{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T16:23:59Z","timestamp":1790526239393,"version":"4.1.0"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100022809","name":"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100022809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Translational Autoimmunity"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jtauto.2025.100338","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T08:26:45Z","timestamp":1764750405000},"page":"100338","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Data-driven classification of primary Sj\u00f6gren\u2019s syndrome: From cluster analysis to clinical immune phenotypes and predictive biomarkers"],"prefix":"10.1016","volume":"12","author":[{"given":"Jianbin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suiran","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtauto.2025.100338_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1216379","article-title":"Unraveling the transcriptome-based network of Tfh cells in primary Sj\u00f6gren syndrome: insights from a systems biology approach","volume":"14","author":"Luo","year":"2023","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.jtauto.2025.100338_bib2","article-title":"Serum growth differentiation factor 15 associates with extra-glandular manifestations and disease activity of primary Sj\u00f6gren\u2019s syndrome","volume":"15","author":"Fu","year":"2025","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.jtauto.2025.100338_bib3","first-page":"837","article-title":"Genetic and clinical basis for two distinct subtypes of primary Sj\u00f6gren\u2019s syndrome","volume":"60","author":"Thorlacius","year":"2021","journal-title":"Rheumatology"},{"issue":"1","key":"10.1016\/j.jtauto.2025.100338_bib4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s41927-024-00384-9","article-title":"Seronegative primary Sj\u00f6gren\u2019s syndrome, a distinct subtype of primary Sj\u00f6gren\u2019s syndrome in Chinese patients","volume":"8","author":"Lan","year":"2024","journal-title":"BMC Rheumatol"},{"issue":"1","key":"10.1016\/j.jtauto.2025.100338_bib5","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1186\/s12967-021-03051-6","article-title":"Longitudinal analysis of symptom-based clustering in patients with primary Sjogren\u2019s syndrome: a prospective cohort study with a 5-year follow-up period","volume":"19","author":"Lee","year":"2021","journal-title":"J. Transl. Med."},{"issue":"6","key":"10.1016\/j.jtauto.2025.100338_bib6","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1080\/03009742.2023.2196781","article-title":"Unsupervised clustering to differentiate rheumatoid arthritis patients based on proteomic signatures","volume":"52","author":"Ferreira","year":"2023","journal-title":"Scand. J. Rheumatol."},{"issue":"1","key":"10.1016\/j.jtauto.2025.100338_bib7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/art.39859","article-title":"2016 American college of Rheumatology\/European league against rheumatism classification criteria for primary Sj\u00f6gren\u2019s syndrome: a consensus and data-driven methodology involving three international patient cohorts","volume":"69","author":"Shiboski","year":"2017","journal-title":"Arthritis Rheumatol."},{"issue":"5","key":"10.1016\/j.jtauto.2025.100338_bib8","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1136\/annrheumdis-2013-204615","article-title":"Validation of EULAR primary Sj\u00f6gren\u2019s syndrome disease activity (ESSDAI) and patient indexes (ESSPRI)","volume":"74","author":"Seror","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jtauto.2025.100338_bib9","doi-asserted-by":"crossref","DOI":"10.1097\/JS9.0000000000002839","article-title":"Non-invasive prediction of NSCLC immunotherapy efficacy and tumor microenvironment through unsupervised machine learning-driven CT radiomic subtypes: a multi-cohort study","author":"Guo","year":"2025","journal-title":"Int. J. Surg."},{"issue":"7","key":"10.1016\/j.jtauto.2025.100338_bib10","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.3899\/jrheum.091165","article-title":"Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis: results from the EULAR scleroderma trial and research group (EUSTAR) database","volume":"37","author":"Avouac","year":"2010","journal-title":"J. Rheumatol."},{"issue":"2","key":"10.1016\/j.jtauto.2025.100338_bib11","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jim.2010.09.022","article-title":"A flow cytometry-based strategy to identify and express IgM from VH1-69+ clonal peripheral B cells","volume":"363","author":"Charles","year":"2011","journal-title":"J. Immunol. Methods"},{"issue":"6","key":"10.1016\/j.jtauto.2025.100338_bib12","doi-asserted-by":"crossref","first-page":"114","DOI":"10.55563\/clinexprheumatol\/volsh1","article-title":"Hypergammaglobulinaemia predicts glandular and extra-glandular damage in primary Sj\u00f6gren\u2019s syndrome: results from the KISS cohort study","volume":"39","author":"Koh","year":"2021","journal-title":"Clin. Exp. Rheumatol."},{"issue":"5","key":"10.1016\/j.jtauto.2025.100338_bib13","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1093\/rheumatology\/keu400","article-title":"Clinical characteristics of RA patients with secondary SS and association with joint damage","volume":"54","author":"Brown","year":"2015","journal-title":"Rheumatology"},{"key":"10.1016\/j.jtauto.2025.100338_bib14","article-title":"Pathogenic mechanisms of disease in idiopathic inflammatory myopathies: autoantibodies as clues","volume":"15","author":"Wu","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jtauto.2025.100338_bib15","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/6363086","article-title":"Autoantibodies as diagnostic markers and mediator of joint inflammation in arthritis","author":"Fang","year":"2019","journal-title":"Mediat. Inflamm."},{"issue":"6","key":"10.1016\/j.jtauto.2025.100338_bib16","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1007\/s00415-023-11613-5","article-title":"Sj\u00f6gren\u2019s syndrome with and without neurological involvement","volume":"270","author":"Seeliger","year":"2023","journal-title":"J. Neurol."},{"key":"10.1016\/j.jtauto.2025.100338_bib17","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13293-017-0137-7","article-title":"Difference in clinical presentation between women and men in incident primary Sj\u00f6gren\u2019s syndrome","volume":"8","author":"Ram\u00edrez Sep\u00falveda","year":"2017","journal-title":"Biol. Sex Differ."},{"issue":"7","key":"10.1016\/j.jtauto.2025.100338_bib18","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1136\/ard-2023-223901","article-title":"Rheumatoid factor autoantibody repertoire profiling reveals distinct binding epitopes in health and autoimmunity","volume":"82","author":"Oskam","year":"2023","journal-title":"Ann. Rheum. Dis."},{"issue":"5","key":"10.1016\/j.jtauto.2025.100338_bib19","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1007\/s10067-019-04438-z","article-title":"Usefulness of rheumatoid factor as an immunological and prognostic marker in PSS patients","volume":"38","author":"Ma\u015bli\u0144ska","year":"2019","journal-title":"Clin. Rheumatol."}],"updated-by":[{"DOI":"10.1016\/j.jtauto.2025.100343","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000}},{"DOI":"10.1016\/j.jtauto.2025.100343","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000}}],"container-title":["Journal of Translational Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589909025000735?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589909025000735?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:44:05Z","timestamp":1782866645000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589909025000735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":19,"alternative-id":["S2589909025000735"],"URL":"https:\/\/doi.org\/10.1016\/j.jtauto.2025.100338","relation":{},"ISSN":["2589-9090"],"issn-type":[{"value":"2589-9090","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Data-driven classification of primary Sj\u00f6gren\u2019s syndrome: From cluster analysis to clinical immune phenotypes and predictive biomarkers","name":"articletitle","label":"Article Title"},{"value":"Journal of Translational Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtauto.2025.100338","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100338"}}