{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:43:36Z","timestamp":1790844216186,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"vor","delay-in-days":841,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplantation and Cellular Therapy"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.jtct.2020.10.009","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T14:02:29Z","timestamp":1609423349000},"page":"176.e1-176.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Clostridioides difficile Infection and Risk of Acute Graft-versus-Host Disease among Allogeneic Hematopoietic Stem Cell Transplantation Recipients"],"prefix":"10.1016","volume":"27","author":[{"given":"Ra'ed","family":"Jabr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wissam","family":"El Atrouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyla","family":"Shune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Telfah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghua","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Abhyankar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"McGuirk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Clough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtct.2020.10.009_bib0001","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1097\/QCO.0b013e3283630c4c","article-title":"Clostridium difficile infection among hematopoietic stem cell transplant recipients: beyond colitis","volume":"26","author":"Alonso","year":"2013","journal-title":"Curr Opin Infect Dis"},{"key":"10.1016\/j.jtct.2020.10.009_bib0002","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF01642866","article-title":"Serum antibody response to Clostridium difficile toxins in patients with Clostridium difficile diarrhoea","volume":"13","author":"Aronsson","year":"1985","journal-title":"Infection"},{"key":"10.1016\/j.jtct.2020.10.009_bib0003","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1093\/cid\/cir1035","article-title":"Epidemiology and outcomes of Clostridium difficile infections in hematopoietic stem cell transplant recipients","volume":"54","author":"Alonso","year":"2012","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jtct.2020.10.009_bib0004","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.bbmt.2012.02.010","article-title":"Clostridium difficile infection after allogeneic hematopoietic stem cell transplantation: incidence, risk factors, and outcome","volume":"18","author":"Willems","year":"2012","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2020.10.009_bib0005","doi-asserted-by":"crossref","first-page":"e145","DOI":"10.1097\/TXD.0000000000000662","article-title":"Risk for Clostridium difficile infection after allogeneic hematopoietic cell transplant remains elevated in the postengraftment period","volume":"3","author":"Dubberke","year":"2017","journal-title":"Transplant Direct"},{"key":"10.1016\/j.jtct.2020.10.009_bib0006","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1111\/j.1365-2141.2012.09114.x","article-title":"What predicts high risk acute graft-versus-host disease (GVHD) at onset?: identification of those at highest risk by a novel acute GVHD risk score","volume":"157","author":"MacMillan","year":"2012","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtct.2020.10.009_bib0007","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1086\/668023","article-title":"Hospital-onset Clostridium difficile infection rates in persons with cancer or hematopoietic stem cell transplant: a C3IC network report","volume":"33","author":"Kamboj","year":"2012","journal-title":"Infect Control Hosp Epidemiol"},{"key":"10.1016\/j.jtct.2020.10.009_bib0008","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1093\/cid\/cis580","article-title":"Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation","volume":"55","author":"Taur","year":"2012","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jtct.2020.10.009_bib0009","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.bbmt.2012.11.008","article-title":"Role of the mycobiome in human acute graft-versus-host disease","volume":"19","author":"van der Velden","year":"2013","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2020.10.009_bib0010","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1056\/NEJMra1609337","article-title":"Acute graft-versus-host disease - biologic process, prevention, and therapy","volume":"377","author":"Zeiser","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jtct.2020.10.009_bib0011","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2174\/1389557515666150722110547","article-title":"The role of intestinal microbiota in graft versus host disease","volume":"16","author":"Qayed","year":"2015","journal-title":"Mini Rev Med Chem"},{"key":"10.1016\/j.jtct.2020.10.009_bib0012","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1146\/annurev-physiol-012110-142150","article-title":"Tight junction pore and leak pathways: a dynamic duo","volume":"73","author":"Shen","year":"2011","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.jtct.2020.10.009_bib0013","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.bbamem.2008.10.028","article-title":"Tight junctions as targets of infectious agents","volume":"1788","author":"Guttman","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jtct.2020.10.009_bib0014","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/sj.bmt.1702627","article-title":"Clostridium difficile infection in allogeneic stem cell transplant recipients is associated with severe graft-versus-host disease and non-relapse mortality","volume":"26","author":"Chakrabarti","year":"2000","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jtct.2020.10.009_bib0015","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1399-0012.2009.01035.x","article-title":"Clostridium difficile-associated disease in allogeneic hematopoietic stem-cell transplant recipients: risk associations, protective associations, and outcomes","volume":"24","author":"Dubberke","year":"2010","journal-title":"Clin Transplant"},{"key":"10.1016\/j.jtct.2020.10.009_bib0016","doi-asserted-by":"crossref","first-page":"e90158","DOI":"10.1371\/journal.pone.0090158","article-title":"Early Clostridium difficile infection during allogeneic hematopoietic stem cell transplantation","volume":"9","author":"Kinnebrew","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.jtct.2020.10.009_bib0017","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.bbmt.2012.10.030","article-title":"Changing epidemiology of Clostridium difficile-associated disease during stem cell transplantation","volume":"19","author":"Trifilio","year":"2013","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2020.10.009_bib0018","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/j.bbmt.2014.06.025","article-title":"Clostridium difficile infection after allogeneic hematopoietic stem cell transplant: strain diversity and outcomes associated with NAP1\/027","volume":"20","author":"Kamboj","year":"2014","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2020.10.009_bib0019","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/s41409-018-0270-x","article-title":"Relationship between Clostridium difficile infection and gastrointestinal graft versus host disease in recipients of allogeneic stem cell transplantation","volume":"54","author":"Bhutani","year":"2019","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jtct.2020.10.009_bib0020","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s11899-018-0433-2","article-title":"Biomarkers in graft-versus-host disease: from prediction and diagnosis to insights into complex graft\/host interactions","volume":"13","author":"He","year":"2018","journal-title":"Curr Hematol Malig Rep"},{"key":"10.1016\/j.jtct.2020.10.009_bib0021","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/j.bbmt.2016.04.022","article-title":"The role of biomarkers in the diagnosis and risk stratification of acute graft-versus-host disease: a systematic review","volume":"22","author":"Ali","year":"2016","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2020.10.009_bib0022","doi-asserted-by":"crossref","first-page":"e12855","DOI":"10.1111\/tid.12855","article-title":"Epidemiology and outcomes of Clostridium difficile infection in allogeneic hematopoietic cell and lung transplant recipients","volume":"20","author":"Dubberke","year":"2018","journal-title":"Transpl Infect Dis"},{"key":"10.1016\/j.jtct.2020.10.009_bib0023","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.bbmt.2014.04.026","article-title":"Clostridium difficile colonization and disease in patients undergoing hematopoietic stem cell transplantation","volume":"20","author":"Bruminhent","year":"2014","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2020.10.009_bib0024","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1056\/NEJM200002103420604","article-title":"Asymptomatic carriage of Clostridium difficile and serum levels of IgG antibody against toxin A","volume":"342","author":"Kyne","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jtct.2020.10.009_bib0025","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1038\/bmt.2017.200","article-title":"Associations between acute gastrointestinal GvHD and the baseline gut microbiota of allogeneic hematopoietic stem cell transplant recipients and donors","volume":"52","author":"Liu","year":"2017","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jtct.2020.10.009_bib0026","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1111\/ajt.15654","article-title":"A gut microbiota score predicting acute graft-versus-host disease following myeloablative allogeneic hematopoietic stem cell transplantation","volume":"20","author":"Han","year":"2020","journal-title":"Am J Transplant"},{"key":"10.1016\/j.jtct.2020.10.009_bib0027","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1080\/21505594.2016.1250982","article-title":"Intestinal microbiome changes and stem cell transplantation: lessons learned","volume":"7","author":"Taur","year":"2016","journal-title":"Virulence"},{"key":"10.1016\/j.jtct.2020.10.009_bib0028","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1007\/s00248-013-0355-4","article-title":"16S rRNA gene pyrosequencing reveals shift in patient faecal microbiota during high-dose chemotherapy as conditioning regimen for bone marrow transplantation","volume":"67","author":"Montassier","year":"2014","journal-title":"Microb Ecol"},{"key":"10.1016\/j.jtct.2020.10.009_bib0029","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1056\/NEJMoa1900623","article-title":"Microbiota as predictor of mortality in allogeneic hematopoietic-cell transplantation","volume":"382","author":"Peled","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jtct.2020.10.009_bib0030","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf2311","article-title":"Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice","volume":"8","author":"Shono","year":"2016","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jtct.2020.10.009_bib0031","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.bbmt.2015.04.016","article-title":"Intestinal Blautia is associated with reduced death from graft-versus-host disease","volume":"21","author":"Jenq","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2020.10.009_bib0032","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.bbmt.2017.10.003","article-title":"Graft-derived reconstitution of mucosal-associated invariant T cells after allogeneic hematopoietic cell transplantation","volume":"24","author":"Bhattacharyya","year":"2018","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2020.10.009_bib0033","doi-asserted-by":"crossref","first-page":"02112","DOI":"10.1128\/AAC.02112-17","article-title":"Impact of oral fidaxomicin administration on the intestinal microbiota and susceptibility to Clostridium difficile colonization in mice","volume":"62","author":"Ajami","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jtct.2020.10.009_bib0034","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.3324\/haematol.2018.198549","article-title":"Fecal microbiota transplantation before or after allogeneic hematopoietic transplantation in patients with hematologic malignancies carrying multidrug-resistance bacteria","volume":"104","author":"Battipaglia","year":"2019","journal-title":"Haematologica"},{"issue":"suppl 1","key":"10.1016\/j.jtct.2020.10.009_bib0035","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1093\/ofid\/ofx162.029","article-title":"SYN-004 (ribaxamase) prevents new onset Clostridium difficile infection by protecting the integrity gut microbiome in a phase 2b study","volume":"4","author":"Kokai-Kun","year":"2017","journal-title":"Open Forum Infect Dis"},{"key":"10.1016\/j.jtct.2020.10.009_bib0036","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.mimet.2017.09.015","article-title":"A two-step approach improves the diagnosis of Clostridium difficile infection","volume":"143","author":"Kachrimanidou","year":"2017","journal-title":"J Microbiol Methods"},{"key":"10.1016\/j.jtct.2020.10.009_bib0037","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1093\/cid\/ciy822","article-title":"Oral vancomycin prophylaxis is highly effective in preventing Clostridium difficile infection in allogeneic hematopoietic cell transplant recipients","volume":"68","author":"Ganetsky","year":"2019","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jtct.2020.10.009_bib0038","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1093\/cid\/ciy484","article-title":"A randomized, placebo-controlled trial of fidaxomicin for prophylaxis of Clostridium difficile-associated diarrhea in adults undergoing hematopoietic stem cell transplantation","volume":"68","author":"Mullane","year":"2019","journal-title":"Clin Infect Dis"}],"container-title":["Transplantation and Cellular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666636720300208?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666636720300208?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T03:00:23Z","timestamp":1763002823000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666636720300208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["S2666636720300208"],"URL":"https:\/\/doi.org\/10.1016\/j.jtct.2020.10.009","relation":{},"ISSN":["2666-6367"],"issn-type":[{"value":"2666-6367","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clostridioides difficile Infection and Risk of Acute Graft-versus-Host Disease among Allogeneic Hematopoietic Stem Cell Transplantation Recipients","name":"articletitle","label":"Article Title"},{"value":"Transplantation and Cellular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtct.2020.10.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}