{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T22:01:17Z","timestamp":1768428077099,"version":"3.49.0"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T00:00:00Z","timestamp":1712966400000},"content-version":"am","delay-in-days":317,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Theoretical Biology"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.jtbi.2023.111490","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T11:04:58Z","timestamp":1681211098000},"page":"111490","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["HIV infection dynamics and viral rebound: Modeling results from humanized mice"],"prefix":"10.1016","volume":"567","author":[{"given":"Ting","family":"Guo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhipeng","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Libin","family":"Rong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtbi.2023.111490_b1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/bs.aivir.2015.04.001","article-title":"Human immunodeficiency virus type 1 cellular entry and exit in the T lymphocytic and monocytic compartments: mechanisms and target opportunities during viral disease","volume":"93","author":"Aiamkitsumrit","year":"2015","journal-title":"Adv. Virus Res."},{"key":"10.1016\/j.jtbi.2023.111490_b2","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.1182\/blood-2005-03-1100","article-title":"Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection","volume":"106","author":"Alter","year":"2005","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.jtbi.2023.111490_b3","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/QCO.0000000000000026","article-title":"Emerging strategies to deplete the HIV reservoir","volume":"27","author":"Archin","year":"2014","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.jtbi.2023.111490_b4","doi-asserted-by":"crossref","first-page":"e01186","DOI":"10.1128\/mBio.01186-17","article-title":"Brain macrophages in simian immunodeficiency virus-infected, antiretroviralsuppressed macaques: a functional latent reservoir","volume":"8","author":"Avalos","year":"2017","journal-title":"Mbio."},{"key":"10.1016\/j.jtbi.2023.111490_b5","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/clpt.2012.202","article-title":"Prospects for treatment of latent HIV","volume":"93","author":"Barton","year":"2013","journal-title":"Clin. Pharmacol. Ther."},{"issue":"Suppl 1","key":"10.1016\/j.jtbi.2023.111490_b6","article-title":"Comparison of empirical and dynamic models for HIV viral load rebound after treatment interruption","volume":"12","author":"Bing","year":"2020","journal-title":"Stat. Commun. Infect. Dis."},{"key":"10.1016\/j.jtbi.2023.111490_b7","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.virol.2009.05.027","article-title":"Donor variation in in vitro HIV-1 susceptibility of monocyte-derived macrophages","volume":"390","author":"Bol","year":"2009","journal-title":"Virology"},{"key":"10.1016\/j.jtbi.2023.111490_b8","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1006\/bulm.2001.0266","article-title":"HIV-1 infection and low steady state viral loads","volume":"64","author":"Callaway","year":"2002","journal-title":"Bull. Math. Biol."},{"issue":"48","key":"10.1016\/j.jtbi.2023.111490_b9","doi-asserted-by":"crossref","first-page":"19079","DOI":"10.1073\/pnas.0707449104","article-title":"Determination of virus burst size in vivo using a single-cycle SIV in rhesus macaques","volume":"104","author":"Chen","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jtbi.2023.111490_b10","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/nm.1972","article-title":"HIV reservoir size and persistence are driven by t cell survival and homeostatic proliferation","volume":"15","author":"Chomont","year":"2009","journal-title":"Nature Med."},{"key":"10.1016\/j.jtbi.2023.111490_b11","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1073\/pnas.0437640100","article-title":"Gene expression and viral prodution in latently infected, resting CD4+ T cells in viremic versus aviremic HIV-infected individuals","volume":"100","author":"Chun","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jtbi.2023.111490_b12","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1056\/NEJM199604183341602","article-title":"Treatment of human immunodeficiency virus infection with saquinavir, zidovudine, and zalcitabine","volume":"334","author":"Collier","year":"1996","journal-title":"N. Engl. J. Med."},{"issue":"17","key":"10.1016\/j.jtbi.2023.111490_b13","doi-asserted-by":"crossref","first-page":"5467","DOI":"10.1073\/pnas.1419162112","article-title":"Post-treatment control of HIV infection","volume":"112","author":"Conway","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jtbi.2023.111490_b14","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/00002030-200201250-00007","article-title":"Homogeneous quasispecies in 16 out of 17 individuals during very early HIV-1 primary infection","volume":"16","author":"Delwart","year":"2002","journal-title":"AIDS"},{"issue":"1","key":"10.1016\/j.jtbi.2023.111490_b15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003872","article-title":"Targeted cytotoxic therapy kills persisting HIV infected cells during ART","volume":"10","author":"Denton","year":"2014","journal-title":"PLoS Pathog."},{"issue":"1","key":"10.1016\/j.jtbi.2023.111490_b16","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1128\/JVI.06120-11","article-title":"Generation of HIV latency in humanized BLT mice","volume":"86","author":"Denton","year":"2012","journal-title":"J. Virol."},{"issue":"23","key":"10.1016\/j.jtbi.2023.111490_b17","doi-asserted-by":"crossref","first-page":"9403","DOI":"10.1073\/pnas.0903107106","article-title":"Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy","volume":"106","author":"Dinoso","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jtbi.2023.111490_b18","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1056\/NEJM199905273402102","article-title":"Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients receiving potent antiretroviral therapy","volume":"340","author":"Furtado","year":"1999","journal-title":"N. Engl. J. Med."},{"issue":"8","key":"10.1016\/j.jtbi.2023.111490_b19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000321","article-title":"The effect of raltegravir intensification on low-level residual viremia in HIV-infected patients on antiretroviral therapy: a randomized controlled trial","volume":"7","author":"Gandhi","year":"2010","journal-title":"PLoS Med."},{"issue":"2","key":"10.1016\/j.jtbi.2023.111490_b20","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1172\/JCI80562","article-title":"In vivo platforms for analysis of HIV persistence and eradication","volume":"126","author":"Garcia","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jtbi.2023.111490_b21","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1189\/jlb.0713368","article-title":"HIV-1 envelope-receptor interactions required for macrophage infection and implications for current HIV-1 cure strategies","volume":"95","author":"Gorry","year":"2014","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jtbi.2023.111490_b22","doi-asserted-by":"crossref","first-page":"6822","DOI":"10.3934\/mbe.2019341","article-title":"The effects of CTL immune response on HIV infection model with potent therapy, latently infected cells and cell-to-cell transmission","volume":"16","author":"Guo","year":"2019","journal-title":"Math. Biosci. Eng."},{"key":"10.1016\/j.jtbi.2023.111490_b23","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00285-020-01513-x","article-title":"Modeling the role of macrophages in hiv persistence during antiretroviral therapy","volume":"81","author":"Guo","year":"2020","journal-title":"J. Math. Biol."},{"key":"10.1016\/j.jtbi.2023.111490_b24","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00285-021-01604-3","article-title":"Dynamics of a new HIV model with the activation status of infected cells","volume":"82","author":"Guo","year":"2021","journal-title":"J. Math. Biol."},{"issue":"5289","key":"10.1016\/j.jtbi.2023.111490_b25","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1126\/science.274.5289.985","article-title":"Quantitative image analysis of HIV-1 infection in lymphoid tissue","volume":"274","author":"Haase","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.jtbi.2023.111490_b26","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1172\/JCI80561","article-title":"Towards HIV-1 remission: potential roles for broadly neutralizing antibodies","volume":"126","author":"Halper-Stromberg","year":"2016","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jtbi.2023.111490_b27","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1086\/506616","article-title":"A multicenter observational study of the potential benefits of initiating combination antiretroviral therapy during acute HIV infection","volume":"194","author":"Hecht","year":"2006","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jtbi.2023.111490_b28","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1097\/QAD.0b013e32833b61ba","article-title":"Long-term immunovirologic control following antiretroviral therapy interruption in patients treated at the time of primary HIV-1 infection","volume":"24","author":"Hocqueloux","year":"2010","journal-title":"AIDS"},{"key":"10.1016\/j.jtbi.2023.111490_b29","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/nm.4319","article-title":"HIV persistence in tissue macrophages of humanized myeloid-only mice during antiretroviral therapy","volume":"23","author":"Honeycutt","year":"2017","journal-title":"Nature Med."},{"issue":"1","key":"10.1016\/j.jtbi.2023.111490_b30","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/1742-4690-10-121","article-title":"HIV-1 infection, response to treatment and establishment of viral latency in a novel humanized T cell-only mouse (TOM) model","volume":"10","author":"Honeycutt","year":"2013","journal-title":"Retrovirology"},{"key":"10.1016\/j.jtbi.2023.111490_b31","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1172\/JCI84456","article-title":"Macrophages sustain HIV replication in vivo independently of T cells","volume":"126","author":"Honeycutt","year":"2016","journal-title":"J. Clin. Invest."},{"issue":"41","key":"10.1016\/j.jtbi.2023.111490_b32","doi-asserted-by":"crossref","first-page":"16538","DOI":"10.1073\/pnas.1315295110","article-title":"HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs inhumanized mice","volume":"110","author":"Horwitz","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"43","key":"10.1016\/j.jtbi.2023.111490_b33","doi-asserted-by":"crossref","first-page":"16725","DOI":"10.1073\/pnas.0804192105","article-title":"HIV rebounds from latently infected cells, rather than from continuing low-level replication","volume":"105","author":"Joos","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jtbi.2023.111490_b34","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1016\/S0140-6736(13)60104-X","article-title":"Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs","volume":"381","author":"Katlama","year":"2013","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.jtbi.2023.111490_b35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000495","article-title":"Epigenetic regulation of HIV-1 latency by cytosine methylation","volume":"5","author":"Kauder","year":"2009","journal-title":"PLoS Pathog."},{"issue":"3","key":"10.1016\/j.jtbi.2023.111490_b36","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.celrep.2017.09.080","article-title":"In vivo suppression of HIV rebound by Didehydro-Cortistatin A, a block-and-lock strategy for HIV-1 treatment","volume":"21","author":"Kessing","year":"2017","journal-title":"Cell Rep."},{"issue":"8","key":"10.1016\/j.jtbi.2023.111490_b37","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1086\/382488","article-title":"Genotypic analysis of HIV-1 drug resistance at the limit of detection: virus production without evolution in treated adults with undetectable HIV loads","volume":"189","author":"Kieffer","year":"2004","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jtbi.2023.111490_b38","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1172\/JCI1269","article-title":"The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors","volume":"101","author":"Kim","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jtbi.2023.111490_b39","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/S1471-4906(01)01925-1","article-title":"The importance of the innate immune system in controlling HIV infection and disease","volume":"22","author":"Levy","year":"2001","journal-title":"Trends Immunol."},{"key":"10.1016\/j.jtbi.2023.111490_b40","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.nonrwa.2013.11.002","article-title":"Backward bifurcation in a mathematical model for HIV infection in vivo with anti-retroviral treatment","volume":"17","author":"Li","year":"2014","journal-title":"Nonlinear Anal.-Real"},{"issue":"439","key":"10.1016\/j.jtbi.2023.111490_b41","doi-asserted-by":"crossref","first-page":"eaao4521","DOI":"10.1126\/scitranslmed.aao4521","article-title":"TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy","volume":"10","author":"Lim","year":"2018","journal-title":"Sci. Transl. Med."},{"issue":"3","key":"10.1016\/j.jtbi.2023.111490_b42","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3390\/v11030256","article-title":"Cellular HIV reservoirs and viral rebound from the lymphoid compartments of 4\u2019-Ethynyl-2-Fluoro-2\u2019-Deoxyadenosine (EFdA)-suppressed humanized mice","volume":"11","author":"Maidji","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.jtbi.2023.111490_b43","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/COH.0b013e32834134ea","article-title":"Targeting viral reservoirs: ability of antiretroviral therapy to stop viral replication","volume":"6","author":"Maldarelli","year":"2011","journal-title":"Curr. Opin. HIV AIDS"},{"key":"10.1016\/j.jtbi.2023.111490_b44","doi-asserted-by":"crossref","first-page":"5087","DOI":"10.1128\/jvi.69.8.5087-5094.1995","article-title":"Lower in vivo mutation-rate of human immunodeficiency virus type-1 than that predicted from the fidelity of purified reverse-transcriptase","volume":"69","author":"Mansky","year":"1995","journal-title":"J. Virol."},{"issue":"9","key":"10.1016\/j.jtbi.2023.111490_b45","article-title":"Tracking HIV rebound following latency reversal using barcoded HIV","volume":"1","author":"Marsden","year":"2020","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.jtbi.2023.111490_b46","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1038\/nm1431","article-title":"Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1","volume":"12","author":"Melkus","year":"2006","journal-title":"Nature Med."},{"key":"10.1016\/j.jtbi.2023.111490_b47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004467","article-title":"CD4 depletion in SIV-infected macaques results in macrophage and microglia infection with rapid turnover of infected cells","volume":"10","author":"Micci","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jtbi.2023.111490_b48","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/imr.12066","article-title":"CD4+ T cell depletion in HIV infection: mechanisms of immunological failure","volume":"254","author":"Okoye","year":"2013","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jtbi.2023.111490_b49","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1073\/pnas.0800050105","article-title":"Low level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy","volume":"105","author":"Palmer","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jtbi.2023.111490_b50","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/387188a0","article-title":"Decay characteristics of HIV-1-infected compartments during combination therapy","volume":"387","author":"Perelson","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.jtbi.2023.111490_b51","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1137\/S0036144598335107","article-title":"Mathematical analysis of HIV-1 dynamics in vivo","volume":"41","author":"Perelson","year":"1999","journal-title":"SIAM Rev."},{"key":"10.1016\/j.jtbi.2023.111490_b52","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1126\/science.271.5255.1582","article-title":"HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time","volume":"271","author":"Perelson","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.jtbi.2023.111490_b53","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/1741-7007-11-96","article-title":"Modeling the within-host dynamics of HIV infection","volume":"11","author":"Perelson","year":"2013","journal-title":"BMC Biol."},{"key":"10.1016\/j.jtbi.2023.111490_b54","series-title":"Viral rebound kinetics following single and combination immunotherapy for HIV\/SIV","author":"Prague","year":"2019"},{"issue":"42","key":"10.1016\/j.jtbi.2023.111490_b55","doi-asserted-by":"crossref","first-page":"eabn9450","DOI":"10.1126\/sciadv.abn9450","article-title":"Models with higher effective dimensions tend to produce more uncertain estimates","volume":"8","author":"Puy","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jtbi.2023.111490_b56","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1016\/S0140-6736(99)02035-8","article-title":"Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis","volume":"354","author":"Ramratnam","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.jtbi.2023.111490_b57","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/71577","article-title":"The decay of the latent reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy","volume":"6","author":"Ramratnam","year":"2000","journal-title":"Nature Med."},{"key":"10.1016\/j.jtbi.2023.111490_b58","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.celrep.2017.07.004","article-title":"The lifespan and turnover of microglia in the human brain","volume":"20","author":"Reu","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.jtbi.2023.111490_b59","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1126\/science.1165706","article-title":"The challenge of finding a cure for HIV infection","volume":"323","author":"Richman","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.jtbi.2023.111490_b60","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.mbs.2008.10.006","article-title":"Asymmetric division of activated latently infected cells may explain the decay kinetics of the HIV-1 latent reservoir and intermittent viral blips","volume":"217","author":"Rong","year":"2009","journal-title":"Math. Biosci."},{"key":"10.1016\/j.jtbi.2023.111490_b61","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jtbi.2009.06.011","article-title":"Modeling HIV persistence, the latent reservoir, and viral blips","volume":"260","author":"Rong","year":"2009","journal-title":"J. Theoret. Biol."},{"issue":"10","key":"10.1016\/j.jtbi.2023.111490_b62","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1000533","article-title":"Modeling latently infected cell activation: viral and latent reservoir persistence, and viral blips in HIV-infected patients on potent therapy","volume":"5","author":"Rong","year":"2009","journal-title":"PLoS Comput. Biol."},{"issue":"3","key":"10.1016\/j.jtbi.2023.111490_b63","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003211","article-title":"Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI study","volume":"9","author":"S\u00e1ez-Ciri\u00f3n","year":"2013","journal-title":"PLoS Pathog."},{"issue":"12","key":"10.1016\/j.jtbi.2023.111490_b64","doi-asserted-by":"crossref","first-page":"6264","DOI":"10.1128\/JVI.00563-15","article-title":"In vivo activation of human NK cells by treatment with an interleukin-15 superagonist potently inhibits acute in vivo HIV-1 infection in humanized mice","volume":"89","author":"Seay","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.jtbi.2023.111490_b65","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1038\/sj.emboj.7600707","article-title":"Macrophages archive HIV-1 virions for dissemination in trans","volume":"24","author":"Sharova","year":"2005","journal-title":"EMBO J."},{"key":"10.1016\/j.jtbi.2023.111490_b66","series-title":"Basic Knowledge and Technical Methods of Medical Animal Experiments","author":"Shi","year":"1974"},{"issue":"6","key":"10.1016\/j.jtbi.2023.111490_b67","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.tim.2013.02.005","article-title":"Reactivation of latent HIV by histone deacetylase inhibitors","volume":"21","author":"Shirakawa","year":"2013","journal-title":"Trends Microbiol."},{"issue":"6","key":"10.1016\/j.jtbi.2023.111490_b68","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002774","article-title":"A highly intensified ART regimen induces long-term viral suppression and restriction of the viral reservoir in a simian AIDS model","volume":"8","author":"Shytaj","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jtbi.2023.111490_b69","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nm880","article-title":"Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells","volume":"9","author":"Siliciano","year":"2003","journal-title":"Nature Med."},{"key":"10.1016\/j.jtbi.2023.111490_b70","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/imm.12906","article-title":"A hitchhiker\u2019s guide to humanized mice: new pathways to studying viral infections","volume":"154","author":"Skelton","year":"2018","journal-title":"Immunology"},{"key":"10.1016\/j.jtbi.2023.111490_b71","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/jlb.56.3.278","article-title":"Cellular and viral determinants that regulate HIV-1 infection in macrophages","volume":"56","author":"Stevenson","year":"1994","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jtbi.2023.111490_b72","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1137\/16M1092003","article-title":"Modeling pharmacodynamics on HIV latent infection: choice of drugs is key to successful cure via early therapy","volume":"77","author":"Vaidya","year":"2017","journal-title":"SIAM J. Appl. Math."},{"key":"10.1016\/j.jtbi.2023.111490_b73","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jtbi.2016.12.015","article-title":"Influence of raltegravir intensification on viral load and 2-LTR dynamics in HIV patients on suppressive antiretroviral therapy","volume":"416","author":"Wang","year":"2017","journal-title":"J. Theoret. Biol."},{"key":"10.1016\/j.jtbi.2023.111490_b74","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jtbi.2014.06.042","article-title":"Stochastic population switch may explain the latent reservoir stability and intermittent viral blips in HIV patients on suppressive therapy","volume":"360","author":"Wang","year":"2014","journal-title":"J. Theoret. Biol."},{"key":"10.1016\/j.jtbi.2023.111490_b75","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.aml.2019.02.019","article-title":"HIV low viral load persistence under treatment: Insights from a model of cell-to-cell viral transmission","volume":"94","author":"Wang","year":"2019","journal-title":"Appl. Math. Lett."},{"key":"10.1016\/j.jtbi.2023.111490_b76","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s11538-016-0145-5","article-title":"Dynamics of an HIV model with multiple infection stages and treatment with different drug classes","volume":"78","author":"Wang","year":"2016","journal-title":"Bull. Math. Biol."},{"issue":"04","key":"10.1016\/j.jtbi.2023.111490_b77","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1142\/S021833901740006X","article-title":"Bistability analysis of an HIV model with immune response","volume":"25","author":"Wang","year":"2017","journal-title":"J. Biol. Syst."},{"key":"10.1016\/j.jtbi.2023.111490_b78","first-page":"149","article-title":"Functional and phenotypic characterization of the humanized BLT mouse model","volume":"324","author":"Wege","year":"2008","journal-title":"Curr. Top. Microbiol. Immunol."},{"issue":"10","key":"10.1016\/j.jtbi.2023.111490_b79","article-title":"Duration of HIV-1 viral suppression on cessation of antiretroviral therapy in primary infection correlates with time on therapy","volume":"8","author":"Wolfgang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jtbi.2023.111490_b80","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1126\/science.278.5341.1291","article-title":"Recovery of replication-competent HIV despite prolonged suppression of plasma viremia","volume":"278","author":"Wong","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.jtbi.2023.111490_b81","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s11538-007-9279-9","article-title":"Parameter identifiability and estimation of HIV\/AIDS dynamic models","volume":"70","author":"Wu","year":"2008","journal-title":"Bull. Math. Biol."},{"issue":"7","key":"10.1016\/j.jtbi.2023.111490_b82","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1007\/s11538-019-00621-0","article-title":"Modeling HIV dynamics under combination therapy with inducers and antibodies","volume":"81","author":"Yan","year":"2019","journal-title":"Bull. Math. Biol."}],"container-title":["Journal of Theoretical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022519323000863?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022519323000863?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T16:36:22Z","timestamp":1758386182000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022519323000863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":82,"alternative-id":["S0022519323000863"],"URL":"https:\/\/doi.org\/10.1016\/j.jtbi.2023.111490","relation":{},"ISSN":["0022-5193"],"issn-type":[{"value":"0022-5193","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HIV infection dynamics and viral rebound: Modeling results from humanized mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Theoretical Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtbi.2023.111490","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111490"}}