{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:59:13Z","timestamp":1787313553337,"version":"build-2736575974"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T00:00:00Z","timestamp":1715990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY21H270006"],"award-info":[{"award-number":["LY21H270006"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074217"],"award-info":[{"award-number":["82074217"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174208"],"award-info":[{"award-number":["82174208"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Traditional and Complementary Medicine"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.jtcme.2024.05.005","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T05:29:18Z","timestamp":1716528558000},"page":"119-127","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Jieduquyuziyin prescription attenuates the side effect of prednisone through regulating gut microbiota when in the combination with prednisone treat MRL\/lpr mice"],"prefix":"10.1016","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1248-1203","authenticated-orcid":false,"given":"Zhengyang","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8857-1550","authenticated-orcid":false,"given":"Zhixing","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jtcme.2024.05.005_bib1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/s41590-020-0677-6","article-title":"Autoimmunity and organ damage in systemic lupus erythematosus","volume":"21","author":"Tsokos","year":"2020","journal-title":"Nat Immunol"},{"issue":"4","key":"10.1016\/j.jtcme.2024.05.005_bib2","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/acr.22173","article-title":"Overall and cause\u2010specific mortality in patients with systemic lupus erythematosus: a meta\u2010analysis of observational studies","volume":"66","author":"Yurkovich","year":"2014","journal-title":"Arthritis Care Res"},{"issue":"12","key":"10.1016\/j.jtcme.2024.05.005_bib3","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/nrrheum.2016.186","article-title":"New insights into the immunopathogenesis of systemic lupus erythematosus","volume":"12","author":"Tsokos","year":"2016","journal-title":"Nat Rev Rheumatol"},{"issue":"8","key":"10.1016\/j.jtcme.2024.05.005_bib4","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1007\/s10067-020-05526-1","article-title":"Interferon-directed therapies for the treatment of systemic lupus erythematosus: a critical update","volume":"40","author":"Chaichian","year":"2021","journal-title":"Clin Rheumatol"},{"issue":"2","key":"10.1016\/j.jtcme.2024.05.005_bib5","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nrrheum.2013.157","article-title":"Pragmatic approaches to therapy for systemic lupus erythematosus","volume":"10","author":"Xiong","year":"2014","journal-title":"Nat Rev Rheumatol"},{"issue":"3","key":"10.1016\/j.jtcme.2024.05.005_bib6","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s40744-020-00212-9","article-title":"Systemic lupus erythematosus (SLE) therapy: the old and the new","volume":"7","author":"Basta","year":"2020","journal-title":"Rheumatology and Therapy"},{"issue":"1","key":"10.1016\/j.jtcme.2024.05.005_bib7","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.autrev.2017.11.002","article-title":"Can we manage lupus nephritis without chronic corticosteroids administration?","volume":"17","author":"Lightstone","year":"2018","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jtcme.2024.05.005_bib8","series-title":"Side Effects of Glucocorticoids. Pharmacokinetics and Adverse Effects of Drugs-Mechanisms and Risks Factors","first-page":"93","author":"Alan","year":"2018"},{"key":"10.1016\/j.jtcme.2024.05.005_bib9","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s11655-007-0180-z","article-title":"Effect of detoxification, removing stasis and nourishing yin method on corticosteroid-induced hyperlipidemia in patients with systemic lupus rythematosus","volume":"13","author":"Wen","year":"2007","journal-title":"Chin J Integr Med"},{"key":"10.1016\/j.jtcme.2024.05.005_bib10","first-page":"1599","article-title":"Investigation on the effect of traditional Chinese medical jieduquyuziyin methods on the quality of life with systemic lupus erythematosus","volume":"25","author":"Wen","year":"2007","journal-title":"Chin Arch Traditi Chin Med."},{"key":"10.1016\/j.jtcme.2024.05.005_bib11","first-page":"336","article-title":"The clinic study of Jieduquyuziyin methods on theraping corticosteroid hyperlipemia in systemic lupus erythematosus","volume":"13","author":"Wang","year":"2003","journal-title":"Zhejiang J Int Tradit Chin West Med (Chin)."},{"issue":"7","key":"10.1016\/j.jtcme.2024.05.005_bib12","first-page":"494","article-title":"Treating systemic lupus erythematosus by toxin removing, stasis removing and yin supplementing therapy combined with glucocorticoid and its effect on hypothalamic-pituitary-adrenal axis","volume":"30","author":"Wen","year":"2007","journal-title":"JOURNAL-BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE"},{"key":"10.1016\/j.jtcme.2024.05.005_bib13","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.3389\/fphar.2020.01049","article-title":"Jieduquyuziyin prescription suppresses inflammatory activity of MRL\/lpr mice and their bone marrow-derived macrophages via inhibiting expression of IRAK1-NF-\u03bab signaling pathway","volume":"11","author":"Ji","year":"2020","journal-title":"Front Pharmacol"},{"issue":"3","key":"10.1016\/j.jtcme.2024.05.005_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccmp.2022.100039","article-title":"Jieduquyuziyin prescription suppresses the inflammatory activity of macrophages via NOTCH1\/NF-\u03baB pathway","volume":"2","author":"Fang","year":"2022","journal-title":"Clinical Complementary Medicine and Pharmacology"},{"key":"10.1016\/j.jtcme.2024.05.005_bib15","article-title":"Jieduquyuziyin prescription-treated rat serum suppresses activation of peritoneal macrophages in MRL\/Lpr lupus mice by inhibiting IRAK1 signaling pathway","volume":"2019","author":"Ji","year":"2019","journal-title":"Evid base Compl Alternative Med"},{"key":"10.1016\/j.jtcme.2024.05.005_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.00282","article-title":"Crosstalk between gut microbiota and innate immunity and its implication in autoimmune diseases","volume":"11","author":"Jiao","year":"2020","journal-title":"Front Immunol"},{"issue":"6","key":"10.1016\/j.jtcme.2024.05.005_bib17","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1080\/19490976.2020.1768644","article-title":"Alteration in gut microbiota is associated with dysregulation of cytokines and glucocorticoid therapy in systemic lupus erythematosus","volume":"11","author":"Guo","year":"2020","journal-title":"Gut Microb"},{"key":"10.1016\/j.jtcme.2024.05.005_bib18","doi-asserted-by":"crossref","first-page":"628","DOI":"10.3389\/fmicb.2020.00628","article-title":"Early and short-term interventions in the gut microbiota affects lupus severity, progression, and treatment in MRL\/lpr mice","volume":"11","author":"Zhang","year":"2020","journal-title":"Front Microbiol"},{"issue":"551","key":"10.1016\/j.jtcme.2024.05.005_bib19","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aax2220","article-title":"Gut microbiota dysbiosis and altered tryptophan catabolism contribute to autoimmunity in lupus-susceptible mice","volume":"12","author":"Choi","year":"2020","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jtcme.2024.05.005_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40168-017-0300-8","article-title":"Control of lupus nephritis by changes of gut microbiota","volume":"5","author":"Mu","year":"2017","journal-title":"Microbiome"},{"key":"10.1016\/j.jtcme.2024.05.005_bib21","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.phrs.2019.02.024","article-title":"Gut microbiota, a new frontier to understand traditional Chinese medicines","volume":"142","author":"Feng","year":"2019","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jtcme.2024.05.005_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104453","article-title":"Gut microbiota modulation with traditional Chinese medicine: a system biology-driven approach","volume":"148","author":"Yue","year":"2019","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jtcme.2024.05.005_bib23","series-title":"Study of Jieduquyuziyin Prescription on Intestinal Microbiota in Systemic Lupus Erythematosus Mice","author":"Shui BingJie","year":"2015"},{"key":"10.1016\/j.jtcme.2024.05.005_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2018.02233","article-title":"Alterations of the gut microbiome associated with the treatment of hyperuricaemia in male rats","volume":"9","author":"Yu","year":"2018","journal-title":"Front Microbiol"},{"issue":"5","key":"10.1016\/j.jtcme.2024.05.005_bib25","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat Methods"},{"issue":"19","key":"10.1016\/j.jtcme.2024.05.005_bib26","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1093\/bioinformatics\/btq461","article-title":"Search and clustering orders of magnitude faster than BLAST","volume":"26","author":"Edgar","year":"2010","journal-title":"Bioinformatics"},{"issue":"D1","key":"10.1016\/j.jtcme.2024.05.005_bib27","doi-asserted-by":"crossref","first-page":"D590","DOI":"10.1093\/nar\/gks1219","article-title":"The SILVA ribosomal RNA gene database project: improved data processing and web-based tools","volume":"41","author":"Quast","year":"2012","journal-title":"Nucleic acids research"},{"issue":"D1","key":"10.1016\/j.jtcme.2024.05.005_bib28","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkab1112","article-title":"Database resources of the national center for biotechnology information","volume":"50","author":"Sayers","year":"2022","journal-title":"Nucleic acids research"},{"key":"10.1016\/j.jtcme.2024.05.005_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome biology"},{"key":"10.1016\/j.jtcme.2024.05.005_bib30","first-page":"447","article-title":"A meta-analysis of glucocorticoids as modulators of oxidative stress in vertebrates","volume":"181","author":"Costantini","year":"2011","journal-title":"J Comp Physiol B"},{"key":"10.1016\/j.jtcme.2024.05.005_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40168-017-0267-5","article-title":"Optimizing methods and dodging pitfalls in microbiome research","volume":"5","author":"Kim","year":"2017","journal-title":"Microbiome"},{"issue":"9","key":"10.1016\/j.jtcme.2024.05.005_bib32","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.3390\/jcm9092709","article-title":"Glucocorticoids in systemic lupus erythematosus. Ten questions and some issues","volume":"9","author":"Porta","year":"2020","journal-title":"J Clin Med"},{"issue":"19","key":"10.1016\/j.jtcme.2024.05.005_bib33","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1056\/NEJMoa1101214","article-title":"Glucocorticoids plus N-acetylcysteine in severe alcoholic hepatitis","volume":"365","author":"Nguyen-Khac","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jtcme.2024.05.005_bib34","volume":"2020","author":"Fan","year":"2020","journal-title":"Evid base Compl Alternative Med"},{"issue":"10","key":"10.1016\/j.jtcme.2024.05.005_bib35","doi-asserted-by":"crossref","first-page":"6797","DOI":"10.1111\/jcmm.14560","article-title":"Berberine attenuates XRCC1\u2010mediated base excision repair and sensitizes breast cancer cells to the chemotherapeutic drugs","volume":"23","author":"Gao","year":"2019","journal-title":"J Cell Mol Med"},{"issue":"6","key":"10.1016\/j.jtcme.2024.05.005_bib36","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1080\/13813455.2020.1773864","article-title":"Dual role of quercetin in enhancing the efficacy of cisplatin in chemotherapy and protection against its side effects: a review","volume":"128","author":"Najafi","year":"2022","journal-title":"Arch Physiol Biochem"},{"key":"10.1016\/j.jtcme.2024.05.005_bib37","doi-asserted-by":"crossref","first-page":"5266","DOI":"10.1039\/D0FO00578A","article-title":"Lactobacillus fermentum CECT5716 Prevents renal damage in the NZBWF1 mouse model of systemic lupus erythematosus","volume":"11","author":"de la Visitaci\u00f3n","year":"2020","journal-title":"Food Funct"},{"key":"10.1016\/j.jtcme.2024.05.005_bib38","article-title":"Gastrointestinal Dysmotility Predisposes to colitis through regulation of gut microbial composition and linoleic acid metabolism","author":"Zhang","year":"2024","journal-title":"Adv Sci"},{"issue":"4","key":"10.1016\/j.jtcme.2024.05.005_bib39","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.00078-24","article-title":"Akkermansia muciniphila and Parabacteroides distasonis synergistically protect from colitis by promoting ILC3 in the gut","volume":"15","author":"Gaifem","year":"2024","journal-title":"mBio"},{"key":"10.1016\/j.jtcme.2024.05.005_bib40","article-title":"Aberrant gut microbiome contributes to intestinal oxidative stress, barrier dysfunction, inflammation and systemic autoimmune responses in MRL\/lpr mice","volume":"12","author":"Wang","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.jtcme.2024.05.005_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173421","article-title":"Bacteroides fragilis alleviates the symptoms of lupus nephritis via regulating CD1d and CD86 expressions in B cells","volume":"884","author":"Li","year":"2020","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jtcme.2024.05.005_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2017.01765","article-title":"Next-generation beneficial microbes: the case of Akkermansia muciniphila","volume":"8","author":"Cani","year":"2017","journal-title":"Front Microbiol"},{"issue":"8","key":"10.1016\/j.jtcme.2024.05.005_bib43","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.1039\/D3FO05213C","article-title":"Tropical postbiotics alleviate the disorders in the gut microbiota and kidney damage induced by ochratoxin A exposure","volume":"15","author":"Jiang","year":"2024","journal-title":"Food Funct"},{"issue":"6","key":"10.1016\/j.jtcme.2024.05.005_bib44","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1038\/s41396-019-0364-5","article-title":"Defining the role of Parasutterella, a previously uncharacterized member of the core gut microbiota","volume":"13","author":"Ju","year":"2019","journal-title":"The ISME journal"},{"key":"10.1016\/j.jtcme.2024.05.005_bib45","doi-asserted-by":"crossref","first-page":"906","DOI":"10.3389\/fimmu.2020.00906","article-title":"The genus Alistipes: gut bacteria with emerging implications to inflammation, cancer, and mental health","volume":"11","author":"Parker","year":"2020","journal-title":"Front Immunol"}],"container-title":["Journal of Traditional and Complementary Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2225411024000610?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2225411024000610?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T17:24:42Z","timestamp":1778865882000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2225411024000610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S2225411024000610"],"URL":"https:\/\/doi.org\/10.1016\/j.jtcme.2024.05.005","relation":{},"ISSN":["2225-4110"],"issn-type":[{"value":"2225-4110","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Jieduquyuziyin prescription attenuates the side effect of prednisone through regulating gut microbiota when in the combination with prednisone treat MRL\/lpr mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Traditional and Complementary Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtcme.2024.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}