{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T15:36:07Z","timestamp":1774107367794,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplantation and Cellular Therapy"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.jtct.2023.03.014","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T22:11:04Z","timestamp":1679091064000},"page":"383.e1-383.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Incidence of Sinusoidal Obstruction Syndrome\/Veno-Occlusive Disease and Treatment with Defibrotide in Allogeneic Transplantation: A Multicenter Australasian Registry Study"],"prefix":"10.1016","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9788-6650","authenticated-orcid":false,"given":"John","family":"Coutsouvelis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl M.","family":"Kirkpatrick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Dooley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0531-7424","authenticated-orcid":false,"given":"Andrew","family":"Spencer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7171-0435","authenticated-orcid":false,"given":"Glen","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maggie","family":"Chau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gillian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Doocey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tandy-Sue","family":"Copeland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6724-7540","authenticated-orcid":false,"given":"Louis","family":"Do","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Bardy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Kerridge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8272-4074","authenticated-orcid":false,"given":"Theresa","family":"Cole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Travis","family":"Perera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4867-291X","authenticated-orcid":false,"given":"Stephen R.","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6915-7442","authenticated-orcid":false,"given":"Kate","family":"Mason","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracey A.","family":"O'Brien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0101-4482","authenticated-orcid":false,"given":"Peter J.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lochie","family":"Teague","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Butler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Marie","family":"Watson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2837-0874","authenticated-orcid":false,"given":"Shanti","family":"Ramachandran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jodie","family":"Marsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zulekha","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nada","family":"Hamad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtct.2023.03.014_bib0001","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/j.bbmt.2011.06.006","article-title":"The incidence of veno-occlusive disease following allogeneic hematopoietic stem cell transplantation has diminished and the outcome improved over the last decade","volume":"17","author":"Carreras","year":"2011","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.03.014_bib0002","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/bjh.12558","article-title":"BCSH\/BSBMT guideline: diagnosis and management of veno-occlusive disease (sinusoidal obstruction syndrome) following haematopoietic stem cell transplantation","volume":"163","author":"Dignan","year":"2013","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtct.2023.03.014_bib0003","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.3748\/wjg.v13.i29.3918","article-title":"Veno-occlusive disease: update on clinical management","volume":"13","author":"Senzolo","year":"2007","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jtct.2023.03.014_bib0004","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/bjh.13215","article-title":"How I manage sinusoidal obstruction syndrome after haematopoietic cell transplantation","volume":"168","author":"Carreras","year":"2015","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtct.2023.03.014_bib0005","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/sj.bmt.1705899","article-title":"Hepatic veno-occlusive disease after hematopoietic stem cell transplantation: update on defibrotide and other current investigational therapies","volume":"41","author":"Ho","year":"2008","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.03.014_bib0006","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/hep.1840040121","article-title":"Venocclusive disease of the liver after bone marrow transplantation: diagnosis, incidence, and predisposing factors","volume":"4","author":"McDonald","year":"1984","journal-title":"Hepatology"},{"key":"10.1016\/j.jtct.2023.03.014_bib0007","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1097\/00007890-198712000-00011","article-title":"Venoocclusive disease of the liver following bone marrow transplantation","volume":"44","author":"Jones","year":"1987","journal-title":"Transplantation"},{"key":"10.1016\/j.jtct.2023.03.014_bib0008","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/bmt.2015.52","article-title":"Sinusoidal obstruction syndrome\/veno-occlusive disease: current situation and perspectives-a position statement from the European Society for Blood and Marrow Transplantation (EBMT)","volume":"50","author":"Mohty","year":"2015","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.03.014_bib0009","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1038\/s41409-020-0918-1","article-title":"Introduction of new pediatric EBMT criteria for VOD diagnosis: is it time-saving or money-wasting? : Prospective evaluation of pediatric EBMT criteria for VOD","volume":"55","author":"Szmit","year":"2020","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.03.014_bib0010","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.bbmt.2015.09.024","article-title":"Hepatic veno-occlusive disease after hematopoietic stem cell transplantation: risk factors and stratification, prophylaxis, and treatment","volume":"22","author":"Dalle","year":"2016","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.03.014_bib0011","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.bbmt.2020.03.011","article-title":"Incidence of anicteric veno-occlusive disease\/sinusoidal obstruction syndrome and outcomes with defibrotide following hematopoietic cell transplantation in adult and pediatric patients","volume":"26","author":"Corbacioglu","year":"2020","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.03.014_bib0012","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/s41409-022-01588-8","article-title":"Defibrotide-treated patients with anicteric or icteric veno-occlusive disease\/sinusoidal obstruction syndrome after hematopoietic cell transplantation: an EBMT study","volume":"57","author":"Mohty","year":"2022","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.03.014_bib0013","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1182\/bloodadvances.2021005410","article-title":"Defibrotide: real-world management of veno-occlusive disease\/sinusoidal obstructive syndrome after stem cell transplant","volume":"6","author":"Nauffal","year":"2022","journal-title":"Blood Adv"},{"key":"10.1016\/j.jtct.2023.03.014_bib0014","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.bbmt.2014.09.026","article-title":"Jodele S. Veno-occlusive disease of the liver in the absence of elevation in bilirubin in pediatric patients after hematopoietic stem cell transplantation","volume":"21","author":"Myers","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.03.014_bib0015","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/bmt.2015.208","article-title":"Anicteric veno-occlusive disease after hematopoietic stem cell transplantation in children","volume":"51","author":"Naples","year":"2016","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.03.014_bib0016","first-page":"3599","volume":"92","author":"Carreras","year":"1998","journal-title":"Blood."},{"key":"10.1016\/j.jtct.2023.03.014_bib0017","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/j.bbmt.2020.03.005","article-title":"Hematopoietic stem cell transplant recipients surviving at least 2 years from transplant have survival rates approaching population levels in the modern era of transplantation","volume":"26","author":"Kliman","year":"2020","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.03.014_bib0018","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/pbc.20934","article-title":"Defibrotide for the treatment of hepatic veno-occlusive disease in children","volume":"48","author":"Bulley","year":"2007","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.jtct.2023.03.014_bib0019","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.bbmt.2004.01.002","article-title":"Prevention of veno-occlusive disease with defibrotide after allogeneic stem cell transplantation","volume":"10","author":"Chalandon","year":"2004","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.03.014_bib0020","first-page":"1122","article-title":"Defibrotide for the treatment of hepatic veno-occlusive disease: results of the European compassionate-use study","volume":"111","author":"Chopra","year":"2000","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtct.2023.03.014_bib0021","doi-asserted-by":"crossref","first-page":"S108","DOI":"10.1016\/j.bbmt.2014.11.135","article-title":"Defibrotide for the treatment of hepatic veno-occlusive disease: an update from the International Compassionate Use Program in 710 patients","volume":"21","author":"Corbacioglu","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.03.014_bib0022","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1586\/ehm.12.18","article-title":"Defibrotide for the treatment of heaptic veno-occlusive disease in children after hematopoietic stem cell transplantation","volume":"5","author":"Corbacioglu","year":"2012","journal-title":"Expert Rev Haematol"},{"key":"10.1016\/j.jtct.2023.03.014_bib0023","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/pbc.21425","article-title":"Defibrotide in the prevention and treatment of veno-occlusive disease in autologous and allogeneic stem cell transplantation in children","volume":"50","author":"Qureshi","year":"2008","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.jtct.2023.03.014_bib0024","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1182\/blood-2015-10-676924","article-title":"Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure","volume":"127","author":"Richardson","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.jtct.2023.03.014_bib0025","doi-asserted-by":"crossref","first-page":"S110","DOI":"10.1016\/j.bbmt.2014.11.138","article-title":"Defibrotide for the treatment of severe hepatic veno-occlusive disease: an analysis of clinical benefit as determined by number needed to treat (NNT) to achieve complete response and to improve survival","volume":"21","author":"Richardson","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.03.014_bib0026","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1016\/j.bbmt.2014.11.137","article-title":"Updated results from the ongoing US treatment IND study using defibrotide for patients with hepatic veno-occlusive disease","volume":"21","author":"Richardson","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.03.014_bib0027","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.transproceed.2007.01.075","article-title":"Treatment of sinusoidal obstruction syndrome with defibrotide: a single-center experience","volume":"39","author":"Sucak","year":"2007","journal-title":"Transplant Proc"},{"key":"10.1016\/j.jtct.2023.03.014_bib0028","first-page":"947","article-title":"Defibrotide for the treatment of sinusoidal obstruction syndrome: evaluation of response to therapy and patient outcomes","volume":"26","author":"Coutsouvelis","year":"2018","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.jtct.2023.03.014_bib0029","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1038\/s41409-021-01265-2","article-title":"A multicentre, multinational, prospective, observational registry study of defibrotide in patients diagnosed with veno-occlusive disease\/sinusoidal obstruction syndrome after haematopoietic cell transplantation: an EBMT study","volume":"56","author":"Mohty","year":"2021","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.03.014_bib0030","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.bbmt.2010.11.019","article-title":"Defibrotide prevents the activation of macrovascular and microvascular endothelia caused by soluble factors released to blood by autologous hematopoietic stem cell transplantation","volume":"17","author":"Palomo","year":"2011","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.03.014_bib0031","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vph.2013.05.001","article-title":"Defibrotide: properties and clinical use of an old\/new drug","volume":"59","author":"Pescador","year":"2013","journal-title":"Vascul Pharmacol"},{"key":"10.1016\/j.jtct.2023.03.014_bib0032","doi-asserted-by":"crossref","first-page":"e27036","DOI":"10.1002\/pbc.27036","article-title":"\"Pre-emptive strike\"\u2014the case for early treatment of hepatic sinusoidal obstruction syndrome with defibrotide","volume":"65","author":"Rajagopal","year":"2018","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.jtct.2023.03.014_bib0033","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(11)61938-7","article-title":"Defibrotide for prophylaxis of hepatic veno-occlusive disease in paediatric haemopoietic stem-cell transplantation: an open-label, phase 3, randomised controlled trial","volume":"379","author":"Corbacioglu","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.jtct.2023.03.014_bib0034","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/bmt.2017.161","article-title":"Diagnosis and severity criteria for sinusoidal obstruction syndrome\/veno-occlusive disease in pediatric patients: a new classification from the European Society for Blood and Marrow Transplantation","volume":"53","author":"Corbacioglu","year":"2018","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.03.014_bib0035","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1016\/j.bbmt.2018.06.013","article-title":"Risk score for the development of veno-occlusive disease after allogeneic hematopoietic cell transplant","volume":"24","author":"Strouse","year":"2018","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.03.014_bib0036","doi-asserted-by":"crossref","first-page":"e28","DOI":"10.1016\/S2352-3026(19)30157-7","volume":"7","author":"Beelen","year":"2020","journal-title":"Lancet Haematol"},{"key":"10.1016\/j.jtct.2023.03.014_bib0037","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1002\/cncr.30646","article-title":"Long-term outcome after a treosulfan-based conditioning regimen for patients with acute myeloid leukemia: a report from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation","volume":"123","author":"Nagler","year":"2017","journal-title":"Cancer"},{"key":"10.1016\/j.jtct.2023.03.014_bib0038","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ctrv.2016.09.014","article-title":"Defibrotide for the management of sinusoidal obstruction syndrome in patients who undergo haemopoietic stem cell transplantation","volume":"50","author":"Coutsouvelis","year":"2016","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.jtct.2023.03.014_bib0039","doi-asserted-by":"crossref","unstructured":"Gratwohl A. Cost-effectiveness of defibrotide for treatment of severe veno-occlusive disease: it is time for evidence based economic evaluations. J Med Econ. 2021;24:727-729.","DOI":"10.1080\/13696998.2021.1929259"}],"container-title":["Transplantation and Cellular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666636723011739?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666636723011739?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T03:10:57Z","timestamp":1763003457000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666636723011739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["S2666636723011739"],"URL":"https:\/\/doi.org\/10.1016\/j.jtct.2023.03.014","relation":{},"ISSN":["2666-6367"],"issn-type":[{"value":"2666-6367","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Incidence of Sinusoidal Obstruction Syndrome\/Veno-Occlusive Disease and Treatment with Defibrotide in Allogeneic Transplantation: A Multicenter Australasian Registry Study","name":"articletitle","label":"Article Title"},{"value":"Transplantation and Cellular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtct.2023.03.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}