":"1994","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.jtauto.2025.100267_bib150","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1042\/bj2610601","article-title":"Purification and characterization of a tartrate-resistant acid phosphatase from human osteoclastomas","volume":"261","author":"Hayman","year":"1989","journal-title":"Biochem. J."},{"issue":"9","key":"10.1016\/j.jtauto.2025.100267_bib151","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/j.bbadis.2016.06.003","article-title":"Iron overload inhibits osteogenic commitment and differentiation of mesenchymal stem cells via the induction of ferritin","volume":"1862","author":"Balogh","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"issue":"5","key":"10.1016\/j.jtauto.2025.100267_bib152","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.bone.2009.07.073","article-title":"Iron overload alters iron-regulatory genes and proteins, down-regulates osteoblastic phenotype, and is associated with apoptosis in fetal rat calvaria cultures","volume":"45","author":"Messer","year":"2009","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.jtauto.2025.100267_bib153","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1681\/ASN.2008070788","article-title":"Ferritin prevents calcification and osteoblastic differentiation of vascular smooth muscle cells","volume":"20","author":"Zarjou","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib154","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1359\/jbmr.091002","article-title":"Ferritin ferroxidase activity: a potent inhibitor of osteogenesis","volume":"25","author":"Zarjou","year":"2010","journal-title":"J. Bone Miner. Res."},{"issue":"12","key":"10.1016\/j.jtauto.2025.100267_bib155","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.3324\/haematol.2016.144808","article-title":"Wnt5a is a key target for the pro-osteogenic effects of iron chelation on osteoblast progenitors","volume":"101","author":"Baschant","year":"2016","journal-title":"Haematologica"},{"issue":"2","key":"10.1016\/j.jtauto.2025.100267_bib156","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/jcb.22559","article-title":"Hypoxia decreases sclerostin expression and increases Wnt signaling in osteoblasts","volume":"110","author":"Genetos","year":"2010","journal-title":"J. Cell. Biochem."},{"issue":"2","key":"10.1016\/j.jtauto.2025.100267_bib157","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s12011-018-1388-9","article-title":"Iron accumulation leads to bone loss by inducing mesenchymal stem cell apoptosis through the activation of Caspase3","volume":"187","author":"Yuan","year":"2019","journal-title":"Biol. Trace Elem. Res."},{"issue":"2","key":"10.1016\/j.jtauto.2025.100267_bib158","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00394-011-0212-5","article-title":"Severe nutritional iron-deficiency anaemia has a negative effect on some bone turnover biomarkers in rats","volume":"51","author":"D\u00edaz-Castro","year":"2012","journal-title":"Eur. J. Nutr."},{"issue":"2","key":"10.1016\/j.jtauto.2025.100267_bib159","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3945\/jn.108.093757","article-title":"Severe iron deficiency decreases both bone formation and bone resorption in rats","volume":"139","author":"Katsumata","year":"2009","journal-title":"J. Nutr."},{"issue":"11","key":"10.1016\/j.jtauto.2025.100267_bib160","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1093\/jn\/134.11.3061","article-title":"Iron deficiency negatively affects vertebrae and femurs of rats independently of energy intake and body weight","volume":"134","author":"Medeiros","year":"2004","journal-title":"J. Nutr."},{"issue":"1\u20133","key":"10.1016\/j.jtauto.2025.100267_bib161","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s12011-012-9511-9","article-title":"A comparison of the biological activities of human osteoblast hFOB1.19 between iron excess and iron deficiency","volume":"150","author":"Zhao","year":"2012","journal-title":"Biol. Trace Elem. Res."},{"issue":"2","key":"10.1016\/j.jtauto.2025.100267_bib162","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3109\/10409231003627991","article-title":"Prolyl 4-hydroxylase","volume":"45","author":"Gorres","year":"2010","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"issue":"2","key":"10.1016\/j.jtauto.2025.100267_bib163","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1432-1033.1977.tb11888.x","article-title":"Mechanism of the prolyl hydroxylase reaction. 1. Role of co-substrates","volume":"80","author":"Tuderman","year":"1977","journal-title":"Eur. J. Biochem."},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib164","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1194\/jlr.R031534","article-title":"Cytochrome P450-mediated metabolism of vitamin D","volume":"55","author":"Jones","year":"2014","journal-title":"J. Lipid Res."},{"issue":"4","key":"10.1016\/j.jtauto.2025.100267_bib165","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00418-018-1648-y","article-title":"Functions of vitamin D in bone","volume":"149","author":"Goltzman","year":"2018","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.jtauto.2025.100267_bib166","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bone.2017.12.021","article-title":"Metabolic properties of the osteoclast","volume":"115","author":"Arnett","year":"2018","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.jtauto.2025.100267_bib167","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nm.1910","article-title":"Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation","volume":"15","author":"Ishii","year":"2009","journal-title":"Nat Med"},{"key":"10.1016\/j.jtauto.2025.100267_bib168","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.toxlet.2019.06.007","article-title":"Deferoxamine inhibits iron-uptake stimulated osteoclast differentiation by suppressing electron transport chain and MAPKs signaling","volume":"313","author":"Zhang","year":"2019","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.jtauto.2025.100267_bib169","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.toxrep.2015.04.005","article-title":"Antioxidant and free radical scavenging activity of iron chelators","volume":"2","author":"Adjimani","year":"2015","journal-title":"Toxicol Rep"},{"issue":"10","key":"10.1016\/j.jtauto.2025.100267_bib170","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1007\/s12011-020-02508-x","article-title":"Iron overload induces apoptosis and cytoprotective autophagy regulated by ROS generation in mc3t3-E1 cells","volume":"199","author":"Xu","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"issue":"4","key":"10.1016\/j.jtauto.2025.100267_bib171","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molcel.2008.04.009","article-title":"Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway","volume":"30","author":"Kaelin","year":"2008","journal-title":"Mol Cell"},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib172","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jcp.10321","article-title":"Hypoxia is a major stimulator of osteoclast formation and bone resorption","volume":"196","author":"Arnett","year":"2003","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.jtauto.2025.100267_bib173","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/path.4906","article-title":"Hypoxia-inducible factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2","volume":"242","author":"Hulley","year":"2017","journal-title":"J. Pathol."},{"issue":"12","key":"10.1016\/j.jtauto.2025.100267_bib174","first-page":"4648","article-title":"Hypoxia-inducible factor regulates osteoclast-mediated bone resorption: role of angiopoietin-like 4","volume":"24","author":"Knowles","year":"2010","journal-title":"Faseb j"},{"issue":"4","key":"10.1016\/j.jtauto.2025.100267_bib175","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.3390\/nu7042324","article-title":"Chronic iron deficiency as an emerging risk factor for osteoporosis: a hypothesis","volume":"7","author":"Toxqui","year":"2015","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib176","first-page":"28","article-title":"Placental umbilical cord whole blood transfusion to combat anemia in the background of advanced rheumatoid arthritis and emaciation and its potential role as immunoadjuvant therapy","volume":"33","author":"Bhattacharya","year":"2006","journal-title":"Clin. Exp. Obstet. Gynecol."},{"issue":"2","key":"10.1016\/j.jtauto.2025.100267_bib177","first-page":"34","article-title":"Rheumatoid arthritis and anemia: the impact of different anti-inflammatory therapies on hemoglobin levels. An observational study","volume":"104","author":"Calisto P\u00e9rez","year":"2012","journal-title":"Bol. Asoc. Med. P. R."},{"key":"10.1016\/j.jtauto.2025.100267_bib178","article-title":"Live macrophages loaded with Fe(3)O(4) and sulfasalazine for ferroptosis and photothermal therapy of rheumatoid arthritis","volume":"24","author":"Ruan","year":"2024","journal-title":"Mater Today Bio"},{"key":"10.1016\/j.jtauto.2025.100267_bib179","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2024.106928","article-title":"Macrophages-mediated delivery of protoporphyrin for sonodynamic therapy of rheumatoid arthritis","volume":"107","author":"Wu","year":"2024","journal-title":"Ultrason. Sonochem."},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib180","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1080\/16078454.2020.1730557","article-title":"The safety of modern intravenous iron infusions in patients with rheumatoid arthritis - a review of the literature","volume":"25","author":"Ooi","year":"2020","journal-title":"Hematology"},{"issue":"12","key":"10.1016\/j.jtauto.2025.100267_bib181","first-page":"4325","article-title":"Iron metabolism in patients with rheumatoid arthritis","volume":"25","author":"Ta\u0144ski","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib182","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/s41467-021-27948-4","article-title":"TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models","volume":"13","author":"Wu","year":"2022","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib183","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1515\/folmed-2017-0068","article-title":"Pathobiochemical mechanisms relating iron homeostasis with parameters of inflammatory activity and autoimmune disorders in rheumatoid arthritis","volume":"60","author":"Stefanova","year":"2018","journal-title":"Folia Med. (Plovdiv)"},{"issue":"12","key":"10.1016\/j.jtauto.2025.100267_bib184","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1016\/j.joca.2015.06.020","article-title":"Autophagy protects chondrocytes from glucocorticoids-induced apoptosis via ROS\/Akt\/FOXO3 signaling","volume":"23","author":"Shen","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.jtauto.2025.100267_bib185","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cbi.2017.12.024","article-title":"Oxidative stress, consequences and ROS mediated cellular signaling in rheumatoid arthritis","volume":"281","author":"Phull","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jtauto.2025.100267_bib186","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.cca.2016.10.007","article-title":"Redox signaling in rheumatoid arthritis and the preventive role of polyphenols","volume":"463","author":"Mateen","year":"2016","journal-title":"Clin. Chim. Acta"},{"issue":"7","key":"10.1016\/j.jtauto.2025.100267_bib187","doi-asserted-by":"crossref","first-page":"10123","DOI":"10.1002\/jcp.27678","article-title":"Icariin protects against iron overload-induced bone loss via suppressing oxidative stress","volume":"234","author":"Jing","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"5","key":"10.1016\/j.jtauto.2025.100267_bib188","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1136\/ard-2022-223568","article-title":"Neutrophil extracellular trap-associated carbamylation and histones trigger osteoclast formation in rheumatoid arthritis","volume":"82","author":"O'Neil","year":"2023","journal-title":"Ann. Rheum. Dis."},{"issue":"3","key":"10.1016\/j.jtauto.2025.100267_bib189","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s12026-021-09202-7","article-title":"The p53 status in rheumatoid arthritis with focus on fibroblast-like synoviocytes","volume":"69","author":"Taghadosi","year":"2021","journal-title":"Immunol. Res."},{"issue":"20","key":"10.1016\/j.jtauto.2025.100267_bib190","doi-asserted-by":"crossref","first-page":"10895","DOI":"10.1073\/pnas.94.20.10895","article-title":"Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium","volume":"94","author":"Firestein","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib191","doi-asserted-by":"crossref","first-page":"R12","DOI":"10.1186\/ar1448","article-title":"p53 tumor suppressor gene mutations in fibroblast-like synoviocytes from erosion synovium and non-erosion synovium in rheumatoid arthritis","volume":"7","author":"Yamanishi","year":"2005","journal-title":"Arthritis Res. Ther."},{"issue":"6","key":"10.1016\/j.jtauto.2025.100267_bib192","first-page":"Ec08","article-title":"Anaemia in systemic lupus erythematosus based on iron studies and soluble transferrin receptor levels","volume":"10","author":"Mittal","year":"2016","journal-title":"J. Clin. Diagn. Res."},{"key":"10.1016\/j.jtauto.2025.100267_bib193","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ejr.2019.04.007","article-title":"Is it useful to measure serum ferritin level in systemic lupus erythematosus patients?","volume":"42","author":"Gamal","year":"2020","journal-title":"The Egyptian Rheumatologist"},{"key":"10.1016\/j.jtauto.2025.100267_bib194","volume":"vol. 2012","author":"Yang","year":"2012"},{"issue":"3","key":"10.1016\/j.jtauto.2025.100267_bib195","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.clim.2006.06.001","article-title":"The biology of nitric oxide and other reactive intermediates in systemic lupus erythematosus","volume":"121","author":"Oates","year":"2006","journal-title":"Clin Immunol"},{"issue":"3","key":"10.1016\/j.jtauto.2025.100267_bib196","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0006-2952(98)00227-5","article-title":"Reactive oxygen intermediates as mediators of programmed cell death in plants and animals","volume":"57","author":"Jabs","year":"1999","journal-title":"Biochem. Pharmacol."},{"issue":"1\u20132","key":"10.1016\/j.jtauto.2025.100267_bib197","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0891-5849(96)00283-3","article-title":"Immunogenicity of DNA damaged by reactive oxygen species--implications for anti-DNA antibodies in lupus","volume":"22","author":"Cooke","year":"1997","journal-title":"Free Radic. Biol. Med."},{"issue":"9","key":"10.1016\/j.jtauto.2025.100267_bib198","doi-asserted-by":"crossref","DOI":"10.1172\/JCI152345","article-title":"Iron-dependent epigenetic modulation promotes pathogenic T cell differentiation in lupus","volume":"132","author":"Gao","year":"2022","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib199","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-13029-4","article-title":"Renal iron accumulation occurs in lupus nephritis and iron chelation delays the onset of albuminuria","volume":"7","author":"Marks","year":"2017","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.jtauto.2025.100267_bib200","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/nm.4027","article-title":"Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease","volume":"22","author":"Lood","year":"2016","journal-title":"Nat Med"},{"key":"10.1016\/j.jtauto.2025.100267_bib201","article-title":"The potential role of ferroptosis in systemic lupus erythematosus","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jtauto.2025.100267_bib202","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112481","article-title":"Promising roles of combined therapy based on immune response and iron metabolism in systemic lupus erythematosus","volume":"138","author":"Xing","year":"2024","journal-title":"Int. Immunopharm."},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib203","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-13029-4","article-title":"Renal iron accumulation occurs in lupus nephritis and iron chelation delays the onset of albuminuria","volume":"7","author":"Marks","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jtauto.2025.100267_bib204","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2022.109213","article-title":"Kidney tubular epithelial cell ferroptosis links glomerular injury to tubulointerstitial pathology in lupus nephritis","volume":"248","author":"Alli","year":"2023","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jtauto.2025.100267_bib205","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2023.109778","article-title":"The role of B-cell ferroptosis in the pathogenesis of systemic lupus erythematosus","volume":"256","author":"Chen","year":"2023","journal-title":"Clin. Immunol."},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib206","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.kint.2020.01.025","article-title":"Modulation of iron homeostasis with hepcidin ameliorates spontaneous murine lupus nephritis","volume":"98","author":"Scindia","year":"2020","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.jtauto.2025.100267_bib207","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/rheumatology\/ket331","article-title":"Iron deficiency in systemic sclerosis patients with and without pulmonary hypertension","volume":"53","author":"Ruiter","year":"2014","journal-title":"Rheumatology"},{"issue":"4","key":"10.1016\/j.jtauto.2025.100267_bib208","doi-asserted-by":"crossref","first-page":"175","DOI":"10.4103\/ejim.ejim_8_18","article-title":"Improvement of iron-deficiency anemia resulting from gastric antral vascular ectasia in patients with systemic sclerosis: cyclophosphamide versus argon plasma coagulation","volume":"30","author":"El-Hawary","year":"2018","journal-title":"The Egyptian Journal of Internal Medicine"},{"issue":"3","key":"10.1016\/j.jtauto.2025.100267_bib209","doi-asserted-by":"crossref","DOI":"10.3390\/life12030430","article-title":"Microvasculopathy-related hemorrhagic tissue deposition of iron may contribute to fibrosis in systemic sclerosis: hypothesis-generating insights from the literature and preliminary findings","volume":"12","author":"Sfikakis","year":"2022","journal-title":"Life"},{"issue":"2","key":"10.1016\/j.jtauto.2025.100267_bib210","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.amjms.2017.08.012","article-title":"Iron enhances hepatic fibrogenesis and activates transforming growth factor-\u03b2 signaling in murine hepatic stellate cells","volume":"355","author":"Mehta","year":"2018","journal-title":"Am. J. Med. Sci."},{"issue":"5","key":"10.1016\/j.jtauto.2025.100267_bib211","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/annrheumdis-2016-210229","article-title":"Endothelial-to-mesenchymal transition contributes to endothelial dysfunction and dermal fibrosis in systemic sclerosis","volume":"76","author":"Manetti","year":"2017","journal-title":"Ann. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib212","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12989-019-0314-4","article-title":"Iron oxide nanoparticles induce reversible endothelial-to-mesenchymal transition in vascular endothelial cells at acutely non-cytotoxic concentrations","volume":"16","author":"Wen","year":"2019","journal-title":"Part. Fibre Toxicol."},{"issue":"11","key":"10.1016\/j.jtauto.2025.100267_bib213","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0014003","article-title":"Reactive oxygen species are required for maintenance and differentiation of primary lung fibroblasts in idiopathic pulmonary fibrosis","volume":"5","author":"Bocchino","year":"2010","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.jtauto.2025.100267_bib214","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.4049\/jimmunol.136.7.2342","article-title":"Desferoxamine blocks IL 2 receptor expression on human T lymphocytes","volume":"136","author":"Carotenuto","year":"1986","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.jtauto.2025.100267_bib215","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3109\/08923978809014331","article-title":"Lymphocyte activation, iron uptake and release by human mononuclear leukocytes in the presence of desferrioxamine","volume":"10","author":"Taylor","year":"1988","journal-title":"Immunopharmacol. Immunotoxicol."},{"issue":"2","key":"10.1016\/j.jtauto.2025.100267_bib216","first-page":"176","article-title":"Mechanisms of inhibition of mononuclear cell activation by the iron-chelating agent desferrioxamine","volume":"71","author":"Polson","year":"1990","journal-title":"Immunology"},{"issue":"2","key":"10.1016\/j.jtauto.2025.100267_bib217","doi-asserted-by":"crossref","first-page":"e0904","DOI":"10.1002\/rcr2.904","article-title":"Iron therapy as a novel treatment of scleroderma-related pulmonary hypertension: a case report and literature review","volume":"10","author":"Neumann","year":"2022","journal-title":"Respirology Case Reports"},{"key":"10.1016\/j.jtauto.2025.100267_bib218","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2015.13","article-title":"Axial spondyloarthritis","volume":"1","author":"Sieper","year":"2015","journal-title":"Nat Rev Dis Primers"},{"issue":"10","key":"10.1016\/j.jtauto.2025.100267_bib219","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1056\/NEJMra041809","article-title":"Anemia of chronic disease","volume":"352","author":"Weiss","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jtauto.2025.100267_bib220","series-title":"Serum Prohepcidin and Hepcidin Levels in Patients with Ankylosing Spondylitis: a Prospective Study","author":"Dagli","year":"2016"},{"issue":"10","key":"10.1016\/j.jtauto.2025.100267_bib221","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1136\/ard.45.10.827","article-title":"Ankylosing spondylitis: a chronic inflammatory disease with iron overload in granulocytes and platelets","volume":"45","author":"Feltelius","year":"1986","journal-title":"Ann. Rheum. Dis."},{"issue":"12","key":"10.1016\/j.jtauto.2025.100267_bib222","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1007\/s00296-007-0352-3","article-title":"Serum oxidative-antioxidative status in patients with ankylosing spondilitis","volume":"27","author":"Karakoc","year":"2007","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.jtauto.2025.100267_bib223","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.12659\/MSM.907589","article-title":"Protective effects of sinomenine against ankylosing spondylitis and the underlying molecular mechanisms","volume":"24","author":"Dong","year":"2018","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.jtauto.2025.100267_bib224","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/4918239","article-title":"Punicalagin exerts protective effects against ankylosing spondylitis by regulating NF-\u03baB-TH17\/JAK2\/STAT3 signaling and oxidative stress","volume":"2020","author":"Feng","year":"2020","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.jtauto.2025.100267_bib225","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2020.155002","article-title":"Immunological and oxidative stress biomarkers in Ankylosing Spondylitis patients with or without metabolic syndrome","volume":"128","author":"Pishgahi","year":"2020","journal-title":"Cytokine"},{"issue":"9","key":"10.1016\/j.jtauto.2025.100267_bib226","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/s41419-020-02993-x","article-title":"Oxidative stress-mediated mitochondrial dysfunction facilitates mesenchymal stem cell senescence in ankylosing spondylitis","volume":"11","author":"Ye","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jtauto.2025.100267_bib227","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113709","article-title":"Ankylosing spondylitis: from pathogenesis to therapy","volume":"145","author":"Wei","year":"2025","journal-title":"Int. Immunopharm."},{"issue":"2","key":"10.1016\/j.jtauto.2025.100267_bib228","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1006\/abbi.1994.1379","article-title":"Complexation of iron cation by sodium urate crystals and gouty inflammation","volume":"313","author":"Ghio","year":"1994","journal-title":"Arch. Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.jtauto.2025.100267_bib229","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s13075-018-1668-y","article-title":"The relationship between ferritin and urate levels and risk of gout","volume":"20","author":"Fatima","year":"2018","journal-title":"Arthritis Res. Ther."},{"issue":"6","key":"10.1016\/j.jtauto.2025.100267_bib230","doi-asserted-by":"crossref","first-page":"C1722","DOI":"10.1152\/ajpcell.00280.2002","article-title":"Regulation of xanthine oxidoreductase by intracellular iron","volume":"283","author":"Martelin","year":"2002","journal-title":"Am J Physiol Cell Physiol"}],"container-title":["Journal of Translational Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589909025000024?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589909025000024?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T20:17:07Z","timestamp":1762633027000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589909025000024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":229,"alternative-id":["S2589909025000024"],"URL":"https:\/\/doi.org\/10.1016\/j.jtauto.2025.100267","relation":{},"ISSN":["2589-9090"],"issn-type":[{"value":"2589-9090","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Iron metabolism in rheumatic diseases","name":"articletitle","label":"Article Title"},{"value":"Journal of Translational Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtauto.2025.100267","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100267"}}