{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T00:38:32Z","timestamp":1793752712388,"version":"4.6.1"},"reference-count":58,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplantation and Cellular Therapy"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.jtct.2023.05.006","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T02:12:44Z","timestamp":1683684764000},"page":"510.e1-510.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Acute Leukemia Relapse after Hematopoietic Stem Cell Transplantation: The Good, the Bad, and the Ugly of Isolated Extramedullary Relapse in a Latin American Population"],"prefix":"10.1016","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5983-6687","authenticated-orcid":false,"given":"Luis","family":"Arias-Espinosa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9414-9153","authenticated-orcid":false,"given":"Aldo A.","family":"Acosta-Medina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5108-4027","authenticated-orcid":false,"given":"Andres","family":"Vargas-Espa\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2734-0067","authenticated-orcid":false,"given":"Valerie","family":"Fuentes-Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9937-439X","authenticated-orcid":false,"given":"Perla R.","family":"Colunga-Pedraza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Angel","family":"Hawing-Zarate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres G\u00f3mez-De","family":"Leon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9173-7440","authenticated-orcid":false,"given":"Adrian","family":"Soto-Mota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Pacheco-Gutierrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar","family":"Vargas-Seraf\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Barrera-Lumbreras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6284-6269","authenticated-orcid":false,"given":"Christianne","family":"Bourlon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtct.2023.05.006_bib0001","doi-asserted-by":"crossref","unstructured":"Giralt S, Bishop MR. Principles and overview of allogeneic hematopoietic stem cell transplantation. In: Bishop MR, ed. Hematopoietic Stem Cell Transplantation. Cancer Treatment and Research. Boston, MA: Springer; 2009. https:\/\/doi.org\/10.1007\/978-0-387-78580-6_1","DOI":"10.1007\/978-0-387-78580-6_1"},{"key":"10.1016\/j.jtct.2023.05.006_bib0002","doi-asserted-by":"crossref","DOI":"10.4084\/mjhid.2014.065","article-title":"Role of allogeneic hematopoietic stem cell transplantation in adult patients with acute lymphoblastic leukemia","volume":"6","author":"Lussana","year":"2014","journal-title":"Mediterr J Hematol Infect Dis"},{"key":"10.1016\/j.jtct.2023.05.006_bib0003","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s12185-018-2412-8","article-title":"Hematopoietic stem cell transplantation for acute myeloid leukemia","volume":"107","author":"Takami","year":"2018","journal-title":"Int J Hematol"},{"key":"10.1016\/j.jtct.2023.05.006_bib0004","doi-asserted-by":"crossref","first-page":"e177","DOI":"10.1016\/j.bbmt.2020.04.013","article-title":"Current use of and trends in hematopoietic cell transplantation in the United States","volume":"26","author":"D'Souza","year":"2020","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.05.006_bib0005","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1200\/EDBK_280175","article-title":"Recent advances in managing acute lymphoblastic leukemia","volume":"40","author":"DeAngelo","year":"2020","journal-title":"Am Soc Clin Oncol Educ Book"},{"key":"10.1016\/j.jtct.2023.05.006_bib0006","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3324\/haematol.2015.139105","article-title":"Risk factors for relapse after allogeneic transplantation in acute myeloid leukemia","volume":"101","author":"Ossenkoppele","year":"2016","journal-title":"Haematologica"},{"key":"10.1016\/j.jtct.2023.05.006_bib0007","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.bbmt.2010.04.004","volume":"16","author":"Pavletic","year":"2010","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.05.006_bib0008","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.3324\/haematol.2019.223032","article-title":"The prevalence of extramedullary acute myeloid leukemia detected by 18FDG-PET\/CT: final results from the prospective PETAML trial","volume":"105","author":"St\u00f6lzel","year":"2020","journal-title":"Haematologica"},{"key":"10.1016\/j.jtct.2023.05.006_bib0009","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.bbmt.2017.03.023","article-title":"Isolated extramedullary relapse of acute leukemia after allogeneic stem cell transplantation: different kinetics and better prognosis than systemic relapse","volume":"23","author":"Shem-Tov","year":"2017","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.05.006_bib0010","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1182\/hematology.2019000005","article-title":"Clonal evolution and immune evasion in posttransplantation relapses","volume":"2019","author":"Vago","year":"2019","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.jtct.2023.05.006_bib0011","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.bbmt.2014.03.030","article-title":"Extramedullary relapse of acute leukemia after allogeneic hematopoietic stem cell transplantation: different characteristics between acute myelogenous leukemia and acute lymphoblastic leukemia","volume":"20","author":"Ge","year":"2014","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.05.006_bib0012","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3324\/haematol.2012.073189","article-title":"Extramedullary relapse of acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation: incidence, risk factors and outcomes","volume":"98","author":"Harris","year":"2013","journal-title":"Haematologica"},{"key":"10.1016\/j.jtct.2023.05.006_bib0013","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.bbmt.2011.05.023","article-title":"Extramedullary relapse of acute myelogenous leukemia after allogeneic hematopoietic stem cell transplantation: better prognosis than systemic relapse","volume":"18","author":"Solh","year":"2012","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.05.006_bib0014","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1590\/S1020-49892011000200004","article-title":"Leukemia mortality trends among children, adolescents, and young adults in Latin America","volume":"29","author":"Curado","year":"2011","journal-title":"Rev Panam Salud Publica"},{"key":"10.1016\/j.jtct.2023.05.006_bib0015","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.blre.2018.08.002","article-title":"The emerging story of acute lymphoblastic leukemia among the Latin American population\u2014biological and clinical implications","volume":"33","author":"Quiroz","year":"2019","journal-title":"Blood Rev"},{"key":"10.1016\/j.jtct.2023.05.006_bib0016","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1182\/blood-2016-06-721662","article-title":"The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127(20):2391\u20132405","volume":"128","author":"Arber","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.jtct.2023.05.006_bib0017","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.annonc.2020.02.018","article-title":"Acute myeloid leukaemia in adult patients: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"31","author":"Heuser","year":"2020","journal-title":"Ann Oncol"},{"issue":"suppl 5","key":"10.1016\/j.jtct.2023.05.006_bib0018","doi-asserted-by":"crossref","first-page":"v69","DOI":"10.1093\/annonc\/mdw025","article-title":"Acute lymphoblastic leukaemia in adult patients: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"27","author":"Hoelzer","year":"2016","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jtct.2023.05.006_bib0019","first-page":"39","article-title":"Isolated extramedullary relapse in acute lymphoblastic leukemia: What can we do before and after transplant?","volume":"34","author":"Riviello-Goya","year":"2020","journal-title":"Oncology (Williston Park)"},{"key":"10.1016\/j.jtct.2023.05.006_bib0020","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.leukres.2012.12.002","article-title":"Clinical characteristics and outcome of isolated extramedullary relapse in acute leukemia after allogeneic stem cell transplantation: a single-center analysis","volume":"37","author":"Shi","year":"2013","journal-title":"Leuk Res"},{"key":"10.1016\/j.jtct.2023.05.006_bib0021","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1182\/blood-2009-07-235358","article-title":"Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet","volume":"115","author":"D\u00f6hner","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jtct.2023.05.006_bib0022","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1056\/NEJMoa1516192","article-title":"Genomic classification and prognosis in acute myeloid leukemia","volume":"374","author":"Papaemmanuil","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jtct.2023.05.006_bib0023","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.4081\/hr.2012.e15","article-title":"B-cell acute lymphoblastic leukemia with t(4;11)(q21;q23) in a young woman: evolution into mixed phenotype acute leukemia with additional chromosomal aberrations in the course of therapy","volume":"4","author":"Carulli","year":"2012","journal-title":"Hematol Rep"},{"key":"10.1016\/j.jtct.2023.05.006_bib0024","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/j.bbmt.2009.07.004","article-title":"Defining the intensity of conditioning regimens: working definitions","volume":"15","author":"Bacigalupo","year":"2009","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.05.006_bib0025","doi-asserted-by":"crossref","first-page":"e157","DOI":"10.1016\/S2352-3026(19)30256-X","article-title":"Prophylaxis and management of graft-versus-host disease after stem-cell transplantation for hematological malignancies: updated consensus recommendations of the European Society for Blood and Marrow Transplantation","volume":"7","author":"Penack","year":"2020","journal-title":"Lancet Haematol"},{"key":"10.1016\/j.jtct.2023.05.006_bib0026","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1038\/s41409-018-0204-7","article-title":"EBMT-NIH-CIBMTR Task Force position statement on standardized terminology and guidance for graft-versus-host disease assessment","volume":"53","author":"Schoemans","year":"2018","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.05.006_bib0027","doi-asserted-by":"crossref","first-page":"7032","DOI":"10.1200\/JCO.2005.01.7269","article-title":"Outcome of ethnic minorities with acute or chronic leukemia treated with hematopoietic stem-cell transplantation in the United States","volume":"23","author":"Baker","year":"2005","journal-title":"J Clin Oncol"},{"issue":"7","key":"10.1016\/j.jtct.2023.05.006_bib0028","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1200\/GO.20.00600","article-title":"Contributions to the American Society of Hematology Meeting from low- and middle-income countries: an in-depth analysis and call to action","author":"G\u00f3mez-De Le\u00f3n","year":"2021","journal-title":"JCO Glob Oncol"},{"key":"10.1016\/j.jtct.2023.05.006_bib0029","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.jtct.2022.08.024","article-title":"Long-term results of allogeneic stem cell transplantation in adult pH- negative high-risk acute lymphoblastic leukemia","volume":"28","author":"Beelen","year":"2022","journal-title":"Transplant Cell Ther"},{"key":"10.1016\/j.jtct.2023.05.006_bib0030","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.bbmt.2006.09.005","article-title":"Treatment of relapsed acute leukemia after allogeneic transplantation: a single center experience","volume":"13","author":"Arellano","year":"2007","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.05.006_bib0031","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.bbmt.2014.11.007","article-title":"Survival of patients with acute myeloid leukemia relapsing after allogeneic hematopoietic cell transplantation: a Center for International Blood and Marrow Transplant Research study","volume":"21","author":"Bejanyan","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.05.006_bib0032","doi-asserted-by":"crossref","first-page":"e183","DOI":"10.1016\/j.clml.2018.02.012","article-title":"Risk factors influencing outcome of acute leukemia patients who experience relapse after allogeneic hematopoietic stem-cell transplantation","volume":"18","author":"El-Ghammaz","year":"2018","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"10.1016\/j.jtct.2023.05.006_bib0033","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/j.bbmt.2013.09.011","article-title":"Outcome and prognostic factors for patients who relapse after allogeneic hematopoietic stem cell transplantation","volume":"19","author":"Thanarajasingam","year":"2013","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.05.006_bib0034","doi-asserted-by":"crossref","first-page":"e15584","DOI":"10.1097\/MD.0000000000015584","article-title":"Extramedullary relapse of leukemia after allogeneic hematopoietic stem cell transplantation: a retrospective study","volume":"98","author":"Xie","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jtct.2023.05.006_bib0035","first-page":"7","article-title":"Cancer statistics, 2017","volume":"67","author":"Siegel","year":"2017","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jtct.2023.05.006_bib0036","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1200\/GO.20.00620","article-title":"Treating acute leukemia during the COVID-19 pandemic in an environment with limited resources: a multicenter experience in four Latin American countries","volume":"7","author":"Demichelis-G\u00f3mez","year":"2021","journal-title":"JCO Glob Oncol"},{"key":"10.1016\/j.jtct.2023.05.006_bib0037","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.clml.2016.09.003","article-title":"Acute leukemia characteristics are different around the world: the Mexican perspective","volume":"17","author":"G\u00f3mez-Almaguer","year":"2017","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"10.1016\/j.jtct.2023.05.006_bib0038","first-page":"379","article-title":"Patterns of leukemia incidence in the United States by subtype and demographic characteristics, 1997-2002","volume":"19","author":"Yamamoto","year":"2008","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.jtct.2023.05.006_bib0039","first-page":"9","article-title":"Epidemiolog\u00eda de las leucemias en Bolivia: 1473 casos enero 1999 a mayo de 2012","volume":"18","author":"Amaru","year":"2012","journal-title":"Rev M\u00e9d La Paz"},{"key":"10.1016\/j.jtct.2023.05.006_bib0040","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1182\/blood-2011-04-347872","article-title":"Acute leukemia incidence and patient survival among children and adults in the United States, 2001-2007","volume":"119","author":"Dores","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jtct.2023.05.006_bib0041","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1002\/cncr.30129","article-title":"Childhood leukemia incidence in California: high and rising in the Hispanic population","volume":"122","author":"Giddings","year":"2016","journal-title":"Cancer"},{"key":"10.1016\/j.jtct.2023.05.006_bib0042","first-page":"167","article-title":"[Acute leukemia frequency observed in a reference hospital]","volume":"50","author":"Gonz\u00e1lez-Salas","year":"2012","journal-title":"Rev Med Inst Mex Seguro Soc"},{"key":"10.1016\/j.jtct.2023.05.006_bib0043","unstructured":"Auletta JJ, Kou J, Chen M, Shaw BE. Current use and outcome of hematopoietic stem cell transplantation: CIBMTR US summary slides, 2021. Available at: https:\/\/cibmtr.org\/CIBMTR\/Resources\/Summary-Slides-Reports. Accessed May 29, 2023."},{"key":"10.1016\/j.jtct.2023.05.006_bib0044","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1038\/s41409-021-01227-8","article-title":"Hematopoietic cell transplantation and cellular therapy survey of the EBMT: monitoring of activities and trends over 30 years","volume":"56","author":"Passweg","year":"2021","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.05.006_bib0045","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1056\/NEJMsa1311707","article-title":"HLA match likelihoods for hematopoietic stem-cell grafts in the US registry","volume":"371","author":"Gragert","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jtct.2023.05.006_bib0046","doi-asserted-by":"crossref","first-page":"903","DOI":"10.3390\/curroncol28010089","article-title":"Total body irradiation for hematopoietic stem cell transplantation: what can we agree on?","volume":"28","author":"Sabloff","year":"2021","journal-title":"Curr Oncol"},{"key":"10.1016\/j.jtct.2023.05.006_bib0047","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.bbmt.2017.12.784","article-title":"Pretransplant consolidation is not beneficial for adults with ALL undergoing myeloablative allogeneic transplantation","volume":"24","author":"Bejanyan","year":"2018","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.05.006_bib0048","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.bbmt.2010.12.703","article-title":"The outcomes of family haploidentical hematopoietic stem cell transplantation in hematologic malignancies are not associated with patient age","volume":"17","author":"Dong","year":"2011","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.05.006_bib0049","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.bbmt.2017.11.025","article-title":"Intravenous busulfan compared with total body irradiation pretransplant conditioning for adults with acute lymphoblastic leukemia","volume":"24","author":"Kebriaei","year":"2018","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.05.006_bib0050","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1182\/bloodadvances.2021004881","article-title":"Risk classification at diagnosis predicts post-HCT outcomes in intermediate-, adverse-risk, and KMT2A-rearranged AML","volume":"6","author":"Menghrajani","year":"2022","journal-title":"Blood Adv"},{"key":"10.1016\/j.jtct.2023.05.006_bib0051","doi-asserted-by":"crossref","first-page":"860","DOI":"10.3324\/haematol.2010.025890","article-title":"Extramedullary relapses after allogeneic stem cell transplantation for acute myeloid leukemia and myelodysplastic syndrome","volume":"95","author":"Clark","year":"2010","journal-title":"Haematologica"},{"key":"10.1016\/j.jtct.2023.05.006_bib0052","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1182\/blood.V84.11.3603.bloodjournal84113603","article-title":"Leukemia relapse after allogeneic bone marrow transplantation: a review","volume":"84","author":"Giralt","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.jtct.2023.05.006_bib0053","doi-asserted-by":"crossref","first-page":"4371","DOI":"10.1182\/blood-2008-03-077974","article-title":"Graft-versus-leukemia effects of transplantation and donor lymphocytes","volume":"112","author":"Kolb","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jtct.2023.05.006_bib0054","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/sj.bmt.1701319","article-title":"High incidence of extramedullary relapse of AML after busulfan\/cyclophosphamide conditioning and allogeneic stem cell transplantation","volume":"22","author":"Simpson","year":"1998","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jtct.2023.05.006_bib0055","doi-asserted-by":"crossref","unstructured":"Shimoni A. Relapse of acute leukemia after a second allogeneic stem cell transplantation; is there any hope for cure? Bone Marrow Transplant. 2022;57:336\u2013337. https:\/\/doi.org\/10.1038\/s41409-021-01508-2","DOI":"10.1038\/s41409-021-01508-2"},{"key":"10.1016\/j.jtct.2023.05.006_bib0056","first-page":"35:e14199","article-title":"Second allogeneic hematopoietic stem cell transplantation in patients with acute leukemia relapsed after allogeneic hematopoietic stem cell transplantation","author":"Choi","year":"2021","journal-title":"Clin Transplant"},{"key":"10.1016\/j.jtct.2023.05.006_bib0057","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s12253-012-9535-7","article-title":"Second allogeneic transplantation for relapsed acute leukemia after initial allogeneic hematopoietic stem cell transplantation","volume":"18","author":"Hanajiri","year":"2012","journal-title":"Pathol Oncol Res"},{"key":"10.1016\/j.jtct.2023.05.006_bib0058","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/j.bbmt.2014.08.023","article-title":"Extramedullary relapse of acute leukemia after haploidentical hematopoietic stem cell transplantation: incidence, risk factors, treatment, and clinical outcomes","volume":"20","author":"Mo","year":"2014","journal-title":"Biol Blood Marrow Transplant"}],"container-title":["Transplantation and Cellular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666636723012903?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666636723012903?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T03:10:56Z","timestamp":1763003456000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666636723012903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":58,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S2666636723012903"],"URL":"https:\/\/doi.org\/10.1016\/j.jtct.2023.05.006","relation":{},"ISSN":["2666-6367"],"issn-type":[{"value":"2666-6367","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute Leukemia Relapse after Hematopoietic Stem Cell Transplantation: The Good, the Bad, and the Ugly of Isolated Extramedullary Relapse in a Latin American Population","name":"articletitle","label":"Article Title"},{"value":"Transplantation and Cellular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtct.2023.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}