{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:36:42Z","timestamp":1790145402875,"version":"4.0.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Theoretical Biology"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.jtbi.2012.08.024","type":"journal-article","created":{"date-parts":[[2012,8,29]],"date-time":"2012-08-29T18:30:16Z","timestamp":1346265016000},"page":"25-34","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Modeling Plasmodium vivax: Relapses, treatment, seasonality, and G6PD deficiency"],"prefix":"10.1016","volume":"316","author":[{"given":"Farida","family":"Chamchod","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Beier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtbi.2012.08.024_bib1","doi-asserted-by":"crossref","first-page":"921715","DOI":"10.1155\/2012\/921715","article-title":"Modeling the effects of relapse in the transmission dynamics of malaria parasites","volume":"2012","author":"Aguas","year":"2012","journal-title":"J. Parasitol. Res."},{"key":"10.1016\/j.jtbi.2012.08.024_bib2","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1461-0248.2005.00879.x","article-title":"Seasonality and the dynamics of infectious diseases","volume":"9","author":"Altizer","year":"2006","journal-title":"Ecol. Lett."},{"key":"10.1016\/j.jtbi.2012.08.024_bib3","series-title":"Infectious Diseases of Humans","author":"Anderson","year":"1991"},{"key":"10.1016\/j.jtbi.2012.08.024_bib4","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1128\/CMR.00008-09","article-title":"Resistance to therapies for infection by Plasmodium vivax","volume":"22","author":"Baird","year":"2009","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.jtbi.2012.08.024_bib5","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1086\/424663","article-title":"Primaquine therapy for malaria","volume":"39","author":"Baird","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jtbi.2012.08.024_bib6","doi-asserted-by":"crossref","unstructured":"Brauer, F., van den Driessche, P., Wu, J., 2008. Mathematical epidemiology. In: Lecture Notes in Mathematics. Springer-Verlag, Berlin.","DOI":"10.1007\/978-3-540-78911-6"},{"key":"10.1016\/j.jtbi.2012.08.024_bib7","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0140-6736(08)60073-2","article-title":"Glucose-6-phosphate dehydrogenase deficiency","volume":"371","author":"Cappellini","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.jtbi.2012.08.024_bib8","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s11538-010-9545-0","article-title":"Analysis of a vector-bias model on malaria transmission","volume":"73","author":"Chamchod","year":"2011","journal-title":"Bull. Math. Biol."},{"key":"10.1016\/j.jtbi.2012.08.024_bib9","doi-asserted-by":"crossref","first-page":"e14275","DOI":"10.1371\/journal.pone.0014275","article-title":"Establishment of an in vitro assay for assessing the effects of drugs on the liver stages of Plasmodium vivax malaria","volume":"5","author":"Chattopadhyay","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jtbi.2012.08.024_bib10","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1086\/512242","article-title":"Relapses of Plasmodium vivax infection result from clonal hypnozoites activated at predetermined intervals","volume":"195","author":"Chen","year":"2007","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jtbi.2012.08.024_bib11","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1098\/rsif.2009.0178","article-title":"The interaction of seasonal forcing and immunity and the resonance dynamics of malaria","volume":"7","author":"Childs","year":"2010","journal-title":"J. R. Soc. Interface"},{"key":"10.1016\/j.jtbi.2012.08.024_bib12","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1128\/CMR.5.1.26","article-title":"The hypnozoite and relapse in primate malaria","volume":"5","author":"Cogswell","year":"1992","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.jtbi.2012.08.024_bib13","doi-asserted-by":"crossref","first-page":"4009","DOI":"10.1128\/IAI.00158-09","article-title":"Strain-specific duffy binding protein antibodies correlate with protection against infection with homologous compared to heterologous plasmodium vivax strains in Papua New Guinean children","volume":"77","author":"Cole-Tobian","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jtbi.2012.08.024_bib14","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/infdis\/174.2.373","article-title":"Molecular analysis of strains of Plasmodium vivax from paired primary and relapse infections","volume":"174","author":"Craig","year":"1996","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jtbi.2012.08.024_bib15","doi-asserted-by":"crossref","first-page":"e174","DOI":"10.1186\/1475-2875-7-174","article-title":"Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing","volume":"7","author":"Culleton","year":"2008","journal-title":"Malar. J."},{"key":"10.1016\/j.jtbi.2012.08.024_bib16","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1086\/644510","article-title":"Evidence for the transmission of Plasmodium vivax in the Republic of the Congo west Central Africa","volume":"200","author":"Culleton","year":"2009","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jtbi.2012.08.024_bib17","first-page":"725","article-title":"A mathematical model for Plasmodium vivax malaria transmission","volume":"69","author":"De Zoysa","year":"1991","journal-title":"Bull. World Heath Organ."},{"key":"10.1016\/j.jtbi.2012.08.024_bib18","series-title":"Mathematical Epidemiology of Infectious Diseases, Model Building, Analysis and Interpretation","author":"Diekmann","year":"2000"},{"key":"10.1016\/j.jtbi.2012.08.024_bib19","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1098\/rsif.2009.0386","article-title":"The construction of next-generation matrices for compartmental epidemic models","volume":"7","author":"Diekmann","year":"2010","journal-title":"J. R. Soc. Interface"},{"key":"10.1016\/j.jtbi.2012.08.024_bib20","first-page":"347","article-title":"A malaria model tested in the Africa Savannah","volume":"50","author":"Dietz","year":"1974","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.jtbi.2012.08.024_bib21","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1128\/CMR.00025-08","article-title":"Acquired immunity to malaria","volume":"22","author":"Doolan","year":"2009","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.jtbi.2012.08.024_bib22","doi-asserted-by":"crossref","first-page":"e225","DOI":"10.1371\/journal.pcbi.0030255","article-title":"Determination of the processes driving the acquisition of immunity to malaria using a mathematical transmission model","volume":"3","author":"Filipe","year":"2007","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.jtbi.2012.08.024_bib23","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.amepre.2008.08.030","article-title":"Climate and vectorborne diseases","volume":"35","author":"Gage","year":"2008","journal-title":"Am. J. Prev. Med."},{"key":"10.1016\/j.jtbi.2012.08.024_bib24","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0169-4758(91)90096-7","article-title":"Why do some African children develop severe malaria?","volume":"7","author":"Greenwood","year":"1991","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.jtbi.2012.08.024_bib25","doi-asserted-by":"crossref","first-page":"e774","DOI":"10.1371\/journal.pntd.0000774","article-title":"The international limits and population at risk of Plasmodium vivax transmission in 2009","volume":"4","author":"Guerra","year":"2009","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.jtbi.2012.08.024_bib26","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/0169-4758(94)90160-0","article-title":"A strain theory of malaria transmission","volume":"10","author":"Gupta","year":"1994","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.jtbi.2012.08.024_bib27","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1086\/512241","article-title":"Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites","volume":"195","author":"Imwong","year":"2007","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jtbi.2012.08.024_bib28","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1383-5769(02)00084-3","article-title":"A mathematical model for the transmission of Plasmodium vivax malaria","volume":"52","author":"Ishikawa","year":"2003","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.jtbi.2012.08.024_bib29","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.pt.2008.01.007","article-title":"Plasmodium vivax in India","volume":"24","author":"Joshi","year":"2008","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.jtbi.2012.08.024_bib30","article-title":"Basic reproduction number for the transmission of Plasmodium vivax malaria","volume":"32","author":"Kammanee","year":"2001","journal-title":"J. Parasitol. Res."},{"key":"10.1016\/j.jtbi.2012.08.024_bib31","series-title":"Modeling Infectious Diseases in Humans and Animals","author":"Keeling","year":"2007"},{"key":"10.1016\/j.jtbi.2012.08.024_bib32","doi-asserted-by":"crossref","first-page":"494","DOI":"10.4269\/ajtmh.2007.76.494","article-title":"Tafenoquine for the treatment of recurrent Plasmodium vivax malaria","volume":"76","author":"Kitchener","year":"2007","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.jtbi.2012.08.024_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0035-9203(85)90221-4","article-title":"Discovery of the hypnozoite and a new theory of malarial relapse","volume":"79","author":"Krotoski","year":"1985","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.jtbi.2012.08.024_bib34","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/1475-2875-9-223","article-title":"Population screening for glucose-6-phosphate dehydrogenase deficiencies in Isabel Province, Solomon Islands, using a modified enzyme assay on filter paper dried bloodspots","volume":"9","author":"Kuwahata","year":"2010","journal-title":"Malar. J."},{"key":"10.1016\/j.jtbi.2012.08.024_bib35","doi-asserted-by":"crossref","first-page":"e1000283","DOI":"10.1371\/journal.pmed.1000283","article-title":"The impact of phenotypic and genotypic G6PD deficiency on risk of Plasmodium vivax infection","volume":"7","author":"Leslie","year":"2010","journal-title":"PLoS Med."},{"key":"10.1016\/j.jtbi.2012.08.024_bib36","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1126\/science.1178849","article-title":"Positively selected G6PD-Mahidol mutation reduces Plasmodium vivax density in Southeast asians","volume":"326","author":"Louicharoen","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.jtbi.2012.08.024_bib37","series-title":"The Epidemiology and Control of Malaria","author":"Macdonald","year":"1957"},{"key":"10.1016\/j.jtbi.2012.08.024_bib38","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/S0035-9203(96)90406-X","article-title":"The interaction between Plasmodium falciparum and Plasmodium vivax children on Espirtu Santo Island, Vanuatu","volume":"90","author":"Maitland","year":"1996","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.jtbi.2012.08.024_bib39","doi-asserted-by":"crossref","first-page":"e1192","DOI":"10.1371\/journal.pntd.0001192","article-title":"Duffy negative antigen is no longer a barrier to Plasmodium vivax-molecular evidences from the African West Coast Angola and Equatorial Guinea","volume":"5","author":"Mendes","year":"2011","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.jtbi.2012.08.024_bib40","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4269\/ajtmh.2001.64.97","article-title":"The neglected burden of Plasmodium vivax malaria","volume":"64","author":"Mendis","year":"2001","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.jtbi.2012.08.024_bib41","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1056\/NEJM197608052950602","article-title":"The resistance factor to Plasmodium vivax in blacks","volume":"295","author":"Miller","year":"1976","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jtbi.2012.08.024_bib42","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S1473-3099(09)70177-X","article-title":"Key gaps in the knowledge of Plasmodium vivax a neglected human malaria parasite","volume":"9","author":"Mueller","year":"2009","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.jtbi.2012.08.024_bib43","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jtbi.2010.06.032","article-title":"The dilution effect of the domestic animal population on the transmission of P. vivax malaria","volume":"266","author":"Nah","year":"2010","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.jtbi.2012.08.024_bib44","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.trstmh.2010.08.009","article-title":"Efficacy and safety of chloroquine for patients with uncomplicated Plasmodium vivax infections in endemic countries","author":"Naing","year":"2010","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.jtbi.2012.08.024_bib45","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.trstmh.2006.11.002","article-title":"Estimates of short- and long-term incubation periods of Plasmodium vivax malaria in the Republic of Korea","volume":"101","author":"Nishiura","year":"2007","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.jtbi.2012.08.024_bib46","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4269\/ajtmh.2007.77.79","article-title":"Vivax malaria","volume":"77","author":"Price","year":"2007","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.jtbi.2012.08.024_bib47","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/0035-9203(76)90132-2","article-title":"A strain of Plasmodium vivax characterized by prolonged incubation","volume":"70","author":"Shute","year":"1977","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.jtbi.2012.08.024_bib48","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/nature04024","article-title":"The entomological inoculation rate and Plasmodium falciparumin African children","volume":"438","author":"Smith","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.jtbi.2012.08.024_bib49","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/1475-2875-8-212","article-title":"The role of simple mathematical models in malaria elimination strategy design","volume":"8","author":"White","year":"2009","journal-title":"Malar. J."},{"key":"10.1016\/j.jtbi.2012.08.024_bib50","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1186\/1475-2875-7-S1-S8","article-title":"The role of anti-malarial drugs in eliminating malaria","volume":"7","author":"White","year":"2008","journal-title":"Malar. J."}],"container-title":["Journal of Theoretical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022519312004468?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022519312004468?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T06:02:50Z","timestamp":1562133770000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022519312004468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":50,"alternative-id":["S0022519312004468"],"URL":"https:\/\/doi.org\/10.1016\/j.jtbi.2012.08.024","relation":{},"ISSN":["0022-5193"],"issn-type":[{"value":"0022-5193","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}