{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:41:27Z","timestamp":1784180487388,"version":"3.55.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"CONACYT","award":["151818"],"award-info":[{"award-number":["151818"]}]},{"name":"CONACYT","award":["225924"],"award-info":[{"award-number":["225924"]}]},{"name":"CONACYT"},{"name":"\u201cR\u00e9gion Centre\u201d Para3B Project","award":["Convention: 20110068745"],"award-info":[{"award-number":["Convention: 20110068745"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Theoretical Biology"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.jtbi.2015.08.003","type":"journal-article","created":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T18:40:15Z","timestamp":1439491215000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["In silico epitope analysis of unique and membrane associated proteins from Mycobacterium avium subsp. paratuberculosis for immunogenicity and vaccine evaluation"],"prefix":"10.1016","volume":"384","author":[{"given":"Perla","family":"Carlos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Roupie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Holbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Ascencio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kris","family":"Huygen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gracia","family":"Gomez-Anduro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Branger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Reyes-Becerril","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7965-1679","authenticated-orcid":false,"given":"Carlos","family":"Angulo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtbi.2015.08.003_bib43","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.imbio.2010.12.004","article-title":"Does a Th1 over Th2 dominancy really exist in the early stages of Mycobacterium avium subspecies paratuberculosis infections?","volume":"216","author":"Begg","year":"2011","journal-title":"Immunobiology"},{"key":"10.1016\/j.jtbi.2015.08.003_bib55","doi-asserted-by":"crossref","first-page":"23168","DOI":"10.1074\/jbc.M110.210534","article-title":"Detailed structural and quantitative analysis reveals the spatial organization of the cell walls of in vivo grown Mycobacterium leprae and in vitro grown Mycobacterium tuberculosis","volume":"286","author":"Bhamidi","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jtbi.2015.08.003_bib56","doi-asserted-by":"crossref","first-page":"11919","DOI":"10.1073\/pnas.93.21.11919","article-title":"The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol","volume":"93","author":"Belanger","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jtbi.2015.08.003_bib58","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.cbpa.2010.04.008","article-title":"The chemical biology of new drugs in the development for tuberculosis","volume":"14","author":"Barry","year":"2010","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.jtbi.2015.08.003_bib2","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.3168\/jds.2011-4787","article-title":"Economic analysis of Mycobacterium avium subspecies paratuberculosis vaccines in dairy herds","volume":"95","author":"Cho","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.jtbi.2015.08.003_bib32","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.vaccine.2007.12.014","article-title":"Immune responses in mice to Mycobacterium avium subsp. paratuberculosis following vaccination with a novel 74F recombinant polyprotein","volume":"26","author":"Chen","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.jtbi.2015.08.003_bib37","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1016\/j.vaccine.2006.12.042","article-title":"The PGRS domain of Mycobacterium tuberculosis PE_PGRS Rv1759c antigen is an efficient subunit vaccine to prevent reactivation in a murine model of chronic tuberculosis","volume":"25","author":"Campuzano","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.jtbi.2015.08.003_bib40","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2172-13-13","article-title":"Potential T cell epitopes of Mycobacterium tuberculosis that can instigate molecular mimicry against host: implications in autoimmune pathogenesis","volume":"13","author":"Chodisetti","year":"2012","journal-title":"BMC Immunol."},{"key":"10.1016\/j.jtbi.2015.08.003_bib42","doi-asserted-by":"crossref","first-page":"453","DOI":"10.4161\/viru.25180","article-title":"Prediction of molecular mimicry candidates in human pathogenic bacteria","volume":"4","author":"Doxey","year":"2013","journal-title":"Virulence"},{"key":"10.1016\/j.jtbi.2015.08.003_bib46","series-title":"Immunity: The Immune Response to Infectious and Inflammatory Disease","author":"DeFranco","year":"2007"},{"key":"10.1016\/j.jtbi.2015.08.003_bib51","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1128\/IAI.71.1.483-493.2003","article-title":"Mapping of murine Th1 helper T-Cell epitopes of mycolyl transferases Ag85A, Ag85B, and Ag85C from Mycobacterium tuberculosis","volume":"71","author":"D\u2019Souza","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jtbi.2015.08.003_bib52","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1128\/IAI.72.4.2412-2415.2004","article-title":"HLA-A2-restricted CD8+-cytotoxic-T-cell responses to novel epitopes in Mycobacterium tuberculosis superoxide dismutase, alanine dehydrogenase, and glutamine synthetase","volume":"72","author":"Dong","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jtbi.2015.08.003_bib62","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1128\/IAI.73.6.3492-3501.2005","article-title":"Contribution of the Mycobacterium tuberculosis MmpL protein family to virulence and drug resistance","volume":"73","author":"Domenech","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jtbi.2015.08.003_bib23","doi-asserted-by":"crossref","first-page":"4580","DOI":"10.1073\/pnas.1201586109","article-title":"Promiscuous binding of extracellular peptides to cell surface class I MHC protein","volume":"109","author":"Eisen","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jtbi.2015.08.003_bib14","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1128\/CVI.00114-12","article-title":"In silico identification of epitopes in Mycobacterium avium subsp. paratuberculosis proteins that were upregulated under stress conditions","volume":"19","author":"Gurung","year":"2012","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.jtbi.2015.08.003_bib19","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3389\/fcimb.2014.00093","article-title":"Cellular and humoral immune responses in sheep vaccinated with candidate antigens MAP2698c and MAP3567 from Mycobacterium avium subspecies paratuberculosis","volume":"4","author":"Gurung","year":"2014","journal-title":"Front. Cell Infect. Microbiol"},{"key":"10.1016\/j.jtbi.2015.08.003_bib20","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1128\/CVI.00775-13","article-title":"Lymphoproliferative and gamma interferon responses to stress-regulated Mycobacterium avium subsp. paratuberculosis recombinant proteins","volume":"21","author":"Gurung","year":"2014","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.jtbi.2015.08.003_bib39","doi-asserted-by":"crossref","first-page":"7092","DOI":"10.1016\/j.vaccine.2010.08.005","article-title":"In silico CD4+ T-cell epitope prediction and HLA distribution analysis for the potential proteins of Neisseria meningitidis Serogroup B\u2014a clue for vaccine development","volume":"28","author":"Gupta","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.jtbi.2015.08.003_bib4","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fcimb.2014.00026","article-title":"Evaluation of novel oral vaccine candidates and validation of a caprine model of Johne\u2019s disease","volume":"4","author":"Hines","year":"2014","journal-title":"Front. Cell Infect Microbiol."},{"key":"10.1016\/j.jtbi.2015.08.003_bib10","first-page":"353","article-title":"Development of new paratuberculosis vaccines","author":"Huygen","year":"2010"},{"key":"10.1016\/j.jtbi.2015.08.003_bib24","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3389\/fimmu.2014.00321","article-title":"The immunodominant T-cell epitopes of the mycolyl-transferases of the antigen 85 complex of M. tuberculosis","volume":"5","author":"Huygen","year":"2014","journal-title":"Front. Immunol"},{"key":"10.1016\/j.jtbi.2015.08.003_bib36","doi-asserted-by":"crossref","first-page":"5910","DOI":"10.1016\/j.vaccine.2010.06.042","article-title":"Epitopes of Mycobacterium avium ssp. paratuberculosis 70kDa heat-shock protein activate bovine helper T cells in outbred cattle","volume":"28","author":"Hoek","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.jtbi.2015.08.003_bib9","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1038\/ni1516","article-title":"Recent advances in antigen processing and presentation","volume":"8","author":"Jensen","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jtbi.2015.08.003_bib17","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.vetimm.2011.03.006","article-title":"The use of binding-prediction models to identify M. bovis-specific antigenic peptides for screening assays in bovine tuberculosis","volume":"141","author":"Jones","year":"2011","journal-title":"Vet. Immunol. Immunop"},{"key":"10.1016\/j.jtbi.2015.08.003_bib13","doi-asserted-by":"crossref","first-page":"12344","DOI":"10.1073\/pnas.0505662102","article-title":"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis","volume":"102","author":"Li","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jtbi.2015.08.003_bib27","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1093\/bioinformatics\/btn128","article-title":"Accurate approximation method for prediction of class I MHC affinities for peptides of length 8, 10 and 11 using prediction tools trained on 9mers","volume":"24","author":"Lundegaard","year":"2008","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jtbi.2015.08.003_bib44","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.imlet.2010.07.007","article-title":"Identification of a novel cytotoxic T lymphocyte epitope from CFP21, a secreted protein of Mycobacterium tuberculosis","volume":"133","author":"Lv","year":"2010","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.jtbi.2015.08.003_bib49","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1002\/pmic.200600988","article-title":"Antigen discovery: a postgenomic approach to paratuberculosis diagnosis","volume":"7","author":"Leroy","year":"2007","journal-title":"Proteomics"},{"key":"10.1016\/j.jtbi.2015.08.003_bib50","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.vetmic.2008.09.065","article-title":"Use of Mycobacterium avium subsp. paratuberculosis specific coding sequences for serodiagnosis of bovine paratuberculosis","volume":"135","author":"Leroy","year":"2009","journal-title":"Vet. Microbiol"},{"key":"10.1016\/j.jtbi.2015.08.003_bib1","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.cvfa.2011.07.008","article-title":"Paratuberculosis in captive and free-ranging wildlife","volume":"27","author":"Manning","year":"2011","journal-title":"Vet. Clin. N. Am. Food A"},{"key":"10.1016\/j.jtbi.2015.08.003_bib34","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.tube.2005.05.001","article-title":"ProPred analysis and experimental evaluation of promiscuous T-cell epitopes of three major secreted antigens of Mycobacterium tuberculosis","volume":"86","author":"Mustafa","year":"2006","journal-title":"Tuberculosis"},{"key":"10.1016\/j.jtbi.2015.08.003_bib53","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3855\/jidc.3114","article-title":"Exploiting the mycobacterial cell wall to design improved vaccines against tuberculosis","volume":"7","author":"Morandi","year":"2013","journal-title":"J. Infect. Dev. Ctries"},{"key":"10.1016\/j.jtbi.2015.08.003_bib3","doi-asserted-by":"crossref","first-page":"e63009","DOI":"10.1371\/journal.pone.0063009","article-title":"Dynamics of specific anti-Mycobacterium avium subsp. paratuberculosis antibody response through age","volume":"8","author":"Nielsen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jtbi.2015.08.003_bib28","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1186\/1471-2105-10-296","article-title":"NN-align: an artificial neural network-based alignment algorithm for MHC class II peptide binding prediction","volume":"10","author":"Nielsen","year":"2009","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.jtbi.2015.08.003_bib54","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.tim.2009.12.005","article-title":"Mycobacterial outer membranes: in search of proteins","volume":"18","author":"Niederweis","year":"2010","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.jtbi.2015.08.003_bib21","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3109\/1040841X.2013.763221","article-title":"Functional, biochemical and 3D studies of Mycobacterium tuberculosis protein peptides for an effective anti-tuberculosis vaccine","volume":"40","author":"Ocampo","year":"2014","journal-title":"Crit. Rev. Microbiol."},{"key":"10.1016\/j.jtbi.2015.08.003_bib16","doi-asserted-by":"crossref","first-page":"7530","DOI":"10.1016\/j.vaccine.2007.08.044","article-title":"Computational analysis of proteome of H5N1 avian influenza virus to define T cell epitopes with vaccine potential","volume":"25","author":"Parida","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.jtbi.2015.08.003_bib25","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.1016\/j.vaccine.2008.06.016","article-title":"Immunization with a DNA vaccine cocktail induces a Th1 response and protects mice against Mycobacterium avium subsp. paratuberculosis challenge","volume":"26","author":"Park","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.jtbi.2015.08.003_bib31","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.1016\/j.vaccine.2008.06.016","article-title":"Immunization with a DNA vaccine cocktail induces a Th1 response and protects mice against Mycobacterium avium subsp. paratuberculosis challenge","volume":"26","author":"Park","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.jtbi.2015.08.003_bib41","doi-asserted-by":"crossref","first-page":"314","DOI":"10.3389\/fimmu.2013.00314","article-title":"Social Changes, Asthma and Allergy in Latin America (SCAALA)\u05f3s Study Group, Alc\u00e2ntara-Neves NM. Antigen mimicry between infectious agents and self or environmental antigens may lead to long-term regulation of inflammation","volume":"4","author":"Pontes-de-Carvalho","year":"2013","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jtbi.2015.08.003_bib29","doi-asserted-by":"crossref","first-page":"4783","DOI":"10.1016\/j.vaccine.2008.07.009","article-title":"Immunogenicity and protective efficacy of DNA vaccines encoding MAP0586c and MAP4308c of Mycobacterium avium subsp. paratuberculosis secretome","volume":"26","author":"Roupie","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.jtbi.2015.08.003_bib30","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.vetimm.2011.10.012","article-title":"Immunogenicity of eight Mycobacterium avium subsp. paratuberculosis specific antigens in DNA vaccinated and Map infected mice","volume":"145","author":"Roupie","year":"2012","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.jtbi.2015.08.003_bib38","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1096\/fasebj.14.3.431","article-title":"Compositional bias and mimicry toward the nonself proteome in immunodominant T cell epitopes of self and nonself antigens","volume":"14","author":"Ristori","year":"2000","journal-title":"FASEB J."},{"key":"10.1016\/j.jtbi.2015.08.003_bib47","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.0105-2896.2005.00301.x","article-title":"Cross-presentation: underlying mechanisms and role in immune surveillance","volume":"207","author":"Rock","year":"2005","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jtbi.2015.08.003_bib7","doi-asserted-by":"crossref","first-page":"754","DOI":"10.2460\/ajvr.2000.61.754","article-title":"Cytokine secretion by peripheral blood mononuclear cells from cows infected with Mycobacterium paratuberculosis","volume":"61","author":"Stabel","year":"2000","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.jtbi.2015.08.003_bib8","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.imbio.2007.11.002","article-title":"Immunology of mycobacterial infections: with special reference to Mycobacterium avium subspecies paratuberculosis","volume":"213","author":"Sohal","year":"2008","journal-title":"Immunobiology"},{"key":"10.1016\/j.jtbi.2015.08.003_bib12","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1469-0691.2012.03939.x","article-title":"Developing vaccines in the era of genomics: a decade of reverse vaccinology","volume":"18","author":"Seib","year":"2012","journal-title":"Clin. Microbiol. Infec"},{"key":"10.1016\/j.jtbi.2015.08.003_bib15","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1016\/j.vaccine.2007.01.079","article-title":"Comparative in silico analysis of two vaccine candidates for group A streptococcus predicts that they both may have similar safety profiles","volume":"25","author":"Shaila","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.jtbi.2015.08.003_bib18","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.tube.2009.03.005","article-title":"Design of immunogenic peptides from Mycobacterium tuberculosis genes expressed during macrophage infection","volume":"89","author":"Seghrouchni","year":"2009","journal-title":"Tuberculosis"},{"key":"10.1016\/j.jtbi.2015.08.003_bib22","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1093\/bioinformatics\/17.12.1236","article-title":"Propred: prediction of HLA-DR biding sites","volume":"17","author":"Singh","year":"2001","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jtbi.2015.08.003_bib33","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/prot.21078","article-title":"Prediction of continuous B-cell epitopes in an antigen using recurrent neural network","volume":"65","author":"Saha","year":"2006","journal-title":"Proteins"},{"key":"10.1016\/j.jtbi.2015.08.003_bib35","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/j.meegid.2012.03.023","article-title":"In silico identification of potential antigenic proteins and promiscuous CTL epitopes in Mycobacterium tuberculosis","volume":"12","author":"Sundaramurthi","year":"2012","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.jtbi.2015.08.003_bib11","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.drudis.2009.04.001","article-title":"Immunoinformatics: current trends and future directions","volume":"14","author":"Tong","year":"2009","journal-title":"Drug Discovery Today"},{"key":"10.1016\/j.jtbi.2015.08.003_bib45","doi-asserted-by":"crossref","first-page":"4907","DOI":"10.1016\/j.vaccine.2012.05.049","article-title":"Immune markers and correlates of protection for vaccine induced immune responses","volume":"30","author":"Thakur","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.jtbi.2015.08.003_bib57","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.cbpa.2009.09.012","article-title":"Recent advances in mycobacterial cell wall glycan biosynthesis","volume":"13","author":"Tam","year":"2009","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.jtbi.2015.08.003_bib61","doi-asserted-by":"crossref","first-page":"5051","DOI":"10.1073\/pnas.1009516108","article-title":"Discovery and characterization of a unique mycobacterial heme acquisition system","volume":"108","author":"Tullius","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jtbi.2015.08.003_bib60","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.chembiol.2012.03.006","article-title":"MmpL Genes are associated with mycolic acid metabolism in Mycobacteria and Corynebacteria","volume":"19","author":"Varela","year":"2012","journal-title":"Chem. Biol."},{"key":"10.1016\/j.jtbi.2015.08.003_bib6","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1354\/vp.45-6-829","article-title":"Modulation of mononuclear phagocyte function by Mycobacterium avium subsp. paratuberculosis","volume":"45","author":"Weiss","year":"2008","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.jtbi.2015.08.003_bib48","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1146\/annurev.immunol.25.022106.141548","article-title":"Effector and memory CTL differentiation","volume":"25","author":"Williams","year":"2007","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jtbi.2015.08.003_bib59","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1128\/AAC.05742-11","article-title":"Antigen 85C inhibition restricts Mycobacterium tuberculosis growth through disruption of cord factor biosynthesis","volume":"56","author":"Warrier","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jtbi.2015.08.003_bib26","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1093\/bioinformatics\/btq249","article-title":"3.0: Improved protein subcellular localization prediction with refined localization subcategories and predictive capabilities for all prokaryotes","volume":"26","author":"Yu","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jtbi.2015.08.003_bib5","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1182\/blood-2008-05-078154","article-title":"CD4 T cells: fates, functions, and faults","volume":"112","author":"Zhu","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jtbi.2015.08.003_bib63","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/j.micinf.2008.07.025","article-title":"Transcriptional analysis of diverse strains Mycobacterium avium subspecies paratuberculosis in primary bovine monocyte derived macrophages","volume":"10","author":"Zhu","year":"2008","journal-title":"Microbes Infect"}],"container-title":["Journal of Theoretical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022519315003811?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022519315003811?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T18:06:13Z","timestamp":1589565973000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022519315003811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":63,"alternative-id":["S0022519315003811"],"URL":"https:\/\/doi.org\/10.1016\/j.jtbi.2015.08.003","relation":{},"ISSN":["0022-5193"],"issn-type":[{"value":"0022-5193","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In silico epitope analysis of unique and membrane associated proteins from Mycobacterium avium subsp. paratuberculosis for immunogenicity and vaccine evaluation","name":"articletitle","label":"Article Title"},{"value":"Journal of Theoretical Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtbi.2015.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}