{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:55:54Z","timestamp":1793386554614,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012285","name":"BC Children&apos;s Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012285","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplantation and Cellular Therapy"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.jtct.2022.02.002","type":"journal-article","created":{"date-parts":[[2022,2,6]],"date-time":"2022-02-06T10:22:02Z","timestamp":1644142922000},"page":"328.e1-328.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Multiple Breath Washout Testing to Identify Pulmonary Chronic Graft Versus Host Disease in Children After Hematopoietic Stem Cell Transplantation"],"prefix":"10.1016","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4955-8876","authenticated-orcid":false,"given":"Jonathan H.","family":"Rayment","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo A.","family":"Sandoval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8123-8261","authenticated-orcid":false,"given":"Juliana P.","family":"Roden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0001-6438","authenticated-orcid":false,"given":"Kirk R.","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtct.2022.02.002_bib0001","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.bbmt.2016.09.023","article-title":"The biology of chronic graft-versus-host disease: a task force report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease","volume":"23","author":"Cooke","year":"2017","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2022.02.002_bib0002","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.bbmt.2014.12.001","article-title":"National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. The 2014 Diagnosis and Staging Working Group report","volume":"21","author":"Jagasia","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2022.02.002_bib0003","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/bmt.2012.241","article-title":"Bronchiolitis obliterans syndrome after allogeneic hematopoietic SCT: phenotypes and prognosis","volume":"48","author":"Bergeron","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jtct.2022.02.002_bib0004","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1182\/blood.2019000216","article-title":"Benefits and challenges with diagnosing chronic and late acute GVHD in children using the NIH consensus criteria","volume":"134","author":"Cuvelier","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.jtct.2022.02.002_bib0005","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/bmt.2012.228","article-title":"Chest health surveillance utility in the early detection of bronchiolitis obliterans syndrome in children after allo-SCT","volume":"48","author":"Gassas","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jtct.2022.02.002_bib0006","doi-asserted-by":"crossref","first-page":"693","DOI":"10.2214\/ajr.164.3.7863896","article-title":"Obstructive lung disease in children after allogeneic bone marrow transplantation: evaluation with high-resolution CT","volume":"164","author":"Sargent","year":"1995","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.jtct.2022.02.002_bib0007","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1056\/NEJMra1204664","article-title":"Obliterative bronchiolitis","volume":"370","author":"Barker","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jtct.2022.02.002_bib0008","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1513\/AnnalsATS.201604-262OC","article-title":"Lung function trajectory in bronchiolitis obliterans syndrome after allogeneic hematopoietic cell transplant","volume":"13","author":"Cheng","year":"2016","journal-title":"Ann Am Thorac Soc"},{"key":"10.1016\/j.jtct.2022.02.002_bib0009","doi-asserted-by":"crossref","first-page":"S106","DOI":"10.1016\/j.bbmt.2009.11.002","article-title":"Bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation\u2014an increasingly recognized manifestation of chronic graft-versus-host disease","volume":"16","author":"Chien","year":"2010","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2022.02.002_bib0010","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/sj.bmt.1705026","article-title":"High-dose corticosteroid therapy for bronchiolitis obliterans after bone marrow transplantation in children","volume":"36","author":"Ratjen","year":"2005","journal-title":"Bone Marrow Transplant"},{"issue":"2","key":"10.1016\/j.jtct.2022.02.002_bib0011","doi-asserted-by":"crossref","first-page":"e13155","DOI":"10.1111\/petr.13155","article-title":"Efficacy of high-dose steroids for bronchiolitis obliterans syndrome post pediatric hematopoietic stem cell transplantation","volume":"22","author":"Even-Or","year":"2018","journal-title":"Pediatr Transplant"},{"key":"10.1016\/j.jtct.2022.02.002_bib0012","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.bbmt.2013.03.017","article-title":"Lung histology predicts outcome of bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation","volume":"19","author":"Holbro","year":"2013","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2022.02.002_bib0013","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.jtct.2021.03.033","article-title":"National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IIa. The 2020 Clinical Implementation and Early Diagnosis Working Group Report","volume":"27","author":"Kitko","year":"2021","journal-title":"Transplant Cell Ther"},{"key":"10.1016\/j.jtct.2022.02.002_bib0014","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.jtct.2021.06.001","article-title":"National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. The 2020 Highly morbid forms report","volume":"27","author":"Wolff","year":"2021","journal-title":"Transplant Cell Ther"},{"key":"10.1016\/j.jtct.2022.02.002_bib0015","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1172\/JCI101161","article-title":"Studies on the intrapulmonary mixture of gases. I. Nitrogen elimination from blood and body tissues during high oxygen breathing","volume":"19","author":"Darling","year":"1940","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jtct.2022.02.002_bib0016","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1183\/09031936.00069712","article-title":"Consensus statement for inert gas washout measurement using multiple- and single- breath tests","volume":"41","author":"Robinson","year":"2013","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jtct.2022.02.002_bib0017","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1159\/000225373","article-title":"Inert gas washout: theoretical background and clinical utility in respiratory disease","volume":"78","author":"Robinson","year":"2009","journal-title":"Respiration"},{"issue":"4","key":"10.1016\/j.jtct.2022.02.002_bib0018","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01302-2019","article-title":"Normative data for multiple breath washout outcomes in school-aged Caucasian children","volume":"55","author":"Anagnostopoulou","year":"2020","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jtct.2022.02.002_bib0019","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1183\/09031936.03.00049502","article-title":"Evaluation of ventilation maldistribution as an early indicator of lung disease in children with cystic fibrosis","volume":"22","author":"Gustafsson","year":"2003","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jtct.2022.02.002_bib0020","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1164\/rccm.200407-895OC","article-title":"Multiple-breath washout as a marker of lung disease in preschool children with cystic fibrosis","volume":"171","author":"Aurora","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jtct.2022.02.002_bib0021","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.chest.2017.12.009","article-title":"Inert gas washout in bronchiolitis obliterans following hematopoietic cell transplantation","volume":"154","author":"Nyilas","year":"2018","journal-title":"Chest"},{"key":"10.1016\/j.jtct.2022.02.002_bib0022","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1183\/09031936.00018311","article-title":"Small airways function declines after allogeneic haematopoietic stem cell transplantation","volume":"38","author":"Lahzami","year":"2011","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jtct.2022.02.002_bib0023","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1002\/ppul.23058","article-title":"Small airways dysfunction in long-term survivors of pediatric stem cell transplantation","volume":"50","author":"Uhlving","year":"2015","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jtct.2022.02.002_bib0024","doi-asserted-by":"crossref","first-page":"e70","DOI":"10.1164\/rccm.201908-1590ST","article-title":"Standardization of spirometry 2019 update. An official American Thoracic Society and European Respiratory Society technical statement","volume":"200","author":"Graham","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jtct.2022.02.002_bib0025","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1164\/rccm.201801-0074ST","article-title":"Preschool multiple-breath washout testing. An official American Thoracic Society technical statement","volume":"197","author":"Robinson","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jtct.2022.02.002_bib0026","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0157523","article-title":"A systematic approach to multiple breath nitrogen washout test quality","volume":"11","author":"Jensen","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jtct.2022.02.002_bib0027","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1183\/09031936.00080312","article-title":"Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations","volume":"40","author":"Quanjer","year":"2012","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jtct.2022.02.002_bib0028","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1177\/1536867X20909693","article-title":"When to consult precision-recall curves","volume":"20","author":"Cook","year":"2020","journal-title":"Stata J"},{"key":"10.1016\/j.jtct.2022.02.002_bib0029","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1164\/rccm.201610-2158OC","article-title":"Progression of lung disease in preschool patients with cystic fibrosis","volume":"195","author":"Stanojevic","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jtct.2022.02.002_bib0030","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1002\/ppul.24340","article-title":"Lung clearance index for early detection of pulmonary complications after allo-HSCT in children","volume":"54","author":"Uhlving","year":"2019","journal-title":"Pediatr Pulmonol"},{"issue":"4","key":"10.1016\/j.jtct.2022.02.002_bib0031","doi-asserted-by":"crossref","first-page":"00234","DOI":"10.1183\/23120541.00234-2018","article-title":"Simultaneous sulfur hexafluoride and nitrogen multiple-breath washout (MBW) to examine inherent differences in MBW outcomes","volume":"5","author":"Bayfield","year":"2019","journal-title":"ERJ Open Res"},{"key":"10.1016\/j.jtct.2022.02.002_bib0032","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1152\/japplphysiol.00326.2018","article-title":"Difference between SF6 and N2 multiple breath washout kinetics is due to N2 back diffusion and error in N2 offset","volume":"125","author":"Guglani","year":"2018","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jtct.2022.02.002_bib0033","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1164\/rccm.201908-1539OC","article-title":"Airway oscillometry detects spirometric-silent episodes of acute cellular rejection","volume":"201","author":"Cho","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jtct.2022.02.002_bib0034","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1111\/ajt.15814","article-title":"Multicenter evaluation of parametric response mapping as an indicator of bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation","volume":"20","author":"Cheng","year":"2020","journal-title":"Am J Transplant"},{"issue":"5","key":"10.1016\/j.jtct.2022.02.002_bib0035","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01779-2018","article-title":"Xenon-129 MRI detects ventilation deficits in paediatric stem cell transplant patients unable to perform spirometry","volume":"53","author":"Walkup","year":"2019","journal-title":"Eur Respir J"},{"issue":"154","key":"10.1016\/j.jtct.2022.02.002_bib0036","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0046-2019","article-title":"Lung clearance index: assessment and utility in children with asthma","volume":"28","author":"Nuttall","year":"2019","journal-title":"Eur Respir Rev"},{"key":"10.1016\/j.jtct.2022.02.002_bib0037","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1038\/bmt.2016.164","article-title":"A scoping review of caregiver burden during allogeneic HSCT: lessons learned and future directions","volume":"51","author":"Applebaum","year":"2016","journal-title":"Bone Marrow Transplant"}],"container-title":["Transplantation and Cellular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666636722000586?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666636722000586?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T03:05:45Z","timestamp":1763003145000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666636722000586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S2666636722000586"],"URL":"https:\/\/doi.org\/10.1016\/j.jtct.2022.02.002","relation":{},"ISSN":["2666-6367"],"issn-type":[{"value":"2666-6367","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multiple Breath Washout Testing to Identify Pulmonary Chronic Graft Versus Host Disease in Children After Hematopoietic Stem Cell Transplantation","name":"articletitle","label":"Article Title"},{"value":"Transplantation and Cellular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtct.2022.02.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}