{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:05:15Z","timestamp":1786993515313,"version":"build-2736575974"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People&apos;s Republic of China","doi-asserted-by":"publisher","award":["2021ZD0113200"],"award-info":[{"award-number":["2021ZD0113200"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Translational Autoimmunity"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jtauto.2025.100303","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T03:53:02Z","timestamp":1754452382000},"page":"100303","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["MiR-122-5p modulates ferroptosis via SLC7A11: A potential therapeutic target in autoimmune hepatitis"],"prefix":"10.1016","volume":"11","author":[{"given":"Yuhong","family":"Suo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4673-8890","authenticated-orcid":false,"given":"Jidong","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jtauto.2025.100303_bib1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s12072-021-10170-1","article-title":"The Asian Pacific Association for the Study of the Liver clinical practice guidance: the diagnosis and management of patients with autoimmune hepatitis","volume":"15","author":"Wang","year":"2021","journal-title":"Hepatol. Int."},{"issue":"5","key":"10.1016\/j.jtauto.2025.100303_bib2","first-page":"482","volume":"30","year":"2022","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"issue":"2","key":"10.1016\/j.jtauto.2025.100303_bib3","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41423-021-00768-8","article-title":"Autoimmmune hepatitis","volume":"19","author":"Terziroli Beretta-Piccoli","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.jtauto.2025.100303_bib4","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2022-070201","article-title":"Diagnosis and management of autoimmune hepatitis","volume":"380","author":"Muratori","year":"2023","journal-title":"Br. Med. J."},{"issue":"1","key":"10.1016\/j.jtauto.2025.100303_bib5","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jhep.2023.09.010","article-title":"Incidence and predictors of hepatocellular carcinoma in patients with autoimmune hepatitis","volume":"80","author":"Colapietro","year":"2024","journal-title":"J. Hepatol."},{"issue":"6","key":"10.1016\/j.jtauto.2025.100303_bib6","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1002\/hep.32591","article-title":"Noninvasive biomarkers for the diagnosis and management of autoimmune hepatitis","volume":"76","author":"Harrington","year":"2022","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.jtauto.2025.100303_bib7","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/hep.31065","article-title":"Diagnosis and management of autoimmune hepatitis in adults and children: 2019 practice guidance and guidelines from the American association for the study of liver diseases","volume":"72","author":"Mack","year":"2020","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.jtauto.2025.100303_bib8","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1111\/liv.14480","article-title":"Incidence, prevalence and mortality of autoimmune hepatitis in England 1997-2015. A population-based cohort study","volume":"40","author":"Gr\u00f8nbaek","year":"2020","journal-title":"Liver Int."},{"issue":"3","key":"10.1016\/j.jtauto.2025.100303_bib9","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.jhep.2013.10.020","article-title":"Autoimmune hepatitis in Denmark: incidence, prevalence, prognosis, and causes of death. A nationwide registry-based cohort study","volume":"60","author":"Gr\u00f8nb\u00e6k","year":"2014","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.jtauto.2025.100303_bib10","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.cgh.2020.05.061","article-title":"Trends in incidence of autoimmune liver diseases and increasing incidence of autoimmune hepatitis","volume":"19","author":"Lamba","year":"2021","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"8","key":"10.1016\/j.jtauto.2025.100303_bib11","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1111\/hepr.13342","article-title":"Increase trend in the prevalence and male-to-female ratio of primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis in Japan","volume":"49","author":"Tanaka","year":"2019","journal-title":"Hepatol. Res."},{"issue":"4","key":"10.1016\/j.jtauto.2025.100303_bib12","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.ccell.2024.03.011","article-title":"The roles of ferroptosis in cancer: Tumor suppression, tumor microenvironment, and therapeutic interventions","volume":"42","author":"Lei","year":"2024","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.jtauto.2025.100303_bib13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41392-024-01769-5","article-title":"Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies","volume":"9","author":"Zhou","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"3","key":"10.1016\/j.jtauto.2025.100303_bib14","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1021\/acs.jafc.3c04495","article-title":"Ochratoxin A induces renal cell ferroptosis by disrupting iron homeostasis and increasing ROS","volume":"72","author":"Wang","year":"2024","journal-title":"J. Agric. Food Chem."},{"issue":"9","key":"10.1016\/j.jtauto.2025.100303_bib15","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1038\/s41418-023-01195-0","article-title":"Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression","volume":"30","author":"Van San","year":"2023","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jtauto.2025.100303_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.103008","article-title":"Heterogeneous ferroptosis susceptibility of macrophages caused by focal iron overload exacerbates rheumatoid arthritis","volume":"69","author":"Liu","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.jtauto.2025.100303_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2022.109213","article-title":"Kidney tubular epithelial cell ferroptosis links glomerular injury to tubulointerstitial pathology in lupus nephritis","volume":"248","author":"Alli","year":"2023","journal-title":"Clin. Immunol."},{"issue":"1","key":"10.1016\/j.jtauto.2025.100303_bib18","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s12943-023-01804-z","article-title":"Exosome-mediated miR-144-3p promotes ferroptosis to inhibit osteosarcoma proliferation, migration, and invasion through regulating ZEB1","volume":"22","author":"Jiang","year":"2023","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.jtauto.2025.100303_bib19","article-title":"ROS-responsive Injectable hydrogel loaded with SLC7A11-modRNA inhibits ferroptosis and mitigates Intervertebral Disc degeneration in rats","author":"Gao","year":"2024","journal-title":"Adv. Healthcare Mater."},{"issue":"1","key":"10.1016\/j.jtauto.2025.100303_bib20","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3350\/cmh.2020.0189","article-title":"Recent updates on the management of autoimmune hepatitis","volume":"27","author":"Komori","year":"2021","journal-title":"Clin. Mol. Hepatol."},{"issue":"9","key":"10.1016\/j.jtauto.2025.100303_bib21","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1111\/liv.15155","article-title":"Epidemiology and surveillance of autoimmune hepatitis in Asia","volume":"42","author":"Katsumi","year":"2022","journal-title":"Liver Int."},{"issue":"10","key":"10.1016\/j.jtauto.2025.100303_bib22","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000269","article-title":"CD4+ T-cell subsets in autoimmune hepatitis: a review","volume":"7","author":"Chen","year":"2023","journal-title":"Hepatol Commun"},{"issue":"3","key":"10.1016\/j.jtauto.2025.100303_bib23","doi-asserted-by":"crossref","first-page":"185","DOI":"10.32074\/1591-951X-241","article-title":"Pathology of autoimmune hepatitis","volume":"113","author":"Covelli","year":"2021","journal-title":"Pathologica"},{"issue":"2","key":"10.1016\/j.jtauto.2025.100303_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.aohep.2023.101183","article-title":"MiR-326 sponges TET2 triggering imbalance of Th17\/Treg differentiation to exacerbate pyroptosis of hepatocytes in concanavalin A-induced autoimmune hepatitis","volume":"29","author":"Zhang","year":"2024","journal-title":"Ann. Hepatol."},{"issue":"12","key":"10.1016\/j.jtauto.2025.100303_bib25","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1111\/hepr.13829","article-title":"Circulating extracellular vesicle-encapsulated microRNA-557 induces a proinflammatory immune response and serves as a diagnostic or relapse marker in autoimmune hepatitis","volume":"52","author":"Abe","year":"2022","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.jtauto.2025.100303_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154859","article-title":"Ginseng polysaccharide reduces autoimmune hepatitis inflammatory response by inhibiting PI3K\/AKT and TLRs\/NF-\u03baB signaling pathways","volume":"116","author":"Qi","year":"2023","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.jtauto.2025.100303_bib27","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.01127-22","article-title":"A novel synbiotic alleviates autoimmune hepatitis by modulating the gut microbiota-liver Axis and inhibiting the hepatic TLR4\/NF-\u03baB\/NLRP3 signaling pathway","volume":"8","author":"Kang","year":"2023","journal-title":"mSystems"},{"issue":"5","key":"10.1016\/j.jtauto.2025.100303_bib28","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1007\/s10787-023-01327-5","article-title":"A low dose of naloxone mitigates autoimmune hepatitis by regulating TLR4\/NF-\u03baB and Nrf2\/HO-1 signaling pathways","volume":"31","author":"Ibrahim","year":"2023","journal-title":"Inflammopharmacology"},{"issue":"7","key":"10.1016\/j.jtauto.2025.100303_bib29","article-title":"Itaconate attenuates autoimmune hepatitis via PI3K\/AKT\/mTOR pathway-mediated inhibition of dendritic cell maturation and autophagy","volume":"9","author":"Zhang","year":"2023","journal-title":"Heliyon"},{"issue":"6","key":"10.1016\/j.jtauto.2025.100303_bib30","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/s41423-024-01163-9","article-title":"Lkb1 orchestrates \u03b3\u03b4 T-cell metabolic and functional fitness to control IL-17-mediated autoimmune hepatitis","volume":"21","author":"Xiao","year":"2024","journal-title":"Cell. Mol. Immunol."},{"issue":"3","key":"10.1016\/j.jtauto.2025.100303_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167016","article-title":"Myeloid-specific deletion of group VIA calcium-independent phospholipase A2 induces pro-inflammatory LPS response predominantly in male mice via MIP-1\u03b1 activation","volume":"1870","author":"Klement","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.jtauto.2025.100303_bib32","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.3389\/fimmu.2018.01612","article-title":"Inflammasome priming mediated via Toll-like receptors 2 and 4, induces Th1-like regulatory T cells in De Novo autoimmune hepatitis","volume":"9","author":"Arterbery","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jtauto.2025.100303_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.921765","article-title":"Epigenetic aspects and Prospects in autoimmune hepatitis","volume":"13","author":"Czaja","year":"2022","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.jtauto.2025.100303_bib34","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1002\/hep.23792","article-title":"A multifaceted imbalance of T cells with regulatory function characterizes type 1 autoimmune hepatitis","volume":"52","author":"Ferri","year":"2010","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.jtauto.2025.100303_bib35","article-title":"MiR-122-5p regulates erastin-induced ferroptosis via CS in nasopharyngeal carcinoma","volume":"14","author":"Guo","year":"2024","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.jtauto.2025.100303_bib36","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1007\/s11064-021-03320-2","article-title":"Isorhynchophylline Relieves ferroptosis-induced nerve damage after intracerebral hemorrhage via miR-122-5p\/TP53\/SLC7A11 pathway","volume":"46","author":"Zhao","year":"2021","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.jtauto.2025.100303_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109762","article-title":"FGF4 improves hepatocytes ferroptosis in autoimmune hepatitis mice via activation of CISD3","volume":"116","author":"Jiang","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.jtauto.2025.100303_bib38","doi-asserted-by":"crossref","DOI":"10.1080\/08916934.2024.2350202","article-title":"Protective effect of quercetin against macrophage-mediated hepatocyte injury via anti-inflammation, anti-apoptosis and inhibition of ferroptosis","volume":"57","author":"Hou","year":"2024","journal-title":"Autoimmunity"},{"key":"10.1016\/j.jtauto.2025.100303_bib39","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.freeradbiomed.2019.12.026","article-title":"Caveolin-1 dictates ferroptosis in the execution of acute immune-mediated hepatic damage by attenuating nitrogen stress","volume":"148","author":"Deng","year":"2020","journal-title":"Free Radic. Biol. Med."},{"issue":"13","key":"10.1016\/j.jtauto.2025.100303_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15133324","article-title":"Expression analysis of hsa-miR-181a-5p, hsa-miR-143-3p, hsa-miR-132-3p and hsa-miR-23a-3p as biomarkers in colorectal cancer-relationship to the body mass index","volume":"15","author":"Tesolato","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"8","key":"10.1016\/j.jtauto.2025.100303_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25084355","article-title":"Serum levels of miR-122-5p and miR-125a-5p predict hepatotoxicity occurrence in patients undergoing autologous hematopoietic stem cell transplantation","volume":"25","author":"Mikulski","year":"2024","journal-title":"Int. J. Mol. Sci."}],"container-title":["Journal of Translational Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589909025000383?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589909025000383?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:17:36Z","timestamp":1778905056000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589909025000383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":41,"alternative-id":["S2589909025000383"],"URL":"https:\/\/doi.org\/10.1016\/j.jtauto.2025.100303","relation":{},"ISSN":["2589-9090"],"issn-type":[{"value":"2589-9090","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MiR-122-5p modulates ferroptosis via SLC7A11: A potential therapeutic target in autoimmune hepatitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Translational Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtauto.2025.100303","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100303"}}