{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T01:46:02Z","timestamp":1786671962470,"version":"build-2736575974"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000072","name":"NIDCR","doi-asserted-by":"publisher","award":["2R01DE019245-06A1"],"award-info":[{"award-number":["2R01DE019245-06A1"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"name":"New Zealand eScience Infrastructure"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Theoretical Biology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.jtbi.2016.04.030","type":"journal-article","created":{"date-parts":[[2016,5,4]],"date-time":"2016-05-04T17:57:38Z","timestamp":1462384658000},"page":"383-393","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Modeling calcium waves in an anatomically accurate three-dimensional parotid acinar cell"],"prefix":"10.1016","volume":"419","author":[{"given":"James","family":"Sneyd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn","family":"Means","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Rugis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Hak","family":"Won","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David I.","family":"Yule","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtbi.2016.04.030_bib1","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1126\/science.1465619","article-title":"Range of messenger action of calcium ion and inositol 1,4,5-trisphosphate","volume":"258","author":"Allbritton","year":"1992","journal-title":"Science"},{"issue":"34","key":"10.1016\/j.jtbi.2016.04.030_bib2","doi-asserted-by":"crossref","first-page":"5774","DOI":"10.2174\/092986712804143321","article-title":"Polarization of calcium signaling and fluid secretion in salivary gland cells","volume":"19","author":"Ambudkar","year":"2012","journal-title":"Curr. Med. Chem."},{"issue":"3","key":"10.1016\/j.jtbi.2016.04.030_bib3","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1152\/physrev.00006.2002","article-title":"Polarized calcium and calmodulin signaling in secretory epithelia","volume":"82","author":"Ashby","year":"2002","journal-title":"Physiol. Rev."},{"issue":"4","key":"10.1016\/j.jtbi.2016.04.030_bib4","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1016\/S0006-3495(93)81191-3","article-title":"A single-pool model for intracellular calcium oscillations and waves in the Xenopus laevis oocyte","volume":"65","author":"Atri","year":"1993","journal-title":"Biophys. J."},{"key":"10.1016\/j.jtbi.2016.04.030_bib5","doi-asserted-by":"crossref","unstructured":"Balay, S., Abhyankar, S., Adams, M.F., Brown, J., Brune, P., Buschelman, K., Dalcin, L., Eijkhout, V., Gropp, W.D., Kaushik, D., Knepley, M.G., McInnes, L.C., Rupp, K., Smith, B.F., Zampini, S., Zhang, H., 2015. PETSc Users Manual. Technical Report ANL-95\/11 \u2013 Revision 3.6, Argonne National Laboratory. URL \u3008http:\/\/www.mcs.anl.gov\/petsc\u3009.","DOI":"10.2172\/1255238"},{"issue":"1","key":"10.1016\/j.jtbi.2016.04.030_bib6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/35036035","article-title":"The versatility and universality of calcium signalling","volume":"1","author":"Berridge","year":"2000","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.jtbi.2016.04.030_bib7","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1074\/jbc.M106609200","article-title":"Phosphorylation of inositol 1,4,5-trisphosphate receptors in parotid acinar cells. A mechanism for the synergistic effects of cAMP on Ca2+ signaling","volume":"277","author":"Bruce","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.jtbi.2016.04.030_bib8","doi-asserted-by":"crossref","first-page":"e1003783","DOI":"10.1371\/journal.pcbi.1003783","article-title":"A deterministic model predicts the properties of stochastic calcium oscillations in airway smooth muscle cells","volume":"10","author":"Cao","year":"2014","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.jtbi.2016.04.030_bib9","unstructured":"Cook, D., Van Lennep, E., Roberts, M.L., Young, J.A., 1994. Secretion by the major salivary glands. In: Johnson, L. (Ed.), Physiology of the Gastrointestinal Tract, 3rd edition. Raven Press, 1994, p. 1061."},{"issue":"20","key":"10.1016\/j.jtbi.2016.04.030_bib10","doi-asserted-by":"crossref","first-page":"9895","DOI":"10.1073\/pnas.89.20.9895","article-title":"A single-pool inositol 1,4,5-trisphosphate-receptor-based model for agonist-stimulated oscillations in Ca2+ concentration","volume":"89","author":"De Young","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"5","key":"10.1016\/j.jtbi.2016.04.030_bib11","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0143-4160(97)90017-8","article-title":"Simulations of the effects of inositol 1,4,5-trisphosphate 3-kinase and 5-phosphatase activities on Ca2+ oscillations","volume":"22","author":"Dupont","year":"1997","journal-title":"Cell Calcium"},{"issue":"2","key":"10.1016\/j.jtbi.2016.04.030_bib12","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1152\/physrev.00035.2006","article-title":"Inositol trisphosphate receptor Ca2+ release channels","volume":"87","author":"Foskett","year":"2007","journal-title":"Physiol. Rev."},{"issue":"4","key":"10.1016\/j.jtbi.2016.04.030_bib13","doi-asserted-by":"crossref","first-page":"519","DOI":"10.14219\/jada.archive.1985.0384","article-title":"Xerostomia","volume":"110","author":"Fox","year":"1985","journal-title":"J. Am. Dent. Assoc."},{"issue":"5","key":"10.1016\/j.jtbi.2016.04.030_bib14","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1016\/S0006-3495(95)80352-8","article-title":"[Ca2+]i oscillations in sympathetic neurons","volume":"68","author":"Friel","year":"1995","journal-title":"Biophys. J."},{"issue":"1","key":"10.1016\/j.jtbi.2016.04.030_bib15","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jtbi.2007.04.021","article-title":"A mathematical model of fluid secretion from a parotid acinar cell","volume":"248","author":"Gin","year":"2007","journal-title":"J. Theor. Biol."},{"issue":"Pt 2","key":"10.1016\/j.jtbi.2016.04.030_bib16","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1113\/jphysiol.2001.013453","article-title":"Cytosolic Ca2+ and Ca2+-activated Cl\u2212 current dynamics","volume":"540","author":"Giovannucci","year":"2002","journal-title":"J. Physiol."},{"issue":"1","key":"10.1016\/j.jtbi.2016.04.030_bib17","doi-asserted-by":"crossref","first-page":"G118","DOI":"10.1152\/ajpgi.00096.2004","article-title":"Local and global calcium signals and fluid and electrolyte secretion in mouse submandibular acinar cells","volume":"288","author":"Harmer","year":"2005","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.jtbi.2016.04.030_bib18","series-title":"Mathematical Physiology","author":"Keener","year":"2008"},{"issue":"Pt 18","key":"10.1016\/j.jtbi.2016.04.030_bib19","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1242\/jcs.02533","article-title":"Ca2+ dynamics in salivary acinar cells","volume":"118","author":"Larina","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.jtbi.2016.04.030_bib20","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1006\/jtbi.1994.1041","article-title":"Equations for InsP3 receptor-mediated Ca2+ oscillations derived from a detailed kinetic model","volume":"166","author":"Li","year":"1994","journal-title":"J. Theor. Biol."},{"issue":"1","key":"10.1016\/j.jtbi.2016.04.030_bib21","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1146\/annurev.physiol.67.041703.084745","article-title":"Regulation of fluid and electrolyte secretion in salivary gland acinar cells","volume":"67","author":"Melvin","year":"2005","journal-title":"Annu. Rev. Physiol."},{"issue":"6","key":"10.1016\/j.jtbi.2016.04.030_bib22","first-page":"795","article-title":"Saliva and dental diseases","volume":"1","author":"Melvin","year":"1991","journal-title":"Curr. Opin. Dent."},{"issue":"2","key":"10.1016\/j.jtbi.2016.04.030_bib23","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1177\/10454411990100020601","article-title":"Chloride channels and salivary gland function","volume":"10","author":"Melvin","year":"1999","journal-title":"Crit. Rev. Oral Biol. Med."},{"issue":"6 Pt 1","key":"10.1016\/j.jtbi.2016.04.030_bib24","first-page":"G823","article-title":"Regulation of electrolyte and fluid secretion in salivary acinar cells","volume":"263","author":"Nauntofte","year":"1992","journal-title":"Am. J. Physiol."},{"issue":"4","key":"10.1016\/j.jtbi.2016.04.030_bib25","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.jtbi.2010.06.027","article-title":"A dynamic model of saliva secretion","volume":"266","author":"Palk","year":"2010","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.jtbi.2016.04.030_bib26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jtbi.2012.04.009","article-title":"Modelling the effects of calcium waves and oscillations on saliva secretion","volume":"305","author":"Palk","year":"2012","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.jtbi.2016.04.030_bib27","unstructured":"Palk, L., 2012. A Mathematical Study of the Role of Calcium in the Regulation of Saliva Secretion (Ph.D. thesis). University of Auckland."},{"issue":"9","key":"10.1016\/j.jtbi.2016.04.030_bib28","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.1529\/biophysj.105.072249","article-title":"Models of IP3 and Ca2+ oscillations","volume":"90","author":"Politi","year":"2006","journal-title":"Biophys. J."},{"key":"10.1016\/j.jtbi.2016.04.030_bib29","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1137\/0907058","article-title":"GMRES","volume":"7","author":"Saad","year":"1986","journal-title":"SIAM J. Sci. Stat. Comput."},{"issue":"4","key":"10.1016\/j.jtbi.2016.04.030_bib30","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.bpj.2012.07.016","article-title":"A kinetic model for type I and II IP3R accounting for mode changes","volume":"103","author":"Siekmann","year":"2012","journal-title":"Biophys. J."},{"issue":"3","key":"10.1016\/j.jtbi.2016.04.030_bib31","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/S0006-3495(03)74572-X","article-title":"A model of calcium waves in pancreatic and parotid acinar cells","volume":"85","author":"Sneyd","year":"2003","journal-title":"Biophys. J."},{"issue":"6","key":"10.1016\/j.jtbi.2016.04.030_bib32","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1073\/pnas.0506135103","article-title":"A method for determining the dependence of calcium oscillations on inositol trisphosphate oscillations","volume":"103","author":"Sneyd","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jtbi.2016.04.030_bib33","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.mbs.2014.06.017","article-title":"Multiscale modelling of saliva secretion","volume":"257","author":"Sneyd","year":"2014","journal-title":"Math. Biosci."},{"issue":"4","key":"10.1016\/j.jtbi.2016.04.030_bib34","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1085\/jgp.116.4.547","article-title":"Calcium wave propagation in pancreatic acinar cells","volume":"116","author":"Straub","year":"2000","journal-title":"J. Gen. Physiol."},{"issue":"13","key":"10.1016\/j.jtbi.2016.04.030_bib35","doi-asserted-by":"crossref","first-page":"8910","DOI":"10.1074\/jbc.M805865200","article-title":"Use of fluorescence resonance energy transfer-based biosensors for the quantitative analysis of inositol 1,4,5-trisphosphate dynamics in calcium oscillations","volume":"284","author":"Tanimura","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.jtbi.2016.04.030_bib36","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1529\/biophysj.104.047357","article-title":"Calcium oscillations in a triplet of pancreatic acinar cells","volume":"88","author":"Tsaneva-Atanasova","year":"2005","journal-title":"Biophys. J."},{"issue":"1","key":"10.1016\/j.jtbi.2016.04.030_bib37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1034\/j.1601-0825.2002.10815.x","article-title":"Understanding salivary fluid and protein secretion","volume":"8","author":"Turner","year":"2002","journal-title":"Oral Dis."},{"issue":"14","key":"10.1016\/j.jtbi.2016.04.030_bib38","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1113\/jphysiol.2012.228320","article-title":"Differential regulation of the InsP3 receptor type-1 and -2 single channel properties by InsP3, Ca2+ and ATP","volume":"590","author":"Wagner","year":"2012","journal-title":"J. Physiol."}],"container-title":["Journal of Theoretical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022519316300583?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022519316300583?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T16:23:00Z","timestamp":1758385380000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022519316300583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":38,"alternative-id":["S0022519316300583"],"URL":"https:\/\/doi.org\/10.1016\/j.jtbi.2016.04.030","relation":{},"ISSN":["0022-5193"],"issn-type":[{"value":"0022-5193","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modeling calcium waves in an anatomically accurate three-dimensional parotid acinar cell","name":"articletitle","label":"Article Title"},{"value":"Journal of Theoretical Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtbi.2016.04.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}