{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:27:03Z","timestamp":1791077223416,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Theoretical Biology"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1016\/j.jtbi.2011.06.017","type":"journal-article","created":{"date-parts":[[2011,6,28]],"date-time":"2011-06-28T08:20:51Z","timestamp":1309249251000},"page":"130-141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Modelling the effect of heterogeneity of shedding on the within herd Coxiella burnetii spread and identification of key parameters by sensitivity analysis"],"prefix":"10.1016","volume":"284","author":[{"given":"Aur\u00e9lie","family":"Courcoul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Monod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"Nielen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don","family":"Klinkenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenny","family":"Hogerwerf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Beaudeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeta","family":"Vergu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtbi.2011.06.017_bib2","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/BF00140132","article-title":"Clinical aspects and prevention of Q fever in animals","volume":"5","author":"Aitken","year":"1989","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.jtbi.2011.06.017_bib10","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/j.1749-6632.2003.tb07422.x","article-title":"Excretion of Coxiella burnetii during an experimental infection of pregnant goats with an abortive goat strain CbC1","volume":"990","author":"Arricau-Bouvery","year":"2003","journal-title":"Ann. N Y Acad. Sci."},{"key":"10.1016\/j.jtbi.2011.06.017_bib12","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1051\/vetres:2005010","article-title":"Is Q fever an emerging or re-emerging zoonosis?","volume":"36","author":"Arricau-Bouvery","year":"2005","journal-title":"Vet. Res."},{"key":"10.1016\/j.jtbi.2011.06.017_bib18","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1051\/vetres:2003017","article-title":"Experimental Coxiella burnetii infection in pregnant goats: excretion routes","volume":"34","author":"Arricau Bouvery","year":"2003","journal-title":"Vet. Res."},{"key":"10.1016\/j.jtbi.2011.06.017_bib45","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.tvjl.2009.01.017","article-title":"Kinetics of Coxiella burnetii excretion in a commercial dairy sheep flock after treatment with oxytetracycline","volume":"184","author":"Astobiza","year":"2009","journal-title":"Vet. J."},{"key":"10.1016\/j.jtbi.2011.06.017_bib47","doi-asserted-by":"crossref","first-page":"4392","DOI":"10.1016\/j.vaccine.2005.04.010","article-title":"Effect of vaccination with phase I and phase II Coxiella burnetii vaccines in pregnant goats","volume":"23","author":"Arricau-Bouvery","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.jtbi.2011.06.017_bib3","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1177\/104063870001200505","article-title":"Coxiella burnetii infection is associated with placentitis in cases of bovine abortion","volume":"12","author":"Bildfell","year":"2000","journal-title":"J. Vet. Diagn. Invest."},{"key":"10.1016\/j.jtbi.2011.06.017_bib4","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1136\/vr.148.16.502","article-title":"Relationships between the shedding of Coxiella burnetii, clinical signs and serological responses of 34 sheep","volume":"148","author":"Berri","year":"2001","journal-title":"Vet. Rec."},{"key":"10.1016\/j.jtbi.2011.06.017_bib33","unstructured":"Bouvier, A., Kobilinsky, A., Monod, H., 2010. PLANOR: an R library for the automatic generation of regular fractional factorial designs. Technical Report, INRA Jouy en Josas."},{"key":"10.1016\/j.jtbi.2011.06.017_bib34","series-title":"Design of comparative experiments","author":"Bailey","year":"2008"},{"key":"10.1016\/j.jtbi.2011.06.017_bib42","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.3168\/jds.2009-2721","article-title":"Assessing economic consequences of foot disorders in dairy cattle using a dynamic stochastic simulation model","volume":"93","author":"Bruijnis","year":"2010","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.jtbi.2011.06.017_bib27","first-page":"2857","article-title":"Spread of Q fever within dairy cattle herds: key parameters inferred using a Bayesian approach","volume":"277","author":"Courcoul","year":"2010","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.jtbi.2011.06.017_bib17","first-page":"935","article-title":"Lacteal and placental excretion of Coxiella burnetti, agent of Q fever, in the cow. Importance and prevention","volume":"177","author":"Durand","year":"1993","journal-title":"Bull. Acad. Natl. Med."},{"key":"10.1016\/j.jtbi.2011.06.017_bib38","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.prevetmed.2007.01.005","article-title":"Sensitivity analysis to identify key-parameters in modelling the spread of bovine viral diarrhoea virus in a dairy herd","volume":"80","author":"Ezanno","year":"2007","journal-title":"Prev. Vet. Med."},{"key":"10.1016\/j.jtbi.2011.06.017_bib28","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1128\/JCM.36.7.1823-1834.1998","article-title":"Diagnosis of Q fever","volume":"36","author":"Fournier","year":"1998","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.jtbi.2011.06.017_bib9","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1051\/vetres:2006038","article-title":"Shedding routes of Coxiella burnetii in dairy cows: implications for detection and control","volume":"37","author":"Guatteo","year":"2006","journal-title":"Vet. Res."},{"key":"10.1016\/j.jtbi.2011.06.017_bib16","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1586\/eri.10.29","article-title":"Q fever: clinical manifestations and treatment","volume":"8","author":"Gikas","year":"2010","journal-title":"Expert Rev. Anti. Infect. Ther."},{"key":"10.1016\/j.jtbi.2011.06.017_bib20","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1051\/vetres:2007038","article-title":"Coxiella burnetii shedding by dairy cows","volume":"38","author":"Guatteo","year":"2007","journal-title":"Vet. Res."},{"key":"10.1016\/j.jtbi.2011.06.017_bib23","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jtbi.2008.02.038","article-title":"The effect of superspreading on epidemic outbreak size distributions","volume":"253","author":"Garske","year":"2008","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.jtbi.2011.06.017_bib49","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3201\/eid1703.101157","article-title":"Reduction of Coxiella burnetii prevalence by vaccination of goats and sheep, the Netherlands","volume":"17","author":"Hogerwerf","year":"2011","journal-title":"Emerging Infect. Dis."},{"key":"10.1016\/j.jtbi.2011.06.017_bib25","series-title":"Modeling infectious diseases in Humans and animals","author":"Keeling","year":"2008"},{"key":"10.1016\/j.jtbi.2011.06.017_bib35","series-title":"Plans d\u2019exp\u00e9riences: applications \u00e0 l\u2019entreprise","first-page":"69","article-title":"Less plans factoriels","author":"Kobilinsky","year":"1997"},{"key":"10.1016\/j.jtbi.2011.06.017_bib5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1023\/A:1007452503863","article-title":"An outbreak of sheep-associated Q fever in a rural community in Germany","volume":"14","author":"Lyytikainen","year":"1998","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.jtbi.2011.06.017_bib24","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1017\/S0950268807000209","article-title":"The effect of heterogeneous infectious period and contagiousness on the dynamics of Salmonella transmission in dairy cattle","volume":"136","author":"Lanzas","year":"2008","journal-title":"Epidemiol. Infect."},{"key":"10.1016\/j.jtbi.2011.06.017_bib30","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jtbi.2009.01.026","article-title":"Sensitivity analysis to identify key parameters influencing Salmonella infection dynamics in a pig batch","volume":"258","author":"Lurette","year":"2009","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.jtbi.2011.06.017_bib31","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.fcr.2009.06.007","article-title":"Multivariate global sensitivity analysis for dynamic crop models","volume":"113","author":"Lamboni","year":"2009","journal-title":"Field Crop. Res."},{"key":"10.1016\/j.jtbi.2011.06.017_bib36","unstructured":"Lamboni, M., Monod, H., 2010. Multisensi: Multivariate Sensitivity Analysis. R package version 1.0-3, \u3008http:\/\/CRAN.R-project.org\/package=multisensi\u3009."},{"key":"10.1016\/j.jtbi.2011.06.017_bib40","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.jtbi.2010.03.034","article-title":"Stochastic simulations of a multi-group compartmental model for Johne's disease on US dairy herds with test-based culling intervention","volume":"264","author":"Lu","year":"2010","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.jtbi.2011.06.017_bib6","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1089\/15303660260613747","article-title":"Q fever in humans and animals in the United States","volume":"2","author":"McQuiston","year":"2002","journal-title":"Vector Borne Zoonotic Dis."},{"key":"10.1016\/j.jtbi.2011.06.017_bib13","first-page":"555","article-title":"Q fever\u2014a review","volume":"31","author":"Marrie","year":"1990","journal-title":"Can. Vet. J."},{"key":"10.1016\/j.jtbi.2011.06.017_bib21","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nrmicro1178","article-title":"New approaches to quantifying the spread of infection","volume":"3","author":"Matthews","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.jtbi.2011.06.017_bib22","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1073\/pnas.0503776103","article-title":"Heterogeneous shedding of Escherichia coli O157 in cattle and its implications for control","volume":"103","author":"Matthews","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jtbi.2011.06.017_bib44","series-title":"Working with Dynamic Crop Models, Evaluation, Analysis, Parameterization, and Applications","first-page":"55","article-title":"Uncertainty and sensitivity analysis for crop models","author":"Monod","year":"2006"},{"key":"10.1016\/j.jtbi.2011.06.017_bib1","first-page":"325","article-title":"Q exp\u00e9rimentale des bovins","volume":"4","author":"Plommet","year":"1973","journal-title":"Ann. Rech. V\u00e9t\u00e9r."},{"key":"10.1016\/j.jtbi.2011.06.017_bib29","first-page":"325","article-title":"Fi\u00e8vre Q exp\u00e9rimentale des bovins","volume":"4","author":"Plommet","year":"1973","journal-title":"Ann. Rech. Vet."},{"key":"10.1016\/j.jtbi.2011.06.017_bib15","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/00005792-200003000-00005","article-title":"Q fever 1985\u20131998. Clinical and epidemiologic features of 1383 infections","volume":"79","author":"Raoult","year":"2000","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jtbi.2011.06.017_bib19","doi-asserted-by":"crossref","first-page":"5352","DOI":"10.3168\/jds.2006-815","article-title":"Comparison of Coxiella burnetii shedding in milk of dairy bovine, caprine, and ovine herds","volume":"90","author":"Rodolakis","year":"2007","journal-title":"J Dairy Sci."},{"key":"10.1016\/j.jtbi.2011.06.017_bib32","series-title":"R: A Language and Environment for Statistical Computing","author":"R Development Core Team","year":"2009"},{"key":"10.1016\/j.jtbi.2011.06.017_bib48","article-title":"Efficiency of a phase 1 vaccine for the reduction of vaginal Coxiella burnetii shedding in a clinically affected goat herd","volume":"9999","author":"Rousset","year":"2009","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.jtbi.2011.06.017_bib43","series-title":"Sensitivity Analysis","author":"Saltelli","year":"2000"},{"key":"10.1016\/j.jtbi.2011.06.017_bib7","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1471-2334-10-69","article-title":"The use of a geographic information system to identify a dairy goat farm as the most likely source of an urban Q-fever outbreak","volume":"10","author":"Schimmer","year":"2010","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.jtbi.2011.06.017_bib37","unstructured":"Taurel, A.F., Guatteo, R., Joly, A., Seegers, H., Beaudeau, F., Q fever within-herd seroprevalence in infected dairy herds: assessment using an ELISA applied to bulk tank milk. \u3008http:\/\/www.svepm.org.uk\/posters\/2010\/Taurel_Q%20fever%20within-herd%20seroprevalence%20in%20infected%20dairy%20herd_assessment%20using%20an%20ELISA%20applied%20to%20bulk%20tan.pdf\u3009. Accessed on 17\/08\/2010."},{"key":"10.1016\/j.jtbi.2011.06.017_bib11","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1128\/br.25.3.285-293.1961","article-title":"Airborne Q fever","volume":"25","author":"Tigertt","year":"1961","journal-title":"Bacteriol. Rev."},{"key":"10.1016\/j.jtbi.2011.06.017_bib39","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.jtbi.2006.01.020","article-title":"A semi-stochastic model of the transmission of Escherichia coli O157 in a typical UK dairy herd: dynamics, sensitivity analysis and intervention\/prevention strategies","volume":"241","author":"Turner","year":"2006","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.jtbi.2011.06.017_bib14","doi-asserted-by":"crossref","DOI":"10.2807\/ese.15.12.19520-en","article-title":"Q fever in the Netherlands: an update on the epidemiology and control measures","volume":"15","author":"van der Hoek","year":"2010","journal-title":"Eur. Surveill."},{"key":"10.1016\/j.jtbi.2011.06.017_bib41","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1051\/vetres:2007050","article-title":"Milk quality assurance for paratuberculosis: simulation of within-herd infection dynamics and economics","volume":"39","author":"Weber","year":"2008","journal-title":"Vet. Res."},{"key":"10.1016\/j.jtbi.2011.06.017_bib46","unstructured":"P. Vellema, R. Van den Brom, D. Dercksen, L. Moll, H.J. Roest, Q fever in the Netherlands: one health in relation to Q fever, in humans and animals. \u3008www.minlnv.nl\/txmpub\/files\/?p_file_id=2000277\u3009. Accessed on 17\/08\/2010."},{"key":"10.1016\/j.jtbi.2011.06.017_bib8","doi-asserted-by":"crossref","DOI":"10.2807\/ese.15.12.19521-en","article-title":"Q fever outbreak in Cheltenham, United Kingdom, in 2007 and the use of dispersion modelling to investigate the possibility of airborne spread","volume":"15","author":"Wallensten","year":"2010","journal-title":"Eur. Surveill."}],"container-title":["Journal of Theoretical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002251931100316X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002251931100316X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T16:13:35Z","timestamp":1758384815000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002251931100316X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S002251931100316X"],"URL":"https:\/\/doi.org\/10.1016\/j.jtbi.2011.06.017","relation":{},"ISSN":["0022-5193"],"issn-type":[{"value":"0022-5193","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modelling the effect of heterogeneity of shedding on the within herd Coxiella burnetii spread and identification of key parameters by sensitivity analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Theoretical Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtbi.2011.06.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}