{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T17:00:47Z","timestamp":1776099647100,"version":"3.50.1"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Theoretical Biology"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.jtbi.2017.05.027","type":"journal-article","created":{"date-parts":[[2017,5,28]],"date-time":"2017-05-28T23:45:17Z","timestamp":1496015117000},"page":"82-95","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Role of the locus coeruleus in the emergence of power law wake bouts in a model of the brainstem sleep-wake system through early infancy"],"prefix":"10.1016","volume":"426","author":[{"given":"Mainak","family":"Patel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaditya","family":"Rangan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtbi.2017.05.027_bib0001","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.bbrc.2010.08.132","article-title":"Ampa receptor-mediated miniature epscs have heterogeneous time courses in orexin neurons","volume":"400","author":"Alberto","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"8","key":"10.1016\/j.jtbi.2017.05.027_bib0002","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1523\/JNEUROSCI.01-08-00876.1981","article-title":"Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle","volume":"1","author":"Aston-Jones","year":"1981","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0003","doi-asserted-by":"crossref","first-page":"6402","DOI":"10.1523\/JNEUROSCI.1204-08.2008","article-title":"Glur6\/ka2 kainate receptors mediate slow-deactivating currents","volume":"28","author":"Barberis","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0004","series-title":"Conference Proceedings of the IEEE Engineeringin Medicine and Biology Society","first-page":"4713","article-title":"Modeling the temporal architecture of rat sleep-wake behavior","volume":"2011","author":"Behn","year":"2011"},{"key":"10.1016\/j.jtbi.2017.05.027_bib0005","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.smrv.2011.12.003","article-title":"Noradrenergic modulation of wakefulness\/arousal","volume":"16","author":"Berridge","year":"2012","journal-title":"Sleep Med. Rev."},{"issue":"41","key":"10.1016\/j.jtbi.2017.05.027_bib0006","doi-asserted-by":"crossref","first-page":"14860","DOI":"10.1073\/pnas.0506340102","article-title":"Dynamics of sleep-wake cyclicity in developing rats","volume":"102","author":"Blumberg","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0007","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.mbs.2014.01.012","article-title":"Physiologically-based modeling of sleep-wake regulatory networks","volume":"250","author":"Booth","year":"2014","journal-title":"Math. Biosci."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0008","doi-asserted-by":"crossref","first-page":"26846","DOI":"10.1074\/jbc.M115.678656","article-title":"Kinetic contributions to gating by interactions unique to n-methyl-d-aspartate (NMDA) receptors","volume":"290","author":"Borschel","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(98)00355-0","article-title":"Pharmacological and functional implications of developmentally-regulated changes in gaba(a) receptor subunit expression in the cerebellum","volume":"352","author":"Carlson","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0010","doi-asserted-by":"crossref","first-page":"E2635","DOI":"10.1073\/pnas.1202526109","article-title":"Mechanism for hypocretin-mediated sleep-to-wake transitions","volume":"109","author":"Carter","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jtbi.2017.05.027_bib0011","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1177\/1073858414529829","article-title":"Heterosynaptic plasticity: multiple mechanisms and multiple roles","volume":"20","author":"Chistiakova","year":"2014","journal-title":"Neuroscientist"},{"issue":"1","key":"10.1016\/j.jtbi.2017.05.027_bib0012","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1006\/scdb.1996.0118","article-title":"Generators of synchronous activity of the locus coeruleus during development","volume":"8","author":"Christie","year":"1997","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0013","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0306-4522(93)90568-Z","article-title":"Dye-coupling among neurons of rat locus coeruleus during postnatal development","volume":"56","author":"Christie","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.jtbi.2017.05.027_bib0014","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1523\/JNEUROSCI.09-10-03584.1989","article-title":"Electrical coupling synchronizes subthreshold activity in locus coeruleus neurons in vitro from neonatal rats","volume":"9","author":"Christie","year":"1989","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0015","doi-asserted-by":"crossref","first-page":"e14204","DOI":"10.1371\/journal.pone.0014204","article-title":"Power law versus exponential state transition dynamics: application to sleep-wake architecture","volume":"5","author":"Chu-Shore","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jtbi.2017.05.027_bib0016","doi-asserted-by":"crossref","first-page":"28594","DOI":"10.1074\/jbc.R115.696468","article-title":"Thematic minireview series: molecular mechanisms of synaptic plasticity","volume":"290","author":"Colbran","year":"2015","journal-title":"J Biol. Chem."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0017","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1126\/science.850788","article-title":"Major innervation of newborn rat cortex by monoaminergic neurons","volume":"196","author":"Coyle","year":"1977","journal-title":"Science"},{"key":"10.1016\/j.jtbi.2017.05.027_bib0018","doi-asserted-by":"crossref","first-page":"e0124694","DOI":"10.1371\/journal.pone.0124694","article-title":"Bursting reverberation as a multiscale neuronal network process driven by synaptic depression-facilitation","volume":"10","author":"Dao Duc","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jtbi.2017.05.027_bib0019","article-title":"Two classes of excitatory synaptic responses in rat thalamic reticular neurons","volume":"ePub ahead of print","author":"Deleuze","year":"2016","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0020","doi-asserted-by":"crossref","first-page":"12355","DOI":"10.1523\/JNEUROSCI.3079-09.2009","article-title":"Parallel regulation of a modulator-activated current via distinct dynamics underlies comodulation of motor circuit output","volume":"29","author":"DeLong","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0021","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.bbr.2010.04.002","article-title":"Ups and downs in the hippocampus: the influence of oscillatory sleep states on \u201cneuroplasticity\u201d at different time scales","volume":"214","author":"Dickson","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0022","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1152\/jn.00795.2009","article-title":"Simulating microinjection experiments in a novel model of the rat sleep-wake regulatory network","volume":"103","author":"Diniz Behn","year":"2010","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0023","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.1152\/jn.01184.2006","article-title":"A mathematical model of network dynamics governing mouse sleep-wake behavior","volume":"97","author":"Diniz Behn","year":"2007","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0024","doi-asserted-by":"crossref","first-page":"e94481","DOI":"10.1371\/journal.pone.0094481","article-title":"Coupled flip-flop model for rem sleep regulation in the rat","volume":"9","author":"Dunmyre","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jtbi.2017.05.027_bib0025","article-title":"Mechanisms of homeostatic plasticity in the excitatory synapse","volume":"ePub ahead of print","author":"Fernandes","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0026","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1152\/jn.00108.2005","article-title":"Spike timing in ca3 pyramidal cells during behavior: implications for synaptic transmission","volume":"94","author":"Frerking","year":"2005","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0027","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/bs.apha.2014.11.006","article-title":"Significance of gaba(a) receptor heterogeneity: clues from developing neurons","volume":"73","author":"Fritschy","year":"2015","journal-title":"Adv. Pharmacol."},{"issue":"7","key":"10.1016\/j.jtbi.2017.05.027_bib0028","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1093\/sleep\/32.7.920","article-title":"Developmental emergence of power-law wake behavior depends upon the functional integrity of the locus coeruleus","volume":"32","author":"Gall","year":"2009","journal-title":"Sleep"},{"key":"10.1016\/j.jtbi.2017.05.027_bib0029","series-title":"Stochastic Methods","author":"Gardiner","year":"2009"},{"key":"10.1016\/j.jtbi.2017.05.027_bib0030","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/0304-3940(89)90229-2","article-title":"Participation of excitatory amino acid receptors in the slow excitatory synaptic transmission in the rat spinal dorsal horn in vitro","volume":"106","author":"Gerber","year":"1989","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0031","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1113\/jphysiol.2014.273763","article-title":"Molecular bases of nmda receptor subtype-dependent properties","volume":"593","author":"Glasgow","year":"2015","journal-title":"J. Physiolo."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0032","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/cne.901930402","article-title":"Fine structure of rat locus coeruleus","volume":"193","author":"Groves","year":"1980","journal-title":"J. Comp. Neurolo."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0033","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1113\/jphysiol.2007.143925","article-title":"Differential modulation of short-term synaptic dynamics by long-term potentiation at mouse hippocampal mossy fibre synapses","volume":"585","author":"Gebert","year":"2007","journal-title":"J. Physiolo."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0034","doi-asserted-by":"crossref","first-page":"e9961","DOI":"10.1371\/journal.pone.0009961","article-title":"Natural spike trains trigger short- and long-lasting dynamics at hippocampal mossy fiber synapses in rodents","volume":"5","author":"Sullivan","year":"2010","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.jtbi.2017.05.027_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2869.2004.00388.x","article-title":"The nature of arousal in sleep","volume":"13","author":"Hal\u00e1sz","year":"2004","journal-title":".J Sleep Res."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0036","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/(SICI)1096-9861(19991213)415:2<145::AID-CNE1>3.0.CO;2-2","article-title":"Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system","volume":"415","author":"Horvath","year":"1999","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0037","doi-asserted-by":"crossref","first-page":"5196","DOI":"10.1523\/JNEUROSCI.16-16-05196.1996","article-title":"Synchronous activity in locus coeruleus results from dendritic interactions in pericoerulear regions","volume":"16","author":"Ishimatsu","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0038","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/288380a0","article-title":"Peptidergic transmitters in synaptic boutons of sympathetic ganglia","volume":"288","author":"Jan","year":"1980","journal-title":"Nature"},{"key":"10.1016\/j.jtbi.2017.05.027_bib0039","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0079-6123(08)63832-7","article-title":"The role of noradrenergic locus coeruleus neurons and neighboring cholinergic neurons of the pontomesencephalic tegmentum in sleep-wake states","volume":"88","author":"Jones","year":"1991","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0040","series-title":"Stochastic Processes in Physics and Chemistry","author":"van Kampen","year":"2007"},{"issue":"1","key":"10.1016\/j.jtbi.2017.05.027_bib0041","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.neuroscience.2004.09.002","article-title":"Active medullary control of atonia in week-old rats","volume":"130","author":"Karlsson","year":"2005","journal-title":"Neuroscience"},{"issue":"5","key":"10.1016\/j.jtbi.2017.05.027_bib0042","doi-asserted-by":"crossref","first-page":"e143","DOI":"10.1371\/journal.pbio.0030143","article-title":"The neural substrates of infant sleep in rats","volume":"3","author":"Karlsson","year":"2005","journal-title":"PLoS Biol."},{"issue":"2","key":"10.1016\/j.jtbi.2017.05.027_bib0043","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.neuroscience.2003.09.025","article-title":"Hypothalamic contribution to sleep-wake cycle development","volume":"123","author":"Karlsson","year":"2004","journal-title":"Neuroscience"},{"issue":"5","key":"10.1016\/j.jtbi.2017.05.027_bib0044","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1152\/jappl.1953.6.5.269","article-title":"Sleep characteristics of infants","volume":"6","author":"Kleitman","year":"1953","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0045","doi-asserted-by":"crossref","first-page":"e42059","DOI":"10.1371\/journal.pone.0042059","article-title":"A mathematical model towards understanding the mechanism of neuronal regulation of wake-nrems-rems states","volume":"7","author":"Kumar","year":"2012","journal-title":"PLoS ONE"},{"issue":"50","key":"10.1016\/j.jtbi.2017.05.027_bib0046","doi-asserted-by":"crossref","first-page":"17545","DOI":"10.1073\/pnas.0408242101","article-title":"Common scale-invariant patterns of sleep\u2013wake transitions across mammalian species","volume":"101","author":"Lo","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0047","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1209\/epl\/i2002-00508-7","article-title":"Dynamics of sleep-wake transitions during sleep","volume":"57","author":"Lo","year":"2002","journal-title":"EPL (Europhys. Lett.)"},{"key":"10.1016\/j.jtbi.2017.05.027_bib0048","doi-asserted-by":"crossref","first-page":"6257","DOI":"10.1523\/JNEUROSCI.3740-12.2013","article-title":"Matched pre- and post-synaptic changes underlie synaptic plasticity over long time scales","volume":"33","author":"Loebel","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0049","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1085\/jgp.201511488","article-title":"Reverberation of excitation in neuronal networks interconnected through voltage-gated gap junction channels","volume":"147","author":"Maciunas","year":"2016","journal-title":"J Gen. Physiol."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0050","doi-asserted-by":"crossref","first-page":"11388","DOI":"10.1073\/pnas.0901290106","article-title":"Optical measurement of mglur1 conformational changes reveals fast activation, slow deactivation, and sensitization","volume":"106","author":"Marcaggi","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jtbi.2017.05.027_bib0051","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.neuron.2016.04.001","article-title":"Transsynaptic modulation of kainate receptor functions by c1q-like proteins","volume":"90","author":"Matsuda","year":"2016","journal-title":"Neuron"},{"issue":"4196","key":"10.1016\/j.jtbi.2017.05.027_bib0052","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1126\/science.1135627","article-title":"Neuronal excitability modulation over the sleep cycle: a structural and mathematical model","volume":"189","author":"McCarley","year":"1975","journal-title":"Science"},{"key":"10.1016\/j.jtbi.2017.05.027_bib0053","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1100\/tsw.2002.74","article-title":"Developmental and activity dependent regulation of ionotropic glutamate receptors at synapses","volume":"2","author":"Molnar","year":"2002","journal-title":"Sci. World J."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0054","doi-asserted-by":"crossref","first-page":"115010","DOI":"10.1088\/1367-2630\/16\/11\/115010","article-title":"Control of sleep-to-wake transitions via fast aminoacid and slow neuropeptide transmission","volume":"16","author":"Mosqueiro","year":"2014","journal-title":"New J. Phys."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0055","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jtbi.2016.01.013","article-title":"A simplified model of mutually inhibitory sleep-active and wake-active neuronal populations employing a noise-based switching mechanism","volume":"394","author":"Patel","year":"2015","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0056","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s10827-013-0464-6","article-title":"Switching mechanisms and bout times in a pair of reciprocally inhibitory neurons","volume":"36","author":"Patel","year":"2014","journal-title":"J. Comput. Neurosci."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0057","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.brainres.2015.05.033","article-title":"Modeling the evolving oscillatory dynamics of the rat locus coeruleus through early infancy","volume":"1618","author":"Patel","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0058","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1177\/0748730406297512","article-title":"A quantitative model of sleep-wake dynamics based on the physiology of the brainstem ascending arousal system","volume":"22","author":"Phillips","year":"2007","journal-title":"J. Biol. Rhythms"},{"key":"10.1016\/j.jtbi.2017.05.027_bib0059","doi-asserted-by":"crossref","first-page":"7075","DOI":"10.1523\/JNEUROSCI.18-18-07075.1998","article-title":"Nicotinic stimulation produces multiple forms of increased glutamatergic synaptic transmission","volume":"18","author":"Radcliffe","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0060","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00285-009-0276-5","article-title":"A mathematical model of the sleep\/wake cycle","volume":"60","author":"Rempe","year":"2010","journal-title":"J. Math. Biol."},{"issue":"12","key":"10.1016\/j.jtbi.2017.05.027_bib0061","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S0166-2236(00)02002-6","article-title":"The sleep switch: hypothalamic control of sleep and wakefulness","volume":"24","author":"Saper","year":"2001","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0062","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jnr.490410102","article-title":"Modulatory actions of gamma aminobutyric acid (gaba) on gaba type a receptor subunit expression and function","volume":"41","author":"Schousboe","year":"1995","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0063","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2174\/157015908787386050","article-title":"Neurophysiology of sleep and wakefulness: basic science and clinical implications","volume":"6","author":"Schwartz","year":"2008","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0064","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.5665\/sleep.2970","article-title":"Statistical properties of sleep-wake behavior in the rat and their relation to circadian and ultradian phases","volume":"36","author":"Stephenson","year":"2013","journal-title":"Sleep"},{"key":"10.1016\/j.jtbi.2017.05.027_bib0065","doi-asserted-by":"crossref","first-page":"9639","DOI":"10.1523\/JNEUROSCI.23-29-09639.2003","article-title":"Target-specific neuropeptide y-ergic synaptic inhibition and its network consequences within the mammalian thalamus","volume":"23","author":"Sun","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0066","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.neuroscience.2010.06.009","article-title":"Locus coeruleus neuronal activity during the sleep-waking cycle in mice","volume":"169","author":"Takahashi","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.jtbi.2017.05.027_bib0067","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1152\/jn.00575.2005","article-title":"A quartet neural system model orchestrating sleep and wakefulness mechanisms","volume":"95","author":"Tamakawa","year":"2006","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0068","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1152\/jn.1995.74.2.519","article-title":"Opioid inhibition in locus coeruleus","volume":"74","author":"Travagli","year":"1995","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0069","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.archoralbio.2006.08.013","article-title":"The development of mastication in rodents: from neurons to behaviors","volume":"52","author":"Turman","year":"2007","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0070","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/ncomms1295","article-title":"Ligand-specific deactivation time course of GluN1\/gluN2d NMDA receptors","volume":"2","author":"Vance","year":"2011","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0071","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1523\/JNEUROSCI.07-11-03687.1987","article-title":"Membrane properties and adrenergic responses in locus coeruleus neurons of young rats","volume":"7","author":"Williams","year":"1987","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jtbi.2017.05.027_bib0072","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-3495(72)86068-5","article-title":"Excitatory and inhibitory interactions in localized populations of model neurons","volume":"12","author":"Wilson","year":"1972","journal-title":"Biophys. J."}],"container-title":["Journal of Theoretical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022519317302497?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022519317302497?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T01:55:18Z","timestamp":1569376518000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022519317302497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":72,"alternative-id":["S0022519317302497"],"URL":"https:\/\/doi.org\/10.1016\/j.jtbi.2017.05.027","relation":{},"ISSN":["0022-5193"],"issn-type":[{"value":"0022-5193","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of the locus coeruleus in the emergence of power law wake bouts in a model of the brainstem sleep-wake system through early infancy","name":"articletitle","label":"Article Title"},{"value":"Journal of Theoretical Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtbi.2017.05.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}