{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:53:46Z","timestamp":1788821626490,"version":"build-2803163510"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82230119"],"award-info":[{"award-number":["82230119"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3504700"],"award-info":[{"award-number":["2023YFC3504700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Translational Autoimmunity"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jtauto.2025.100285","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T04:19:53Z","timestamp":1742357993000},"page":"100285","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Unveiling the crucial role of CD8+ T cell and endothelial cell interaction in rheumatoid arthritis through the integrated analysis of spatial transcriptomics and bulk\/single-cell RNA-seq"],"prefix":"10.1016","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5987-8454","authenticated-orcid":false,"given":"Yu","family":"Lai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zishao","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runze","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuliang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xizi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6769-666X","authenticated-orcid":false,"given":"Yuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanhai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hudan","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtauto.2025.100285_bib1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/art.42726","article-title":"Associations between Rheumatoid Arthritis clinical factors and synovial cell types and states","volume":"76","author":"Weisenfeld","year":"2024","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.jtauto.2025.100285_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2024.148798","article-title":"Integrated single-cell and bulk rna sequencing identifies postn as a potential biomarker and therapeutic target for Rheumatoid Arthritis","volume":"928","author":"Li","year":"2024","journal-title":"Gene"},{"key":"10.1016\/j.jtauto.2025.100285_bib3","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.jconrel.2024.06.010","article-title":"Nanomedicines targeting activated immune cells and effector cells for Rheumatoid Arthritis treatment","volume":"371","author":"Deng","year":"2024","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.jtauto.2025.100285_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107392","article-title":"Fibroblast-like synoviocytes in Rheumatoid Arthritis: surface markers and phenotypes","volume":"93","author":"Wu","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jtauto.2025.100285_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-60860-7","article-title":"Regulation of cytokine and chemokine expression by histone lysine methyltransferase Mll1 in Rheumatoid Arthritis synovial fibroblasts","volume":"14","author":"Okamoto","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jtauto.2025.100285_bib6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/imr.12757","article-title":"Exploring the complex role of chemokines and chemoattractants in vivo on leukocyte dynamics","volume":"289","author":"David","year":"2019","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jtauto.2025.100285_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1100869","article-title":"Chemokines and chemokine receptors as promising targets in Rheumatoid Arthritis","volume":"14","author":"Murayama","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jtauto.2025.100285_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118286","article-title":"Chinese medicine di-long (Pheretima Vulgaris) and its active Fraction exhibit anti-Rheumatoid Arthritis effects by inhibiting Cxcl10\/Cxcr3 chemotaxis in synovium","volume":"332","author":"Bao","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jtauto.2025.100285_bib9","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s11926-025-01180-1","article-title":"T cell dysregulation in Rheumatoid Arthritis: from genetic susceptibility to established disease","volume":"27","author":"Chin","year":"2025","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.jtauto.2025.100285_bib10","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1002\/art.42839","article-title":"Expansion of hla-Dr positive peripheral helper T and naive B cells in anticitrullinated protein antibody-positive individuals at risk for Rheumatoid Arthritis","volume":"76","author":"Takada","year":"2024","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.jtauto.2025.100285_bib11","doi-asserted-by":"crossref","first-page":"4991","DOI":"10.1038\/s41467-024-49186-0","article-title":"Clonal associations between lymphocyte subsets and functional states in Rheumatoid Arthritis synovium","volume":"15","author":"Dunlap","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jtauto.2025.100285_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.berh.2024.101930","article-title":"Granzyme K(+) Cd8 T cells in autoimmunity","volume":"38","author":"Jonsson","year":"2024","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.jtauto.2025.100285_bib13","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.18632\/aging.205435","article-title":"Identification of Cd8(+) T cell-related biomarkers and immune infiltration characteristic of Rheumatoid Arthritis","volume":"16","author":"Wang","year":"2024","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jtauto.2025.100285_bib14","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s10238-024-01401-4","article-title":"Role of chemokines Cxcl9, Cxcl10, Cxcl11, and Cxcr3 in the serum and minor salivary gland tissues of patients with Sj\u00f6gren's syndrome","volume":"24","author":"Kim","year":"2024","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.jtauto.2025.100285_bib15","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s10875-012-9674-3","article-title":"Characterization of effector memory Cd8+ T cells in the synovial fluid of Rheumatoid Arthritis","volume":"32","author":"Cho","year":"2012","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.jtauto.2025.100285_bib16","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1136\/ard.49.2.81","article-title":"Lymphocyte surface marker expression in rheumatic diseases: evidence for prior activation of lymphocytes in vivo","volume":"49","author":"Smith","year":"1990","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jtauto.2025.100285_bib17","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s41467-022-35264-8","article-title":"Cytotoxic Cd8(+) T cells target citrullinated antigens in Rheumatoid Arthritis","volume":"14","author":"Moon","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jtauto.2025.100285_bib18","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/s41590-019-0378-1","article-title":"Defining inflammatory cell states in Rheumatoid Arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry","volume":"20","author":"Zhang","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jtauto.2025.100285_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109902","article-title":"Arthritis flares mediated by tissue-resident memory T cells in the joint","volume":"37","author":"Chang","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.jtauto.2025.100285_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2022.102950","article-title":"Tissue-resident memory T cells: the key frontier in local synovitis memory of Rheumatoid Arthritis","volume":"133","author":"Gao","year":"2022","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jtauto.2025.100285_bib21","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/s41467-024-45213-2","article-title":"Single-cell insights into immune dysregulation in Rheumatoid Arthritis flare versus drug-free remission","volume":"15","author":"Baker","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jtauto.2025.100285_bib22","first-page":"1105","article-title":"A link between Cd8+Cd27-Cd28- T cells expressing chemerin chemokine-like receptor 1 and Rheumatoid Arthritis","volume":"41","author":"Jeong","year":"2023","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.jtauto.2025.100285_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174500","article-title":"Angiogenesis as a potential treatment strategy for Rheumatoid Arthritis","volume":"910","author":"Wang","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jtauto.2025.100285_bib24","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nrrheum.2011.205","article-title":"Hypoxia--a key regulator of angiogenesis and inflammation in Rheumatoid Arthritis","volume":"8","author":"Konisti","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jtauto.2025.100285_bib25","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.171467","article-title":"Endothelial cell sphingosine 1-phosphate receptor 1 restrains ve-cadherin cleavage and attenuates experimental inflammatory arthritis","volume":"9","author":"Burg","year":"2024","journal-title":"JCI Insight"},{"key":"10.1016\/j.jtauto.2025.100285_bib26","doi-asserted-by":"crossref","first-page":"222","DOI":"10.5830\/CVJA-2011-068","article-title":"Endothelial dysfunction: the early predictor of atherosclerosis","volume":"23","author":"Mudau","year":"2012","journal-title":"Cardiovasc J Afr"},{"key":"10.1016\/j.jtauto.2025.100285_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111850","article-title":"Cpd-002, a novel Vegfr2 inhibitor, relieves Rheumatoid Arthritis by reducing angiogenesis through the suppression of the vegfr2\/Pi3k\/Akt signaling pathway","volume":"131","author":"Jiang","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jtauto.2025.100285_bib28","doi-asserted-by":"crossref","DOI":"10.1007\/s10557-024-07561-5","article-title":"Isoimperatorin inhibits angiogenesis by suppressing Vegfr2 signaling pathway","author":"Xu","year":"2024","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.jtauto.2025.100285_bib29","doi-asserted-by":"crossref","first-page":"4490","DOI":"10.4049\/jimmunol.1601988","article-title":"Cd40l-Dependent pathway is active at various stages of Rheumatoid Arthritis disease progression","volume":"198","author":"Guo","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.jtauto.2025.100285_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0183928","article-title":"Triple dmard treatment in early Rheumatoid Arthritis modulates synovial T cell activation and plasmablast\/plasma cell differentiation pathways","volume":"12","author":"Walsh","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jtauto.2025.100285_bib31","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1136\/annrheumdis-2021-221761","article-title":"Distinct stromal and immune cell interactions shape the pathogenesis of rheumatoid and psoriatic arthritis","volume":"81","author":"Floudas","year":"2022","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jtauto.2025.100285_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-67730-y","article-title":"Synovial cell cross-talk with cartilage plays a major role in the pathogenesis of osteoarthritis","volume":"10","author":"Chou","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jtauto.2025.100285_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2023.109812","article-title":"Comprehensive characterization of pathogenic synovial fluid extracellular vesicles from knee osteoarthritis","volume":"257","author":"Zhang","year":"2023","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jtauto.2025.100285_bib34","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/s41591-020-0939-8","article-title":"Distinct synovial tissue macrophage subsets regulate inflammation and remission in Rheumatoid Arthritis","volume":"26","author":"Alivernini","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.jtauto.2025.100285_bib35","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1038\/s41590-023-01527-9","article-title":"Drivers of heterogeneity in synovial fibroblasts in Rheumatoid Arthritis","volume":"24","author":"Smith","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jtauto.2025.100285_bib36","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1101\/gr.276851.122","article-title":"Scalable and model-free detection of spatial patterns and colocalization","volume":"32","author":"Liu","year":"2022","journal-title":"Genome Res."},{"key":"10.1016\/j.jtauto.2025.100285_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1345381","article-title":"Chemokines and lymphocyte homing in sj\u00f6gren's syndrome","volume":"15","author":"Liao","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jtauto.2025.100285_bib38","doi-asserted-by":"crossref","first-page":"721","DOI":"10.2147\/JIR.S449329","article-title":"Role of chemotaxis of V\u03b42 T cells to the synovium in the pathogenesis of acute gouty arthritis","volume":"17","author":"Di","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.jtauto.2025.100285_bib39","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41422-021-00540-7","article-title":"Identification of Hsc\/Mpp expansion units in fetal liver by single-cell spatiotemporal transcriptomics","volume":"32","author":"Gao","year":"2022","journal-title":"Cell Res."},{"key":"10.1016\/j.jtauto.2025.100285_bib40","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/1756-185X.14560","article-title":"The role, targets and mechanisms of traditional Chinese medicine in regulating the balance of T helper type 17\/regulatory Tcells in Rheumatoid Arthritis","volume":"26","author":"Wang","year":"2023","journal-title":"Int J Rheum Dis"},{"key":"10.1016\/j.jtauto.2025.100285_bib41","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1136\/ard.62.4.303","article-title":"Microarchitecture and protective mechanisms in synovial tissue from clinically and arthroscopically normal knee joints","volume":"62","author":"Smith","year":"2003","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jtauto.2025.100285_bib42","doi-asserted-by":"crossref","first-page":"368","DOI":"10.3892\/etm.2022.11295","article-title":"Identification of key candidate genes and biological pathways in the synovial tissue of patients with Rheumatoid Arthritis","volume":"23","author":"Yu","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.jtauto.2025.100285_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/art.42937","article-title":"Another notch in the belt of Rheumatoid Arthritis","author":"Zack","year":"2024","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.jtauto.2025.100285_bib44","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1002\/ptr.8094","article-title":"A new look at angiogenesis inhibition of geniposide in experimental arthritis by blocking angiopoietin-2 exocytosis","volume":"38","author":"Gan","year":"2024","journal-title":"Phytother Res."},{"key":"10.1016\/j.jtauto.2025.100285_bib45","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1161\/CIRCULATIONAHA.121.054071","article-title":"Role of venous endothelial cells in developmental and pathologic angiogenesis","volume":"144","author":"Lee","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.jtauto.2025.100285_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e35511","article-title":"Identification of diagnostic biomarkers of Rheumatoid Arthritis based on machine learning-assisted comprehensive Bioinformatics and its correlation with immune cells","volume":"10","author":"Mu","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.jtauto.2025.100285_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20225552","article-title":"Wnt signaling and biological therapy in Rheumatoid Arthritis and spondyloarthritis","volume":"20","author":"Cici","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jtauto.2025.100285_bib48","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/s41467-022-28120-2","article-title":"Lymphocyte infiltration and thyrocyte destruction are driven by stromal and immune cell components in Hashimoto's thyroiditis","volume":"13","author":"Zhang","year":"2022","journal-title":"Nat. Commun."}],"container-title":["Journal of Translational Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589909025000206?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589909025000206?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T20:18:01Z","timestamp":1762633081000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589909025000206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":48,"alternative-id":["S2589909025000206"],"URL":"https:\/\/doi.org\/10.1016\/j.jtauto.2025.100285","relation":{},"ISSN":["2589-9090"],"issn-type":[{"value":"2589-9090","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unveiling the crucial role of CD8+ T cell and endothelial cell interaction in rheumatoid arthritis through the integrated analysis of spatial transcriptomics and bulk\/single-cell RNA-seq","name":"articletitle","label":"Article Title"},{"value":"Journal of Translational Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtauto.2025.100285","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100285"}}