{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T08:51:26Z","timestamp":1791535886395,"version":"4.3.4"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T00:00:00Z","timestamp":1518998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Traditional and Complementary Medicine"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.jtcme.2018.02.001","type":"journal-article","created":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T04:46:53Z","timestamp":1525063613000},"page":"73-84","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"title":["Mechanism & inhibition kinetics of bioassay-guided fractions of Indian medicinal plants and foods as ACE inhibitors"],"prefix":"10.1016","volume":"9","author":[{"given":"Mohammad Yaseen","family":"Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vimal","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtcme.2018.02.001_bib1","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1056\/NEJMoa003417","article-title":"Impact of high-normal blood pressure on the risk of cardiovascular disease","volume":"345","author":"Vasan","year":"2001","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jtcme.2018.02.001_bib2","first-page":"365217","article-title":"Global burden of hypertension: analysis of worldwide data","author":"Kearney","year":"2005","journal-title":"Lancet"},{"issue":"S9","key":"10.1016\/j.jtcme.2018.02.001_bib3","article-title":"The renin-angiotensin-aldosterone system: a specific target for hypertension management","volume":"12","author":"Weir","year":"1999","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.jtcme.2018.02.001_bib4","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1067\/mhj.2000.109215","article-title":"Rationale for the use of combination angiotensin-converting enzyme inhibitor\/angiotensin II receptor blocker therapy in heart failure","volume":"140","author":"Carson","year":"2000","journal-title":"Am Heart J"},{"key":"10.1016\/j.jtcme.2018.02.001_bib5","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0002-9343(01)00652-0","article-title":"Comparison of the effects of angiotensin converting\u2013enzyme inhibitors and beta blockers on survival in elderly patients with reduced left ventricular function after myocardial infarction","volume":"110","author":"Shlipak","year":"2001","journal-title":"Am J Med"},{"key":"10.1016\/j.jtcme.2018.02.001_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000013417","article-title":"Combination ACE inhibitor and angiotensin II receptor antagonist therapy in diabetic nephropathy","volume":"19","author":"Hebert","year":"1999","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.jtcme.2018.02.001_bib7","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1345\/aph.1C339","article-title":"HOPE study impact on ACE inhibitors use","volume":"37","author":"Hemels","year":"2003","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.jtcme.2018.02.001_bib8","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1177\/106002809603000110","article-title":"Adverse effects of the angiotensin-converting enzyme inhibitors","volume":"30","author":"Alderman","year":"1996","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.jtcme.2018.02.001_bib9","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1365-2125.1995.tb04447.x","article-title":"Bronchospasm and cough as adverse reactions to the ACE inhibitors captopril, enalapril and lisinopril. A controlled retrospective cohort study","volume":"39","author":"Wood","year":"1995","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.jtcme.2018.02.001_bib10","first-page":"37","article-title":"Global promotion of herbal medicine: India's opportunity","volume":"86","author":"Dubey","year":"2004","journal-title":"Curr Sci"},{"key":"10.1016\/j.jtcme.2018.02.001_bib11","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0378-8741(98)00201-3","article-title":"An ethnopharmacological survey for potential angiotensin converting enzyme inhibitors from Indian medicinal plants","volume":"65","author":"Somanadhan","year":"1999","journal-title":"J\u00a0Ethnopharmacol"},{"key":"10.1016\/j.jtcme.2018.02.001_bib12","first-page":"15","article-title":"Evaluation of natural products as inhibitors of angiotension I \u2014 converting enzyme (ACE)","volume":"1","author":"Wagner","year":"1991","journal-title":"Pharmacol Lett"},{"key":"10.1016\/j.jtcme.2018.02.001_bib13","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0924-8579(02)00349-7","article-title":"In\u00a0vitro activity of Brazilian medicinal plants, naturally occurring naphthoquinones and their analogues, against methicillin-resistant Staphylococcus aureus","volume":"21","author":"Machado","year":"2003","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jtcme.2018.02.001_bib14","doi-asserted-by":"crossref","first-page":"4959","DOI":"10.1021\/jf0255937","article-title":"Processed sweet corn has higher antioxidant activity","volume":"50","author":"Dewanto","year":"2002","journal-title":"J\u00a0Agric Food Chem"},{"key":"10.1016\/j.jtcme.2018.02.001_bib15","first-page":"178","article-title":"Estimation of total flavonoid content in propolis by two complementary colorimetric methods","volume":"10","author":"Chang","year":"2002","journal-title":"J\u00a0Food Drug Anal"},{"key":"10.1016\/j.jtcme.2018.02.001_bib16","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/0006-2952(71)90292-9","article-title":"Spectrophotometric assay and properties of the angiotensin I-converting enzyme of rabbit lung","volume":"20","author":"Cushman","year":"1971","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jtcme.2018.02.001_bib17","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/0024-3205(68)90086-6","article-title":"A\u00a0simple method for the determination of angiotensin I converting enzyme","volume":"7","author":"Huggins","year":"1968","journal-title":"Life Sci"},{"key":"10.1016\/j.jtcme.2018.02.001_bib18","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1432-1033.1978.tb12375.x","article-title":"An intramolecularly quenched fluorescent tripeptide as a fluorogenic substrate of angiotensin-I-converting enzyme and of bacterial dipeptidyl carboxypeptidase","volume":"87","author":"Carmel","year":"1978","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.jtcme.2018.02.001_bib19","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/0003-2697(79)90769-3","article-title":"A\u00a0continuous spectrophotometric assay for angiotensin converting enzyme","volume":"95","author":"Holmquist","year":"1979","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jtcme.2018.02.001_bib20","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0021-9673(02)00052-3","article-title":"Improved method for direct high-performance liquid chromatography assay of angiotensin-converting enzyme-catalyzed reactions","volume":"950","author":"Wu","year":"2002","journal-title":"J\u00a0Chromatogr A"},{"key":"10.1016\/j.jtcme.2018.02.001_bib21","doi-asserted-by":"crossref","first-page":"9388","DOI":"10.1021\/ac901775h","article-title":"Colorimetric, high-throughput assay for screening angiotensin I-converting enzyme inhibitors","volume":"81","author":"Jimsheena","year":"2009","journal-title":"Anal Chem"},{"key":"10.1016\/j.jtcme.2018.02.001_bib22","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1016\/j.jff.2013.07.013","article-title":"Angiotensin-I converting enzyme (ACE) inhibitory tripeptides from rice protein hydrolysate: purification and characterization","volume":"5","author":"Chen","year":"2013","journal-title":"Journal of Functional Foods"},{"key":"10.1016\/j.jtcme.2018.02.001_bib23","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.jprot.2015.08.018","article-title":"Screening, discovery, and characterization of angiotensin-I converting enzyme inhibitory peptides derived from proteolytic hydrolysate of bitter melon seed proteins","volume":"128","author":"Priyanto","year":"2015","journal-title":"Journal of proteomics"},{"key":"10.1016\/j.jtcme.2018.02.001_bib24","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/S0024-3205(03)00481-8","article-title":"Antihypertensive effects of tannins isolated from traditional Chinese herbs as non-specific inhibitors of angiontensin converting enzyme","volume":"73","author":"Liu","year":"2003","journal-title":"Life Sci"},{"key":"10.1016\/j.jtcme.2018.02.001_bib25","doi-asserted-by":"crossref","first-page":"389","DOI":"10.2165\/00129784-200303060-00002","article-title":"Therapeutic potential of renin inhibitors in the management of cardiovascular disorders","volume":"3","author":"Stanton","year":"2003","journal-title":"Am J Cardiovasc Drugs"},{"key":"10.1016\/j.jtcme.2018.02.001_bib26","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1093\/cvr\/28.2.146","article-title":"Converting enzyme inhibitors in cardiovascular therapy: current status and future potential","volume":"28","author":"Unger","year":"1994","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jtcme.2018.02.001_bib27","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1055\/s-2006-960050","article-title":"A\u00a0new method for the in\u00a0vitro screening of inhibitors of angiotensin-converting enzyme (ACE), using the chromophore-and fluorophore-labelled substrate, dansyltriglycine","volume":"57","author":"Elbl","year":"1991","journal-title":"Planta Med"},{"key":"10.1016\/j.jtcme.2018.02.001_bib28","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1161\/01.RES.34.6.824","article-title":"Hydrolysis of bradykinin by angiotensin-converting enzyme","volume":"34","author":"Dorer","year":"1974","journal-title":"Circ Res"},{"key":"10.1016\/j.jtcme.2018.02.001_bib29","doi-asserted-by":"crossref","first-page":"9496","DOI":"10.1016\/S0021-9258(18)98378-X","article-title":"Differences in the properties and enzymatic specificities of the two active sites of angiotensin I-converting enzyme (kininase II). Studies with bradykinin and other natural peptides","volume":"268","author":"Jaspard","year":"1993","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jtcme.2018.02.001_bib30","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1111\/j.1440-1681.1995.tb02325.x","article-title":"Angiotensin converting enzyme (ACE) inhibitors and kinin metabolism: evidence that ACE inhibitors may inhibit a kininase other than ACE","volume":"22","author":"Campbell","year":"1995","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.jtcme.2018.02.001_bib31","series-title":"Enzyme Kinetics","author":"Segel","year":"1975"},{"key":"10.1016\/j.jtcme.2018.02.001_bib32","doi-asserted-by":"crossref","first-page":"8030","DOI":"10.1016\/S0021-9258(19)42067-X","article-title":"The conformation of thermolysin","volume":"249","author":"Matthews","year":"1974","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jtcme.2018.02.001_bib33","series-title":"Enzyme and Metabolic Inhibitors","first-page":"149","author":"Webb","year":"1963"},{"key":"10.1016\/j.jtcme.2018.02.001_bib34","doi-asserted-by":"crossref","first-page":"e81","DOI":"10.1111\/j.1365-2893.2011.01507.x","article-title":"Suppression of hepatitis C virus by the flavonoid quercetin is mediated by inhibition of NS3 protease activity","volume":"19","author":"Bachmetov","year":"2012","journal-title":"J\u00a0Viral Hepat"},{"key":"10.1016\/j.jtcme.2018.02.001_bib35","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.fitote.2009.09.008","article-title":"Cassia occidentalis L.: a review on its ethnobotany, phytochemical and pharmacological profile","volume":"81","author":"Yadav","year":"2010","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jtcme.2018.02.001_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13596-012-0094-y","article-title":"Medicinal use of Coscinium fenestratum (Gaertn.) Colebr.: an short review","volume":"13","author":"Rai","year":"2013","journal-title":"Oriental Pharmacy and Experimental Medicine"},{"key":"10.1016\/j.jtcme.2018.02.001_bib37","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1021\/np50083a025","article-title":"Inhibition of angiotensin-I-converting enzyme by tetrahydroxyxanthones isolated from Tripterospermum lanceolatum","volume":"55","author":"Chen","year":"1992","journal-title":"J\u00a0Nat Prod"},{"key":"10.1016\/j.jtcme.2018.02.001_bib38","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1078\/0944-7113-00003","article-title":"Search for potential angiotensin converting enzyme (ACE)-inhibitors from plants","volume":"8","author":"Lacaille-Dubois","year":"2001","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jtcme.2018.02.001_bib39","doi-asserted-by":"crossref","first-page":"172","DOI":"10.31989\/ffhd.v1i5.132","article-title":"Plant flavonoids as angiotensin converting enzyme inhibitors in regulation of hypertension","volume":"1","author":"Balasuriya","year":"2011","journal-title":"Functional Foods in Health and Disease"},{"key":"10.1016\/j.jtcme.2018.02.001_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0049493","article-title":"Inhibition of angiotensin-converting enzyme activity by flavonoids: structure-activity relationship studies","volume":"7","author":"Guerrero","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jtcme.2018.02.001_bib41","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1021\/jf052263o","article-title":"Inhibition of angiotensin converting enzyme activity by flavanol-rich foods","volume":"54","author":"Actis-Goretta","year":"2006","journal-title":"J\u00a0Agric Food Chem"},{"key":"10.1016\/j.jtcme.2018.02.001_bib42","doi-asserted-by":"crossref","first-page":"11832","DOI":"10.1021\/jf404641v","article-title":"Angiotensin-converting enzyme inhibitory effects by plant phenolic compounds: a study of structure activity relationships","volume":"61","author":"Al Shukor","year":"2013","journal-title":"J\u00a0Agric Food Chem"},{"key":"10.1016\/j.jtcme.2018.02.001_bib43","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ejphar.2010.12.012","article-title":"Protective effect of embelin against acetic acid induced ulcerative colitis in rats","volume":"654","author":"Thippeswamy","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jtcme.2018.02.001_bib44","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.foodchem.2011.01.103","article-title":"Quantitative analysis of phenolic compounds in Chinese hawthorn (Crataegus spp.) fruits by high performance liquid chromatography\u2013electrospray ionisation mass spectrometry","volume":"127","author":"Liu","year":"2011","journal-title":"Food Chem"},{"key":"10.1016\/j.jtcme.2018.02.001_bib45","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0304-4211(76)90129-2","article-title":"Accumulation of L-DOPA in cultures from Mucuna pruriens","volume":"7","author":"Brain","year":"1976","journal-title":"Plant Sci Lett"},{"key":"10.1016\/j.jtcme.2018.02.001_bib46","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1590\/S0103-50532002000500010","article-title":"Antimicrobial ellagitannin of Punica granatum fruits","volume":"13","author":"Machado","year":"2002","journal-title":"J\u00a0Braz Chem Soc"},{"key":"10.1016\/j.jtcme.2018.02.001_bib47","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/j.foodchem.2006.10.054","article-title":"Chemical composition of white (Morus alba), red (Morus rubra) and black (Morus nigra) mulberry fruits","volume":"103","author":"Ercisli","year":"2007","journal-title":"Food Chem"},{"key":"10.1016\/j.jtcme.2018.02.001_bib48","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1476-0711-9-7","article-title":"In\u00a0vitro antifungal activity of hydroxychavicol isolated from Piper betle L","volume":"9","author":"Ali","year":"2010","journal-title":"Ann Clin Microbiol Antimicrob"},{"key":"10.1016\/j.jtcme.2018.02.001_bib49","doi-asserted-by":"crossref","first-page":"7272","DOI":"10.1021\/jf0490192","article-title":"Phenolic compounds from the leaf extract of artichoke (Cynara scolymus L.) and their antimicrobial activities","volume":"52","author":"Zhu","year":"2004","journal-title":"J\u00a0Agric Food Chem"},{"key":"10.1016\/j.jtcme.2018.02.001_bib50","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/j.lwt.2010.12.003","article-title":"The antioxidant activity and the bioactive compound content of Stevia rebaudiana water extracts","volume":"44","author":"Kim","year":"2011","journal-title":"LWT-Food Science and Technology"}],"container-title":["Journal of Traditional and Complementary Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2225411018300130?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2225411018300130?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T06:51:18Z","timestamp":1762411878000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2225411018300130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S2225411018300130"],"URL":"https:\/\/doi.org\/10.1016\/j.jtcme.2018.02.001","relation":{},"ISSN":["2225-4110"],"issn-type":[{"value":"2225-4110","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanism & inhibition kinetics of bioassay-guided fractions of Indian medicinal plants and foods as ACE inhibitors","name":"articletitle","label":"Article Title"},{"value":"Journal of Traditional and Complementary Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtcme.2018.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}